Signal Transduction

Companies Signal Transduction

Biomol GmbH, Germany

Biomol GmbH offers antibodies, enzymes, bioactive lipids, microarrays and reagents for biomedical research. Our focus is on cellular regulation and signal transduction. Together with our partners, we also provide a variety of specialized kits for drug discovery. more

News Signal Transduction

• Cornell: $4M grant to study plant-microbe interactions

  The arms race between plants and pathogens prompts both to evolve: Pathogens continually find new strategies to infect plants, and plants counter by foiling those strategies.Now, Cornell and Boyce Thompson Institute (BTI) researchers have received a $4 million National Science Foundation Plant Genom more

• Protein highways keep tissues organize
  

  Precise regulation of tissue architecture is critical for organ function. Single cells build up a tissue by communicating with their environment and with other cells, thereby receiving instructions on whether to divide, change shape or migrate. An interdisciplinary group of researchers from several more

• KINAXO and Daiichi Sankyo Sign Collaboration Agreement

  KINAXO Biotechnologies GmbH and Daiichi Sankyo Company Limited entered a long-term partnership in cancer research. Under the agreement, Daiichi Sankyo will employ KINAXO’s technology platform to support the development of Daiichi Sankyo’s targeted cancer drugs. This will involve KINAXO applying its more

White papers Signal Transduction

• High sensitive detection of follistatin by Imperacer®: an initial study on the way to analytical gene-doping tests
  

  For the understanding of interactions in the muscle-growth directing myostatin-pathway and therefore also for the establishment of high sensitive detection strategies for gene-doping, detailed studies of protein concentration levels in biological matrices and appropriate highly sensitive analytic techniques for quantitative monitoring of these biomarkers are required. In this work, the development of a high sensitive assay for follistatin based on the Imperacer® technology is described. The quantification limit in human serum was found at 60 pg/ml in only 6 µl sample volume. With this initial assay we demonstrate the first application in a set of analytical tests for a high sensitive myostatin pathway related profiling. more

• Efficient Reverse Transfection of Both siRNA and Expression Plasmids on Transfected Cell Microarrays Using X-tremeGENE siRNA Transfection Reagent
  

  Transfected cell microarray is a versatile, efficient, and cost-reducing technology [1,3,4] that can contribute to further understanding of gene functions and regulatory mechanisms governing gene expression. We have optimized the protocol of transfected cell microarrays using X-tremeGENE siRNA Transfection Reagent to transfect both expression plasmids and siRNAs, and have shown that this technology can be used to reliably detect even quantitatively minor biological effects of gene perturbations by including several technical and experimental replicates and using linear regression (ANOVA) modeling to estimate the biological effects [2] more

• Altered Expression of Broad Range of Protease Genes in SH-SY5Y Neuroblastoma Cells after Bortezomib Exposure
  

  Neuroblastoma cell lines can be models for the responsiveness of neuroblastomas to chemotherapy-induced cell death as well as for the sensitivity of untransformed neuro-nal cells to toxic side-effects of chemotherapy. Both phenom-ena are relevant to neuroblastoma cells exposed to bortezomib, a proteasome inhibitor in clinical use. It has been shown previously that neuroblastoma cell lines are prone to undergo apoptosis when treated with bortezomib, but the precise molecular mechanism has not been revealed. In addition to this, peripheral neuropathy is the main side effect of chemotherapy that includes bortezomib more

Job offers Signal Transduction

• 12 PhD scholarships (f/m)
  

  DFG- Research Training Group GRK 1885/1 Molecular Basis of Sensory Biology Excellent qualification in the framework of research topics in molecular biosensing at the University of Oldenburg The Deutsche Forschungsgemeinschaft (DFG) supports the Research Training Group "Molecular Basis of Sensory B more

Publications Signal Transduction

• Enhanced Effector Responses in Activated CD8+ T Cells Deficient in Diacylglycerol Kinases

  Recent clinical trials have shown promise in the use of chimeric antigen receptor (CAR)-transduced T cells; however, augmentation of their activity may broaden their clinical use and improve their efficacy. We hypothesized that because CAR action requires proteins essential for T-cell receptor (TCR) more

• The interaction between glucose and cytokinin signal transduction pathway in Arabidopsis thaliana

  Abstract Cytokinins (CKs) and glucose (GLC) control a number of common responses in plants. We hypothesize that there may be an extensive overlap between CK and GLC signaling pathways. Microarray along with physiological analysis has been performed to find out the interdependence/overlap between more

• SCFKMD controls cytokinin signaling by regulating the degradation of type-B response regulators [Plant Biology]

  Cytokinins are plant hormones that play critical roles in growth and development. In Arabidopsis, the transcriptional response to cytokinin is regulated by action of type-B Arabidopsis response regulators (ARRs). Although central elements in the cytokinin signal transduction pathway have been identi more

Market studies Signal Transduction

• Pipeline Insight: Small Molecule Targeted Cancer Therapies - New targets set to drive growth

  Introduction Small molecule targeted therapies represent a highly lucrative class of anticancer therapies with 12 drugs currently approved for various tumor types. This promise of high commercial rewards has driven considerable pipeline activity for small molecule targeted therapies within cancer. more

• Stakeholder Opinions: Targeting Nerve Growth Factor for Pain Therapy - Groundbreaking class to breathe new life into saturated market

  Introduction Pain treatment is a multibillion dollar market that is saturated with a wide variety of branded and generic drugs. The NGF class has potential to be first of an entirely new type of painkiller to enter the sector in decades. Nevertheless, high expectations need to be tempered once the more

Websites Signal Transduction