T Cells

News T Cells

• Exposed region is indispensable

  A team headed by Prof. Dr. Wolfgang Schamel from the Institute of Biology III of the University of Freiburg and Prof. Dr. Balbino Alarcón from the Center for Molecular Biology Severo Ochoa of the Autonomous University of Madrid has succeeded in explaining an important step in the activation of the s more

• VAXIMM receives grant to expand pipeline of oral cancer vaccines

  VAXIMM AG announced that its German subsidiary VAXIMM GmbH has been awarded a grant from the BioRN cluster “Cell-based and Molecular Medicine” to expand its oral T-cell vaccine technology platform. The cluster competition is a program of Germany´s Federal Ministry of Education and Research (BMBF) to more

• How to rescue the immune system

  In a study published in Nature Medicine, Loyola researchers report on a promising new technique that potentially could turn immune system killer T cells into more effective weapons against infections and possibly cancer.The technique involves delivering DNA into the immune system's instructor cells. more

White papers T Cells

• Optimization of Transfection Efficiency in Chick Embryo Hepatocytes and HepG2 Cells
  

  Cell and molecular biology studies have been facilitated by transfection, a technology that can deliver material like DNA, RNA, and protein into cells. However, there are multiple reagents on the market, and a careful study must be perform­ed in order to find a suitable technique for your particular cellular system. One of the most effective re-agents that was available on the market in the early 90's was DOTMA (N-[1-(2,3-dioleyloxy)propyl]-N,N,N-tri-methylammonium chloride). more

• Optimization of Transfection Conditions for the Human HL-60 Promyelocytic Leukemic T-Cell Line Using FuGENE® HD Transfection Reagent
  

  Transfection is commonly performed to introduce many different types of molecules (plasmid DNA, RNA, siRNA, miRNA) into eukaryotic cell lines. Once inside, these molecules can be expressed in a transient or a stable fashion. In the case of transient transfection, molecules do not integrate into the host cell genome and are only expressed for approximately 24 hours - 96 hours post-transfection. more

• Superiority of FuGENE® HD Transfection Reagent in Minimizing Non-Specific Cellular Interferon Responses
  

  Many viruses, including human cytomegalovirus (HCMV), encode for genes that can modulate or interfere with the ability of cells to mount an effective antiviral response to infection. Transfection of viral genes into cultures of mammalian cells is an important research tool to evaluate the function of viral gene products. We utilized this approach to identify viral genes involved in modulation of interferon (IFN)-mediated cell signaling pathways. more

Publications T Cells

• Polymorphisms in the F8 Gene and MHC-II Variants as Risk Factors for the Development of Inhibitory Anti-Factor VIII Antibodies during the Treatment of Hemophilia A: A Computati ...

  by Gouri Shankar Pandey, Chen Yanover, Tom E. Howard, Zuben E. Sauna The development of neutralizing anti-drug-antibodies to the Factor VIII protein-therapeutic is currently the most significant impediment to the effective management of hemophilia A. Common non-synonymous single nucleotide polymo more

• Efficacy and Mechanism-of-Action of a Novel Superagonist Interleukin-15: Interleukin-15 Receptor {alpha}Su/Fc Fusion Complex in Syngeneic Murine Models of Multiple Myeloma

  ALT-803, a complex of an interleukin (IL)-15 superagonist mutant and a dimeric IL-15 receptor αSu/Fc fusion protein, was found to exhibit significantly stronger in vivo biologic activity on NK and T cells than IL-15. In this study, we show that a single dose of ALT-803, but not IL-15 alone, eliminat more

• Lipid phosphatases identified by screening a mouse phosphatase shRNA library regulate T-cell differentiation and Protein kinase B AKT signaling [Immunology]

  Screening a complete mouse phosphatase lentiviral shRNA library using high-throughput sequencing revealed several phosphatases that regulate CD4 T-cell differentiation. We concentrated on two lipid phosphatases, the myotubularin-related protein (MTMR)9 and -7. Silencing MTMR9 by shRNA or siRNA resul more

Market studies T Cells

• Angioimmunoblastic T-Cell Lymphoma (AILT)/Immunoblastic Lymphadenopathy Global Clinical Trials Review, H1, 2012

  Introduction GlobalData's clinical trial report, “Angioimmunoblastic T-Cell Lymphoma (AILT)/Immunoblastic Lymphadenopathy Global Clinical Trials Review, H1, 2012" provides data on the Angioimmunoblastic T-Cell Lymphoma (AILT)/Immunoblastic Lymphadenopathy Global Clinical Trials Review, H1, 2012 cli more

• Angioimmunoblastic T-Cell Lymphoma (AILT)/Immunoblastic Lymphadenopathy – Pipeline Review, H2 2012

  Introduction Global Markets Direct’s, 'Angioimmunoblastic T-Cell Lymphoma (AILT)/Immunoblastic Lymphadenopathy - Pipeline Review, H2 2012', provides an overview of the Angioimmunoblastic T-Cell Lymphoma (AILT)/Immunoblastic Lymphadenopathy therapeutic pipeline. This report provides information on more

• T-Cell Leukemia – Pipeline Review, H2 2012

  Introduction Global Markets Direct’s, 'T-Cell Leukemia - Pipeline Review, H2 2012', provides an overview of the T-Cell Leukemia therapeutic pipeline. This report provides information on the therapeutic development for T-Cell Leukemia, complete with latest updates, and special features on late-stag more

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