Topic validation

Companies validation

CANDOR Bioscience GmbH, Germany

CANDOR - The ELISA Experts Stabilizers and Optimizers for Immunoassays CANDOR Bioscience GmbH offers buffer and solutions for optimising and stabilising immunoassays. For reliable results. • LowCross-Buffer® - Optimizer developed to minimise interference such as non-specific binding, cross react more

Products validation

Safety beyond the visible: Merck Millipore BioMonitoring

BioMonitoring is about innovative testing solutions, regulatory expertise, comprehensive service, and trust more

Complete traceability and excellent reliability of your measurement results

Regular calibrations of spectrophotometers are vitally important for securing measurement results. With UV/Vis calibration standards from an accredited DKD more

News validation

• Affimed enrolls first patients in Phase I Hodgkin's Lymphoma Study

  Affimed Therapeutics AG announced that the first patients with Hodgkin's Lymphoma have been treated with the AFM13 TandAb® antibody in a Phase I clinical study. The Phase I repeat dose escalation study will enroll approximately 40 Hodgkin's Lymphoma patients across two centers in Europe and the US. more

• Singapore Launches Infrastructure for Metrology in Chemistry (MiC)

  The National Metrology Centre (NMC) of the Agency for Science, Technology and Research (A*STAR) and the Health Sciences Authority (HSA) have jointly set up a national Metrology in Chemistry (MiC) infrastructure. Senior Minister of State for Trade and Industry and Education, Mr S. Iswaran announced t more

• Dako and Quintiles form alliance to speed development of personalized medicine

  Dako and Quintiles announced a strategic alliance to advance personalized medicine by collaborating on the co-development of targeted therapies and companion diagnostics. Under the non-exclusive alliance, Dako and Quintiles will offer integrated drug-diagnostic development services and companion dia more

White papers validation

• Characterizing Biotherapeutics with HPLC
  

  As demonstrated here, there are a broad range of HPLC applications used in development, production, validation and release of protein therapeutics for human use. Some of the applications mentioned above are mandatory when submitting a new biopharmaceutical to approval at the regulatory agencies. The introduction of the first so-called biosimilars in Europe further increased the demand for highly efficient analysis methods. The continuous development of new stationary phases for the common modes of biochromatography, such as size exclusion, ion exchange and hydrophilic interaction chromatography support biochemists in increasing lab productivity and establishing high-throughput HPLC analysis not only for small molecules but also for large biopolymers more

• Array Capture-mediated Resequencing Leads to the Discovery of Four Novel Mutations in the Mouse
  

  By using array-based sequence capture and pyrosequencing to sequence an allelic series from the classically defined Kit locus (~200 kb) from each of five noncomplementing Kit mutants (one known allele and four unknown alleles), D'Ascenzo and co-workers discovered and validated a nonsynonymous coding mutation for each allele. These data represent the first documentation and confirmation of the fact that the new technologies can be used to efficiently discover causative mutations. Importantly, these results also provide the framework for constructing the efficient detection of causative mutations in mutant mouse strains moving forward. The standards presented here, coupled with the latest sequence capture methods (e.g., whole-exome arrays or solution-based methods) and next-generation sequencing technologies, promise to signicantly close the gap between phenotype and genotype in the mouse more

• Acquired Copy Number Alterations in Adult Acute Myeloid Leukemia Genomes
  

  To complement cytogenetic studies and to identify genes altered in AML genomes, Walter and co-workers performed a genome-wide copy number analysis with paired normal and tumor DNA obtained from 86 adult subjects with de novo AML using 1.85 million feature SNP arrays. A total of 201 somatic CNAs were found in the 86 AML genomes (mean, 2.34 CNAs per genome), with FAB-System M6 and M7 genomes containing the most changes (10-29 CNAs per genome). According to the authors' conclusions, the use of an unbiased high-resolution genomic screen identified many genes not previously implicated in AML that may be relevant for pathogenesis, along with many known oncogenes and tumor suppressor genes. Despite the ability of next-generation sequencing platforms to accurately identify amplifications, deletions, and translocations, a multiplatform approach (traditional cytogenetics, FISH, SNP array, array CGH, and targeted gene resequencing) will continue to be the most practical approach to studying AML genomes at most institut more

Publications validation

• Development and validation of a highly sensitive method for the determination of abiraterone in rat and human plasma by LC‐MS/MS‐ESI: application to a pharmacokinetic study

  ABSTRACT A highly sensitive, rapid assay method has been developed and validated for the estimation of abiraterone (ART) in rat and human plasma with liquid chromatography coupled to tandem mass spectrometry and electrospray ionization in the positive‐ion mode. The assay procedure involves extrac more

• The self‐report Barthel Index: preliminary validation in people with Parkinson’s disease

  Background and purpose:  To make a preliminary assessment of the reliability and validity of the self‐report Barthel Index (SRBI) in people with Parkinson’s (PWP) disease. Methods:  Thirty‐nine PWP completed the SRBI, the self‐report Schwab & England (S & E) scale and the PDQ‐39. Standard stati more

• MageComet—web application for harmonizing existing large-scale experiment descriptions

  Motivation: Meta-analysis of large gene expression datasets obtained from public repositories requires consistently annotated data. Curation of such experiments, however, is an expert activity which involves repetitive manipulation of text. Existing tools for automated curation are few, which bottl more

Market studies validation

• Miraculins Inc. - Strategic SWOT Analysis Review

  Miraculins Inc (Miraculins) is a research and development company engaged in the discovery and validation of cancer biomarkers, which enable the development of diagnostic tools and therapeutic products. The company focuses on biomarker discovery using its proprietary B.E.S.T Platform for the screeni more

• Arvind Remedies Ltd (531823) - Financial and Strategic SWOT Analysis Review

  Arvind Remedies Ltd (Arvind Remedies) is a publicly held pharmaceutical company. It is engaged in manufacturing and marketing of allopathic and ayurvedic pharmaceutical products. The company's main focus areas are development of drug delivery systems, new formulations and process development of vari more

• GE Measurement & Control Solutions - Strategic SWOT Analysis Review

  GE Measurement & Control Solutions is a technology instruments company, engaged in the design, manufacture and sale of the advanced sensing and measurement solutions. The company develops products such as sensing elements, devices, instruments, and systems which are utilized in monitor, protect, con more

Websites validation