05-06-2013 | Colin Sumners, Masatsugu Horiuchi, Robert E. Widdop, Claudia McCarthy, Thomas Unger, U. Muscha Steckelings, Clinical and Experimental Pharmacology and Physiology, 2013

Summary In recent years it has been firmly established that apart from the classical renin‐angiotensin‐system (RAS) comprising angiotensin II (Ang II), angiotensin converting enzyme (ACE) ‐ being responsible for Ang II generation ‐ and the angiotensin type 1 receptor (AT1R), there also ...

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21-05-2013 | Anna Häggmark, Sanna Byström, Burcu Ayoglu, Ulrika Qundos, Mathias Uhlén, Mohsen Khademi, Tomas Olsson, Jochen M. Sc ..., PROTEOMICS, 2013

Antibody suspension bead arrays have proven to enable multiplexed and high‐throughput protein profiling in unfractionated plasma and serum samples through a direct labelling approach. We herein describe the development and application of an assay for protein profiling of cerebrospinal fluid ...

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02-05-2013 | Fernando Calahorro, Manuel Ruiz‐Rubio, Genes, Brain and Behavior, 2013

Abstract Neurexins are cell adhesion proteins that interact with neuroligin and other ligands at the synapse. In humans, mutations in neurexin or neuroligin genes have been associated with autism and other mental disorders. The human neurexin and neuroligin genes are orthologous to the C. ...

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02-05-2013 | Lisa Hui, Heather C. Wick, Kenneth J. Moise, Anthony Johnson, Francois Luks, Sina Haeri, Kirby L. Johnson, Diana W. ..., Prenatal Diagnosis, 2013

ABSTRACT Objective To understand the biological pathways involved in twin‐twin transfusion syndrome (TTTS) by performing global gene expression analysis of amniotic fluid (AF) cell‐free RNA. Methods Prospective whole transcriptome microarray study analyzing cell‐free RNA in AF ...

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01-05-2013 | Jessica A. Tiedeken; John S. Ramsdell, Toxicological Sciences, 2013

The harmful alga Pseudo-nitzschia sp. is the cause of human amnesic shellfish poisoning and the stranding of thousands of sea lions with seizures as a hallmark symptom. A human case study and epidemiological report of hundreds of stranded sea lions found individuals presenting months after ...

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01-05-2013 | Kasandra Lovette Burgos; Ashkan Javaherian; Roberto Bomprezzi; Layla Ghaffari; Susan Rhodes; Amanda Courtright; Waib ..., RNA, 2013

There has been a growing interest in using next-generation sequencing (NGS) to profile extracellular small RNAs from the blood and cerebrospinal fluid (CSF) of patients with neurological diseases, CNS tumors, or traumatic brain injury for biomarker discovery. Small sample volumes and samples ...

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24-04-2013 | Olaf Prante, Simone Maschauer, Ashutosh Banerjee, Journal of Labelled Compounds and Radiopharmaceuticals, 2013

The actions of the predominant neurotransmitter in the brain, dopamine, are mediated by the postsynaptic dopamine receptors. The five dopamine receptor subtypes and their regulation have been associated with a large variety of psychiatric diseases. Therefore, positron emission tomography ...

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24-04-2013 | Uta Funke, Danielle J. Vugts, Bieneke Janssen, Arnold Spaans, Perry S. Kruijer, Adriaan A. Lammertsma, Lars R. Perk, ..., Journal of Labelled Compounds and Radiopharmaceuticals, 2013

The signaling molecule histamine plays a key role in the mediation of immune reactions, in gastric secretion, and in the sensory system. In addition, it has an important function as a neurotransmitter in the central nervous system, acting in pituitary hormone secretion, wakefulness, motor ...

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16-04-2013 | Federico W. Grillo; Sen Song; Leonor M. Teles-Grilo Ruivo; Lieven Huang; Ge Gao; Graham W. Knott; Bohumil Maco; Vale ..., Proceedings of the National Academy of Sciences current issue, 2013

Aging is a major risk factor for many neurological diseases and is associated with mild cognitive decline. Previous studies suggest that aging is accompanied by reduced synapse number and synaptic plasticity in specific brain regions. However, most studies, to date, used either postmortem or ...

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15-04-2013 | Brandon M. Kitay; Ryan McCormack; Yunfang Wang; Pantelis Tsoulfas; R. Grace Zhai, Human Molecular Genetics, 2013

Axon degeneration is a common and often early feature of neurodegeneration that correlates with the clinical manifestations and progression of neurological disease. Nicotinamide mononucleotide adenylytransferase (NMNAT) is a neuroprotective factor that delays axon degeneration following ...

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