01-05-2013 | Kasandra Lovette Burgos; Ashkan Javaherian; Roberto Bomprezzi; Layla Ghaffari; Susan Rhodes; Amanda Courtright; Waib ..., RNA, 2013

There has been a growing interest in using next-generation sequencing (NGS) to profile extracellular small RNAs from the blood and cerebrospinal fluid (CSF) of patients with neurological diseases, CNS tumors, or traumatic brain injury for biomarker discovery. Small sample volumes and samples ...

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30-04-2013 | Christine L. Hsieh, Charles C. Kim, Bryan E. Ryba, Erene C. Niemi, Jennifer K. Bando, Richard M. Locksley, Jialing L ..., European Journal of Immunology, 2013

Traumatic brain injury (TBI) elicits innate inflammatory responses that can lead to secondary brain injury. To better understand the mechanisms involved in TBI‐induced inflammation, we examined the nature of macrophages responding to TBI in mice. In this model, brain macrophages were ...

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29-04-2013 | M. V. Forslund, C. Roe, S. Sigurdardottir, N. Andelic, Acta Neurologica Scandinavica, 2013

Aims To describe health‐related quality of life (HRQL) 2years after moderate‐to‐severe traumatic brain injury (TBI) and to assess predictors of HRQL. Materials and methods A prospective cohort study of 91 patients, aged 16–55years, admitted with moderate‐to‐severe TBI to a trauma ...

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23-04-2013 | Dasuni S Alwis, Victoria Johnstone, Edwin Yan, Ramesh Rajan, Clinical and Experimental Pharmacology and Physiology, 2013

Summary In this review, we discuss the consequences to the brain's cortex, specifically to the sensory cortex, of traumatic brain injury. The thesis underlying this approach is that long‐term deficits in cognition seen after brain damage in humans are likely underpinned by an impaired ...

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05-04-2013 | P. M. Aslaksen, M. Ørbo, R. Elvestad, C. Schäfer, A. Anke, European Journal of Neurology, 2013

Background and purpose The aim of the study was to examine the predictive value of widely used standardized neuropsychological tests in a clinical setting for on‐road driving performance in patients with cerebral stroke or traumatic brain injury (TBI), and to provide cut‐off values for ...

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29-03-2013 | Peng Cao, Yong Liang, Xu Gao, Ming‐Guang Zhao, Guo‐Biao Liang, CNS Neuroscience & Therapeutics, 2013

Summary Aims The MS‐275 is a selective inhibitor of class I histone deacetylases (HDACs), which has been reported as a potential strategy in some central nervous system diseases associated with neurodegeneration and disturbed learning. However, its role in traumatic brain injury is not ...

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19-03-2013 | Hassan Al-Ali; Stephan C. Schürer; Vance P. Lemmon; John L. Bixby, ACS Chemical Biology, 2013

A fundamental impediment to functional recovery from spinal cord injury (SCI) and traumatic brain injury is the lack of sufficient axonal regeneration in the adult central nervous system. There is thus a need to develop agents that can stimulate axon growth to re-establish severed ...

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11-03-2013 | Lee C. Chang, Sally R. Raty, Jaime Ortiz, Neil S. Bailard, Sanjay J. Mathew, CNS Neuroscience & Therapeutics, 2013

Summary Background Traditionally, the use of ketamine for patients with traumatic brain injuries is contraindicated due to the concern of increasing intracranial pressure (ICP). These concerns, however, originated from early studies and case reports that were inadequately controlled and ...

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05-03-2013 | J. Flygt, A. Djupsjö, F. Lenne, N. Marklund, European Journal of Neuroscience, 2013

Abstract Axonal injury is an important contributor to the behavioral deficits observed following traumatic brain injury (TBI). Additionally, loss of myelin and/or oligodendrocytes can negatively influence signal transduction and axon integrity. Apoptotic oligodendrocytes, changes in the ...

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28-02-2013 | X Antón Álvarez; Jesús Figueroa; Dafin Muresanu, Future Neurology, 2013

Traumatic brain injury (TBI) is a devastating medical condition that has an enormous socioeconomic impact because it affects more than 10 million people annually worldwide and is associated with high rates of hospitalization, mortality and disability. Although TBI survival has improved ...

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