Ubiquitin

Companies Ubiquitin

Biomol GmbH, Germany

Biomol GmbH offers antibodies, enzymes, bioactive lipids, microarrays and reagents for biomedical research. Our focus is on cellular regulation and signal transduction. Together with our partners, we also provide a variety of specialized kits for drug discovery. more

News Ubiquitin

• Protein improves efficacy of tumor-killing enzyme

  Scientists have devised a method for delivering tumor cell-killing enzymes in a way that protects the enzyme until it can do its work inside the cell. In their study in mBio®, researchers assembled microscopic protein packages that can deliver an enzyme called PEIII to the insides of cells. By attac more

• Researchers identify a molecular switch that controls neuronal migration in the developing brain

  St. Jude Children's Research Hospital investigators have identified key components of a signaling pathway that controls the departure of neurons from the brain niche where they form and allows these cells to start migrating to their final destination. Defects in this system affect the architecture o more

• New insight into Parkinson's disease

  New research provides crucial insight into the pathogenic mechanisms of Parkinson's disease (PD), a prevalent neurodegenerative disorder. The study appears in the Journal of Cell Biology. The identification of inherited mutations in genes such as Parkin and PINK1 ( PTEN-induced putative kinase 1 ) more

White papers Ubiquitin

• Transfection of Human Tooth-Specific Lineage Cells with FuGENE® HD Transfection Reagent
  

  Similar to other epithelial appendages, teeth form through reciprocal signaling interactions between the ectodermally derived dental epithelium and the mesenchyme. These signaling interactions program enamel matrix-secreting ameloblasts and dentin-forming odontoblasts. To study the signaling network involved in odontogenesis, we co-cultured primary human fetal dental epithelial cells and dental pulp cells to reconstitute the reciprocal signaling. more

Publications Ubiquitin

• AF-6 is a positive modulator of the PINK1/parkin pathway and is deficient in Parkinson's disease

  Parkin E3 ubiquitin-ligase activity and its role in mitochondria homeostasis are thought to play a role in Parkinson's disease (PD). We now report that AF-6 is a novel parkin interacting protein that modulates parkin ubiquitin-ligase activity and mitochondrial roles. Parkin interacts with the AF-6 more

• NEDD9 Depletion Destabilizes Aurora A Kinase and Heightens the Efficacy of Aurora A Inhibitors: Implications for Treatment of Metastatic Solid Tumors

  Aurora A kinase (AURKA) is overexpressed in 96% of human cancers and is considered an independent marker of poor prognosis. While the majority of tumors have elevated levels of AURKA protein, few have AURKA gene amplification, implying that posttranscriptional mechanisms regulating AURKA protein lev more

• Molecular Basis of NF-κB Signaling

  NF-κB (nuclear factor kappa B) family transcription factors are master regulators of immune and inflammatory processes in response to both injury and infection. In the latent state, NF-κBs are sequestered in the cytosol by their inhibitor IκB (inhibitor of NF-κB) proteins. Upon stimulations of innat more

Market studies Ubiquitin

• Hybrigenics S.A. (ALHYG) - Financial and Strategic SWOT Analysis Review

  Hybrigenics S.A. (ALHYG) - Financial and Strategic SWOT Analysis Review Summary Hybrigenics S.A. (Hybrigenics) is a France-based bio-pharmaceutical company engaged in discovery and development of therapies for the treatment of cancer and commercialization of its technology and bioinformatics platf more

Websites Ubiquitin