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, and REALTIME READY are trademarks of Roche. Exiqon, LNA, ProbeFinder and ProbeLibrary are registered trademarks of Exiqon A/S, Vedbaek, Denmark. Other brands or product names are trademarks of their respective...
. ProbeLibrary is covered by US and other patent applications owned by Exiqon A/S. Locked Nucleic Acids (LNA) are covered by U.S. Patents No US 6,794,499 (exp. 9/11/2018), US 6,670,461 (exp. 9/11/2018), US 6...
RNA silencing is a mechanism of gene regulation whereby small double-stranded RNAs (dsRNAs) of 21-18 nucleotides in length cause mRNA degradation, mRNA translation, or chromatin modification. In the past years, more than 500 novel genes have been identified in animals and plants encoding small transcripts that can form small dsRNA hairpin structures. From these hairpin precursors, small 22-nt RNAs - so called microRNAs (miRNA) - are excised by dsRNA-specific endonucleases. The miRNAs are then integrated in ribonucleoprotein particles (RNPs). Most miRNAs in animals act by binding to partially complementary regions of the 3' untranslated region of their target mRNA, thereby blocking translation....