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113 Newest Publications about the topic viral diseases


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Viruses, Vol. 7, Pages 3226-3240: RNA Viruses and RNAi: Quasispecies Implications for Viral Escape

19-Jun-2015 | Presloid, John B.; Novella, Isabel S., Viruses, 2015

Due to high mutation rates, populations of RNA viruses exist as a collection of closely related mutants known as a quasispecies. A consequence of error-prone replication is the potential for rapid adaptation of RNA viruses when a selective pressure is applied, including host immune systems and ...


A Neuron-Specific Antiviral Mechanism Prevents Lethal Flaviviral Infection of Mosquitoes

27-Apr-2015 | Xiaoping Xiao et al., PLoS Pathogens, 2015

by Xiaoping Xiao, Rudian Zhang, Xiaojing Pang, Guodong Liang, Penghua Wang, Gong Cheng Mosquitoes are natural vectors for many etiologic agents of human viral diseases. Mosquito-borne flaviviruses can persistently infect the mosquito central nervous system without causing dramatic pathology or ...


Computational framework for next-generation sequencing of heterogeneous viral populations using combinatorial pooling

01-Mar-2015 | Pavel Skums; Alexander Artyomenko; Olga Glebova; Sumathi Ramachandran; Ion Mandoiu; David S. Campo; Zoya Dimitrova; ..., Bioinformatics, 2015

Motivation: Next-generation sequencing (NGS) allows for analyzing a large number of viral sequences from infected patients, providing an opportunity to implement large-scale molecular surveillance of viral diseases. However, despite improvements in technology, traditional protocols for NGS of ...


Viruses, Vol. 7, Pages 751-780: Aptamers in Diagnostics and Treatment of Viral Infections

16-Feb-2015 | Wandtke, Tomasz ; Woźniak, Joanna ; Kopiński, Piotr, Viruses, 2015

Aptamers are in vitro selected DNA or RNA molecules that are capable of binding a wide range of nucleic and non-nucleic acid molecules with high affinity and specificity. They have been conducted through the process known as SELEX (Systematic Evolution of Ligands by Exponential Enrichment). It ...


The Evolution and Genetics of Virus Host Shifts

06-Nov-2014 | Ben Longdon et al., PLoS Pathogens, 2014

by Ben Longdon, Michael A. Brockhurst, Colin A. Russell, John J. Welch, Francis M. Jiggins Emerging viral diseases are often the product of a host shift, where a pathogen jumps from its original host into a novel species. Phylogenetic studies show that host shifts are a frequent event in the ...


Cholesterol‐conjugated peptide antivirals: a path to a rapid response to emerging viral diseases

21-Oct-2014 | Antonello Pessi, Journal of Peptide Science, 2014

While it is now possible to identify and genetically fingerprint the causative agents of emerging viral diseases, often with extraordinary speed, suitable therapies cannot be developed with equivalent speed, because drug discovery requires information that goes beyond knowledge of the viral ...


RNA-guided endonuclease provides a therapeutic strategy to cure latent herpesviridae infection [Medical Sciences]

09-Sep-2014 | Jianbin Wang; Stephen R. Quake, Proceedings of the National Academy of Sciences current issue, 2014

Latent viral infection is a persistent cause of human disease. Although standard antiviral therapies can suppress active viral replication, no existing treatment can effectively eradicate latent infection and therefore a cure is lacking for many prevalent viral diseases. The prokaryotic immune ...


A Hepatitis C Virus Infection Model with Time-Varying Drug Effectiveness: Solution and Analysis

07-Aug-2014 | Jessica M. Conway et al., PLoS Computational Biology, 2014

by Jessica M. Conway, Alan S. Perelson Simple models of therapy for viral diseases such as hepatitis C virus (HCV) or human immunodeficiency virus assume that, once therapy is started, the drug has a constant effectiveness. More realistic models have assumed either that the drug effectiveness ...


Original antigenic sin in dengue revisited [Immunology]

28-May-2013 | Simona Zompi; Eva Harris, Proceedings of the National Academy of Sciences current issue, 2013

The four dengue virus serotypes (DENV-1 to -4) cause the most important arthropod-borne viral disease of humans, with ∼100 million cases each year and over 3 billion people at risk for infection (1). The immune response to DENV infection is complex, because it can be either protective or ...


Genomic analysis reveals MATH gene(s) as candidate(s) for Plum pox virus (PPV) resistance in apricot (Prunus armeniaca L.)

15-May-2013 | Elena Zuriaga, José Miguel Soriano, Tetyana Zhebentyayeva, Carlos Romero, Chris Dardick, Joaquín Cañizares, Maria Lu ..., Molecular Plant Pathology, 2013

Summary Sharka disease, caused by Plum pox virus (PPV), is the most important viral disease affecting Prunus species. A major PPV resistance locus (PPVres) has been mapped to the upper part of apricot (Prunus armeniaca) linkage group 1. In this study, a physical map of the PPVres locus in the ...


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