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108 Newest Publications about the topic viral diseases

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Cholesterol‐conjugated peptide antivirals: a path to a rapid response to emerging viral diseases

21-10-2014 | Antonello Pessi, Journal of Peptide Science, 2014

While it is now possible to identify and genetically fingerprint the causative agents of emerging viral diseases, often with extraordinary speed, suitable therapies cannot be developed with equivalent speed, because drug discovery requires information that goes beyond knowledge of the viral ...

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RNA-guided endonuclease provides a therapeutic strategy to cure latent herpesviridae infection [Medical Sciences]

09-09-2014 | Jianbin Wang; Stephen R. Quake, Proceedings of the National Academy of Sciences current issue, 2014

Latent viral infection is a persistent cause of human disease. Although standard antiviral therapies can suppress active viral replication, no existing treatment can effectively eradicate latent infection and therefore a cure is lacking for many prevalent viral diseases. The prokaryotic immune ...

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A Hepatitis C Virus Infection Model with Time-Varying Drug Effectiveness: Solution and Analysis

07-08-2014 | Jessica M. Conway et al., PLoS Computational Biology, 2014

by Jessica M. Conway, Alan S. Perelson Simple models of therapy for viral diseases such as hepatitis C virus (HCV) or human immunodeficiency virus assume that, once therapy is started, the drug has a constant effectiveness. More realistic models have assumed either that the drug effectiveness ...

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Original antigenic sin in dengue revisited [Immunology]

28-05-2013 | Simona Zompi; Eva Harris, Proceedings of the National Academy of Sciences current issue, 2013

The four dengue virus serotypes (DENV-1 to -4) cause the most important arthropod-borne viral disease of humans, with ∼100 million cases each year and over 3 billion people at risk for infection (1). The immune response to DENV infection is complex, because it can be either protective or ...

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Genomic analysis reveals MATH gene(s) as candidate(s) for Plum pox virus (PPV) resistance in apricot (Prunus armeniaca L.)

15-05-2013 | Elena Zuriaga, José Miguel Soriano, Tetyana Zhebentyayeva, Carlos Romero, Chris Dardick, Joaquín Cañizares, Maria Lu ..., Molecular Plant Pathology, 2013

Summary Sharka disease, caused by Plum pox virus (PPV), is the most important viral disease affecting Prunus species. A major PPV resistance locus (PPVres) has been mapped to the upper part of apricot (Prunus armeniaca) linkage group 1. In this study, a physical map of the PPVres locus in the ...

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Relative incidence, spatial distribution and genetic diversity of cucurbit viruses in eastern Spain

24-04-2013 | M. Juarez, P. Legua, C.M. Mengual, M.A. Kassem, R.N. Sempere, P. Gómez, V. Truniger, M.A. Aranda, Annals of Applied Biology, 2013

Abstract Viral diseases that could cause important economic losses often affect cucurbits, but only limited information on the incidence and spatial distribution of specific viruses is currently available. During the 2005 and 2006 growing seasons, systematic surveys were carried out in open ...

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Broadly Neutralizing Antiviral Antibodies

21-03-2013 | Davide Corti; Antonio Lanzavecchia, Annual Review of Immunology, 2013

A fascinating aspect of viral evolution relates to the ability of viruses to escape the adaptive immune response. The widely held view has been that the great variability of viral glycoproteins would be an absolute obstacle to the development of antibody-based therapies or vaccines that could ...

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An Integrated Proteomics Reveals Pathological Mechanism of Honeybee (Apis cerena) Sacbrood Disease

04-03-2013 | Bin Han; Lan Zhang; Mao Feng; Yu Fang; Jianke Li, Journal of Proteome Research, 2013

Viral diseases of honeybees are a major challenge for the global beekeeping industry. Chinese indigenous honeybee (Apis cerana cerana, Acc) is one of the major Asian honeybee species and has a dominant population with more than 3 million colonies. However, Acc is frequently threatened by a viral ...

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Integrating Phylodynamics and Epidemiology to Estimate Transmission Diversity in Viral Epidemics

31-01-2013 | Gkikas Magiorkinis et al., PLoS Computational Biology, 2013

by Gkikas Magiorkinis, Vana Sypsa, Emmanouil Magiorkinis, Dimitrios Paraskevis, Antigoni Katsoulidou, Robert Belshaw, Christophe Fraser, Oliver George Pybus, Angelos Hatzakis The epidemiology of chronic viral infections, such as those caused by Hepatitis C Virus (HCV) and Human ...

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Phylodynamic Inference and Model Assessment with Approximate Bayesian Computation: Influenza as a Case Study

27-12-2012 | Oliver Ratmann et al., PLoS Computational Biology, 2012

by Oliver Ratmann, Gé Donker, Adam Meijer, Christophe Fraser, Katia Koelle A key priority in infectious disease research is to understand the ecological and evolutionary drivers of viral diseases from data on disease incidence as well as viral genetic and antigenic variation. We propose ...

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