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• Down syndrome neurons grown from stem cells show signature problems

  Down syndrome, the most common genetic form of intellectual disability, results from an extra copy of one chromosome. Although people with Down syndrome experience intellectual difficulties and other problems, scientists have had trouble identifying why that extra chromosome causes such widespread e more

• Evotec and Roche agree to develop compound that could slow the progression of Alzheimer's disease

  Evotec AG and Roche AG announced that they have entered into an exclusive worldwide agreement for the development and commercialization of Evotec's MAO-B inhibitor in patients with Alzheimer's disease (AD).Under the terms of the agreement, Roche will pay Evotec an upfront fee of $10 million. Evotec more

• Free radicals maybe good for you

  Fear of free radicals may be exaggerated, according to scientists from the Swedish medical university Karolinska Institutet. A new study, published in The Journal of Physiology, shows that free radicals act as signal substances that cause the heart to beat with the correct force. Free radicals are m more

White papers Radicals

• ORAC Assay Performed on the POLARstar Omega and PHERAstar FS microplate reader
  

  In all oxygen consuming cells, metabolism and oxidative stress generate several intermediates and byproducts that are collectively known as reactive oxygen species (ROS). ROS are necessary intermediates in the human body, but they are also involved in the aging process and in the development of many degenerative diseases, including cancer, heart disease, Alzheimer's and Parkinson's. Herein we describe the determination of the antioxidant capacity of different fruit juices using the ORAC assay; a standardized method that uses Trolox®, a water-soluble analogue of vitamin E, as a standard substance more

Publications Radicals

• Physiological and transcriptional response of Bacillus cereus treated with low‐temperature nitrogen gas plasma

  Abstract Aims This study was conducted to investigate the inactivation kinetics of Bacillus cereus vegetative cells upon exposure to low‐temperature nitrogen gas plasma and to reveal the mode of inactivation by transcriptome profiling. Methods and results Exponentially growing B. cereus more

• Hydrogen therapy may be an effective and specific novel treatment for Acute Graft‐versus‐host disease (GVHD)

  Abstract Allogeneic haematopoietic stem cell transplantation (HSCT) has been widely used for the treatment of haematological malignant and non‐malignant haematologic diseases. However, acute graft‐versus‐host disease (aGVHD) is a kind of severe complication of HSCT limiting its application. Cyto more

• Molecular cloning and functional characterization of MnSOD from Dunaliella salina

  Dunaliella salina, a unicellular green alga, has the potential to grow in hypersaline environments via one of its gene products, superoxide dismutase (SOD). The superoxide radicals (O2−) produced by environmental stresses can cause damage to cells, and SOD catalyzes the turnover of such free radi more

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