Rearrangement

News Rearrangement

• Stay Calm with Domino

  Drugs such as sedatives, hypnotics, and anticonvulsants often contain a benzodiazepine moiety. They are useful in the treatment of, for example, anxiety, insomnia, agitation, and seizures. The 1,5-benzodiazepin-2-one skeleton in particular is considered a “privileged” scaffold in medicinal chemistry more

• A molecular switch for memory and addiction

  Learning and memory formation are based on the creation of new connections between neurons in the brain. Also, behaviors such as nicotine addiction manifest themselves in long-term changes of neuronal connectivity and can - at least in this respect - be viewed as a form of learning. A team around Pi more

• New technique transforms iPS cells into natural tumor killers

  A technique for producing natural killer T (NKT) cells, known for their role in suppressing tumor growth, has been successfully demonstrated for the first time using induced pluripotent stem (iPS) cells. Developed by researchers at RIKEN the technique opens the door to effective new cell-targeted tr more

White papers Rearrangement

• The New Genome Sequencer FLX System
  

  In 2005, the Genome Sequencer 20 System was introduced into the global life science market. Based on the revolutionary 454 sequencing technology, this system is able to generate hundreds of thousands of sequence reads in a few hours at a fraction of costs compared with the traditional Sanger technology. more

• Aphidicolin-Mediated Replication Stress Induces Submicroscopic Tumor-Like Deletions in FHIT/FRA3B
  

  Common fragile sites (CFSs) are loci that are particularly susceptible to forming gaps and breaks on metaphase chromosomes after partial inhibition of DNA synthesis, for example induced by aphidicolin (APH). FRA3B, a fragile site lying within the FHIT tumor suppressor gene, is a site of frequent heterozygous and homozygous deletions in cancer cells and precancerous lesions. Most FHIT and other CFS-associated gene rearrangements in tumors are deletions of hundreds of kilobases often resulting in the inactivation of associated genes. However, there has been no direct evidence showing that CFS instability or replication stress can induce submicroscopic deletions like the ones found in cancer cells. Durkin et al. produced FHIT/FRA3B deletions similar to those in tumor cells by inducing replication stress in human-mouse chromosome 3 somatic hybrid cells with APH. more

Publications Rearrangement

• Mosaic Isochromosome 15q and Maternal Uniparental Isodisomy for Chromosome 15 in a Patient With Morbid Obesity and Variant PWS‐Like Phenotype

  Abstract Angelman and Prader–Willi syndromes are reciprocal imprinting disorders caused by loss of maternally or paternally expressed genes, respectively, within 15q11.2–q13. Angelman syndrome (AS; OMIM 105830) is a neurodevelopmental disorder and is due to the loss of maternally expressed UBE3 more

• Familial Trisomy 6p in Mother and Daughter

  Abstract Several patients with partial trisomy 6p resulting from parental balanced translocations or from a de novo duplication or insertion have already been described. Here, we report on the first case of familial pure trisomy 6p as a result of interstitial tandem duplication. The patient, an more

• The Impact of a Ligand Binding on Strand Migration in the SAM-I Riboswitch

  by Wei Huang, Joohyun Kim, Shantenu Jha, Fareed Aboul-ela Riboswitches sense cellular concentrations of small molecules and use this information to adjust synthesis rates of related metabolites. Riboswitches include an aptamer domain to detect the ligand and an expression platform to control gene more

Websites Rearrangement