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20,714 Newest Publications about the topic proteins
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Kinetics of nuclear phosphorylation ({gamma}-H2AX) in human lymphocytes treated in vitro with UVB, bleomycin and mitomycin C
01-07-2013 | Roberto Scarpato; Sara Castagna; Rosamaria Aliotta; Alessia Azzarà; Francesco Ghetti; Erika Filomeni; Caterina Giova ..., Mutagenesis, 2013
After double-strand break induction, formation of -H2AX foci due to phosphorylation at Ser-139 of histone H2AX represents an early event of the DNA damage response (DDR). -H2AX foci are then rapidly dephosphorylated as signal for the subsequent recruitment of effector proteins. The induction ...
DNA damage-independent apoptosis induced by curcumin in normal resting human T cells and leukaemic Jurkat cells
01-07-2013 | Zbigniew Korwek; Anna Bielak-Zmijewska; Grazyna Mosieniak; Olga Alster; Maria Moreno-Villanueva; Alexander Burkle; E ..., Mutagenesis, 2013
Curcumin, a phytochemical derived from the rhizome of Curcuma longa, is a very potent inducer of cancer cell death. It is believed that cancer cells are more sensitive to curcumin treatment than normal cells. Curcumin has been shown to act as a prooxidant and induce DNA lesions in normal ...
A genetic variant in ERCC2 is associated with gastric cancer prognosis in a Chinese population
01-07-2013 | Haiyan Chu; Dongying Gu; Ming Xu; Zhi Xu; Yonglin Gong; Weida Gong; Yongfei Tang; Jianwei Zhou; Na Tong; Zhengdong Z ..., Mutagenesis, 2013
Endogenous and exogenous factors can induce DNA damage, leading to increased risk of cancer. Nucleotide excision repair (NER) is considered as the most versatile DNA repair pathway to deal with a variety of different DNA lesions. ERCC1 and ERCC2 are the two important proteins in NER pathway. ...
Meta-analysis of genome-wide association studies in five cohorts reveals common variants in RBFOX1, a regulator of tissue-specific splicing, associated with refractive error
01-07-2013 | Dwight Stambolian; Robert Wojciechowski; Konrad Oexle; Mario Pirastu; Xiaohui Li; Leslie J. Raffel; Mary Frances Cot ..., Human Molecular Genetics, 2013
Visual refractive errors (REs) are complex genetic traits with a largely unknown etiology. To date, genome-wide association studies (GWASs) of moderate size have identified several novel risk markers for RE, measured here as mean spherical equivalent (MSE). We performed a GWAS using a total ...
Lack of galectin-1 or galectin-3 alters B cell deletion and anergy in an autoantibody transgene model
01-07-2013 | Amy G Clark; Melissa L Weston; Mary H Foster, Glycobiology , 2013
Members of the galectin family of proteins have been shown to regulate the development and the function of immune cells. We previously identified the increased expression of galectin-1 and galectin-3 mRNA and protein in anergic B cells relative to their naïve counterparts. To investigate the ...
Increased levels of phosphoinositides cause neurodegeneration in a Drosophila model of amyotrophic lateral sclerosis
01-07-2013 | Stuart Forrest; Andrea Chai; Mario Sanhueza; Manuela Marescotti; Katherine Parry; Atanas Georgiev; Virender Sahota; ..., Human Molecular Genetics, 2013
The Vesicle-associated membrane protein (VAMP)-Associated Protein B (VAPB) is the causative gene of amyotrophic lateral sclerosis 8 (ALS8) in humans. Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease characterized by selective death of motor neurons leading to ...
ALS mutant FUS disrupts nuclear localization and sequesters wild-type FUS within cytoplasmic stress granules
01-07-2013 | Caroline Vance; Emma L. Scotter; Agnes L. Nishimura; Claire Troakes; Jacqueline C. Mitchell; Claudia Kathe; Hazel Ur ..., Human Molecular Genetics, 2013
Mutations in the gene encoding Fused in Sarcoma (FUS) cause amyotrophic lateral sclerosis (ALS), a fatal neurodegenerative disorder. FUS is a predominantly nuclear DNA- and RNA-binding protein that is involved in RNA processing. Large FUS-immunoreactive inclusions fill the perikaryon of ...
Regulation of Mac-2BP secretion is mediated by its N-glycan binding to ERGIC-53
01-07-2013 | Yang Chen; Sanae Hojo; Naoki Matsumoto; Kazuo Yamamoto, Glycobiology , 2013
The leguminous-type (L-type) lectin ER-Golgi intermediate compartment (ERGIC)-53, a homo-oligomeric endoplasmic reticulum (ER)-Golgi recycling protein, functions as a transport receptor for newly synthesized glycoproteins in the early secretory pathway. Although a limited subset of cargo ...
Mutation of the iron-sulfur cluster assembly gene IBA57 causes severe myopathy and encephalopathy
01-07-2013 | Nikhita Ajit Bolar; Arnaud Vincent Vanlander; Claudia Wilbrecht; Nathalie Van der Aa; Joél Smet; Boel De Paepe; Geer ..., Human Molecular Genetics, 2013
Two siblings from consanguineous parents died perinatally with a condition characterized by generalized hypotonia, respiratory insufficiency, arthrogryposis, microcephaly, congenital brain malformations and hyperglycinemia. Catalytic activities of the mitochondrial respiratory complexes I ...
Mucin-type proteins produced in the Trichoplusia ni and Spodoptera frugiperda insect cell lines carry novel O-glycans with phosphocholine and sulfate substitutions
01-07-2013 | Stefan Gaunitz; Chunsheng Jin; Anki Nilsson; Jining Liu; Niclas G Karlsson; Jan Holgersson, Glycobiology , 2013
The O-glycans of a recombinant mucin-type protein expressed in insect cell lines derived from Trichoplusia ni (Hi-5) and Spodoptera frugiperda (Sf9) were characterized. The P-selectin glycoprotein ligand-1/mouse IgG2b (PSGL-1/mIgG2b) fusion protein carrying 106 potential O-glycosylation ...
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