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Companies Sigma-Aldrich

News Sigma-Aldrich

• Preliminary registration report: analytica 2012 on the road to success

  It is still six months before the beginning of the fair, and analytica is already boasting some impressive, possibly record-breaking preliminary results: A total of 633 exhibitors have already registered for the fair (compared to 586 in 2009). As a result, the International Trade Fair for Laboratory more

• analytica Anacon India 2011: Growth on Indian market for laboratory and analysis equipment

  During the past few years, India has seen a continuous increase in demand for laboratory and analysis equipment. The food industry and pharmaceuticals industry in particular are noticing growing interest in high-quality equipment. This development will also be reflected at this year’s analytica Anac more

• Sigma Life Science Announces Scientific Advisory Board to drive ADME/Tox program

  Sigma Life Science, the biological products and services research business of Sigma-Aldrich Corporation, announced the formation of an ADME/Toxicology Scientific Advisory Board (ADME/Tox SAB) in an effort to help drive development of new cell-based assays using the Company's innovative CompoZr ZFN t more

White papers Sigma-Aldrich

• Molecular Probes® NanoOrange® Assay Performed on BMG LABTECH FLUOstar OPTIMA Microplate Reader
  

  The field of proteomics has expanded dramatically in recent years with research on a whole host of organisms. Techniques such as two dimensional difference gel electrophoresis (2D DIGE) require the accurate quantitation of protein, as up to three labelled samples can be loaded on a single gel for comparison. Assay methods for determining protein quantitation include absorbance at 280 nm(1), the Bradford assay(2), Lowry assay(3), BCA method(4) and more sensitive assays such as Fluoroprofile® (Sigma-Aldrich) and NanoOrange® (Molecular Probes®)5(). more

• Optimization of Transfection Efficiency in Chick Embryo Hepatocytes and HepG2 Cells
  

  Cell and molecular biology studies have been facilitated by transfection, a technology that can deliver material like DNA, RNA, and protein into cells. However, there are multiple reagents on the market, and a careful study must be perform­ed in order to find a suitable technique for your particular cellular system. One of the most effective re-agents that was available on the market in the early 90's was DOTMA (N-[1-(2,3-dioleyloxy)propyl]-N,N,N-tri-methylammonium chloride). more

• Detection of NADH and NADPH with the Omega's High Speed, Full UV/Vis Absorbance Spectrometer
  

  Nicotinamide Adenine Dinucleotide (NAD+), reduced nicotinamide adenine dinucleotide (NADH), nicotinamide adenine dinucleotide phosphate (NADP+) and reduced nicotinamide adenine dinucleotide phosphate (NADPH) have been known to play vital roles in energy metabolism, antioxidation, and reductive biosynthesis. In recent years, these co-factors have been shown to be involved in other physiological functions as well, including aging, oxidative stress, intracellular calcium homeostasis, ROS production, cell death and gene expression. more

Publications Sigma-Aldrich

• Efficient Methods for Targeted Mutagenesis in Zebrafish Using Zinc-Finger Nucleases: Data from Targeting of Nine Genes Using CompoZr or CoDA ZFNs

  by Raman Sood, Blake Carrington, Kevin Bishop, MaryPat Jones, Alberto Rissone, Fabio Candotti, Settara C. Chandrasekharappa, Paul Liu Recently, it has been shown that targeted mutagenesis using zinc-finger nucleases (ZFNs) and transcription activator-like effector nucleases (TALENs) can b more

• Assessment of Two Immunodepletion Methods: Off-Target Effects and Variations in Immunodepletion Efficiency May Confound Plasma Proteomics

  Immunodepletion of abundant plasma proteins increases the depth of proteome penetration by mass spectrometry. However, the nature and extent of immunodepletion and the effect of off-target depletion on the quantitative comparison of the residual proteins have not been critically addressed. We perfor more

Market studies Sigma-Aldrich

• Qiagen N.V. (QIA) - Product Pipeline Analysis

  Qiagen N.V. (QIA) - Product Pipeline Analysis Summary This report is a source for data, analysis and actionable intelligence on the Qiagen N.V. portfolio of pipeline products. The report provides detailed analysis on each pipeline product with information on the indication, the development stage, more

• Upstream Processing in Biopharmaceuticals - Increasing use of Low-Cost Disposable Bioreactors to Drive the Upstream Bioprocessing Market

  GBI Research's report, “Upstream Processing in Biopharmaceuticals - Increasing Use of Low-Cost Disposable Bioreactors to Drive the Upstream Bioprocessing Market”, provides the key to market data on overall upstream process, Contract Manufacturing Organization (CMO) market for upstream processing, an more

• Enzo Biochem, Inc. (ENZ) - Financial and Strategic SWOT Analysis Review

  Enzo Biochem, Inc. (ENZ) - Financial and Strategic SWOT Analysis Review Summary Enzo Biochem, Inc. (Enzo Biochem) is a life sciences and biotechnology company and is principally engaged in research, development, manufacturing and marketing of diagnostic and therapeutic products based on genetic en more

Websites Sigma-Aldrich