Synthesis

Products Synthesis

Focused Microwave Synthesis with CEM Systems

The Discover line of microwave synthesis systems is built upon CEM's Focused™ Microwave Technology designed to automatically focus microwave energy with maximum efficiency to the reaction more

Liberty Microwave-Enhanced Peptide Synthesis

Microwave peptide synthesis is a well-accepted technology that has been cited in over 300 publications. Microwave energy offers benefits for both the coupling and deprotection reactions during peptide synthesis more

GFD® FilterBox for easy and safe high containment lab filtration and drying

PSL’s GFD FilterBox is an acrylic glove box surrounding a Glass Filter Dryer, a miniature version of a production filter dryer with highly contained handling more

Videos Synthesis

Focused Microwave Synthesis with CEM Systems

Single-mode cavity design At the heart of the new Discover System resides the technology which makes it so unique. The patented circular single-mode cavity design directs the microwave energy into a defined area, resulting in a homogenous field pattern surrounding the sample. "Focusing" the microwav more

The smallest automated microwave synthesizer commercially available

The Explorer-12 Hybrid combines the best of automation with all of the flexibility associated with the Discover Focused Microwave Synthesis System. Perform reactions at reflux, add gaseous reagents, or set up a series of reactions to run overnight. All of the accessories commonly available on the Di more

Liberty Microwave-Enhanced Peptide Synthesis

Over the past several years, chemists have been using microwave energy to conduct a multitude of organic reactions with transformations taking place in a matter of minutes compared to hours with traditional methods. Now for the first time, microwave synthesis has been applied to the complete proces more

News Synthesis

• Evotec and Harvard University to collaborate on development of new class of antibacterials

  Evotec AG announced a research collaboration with Harvard University aimed at discovering and developing novel anti-bacterial agents based on a highly validated target family involved in bacterial cell wall biosynthesis. Under the Agreement, researchers at Harvard and Evotec will collaboratively ide more

• Skin-deep communication: Messenger substance and signaling molecule influence the development of the skin’s immune cells

  A signalling molecule known as Axl has been discovered on immune cells of the epidermis. This recently published finding provides new insight into the development of important skin immune cells known as Langerhans cells. These cells fight off invading microorganisms and play a crucial role in our he more

• Awards from the Bayer Science & Education Foundation

  The winners of the Bayer Early Excellence in Science Award 2012 have been announced. The prizes, each worth EUR 10,000, have been awarded by an independent scientific committee of the Bayer Science & Education Foundation. The Bayer foundation presents for the fourth time the Bayer Early Excellence i more

White papers Synthesis

• Aphidicolin-Mediated Replication Stress Induces Submicroscopic Tumor-Like Deletions in FHIT/FRA3B
  

  Common fragile sites (CFSs) are loci that are particularly susceptible to forming gaps and breaks on metaphase chromosomes after partial inhibition of DNA synthesis, for example induced by aphidicolin (APH). FRA3B, a fragile site lying within the FHIT tumor suppressor gene, is a site of frequent heterozygous and homozygous deletions in cancer cells and precancerous lesions. Most FHIT and other CFS-associated gene rearrangements in tumors are deletions of hundreds of kilobases often resulting in the inactivation of associated genes. However, there has been no direct evidence showing that CFS instability or replication stress can induce submicroscopic deletions like the ones found in cancer cells. Durkin et al. produced FHIT/FRA3B deletions similar to those in tumor cells by inducing replication stress in human-mouse chromosome 3 somatic hybrid cells with APH. more

• Quantification of Zea mays mRNAs by Real-Time PCR Using the Universal ProbeLibrary
  

  The Universal ProbeLibrary (UPL) is a detection system for real-time PCR based on locked nucleic acid (LNA) probes. We tested the efficiency of the UPL for the quantification of maize transcripts on two detection platforms. The results indicate that the UPL is an attractive alternative to assays based on intercalating dyes or conventional probes. more

• qPCR Identification of Genes Involved in Apoptosis and Cell Cycle Regulation
  

  Systematic high-throughput functional genomic screens with the targeted silencing of genes by the introduction of small interfering RNA (siRNA) have emerged as an extremely powerful tool for analysis of biological functions. Such screens commonly result in a huge amount of "hits", genes that potentially play a role in the specific biological function being investigated. However, it proves difficult to distinguish true- from false-positive hits and to carefully assess the mechanisms by which the genes act in the analyzed conditions. Many of these assays employ, as a phenotypic/functional readout, changes in apoptosis or cell cycle. However, a change in these key cellular processes can be induced by a wide range of different pathways. To obtain a deeper understanding of how a gene knockdown leads to changes in apoptosis or cell cycle, an analysis of the expression of other genes involved in these processes is very useful, as this may elucidate the involved pathways and identify functional gene networks. more

Events Synthesis

• 12th International Conference on the Chemistry of Selenium and Tellurium

  ICCST is a well-established conference dealing with all aspects of the chemistry involving selenium and tellurium. more

• Sample Preparation and Particle Sizing
  

  Take the advantage and learn more about the theoretical foundations and instrumental possibilities of sample preparation and particle size determination. Contents of the workshop Sample preparation via size-reduction and dividing - Introduction to sample preparation - presentation of various grindi more

• Sample Preparation and Particle Sizing
  

  Take the advantage and learn more about the theoretical foundations and instrumental possibilities of sample preparation and particle size determination. Contents of the workshop Sample preparation via size-reduction and dividing - Introduction to sample preparation - presentation of various grindi more

Publications Synthesis

• Splicing kinetics and transcript release from the chromatin compartment limit the rate of Lipid A-induced gene expression [ARTICLES]

  The expression of eukaryotic mRNAs is achieved though an intricate series of molecular processes that provide many steps for regulating the production of a final gene product. However, the relationships between individual steps in mRNA biosynthesis and the rates at which they occur are poorly under more

• The cytochrome b p.278Y>C mutation causative of a multisystem disorder enhances superoxide production and alters supramolecular interactions of respiratory chain complexes

  Cytochrome b is the only mtDNA-encoded subunit of the mitochondrial complex III (CIII), the functional bottleneck of the respiratory chain. Previously, the human cytochrome b missense mutation m.15579A>G, which substitutes the Tyr 278 with Cys (p.278Y>C), was identified in a patient with severe exe more

• Synthesis and Evaluation of Degradable Polyurea Block Copolymers as siRNA Delivery Agents

  Publication date: Available online 16 May 2013 Source:Acta Biomaterialia Author(s): Peter Cass , Warren Knower , Tracey Hinton , Shuning Shi , Felix Grusche , Mark Tizard , Pathiraja Gunatillake Chain extension by diisocyanate condensation provides a versatile and convenient means for p more

Market studies Synthesis

• NGL Fine-chem Ltd. - Strategic SWOT Analysis Review

  NGL Fine-chem Ltd. (NGL) is a publicly held pharmaceutical company. It is principally engaged in the manufacture of pharmaceutical ingredients and intermediate products that are used in animal and human health. The company's products include finished dosage forms, diminazene aceturate granules and h more

• Type 2 Diabetes - Global Drug Forecasts and Treatment Analysis to 2020

  Introduction GlobalData, the industry analysis specialist, has released its new report, “Type 2 Diabetes - Global Drug Forecasts and Treatment Analysis to 2020”. The report is an essential source of information and analysis on the global type 2 diabetes therapeutics market. The report provides comp more

• Accelerating Drugs to Market - Despite Challenges, Adaptive Clinical Trials Reduce Drug Development Costs and Time to Market

  GBI Research’s new report, “Accelerating Drugs to Market - Despite Challenges, Adaptive Clinical Trials Reduce Drug Development Costs and Time to Market”, presents various tools and strategies which can accelerate a drug to the market. In this report, GBI Research has studied various hurdles at diff more

Websites Synthesis