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• Mammograms reveal response to common cancer drug
  

  Researchers at Karolinska Institutet have developed a method for assessing the effect of tamoxifen, a common drug to prevent the relapse of breast cancer. The key lies in monitoring changes in the proportion of dense tissue, which appears white on a mammogram, during treatment. Women who show a pron more

• Iterative reconstruction plus longitudinal dose modulation reduces radiation dose for abdominal CT

  Radiation dose reduction has moved to the forefront of importance in medical imaging with new techniques being developed in an effort to bring doses down as low as possible. What difference can these techniques make? Researchers at Indiana University School of Medicine aimed to find out. "We conduct more

• Cyrenaic Pharmaceuticals Reports Improvement of Negative Symptoms and Cognition in Schizophrenia Patients Treated with CYR-101

  Cyrenaic Pharmaceuticals Inc., a private drug development company focused on the treatment of CNS disorders, announced Phase IIa clinical results for CYR-101, its novel investigational drug for the treatment of schizophrenia. The results from the study showed that the drug alleviated the symptoms of more

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• LightCycler® 480 System: High-throughput Gene Expression and Genotyping Analysis - A Performance Study
  

  The LightCycler® 480 System is a novel platform for rapid gene expression and melting curve-based genotyping for medium- and high-throughput. In order to assess the performance and ease-of-use of the complete LightCycler® 480 System (instrument, software, and reagents) in an academic laboratory setting we scheduled a high-throughput project including gene expression (39 targets in 88 samples = 3,400 expression values) as well as genotyping applications (3,808 genotypes; 14 SNPs in 288 samples). The project, involving five technicians and two graduate students, was accomplished within 15 working days. more

• Accurate Mass and TIPTM: Two Dimensions for Elemental Composition Determination: microTOFTM Featuring Unique TIPTM
  

  The ESI-TOF mass spectrometers micrOTOF and micrOTOF focus do not only provide accurate mass measurements but additionally describe the True Isotopic Pattern TIPTM. For molecular formula generation this unique combination significantly reduces the number of possible formula candidates and the elemental composition of compounds with molecular weights far higher than 500 Da can unequivocally be determined more

• Agrisera Western Blot recommendations, troubleshooting and protocol
  

  Each antibody-antigen interaction has unique characteristics. A protocol giving good results for one antibody-antigen pair might found to be unsatisfactory for a second antibody even on the same sample. The interaction of antisera with protein epitopes in Western blot dependens upon a number of factors, all contributing to the final signal/noise ratio. Knowledge and control of those factors allows for modifications and optimization of the procedure. Polyclonal antibodies (serum or IgY-fractions from egg yolk) usually contain a number of different antibodies interacting independently with different epitopes on the target used for immunization. This number is limited for peptide-antigens but if recombinant or native proteins have been used for immunization the signal obtained has to be regarded as cumulative (=caused by several different types of antibodies present in the serum/IgY used) more

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• Inhibition of galectin-3 reduces atherosclerosis in apolipoprotein E-deficient mice

  Atherosclerosis is a major risk factor for cardiovascular disease (CVD) and stroke. Galectin-3 is a carbohydrate-binding lectin implicated in the pathophysiology of CVD and is highly expressed within atherosclerotic lesions in mice and humans. The object of this present study was to use genetic del more

• A Stochastic Simulator of Birth–Death Master Equations with Application to Phylodynamics

  In this article, we present a versatile new software tool for the simulation and analysis of stochastic models of population phylodynamics and chemical kinetics. Models are specified via an expressive and human-readable XML format and can be used as the basis for generating either single population more

• Interspecific Divergence of Transcription Networks along Lines of Genetic Variance in Drosophila: Dimensionality, Evolvability, and Constraint

  Change in gene expression is a major facilitator of phenotypic evolution. Understanding the evolutionary potential of gene expression requires taking into account complex systems of regulatory networks, the structure of which could potentially bias evolutionary trajectories. We analyzed the evoluti more

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• NGL Fine-chem Ltd. - Strategic SWOT Analysis Review

  NGL Fine-chem Ltd. (NGL) is a publicly held pharmaceutical company. It is principally engaged in the manufacture of pharmaceutical ingredients and intermediate products that are used in animal and human health. The company's products include finished dosage forms, diminazene aceturate granules and h more

• Accelerating Drugs to Market - Despite Challenges, Adaptive Clinical Trials Reduce Drug Development Costs and Time to Market

  GBI Research’s new report, “Accelerating Drugs to Market - Despite Challenges, Adaptive Clinical Trials Reduce Drug Development Costs and Time to Market”, presents various tools and strategies which can accelerate a drug to the market. In this report, GBI Research has studied various hurdles at diff more

• Canada Pharmaceuticals and Healthcare Report Q4 2012

  BMI View: The stable economic and political environment in Canada will help pharmaceutical companies to generate a consistent market growth in Q412. However, drugmakers will continue to face pricing pressure from the government and patent cliff effects in the country. Nevertheless, the epidemiologic more

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