Toxicity

Products Toxicity

A flexible Single Tube Luminometer of Highest Sensitivity

The new developed Sirius L Tube Luminometer allows high quality luminescence measurements with state-of-the-art technique more

News Toxicity

• Nanoparticles for remote-controlled drug delivery

  Scientists from Singapore report the development of a nanoparticle-based drug delivery vehicle that is capable of releasing drugs upon external stimuli. They have made amphiphilic polymer coated gold nanoparticles which self-assemble into vesicles. The hydrophobic polymer on the gold nanoparticle su more

• UF medicinal chemists modify sea bacteria byproduct for use as potential cancer drug

  University of Florida researchers have modified a toxic chemical produced by tiny marine microbes and successfully deployed it against laboratory models of colon cancer.Writing in ACS Medicinal Chemistry Letters, UF medicinal chemists describe how they took a generally lethal byproduct of marine cya more

• CIT joins EUR 10 million R&D project funded by EU and European cosmetic industry

  CIT, a European non-clinical CRO, announced it will be joining with other partners in a five-year joint research and development project to address the unmet need for test methods for predicting toxicity of drugs, chemicals and cosmetic ingredients. The project is called ScreenTox (Stem Cells for Re more

White papers Toxicity

• Altered Expression of Broad Range of Protease Genes in SH-SY5Y Neuroblastoma Cells after Bortezomib Exposure
  

  Neuroblastoma cell lines can be models for the responsiveness of neuroblastomas to chemotherapy-induced cell death as well as for the sensitivity of untransformed neuro-nal cells to toxic side-effects of chemotherapy. Both phenom-ena are relevant to neuroblastoma cells exposed to bortezomib, a proteasome inhibitor in clinical use. It has been shown previously that neuroblastoma cell lines are prone to undergo apoptosis when treated with bortezomib, but the precise molecular mechanism has not been revealed. In addition to this, peripheral neuropathy is the main side effect of chemotherapy that includes bortezomib more

• Efficient Transfection of Neuroblastoma Cell Lines Using FuGENE® HD Transfection Reagent
  

  Efficient transfection of cells is a prerequisite for genetic manipulation. However, many cell lines remain hard to transfect with established protocols, hampering consecutive analysis. Here, we compare three different methods (FuGENE® HD Transfection Reagent, transfection reagent L, and calcium phosphate) for the transfection of neuroblastoma cell lines. We show that FuGENE® HD Transfection Reagent is able to transfect all of these cell lines with high efficiency for further analysis. more

• Optimization of Transfection Efficiency in Chick Embryo Hepatocytes and HepG2 Cells
  

  Cell and molecular biology studies have been facilitated by transfection, a technology that can deliver material like DNA, RNA, and protein into cells. However, there are multiple reagents on the market, and a careful study must be perform­ed in order to find a suitable technique for your particular cellular system. One of the most effective re-agents that was available on the market in the early 90's was DOTMA (N-[1-(2,3-dioleyloxy)propyl]-N,N,N-tri-methylammonium chloride). more

Publications Toxicity

• Editors' Choice

  Biomedicine: The Benefits of Sequestration | Education: Motivation + Skill = Success | Animal Behavior: A Social Shake-up by Song | Chemistry: Brushing Away Toxicity | Chemistry: Mimicking Rodlike Viruses | Biomedicine: Peptide Prevention | Biochemistry: Attacked by Radicals more

• Fluorescent non-porous silica nanoparticles for long term cell monitoring: cytotoxicity and particle functionality

  Publication date: Available online 9 May 2013 Source:Acta Biomaterialia Author(s): Stefaan J. Soenen , Bella Manshian , Shareen H. Doak , Stefaan C. De Smedt , Kevin Braeckmans Inorganic nanoparticles such as silica particles offer many exciting possibilities for biomedical applications. more

• Synthesis, anti‐MRSA and anti‐VRE activity of hemin conjugates with amino acids and branched peptides

  Abstract The increasing prevalence of antibiotic‐resistant bacterial strains has necessitated the synthesis of novel antibacterial agents. It was previously shown that naturally occurring metalloporphyrin hemin possesses dark antibacterial activity against Gram‐positive bacteria. To improve hemi more

Market studies Toxicity

• Accelerating Drugs to Market - Despite Challenges, Adaptive Clinical Trials Reduce Drug Development Costs and Time to Market

  GBI Research’s new report, “Accelerating Drugs to Market - Despite Challenges, Adaptive Clinical Trials Reduce Drug Development Costs and Time to Market”, presents various tools and strategies which can accelerate a drug to the market. In this report, GBI Research has studied various hurdles at diff more

• Epigenetics R&D Pipeline - Histone Deacetylases (HDACs) Offer the Most Promising Targets and Outnumber Other Classes of Epigenetic Targets

  GBI Research, a leading business intelligence provider, has released its latest research, entitled “Epigenetics R&D Pipeline - Histone Deacetylases (HDACs) Offer the Most Promising Targets and Outnumber Other Classes of Epigenetic Targets”. The report is built using data and information sourced from more

• Pharmaceutical Pricing and Reimbursement in Oncology - Payer Pressure to Justify Premium Pricing of Novel Agents, Pushing Companies to Risk-Sharing Modalities

  GBI Research, leading business intelligence provider, has released its latest research report, entitled “Pharmaceutical Pricing and Reimbursement in Oncology - Payer Pressure to Justify Premium Pricing of Novel Agents, Pushing Companies to Risk-Sharing Modalities”. It provides a comprehensive overvi more

Websites Toxicity