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8,149 Newest Publications about the topic transcription
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Androgen receptor-induced tumor suppressor, KLLN, inhibits breast cancer growth and transcriptionally activates p53/p73-mediated apoptosis in breast carcinomas
01-06-2013 | Yu Wang; Xin He; Qi Yu; Charis Eng, Human Molecular Genetics, 2013
Androgen receptor (AR) expression by immunohistochemistry correlates with better prognosis and survival among breast cancer patients. We and others have shown that AR inhibits proliferation and induces apoptosis in breast cancer cells. However, the mechanism of AR's anti-tumor effect in ...
Expression of a novel mRNA transcript for human microsomal epoxide hydrolase (EPHX1) is regulated by short open reading frames within its 5'-untranslated region [ARTICLES]
01-06-2013 | Hong Loan Nguyen; Xi Yang; Curtis J. Omiecinski, RNA, 2013
Microsomal epoxide hydrolase (mEH, EPHX1) is a critical xenobiotic-metabolizing enzyme, catalyzing both detoxification and bioactivation reactions that direct the disposition of chemical epoxides, including the carcinogenic metabolites of several polycyclic aromatic hydrocarbons. Recently, ...
Splicing kinetics and transcript release from the chromatin compartment limit the rate of Lipid A-induced gene expression [ARTICLES]
01-06-2013 | Amy Pandya-Jones; Dev M. Bhatt; Chia-Ho Lin; Ann-Jay Tong; Stephen T. Smale; Douglas L. Black, RNA, 2013
The expression of eukaryotic mRNAs is achieved though an intricate series of molecular processes that provide many steps for regulating the production of a final gene product. However, the relationships between individual steps in mRNA biosynthesis and the rates at which they occur are ...
Interspecific Divergence of Transcription Networks along Lines of Genetic Variance in Drosophila: Dimensionality, Evolvability, and Constraint
01-06-2013 | Paolo Innocenti; Stephen F. Chenoweth, Molecular Biology and Evolution, 2013
Change in gene expression is a major facilitator of phenotypic evolution. Understanding the evolutionary potential of gene expression requires taking into account complex systems of regulatory networks, the structure of which could potentially bias evolutionary trajectories. We analyzed the ...
The Evolution of the knirps Family of Transcription Factors in Arthropods
01-06-2013 | Tal Naggan Perl; Bernhard G.M. Schmid; Jonas Schwirz; Ariel D. Chipman, Molecular Biology and Evolution, 2013
The orphan nuclear receptor gene knirps and its relatives encode a small family of highly conserved proteins. We take advantage of the conservation of the family, using the recent prevalence of genomic data, to reconstruct its evolutionary history, identifying duplication events and tracing ...
Coevolution and Life Cycle Specialization of Plant Cell Wall Degrading Enzymes in a Hemibiotrophic Pathogen
01-06-2013 | Patrick C. Brunner; Stefano F.F. Torriani; Daniel Croll; Eva H. Stukenbrock; Bruce A. McDonald, Molecular Biology and Evolution, 2013
Zymoseptoria tritici is an important fungal pathogen on wheat that originated in the Fertile Crescent. Its closely related sister species Z. pseudotritici and Z. ardabiliae infect wild grasses in the same region. This recently emerged host–pathogen system provides a rare opportunity to ...
Retention of exogenous mRNAs selectively in the germ cells of the sea urchin requires only a 5'‐cap and a 3'UTR
18-05-2013 | Nathalie Oulhen, Gary M. Wessel, Molecular Reproduction and Development, 2013
Abstract The abundance of an mRNA in a cell depends on its overall rates of synthesis and decay. RNA stability is an important element in the regulation of gene expression, and is achieved by a variety of processes including specific recruitment of nucleases and RNAi‐associated ...
pCGR2 copy number depends on the par locus that forms a ParC‐ParB‐DNA partition complex in Corynebacterium glutamicum
18-05-2013 | Naoko Okibe, Nobuaki Suzuki, Masayuki Inui, Hideaki Yukawa, Journal of Applied Microbiology, 2013
Abstract Aims To characterize the par system of C. glutamicum pCGR2 and to manipulate the par components to effectively manipulate plasmid copy number. Methods and Results ParB binds sequence‐specifically to centromere‐binding sites around the parAB operon and serves as an ...
An adenosine kinase in apoplastic location is involved in Magnaporthe oryzae cold acclimation
17-05-2013 | Jian Li, Baolei Jia, Xilong Liang, Jinliang Liu, Yanli Wang, Xunna Liang, Hai Yan, Yuhan Wang, Shihong Zhang, Journal of Basic Microbiology, 2013
Abstract Cold acclimation is an important process to increase freezing tolerance for over‐winter survival in many organisms. The apoplastic area is very important in cold acclimation. Two‐dimensional electrophoresis was used to identify apoplastic proteins involved in the cold ...
A regulatory gene (ECO‐orf4) required for ECO‐0501 biosynthesis in Amycolatopsis orientalis
17-05-2013 | Yang Shen, He Huang, Li Zhu, Minyu Luo, Daijie Chen, Journal of Basic Microbiology, 2013
Abstract ECO‐0501 is a novel linear polyene antibiotic, which was discovered from Amycolatopsis orientalis. Recent study of ECO‐0501 biosynthesis pathway revealed the presence of regulatory gene: ECO‐orf4. The A. orientalis ECO‐orf4 gene from the ECO‐0501 biosynthesis cluster was ...
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