Transgenic Mice

News Transgenic Mice

• Crescendo announces the Crescendo Mouse

  Crescendo Biologics Limited announces the Crescendo Mouse, an antibody fragment technology which allows the generation of human single domain antibody VH fragments from a transgenic mouse. VH fragments are antibody-based therapeutic proteins that have applications beyond the scope of full length ant more

• Peripheral Induction of Alzheimer-Like Brain Pathology in Mice

  Pathological protein deposits linked to Alzheimer's disease and cerebral amyloid angiopathy can be triggered not only by the administration of pathogenic misfolded protein fragments directly into the brain but also by peripheral administration outside the brain. This is shown in a new study done by more

• Jasmine as valium substitute: researchers discover unexpected effect of scents

  Instead of a sleeping pill or a mood enhancer, a nose full of jasmine from Gardenia jasminoides could also help: in collaboration with Dr. Olga Sergeeva and Prof. Helmut Hass from the Heinrich Heine University in Düsseldorf, researchers from Bochum led by Prof. Dr. Dr. Dr. Hanns Hatt have discovered more

Publications Transgenic Mice

• Modifying expression of EphA4 and its downstream targets improves functional recovery after stroke

  Functional recovery after stroke varies greatly between patients, potentially due to differences in gene expression. Several processes like angiogenesis, neurogenesis, axonal reorganization and synaptic plasticity act in concert to restore neurological functions. The ephrin family has known roles i more

• Analysis of the effect of estrogen/androgen perturbation on penile development in transgenic and diethylstilbestrol‐Treated mice

  ABSTRACT Because both androgens and estrogens have been implicated in penile morphogenesis, we evaluated penile morphology in transgenic mice with known imbalance of androgen and estrogen signaling using scanning electron microscopy (SEM), histology, and immunohistochemistry of androgen and estr more

• Evidence for miR‐181 involvement in neuroinflammatory responses of astrocytes

  Inflammation is a common component of acute injuries of the central nervous system (CNS) such as ischemia, and degenerative disorders such as Alzheimer's disease. Glial cells play important roles in local CNS inflammation, and an understanding of the roles for microRNAs in glial reactivity in inju more

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