Structural Biology

News Structural Biology

• EU offensive against multi-resistant bacteria
  

  Bacteria resistant to multiple antibiotics are one of the biggest health hazards of our time. In order to push the development of new antibiotic drugs fighting antimicrobial resistance (AMR), the research project TRANSLOCATION has been set up as part of the Euroepan public-private partnership Innova more

• UCB and Domainex Collaboration Provides Valuable Information on Cancer Drug Target

  UCB and Domainex Ltd have jointly published the results of a collaboration in the field of cancer drug discovery. Working together, the two companies have developed an experimental system to study the three-dimensional structure of Mitogen-activated protein kinase kinase (MAPKK, also known as MEK), more

• Several baffling puzzles in protein molecular structure solved with new method
  

  The structures of many protein molecules remain unsolved even after experts apply an extensive array of approaches. An international collaboration has led to a new, high-performance method that rapidly determined the structure of protein molecules in several cases where previous methods had failed.T more

Publications Structural Biology

• Structural Biology of the Proteasome

  The proteasome refers to a collection of complexes centered on the 20S proteasome core particle (20S CP), a complex of 28 subunits that houses proteolytic sites in its hollow interior. Proteasomes are found in eukaryotes, archaea, and some eubacteria, and their activity is critical for many cellular more

• Advances, Interactions, and Future Developments in the CNS, Phenix, and Rosetta Structural Biology Software Systems

  Advances in our understanding of macromolecular structure come from experimental methods, such as X-ray crystallography, and also computational analysis of the growing number of atomic models obtained from such experiments. The later analyses have made it possible to develop powerful tools for struc more

• Structure‐Based DNA‐Targeting Strategies with Small Molecule Ligands for Drug Discovery

  Abstract Nucleic acids are the molecular targets of many clinical anticancer drugs. However, compared with proteins, nucleic acids have traditionally attracted much less attention as drug targets in structure‐based drug design, partially because limited structural information of nucleic acids co more

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