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115 Newest Publications about the topic viral diseases


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CD40 ligand‐expressing recombinant vaccinia virus (rVV40L) promotes the generation of CD8+ central memory T cells

12-Nov-2015 | Emanuele Trella, Nermin Raafat, Chantal Mengus, Emmanuel Traunecker, Valeria Governa, Swantje Heidtmann, Michael Heb ..., European Journal of Immunology, 2015

Central memory CD8+ T cells (TCM) play key roles in the protective immunity against infectious agents, cancer immunotherapy, and in adoptive treatments of malignant and viral diseases. CD8+ TCM cells are characterized by specific phenotypes, homing and proliferative capacities. However, CD8+ ...


Genome sequence of the Asian Tiger mosquito, Aedes albopictus, reveals insights into its biology, genetics, and evolution [Applied Biological Sciences]

03-Nov-2015 | Xiao-Guang Chen; Xuanting Jiang; Jinbao Gu; Meng Xu; Yang Wu; Yuhua Deng; Chi Zhang; Mariangela Bonizzoni; Wannes De ..., Proceedings of the National Academy of Sciences current issue, 2015

The Asian tiger mosquito, Aedes albopictus, is a highly successful invasive species that transmits a number of human viral diseases, including dengue and Chikungunya fevers. This species has a large genome with significant population-based size variation. The complete genome sequence was ...


Viruses, Vol. 7, Pages 3226-3240: RNA Viruses and RNAi: Quasispecies Implications for Viral Escape

19-Jun-2015 | Presloid, John B.; Novella, Isabel S., Viruses, 2015

Due to high mutation rates, populations of RNA viruses exist as a collection of closely related mutants known as a quasispecies. A consequence of error-prone replication is the potential for rapid adaptation of RNA viruses when a selective pressure is applied, including host immune systems and ...


A Neuron-Specific Antiviral Mechanism Prevents Lethal Flaviviral Infection of Mosquitoes

27-Apr-2015 | Xiaoping Xiao et al., PLoS Pathogens, 2015

by Xiaoping Xiao, Rudian Zhang, Xiaojing Pang, Guodong Liang, Penghua Wang, Gong Cheng Mosquitoes are natural vectors for many etiologic agents of human viral diseases. Mosquito-borne flaviviruses can persistently infect the mosquito central nervous system without causing dramatic pathology or ...


Computational framework for next-generation sequencing of heterogeneous viral populations using combinatorial pooling

01-Mar-2015 | Pavel Skums; Alexander Artyomenko; Olga Glebova; Sumathi Ramachandran; Ion Mandoiu; David S. Campo; Zoya Dimitrova; ..., Bioinformatics, 2015

Motivation: Next-generation sequencing (NGS) allows for analyzing a large number of viral sequences from infected patients, providing an opportunity to implement large-scale molecular surveillance of viral diseases. However, despite improvements in technology, traditional protocols for NGS of ...


Viruses, Vol. 7, Pages 751-780: Aptamers in Diagnostics and Treatment of Viral Infections

16-Feb-2015 | Wandtke, Tomasz ; Woźniak, Joanna ; Kopiński, Piotr, Viruses, 2015

Aptamers are in vitro selected DNA or RNA molecules that are capable of binding a wide range of nucleic and non-nucleic acid molecules with high affinity and specificity. They have been conducted through the process known as SELEX (Systematic Evolution of Ligands by Exponential Enrichment). It ...


The Evolution and Genetics of Virus Host Shifts

06-Nov-2014 | Ben Longdon et al., PLoS Pathogens, 2014

by Ben Longdon, Michael A. Brockhurst, Colin A. Russell, John J. Welch, Francis M. Jiggins Emerging viral diseases are often the product of a host shift, where a pathogen jumps from its original host into a novel species. Phylogenetic studies show that host shifts are a frequent event in the ...


Cholesterol‐conjugated peptide antivirals: a path to a rapid response to emerging viral diseases

21-Oct-2014 | Antonello Pessi, Journal of Peptide Science, 2014

While it is now possible to identify and genetically fingerprint the causative agents of emerging viral diseases, often with extraordinary speed, suitable therapies cannot be developed with equivalent speed, because drug discovery requires information that goes beyond knowledge of the viral ...


RNA-guided endonuclease provides a therapeutic strategy to cure latent herpesviridae infection [Medical Sciences]

09-Sep-2014 | Jianbin Wang; Stephen R. Quake, Proceedings of the National Academy of Sciences current issue, 2014

Latent viral infection is a persistent cause of human disease. Although standard antiviral therapies can suppress active viral replication, no existing treatment can effectively eradicate latent infection and therefore a cure is lacking for many prevalent viral diseases. The prokaryotic immune ...


A Hepatitis C Virus Infection Model with Time-Varying Drug Effectiveness: Solution and Analysis

07-Aug-2014 | Jessica M. Conway et al., PLoS Computational Biology, 2014

by Jessica M. Conway, Alan S. Perelson Simple models of therapy for viral diseases such as hepatitis C virus (HCV) or human immunodeficiency virus assume that, once therapy is started, the drug has a constant effectiveness. More realistic models have assumed either that the drug effectiveness ...


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