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• Cyrenaic Pharmaceuticals Reports Improvement of Negative Symptoms and Cognition in Schizophrenia Patients Treated with CYR-101

  Cyrenaic Pharmaceuticals Inc., a private drug development company focused on the treatment of CNS disorders, announced Phase IIa clinical results for CYR-101, its novel investigational drug for the treatment of schizophrenia. The results from the study showed that the drug alleviated the symptoms of more

• Allumera shows significant improvements in appearance of skin compared to light

  Photocure announced positive preliminary results from its consumer trial on Allumera™, demonstrating that the product can improve the appearance of skin. The RevitAll ™ study was designed to determine the ability of Allumera™ cream to improve the appearance of skin compared to illumination by light more

• A decade of refinements in marrow and stem cell transplantation improves long-term survival of blood cancers

  A decade of refinements in marrow and stem cell transplantation to treat blood cancers significantly reduced the risk of treatment-related complications and death, according to an institutional self-analysis of transplant-patient outcomes conducted at Fred Hutchinson Cancer Research Center. Among t more

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• Agrisera Western Blot recommendations, troubleshooting and protocol
  

  Each antibody-antigen interaction has unique characteristics. A protocol giving good results for one antibody-antigen pair might found to be unsatisfactory for a second antibody even on the same sample. The interaction of antisera with protein epitopes in Western blot dependens upon a number of factors, all contributing to the final signal/noise ratio. Knowledge and control of those factors allows for modifications and optimization of the procedure. Polyclonal antibodies (serum or IgY-fractions from egg yolk) usually contain a number of different antibodies interacting independently with different epitopes on the target used for immunization. This number is limited for peptide-antigens but if recombinant or native proteins have been used for immunization the signal obtained has to be regarded as cumulative (=caused by several different types of antibodies present in the serum/IgY used) more

• Analysis of water soluble polymers using linear size exclusion HPLC columns and a semi-micro SEC system
  

  One of the most widely used water-soluble polymers is Polyvinylpyrrolidone (PVP). For more than 70 years it is applied in a variety of applications in medicine, pharmacy, cosmetics and industrial production. PVP binds to polar molecules exceptionally well. It supports the solubility of tablets in water, makes the glue stick adhesive and plays an essential role in the production of membranes. In ceramic, paper and dye applications, it produces visual effects such as gloss and brilliancy. As a food additive, PVP is a stabilizer (E1201). A characteristic feature of a certain polymer is its molecular weight distribution curve, which is usually obtained by SEC Analysis more

• alamarBlue® Assay for Assessment of Cell Proliferation using the FLUOstar OPTIMA
  

  The alamarBlue® cell proliferation assay is based on a reducing environment that indicates metabolic active cells. Active cells are able to convert resazurin into the resorufin. Resazurin is blue and non-fluorescent whereas resorufin is red and highly fluorescent; therefore a fluorescent and a colorimetric detection are possible. This application notes focuses on the quantification of cell proliferation in a Human Osteoblast cell culture by measuring alamarBlue® fluorescence on the FLUOstar OPTIMA microplate reader more

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• Transforming growth factor‐α mediates estrogen‐induced upregulation of glutamate transporter GLT‐1 in rat primary astrocytes

  Abstract Glutamate transporter‐1 (GLT‐1) plays a central role in preventing excitotoxicity by removing excess glutamate from the synaptic clefts. 17β‐Estradiol (E2) and tamoxifen (TX), a selective estrogen receptor (ER) modulator, afford neuroprotection in a range of experimental models. However, more

• Local tissue reaction after the application of topical hemostatic agents in a rat partial nephrectomy model

  Abstract Various hemostatics are used for renal surgical procedures. We investigated the hemostatic efficacy of cellulose derivatives on the model of partial nephrectomy in rats focusing on the local reaction of renal parenchyma. A total of 50 Wistar rats were divided into five groups of 10 anima more

• Glutathione peroxidase tagSNPs: Associations with rectal cancer but not with colon cancer

  Abstract Glutathione peroxidases (GPXs) are selenium‐dependent enzymes that reduce and, thus, detoxify hydrogen peroxide and a wide variety of lipid hydroperoxides. We investigated tagSNPs in GPX1‐4 in relation to colorectal neoplasia in three independent study populations capturing the range of more

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• NGL Fine-chem Ltd. - Strategic SWOT Analysis Review

  NGL Fine-chem Ltd. (NGL) is a publicly held pharmaceutical company. It is principally engaged in the manufacture of pharmaceutical ingredients and intermediate products that are used in animal and human health. The company's products include finished dosage forms, diminazene aceturate granules and h more

• United States Pharmaceuticals and Healthcare Report Q1 2012

  BMI View: Healthcare spending in the US will continue to account for a disproportionately large percentage of its GDP. Citizens of the world's largest economy are accustomed to regular health checkups, access to the latest diagnostics and therapeutics, choice of provider and outlet, insurance premiu more

• Diagnostic Imaging Market to 2017 - Fusion Technology to Increase Adoption Rates of Hybrid Imaging Systems

  GBI Research’s report, “Diagnostic Imaging Market to 2017 - Fusion Technology to Increase Adoption Rates of Hybrid Imaging Systems” provides information and analysis on the global diagnostic imaging market. The report provides market landscape, competitive landscape and market trends information on more

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