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1,595 Newest Publications about the topic mitochondria
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Integrative Toxicoproteomics Implicates Impaired Mitochondrial Glutathione Import as an Off-Target Effect of Troglitazone
28-05-2013 | Yie Hou Lee; Wilson Wen Bin Goh; Choon Keow Ng; Manfred Raida; Limsoon Wong; Qingsong Lin; Urs A. Boelsterli; Maxey ..., Journal of Proteome Research, 2013
Troglitazone, a first-generation thiazolidinedione of antihyperglycaemic properties, was withdrawn from the market due to unacceptable idiosyncratic hepatotoxicity. Despite intensive research, the underlying mechanism of troglitazone-induced liver toxicity remains unknown. Here we report the ...
OPA1 promotes pH flashes that spread between contiguous mitochondria without matrix protein exchange
28-05-2013 | Jaime Santo-Domingo, Marta Giacomello, Damon Poburko, Luca Scorrano, Nicolas Demaurex, The EMBO Journal AOP, 2013
The EMBO Journal. doi:10.1038/emboj.2013.124 Authors: Jaime Santo-Domingo, Marta Giacomello, Damon Poburko, Luca Scorrano & Nicolas Demaurex
Extraplastidial Cytidinediphosphate Diacylglycerol Synthase Activity is Required for Vegetative Development in Arabidopsis thaliana
25-05-2013 | Yonghong Zhou, Helga Peisker, Agnes Weth, Werner Baumgartner, Peter Dörmann, Margrit Frentzen, The Plant Journal, 2013
Summary Cytidinediphosphate diacylglycerol synthase (CDS) catalyzes the activation of phosphatidic acid to CDP‐diacylglycerol, a central intermediate in glycerolipid biosynthesis of prokaryotic and eukaryotic organisms. CDP‐diacylglycerol is the precursor to phosphatidylinositol, ...
Characterization of fungal RTG2 genes in retrograde signaling of Saccharomyces cerevisiae
24-05-2013 | Ercan Selçuk Ünlü, Lakshmi Narayanan, Donna M. Gordon, FEMS Yeast Research, 2013
Abstract Changes in the functional status of mitochondria result in the transcriptional activation of a subset of nuclear‐encoded genes in a process referred to as retrograde signaling. In Saccharomyces cerevisiae this molecular link between mitochondria and the nuclear genome is ...
Wolfram Syndrome protein, Miner1, regulates sulphydryl redox status, the unfolded protein response, and Ca2+ homeostasis
24-05-2013 | Sandra E. Wiley, Alexander Y. Andreyev, Ajit S. Divakaruni, Robert Karisch, Guy Perkins, Estelle A. Wall, Peter van ..., EMBO Molecular Medicine, 2013
Abstract Miner1 is a redox‐active 2Fe2S cluster protein. Mutations in Miner1 result in Wolfram Syndrome, a metabolic disease associated with diabetes, blindness, deafness, and a shortened lifespan. Embryonic fibroblasts from Miner1−/− mice displayed ER stress and showed hallmarks of the ...
Mechanisms of respiration intensification of rat pancreatic acini upon carbachol‐induced Ca2+ release
21-05-2013 | Bohdan O. Manko, Volodymyr V. Manko, Acta Physiologica, 2013
Abstract Aim Acetylcholine as one of the main secretagogues modulates mitochondrial functions in acinar pancreacytes, presumably due to increase of ATP hydrolysis or Ca2+‐transport into mitochondria. The aim of this work was to investigate mechanisms of carbachol (CCh) action on ...
HAPLOFIND: A New Method for High‐Throughput mtDNA Haplogroup Assignment
20-05-2013 | Dario Vianello, Federica Sevini, Gastone Castellani, Lomartire Laura, Miriam Capri, Claudio Franceschi, Human Mutation, 2013
ABSTRACT Deep sequencing technologies are completely revolutionizing the approach to DNA analysis. Mitochondrial DNA (mtDNA) studies entered in the “post‐genomic era”: the burst in sequenced samples observed in nuclear genomics is expected also in mitochondria, a trend that can already be ...
The outcome of the movement disorder in methcathinone abusers: clinical, MRI and manganesemia changes, and neuropathology
17-05-2013 | A. Stepens, V. Groma, S. Skuja, A. Platkājis, P. Aldiņš, I. Ekšteina, I. Mārtiņsone, R. Bricis, M. Donaghy, European Journal of Neurology, 2013
Background and purpose There is limited knowledge regarding the long‐term outcome of the methcathinone/manganese‐induced movement disorder. Our purpose was to define prognosis in intravenous methcathinone abusers affected by this distinctive disorder attributed to manganese (Mn) toxicity. ...
Mitochondrial Respiratory Pathways Inhibition in Rhizopus oryzae Potentiates Activity of Posaconazole and Itraconazole via Apoptosis
17-05-2013 | Fazal Shirazi et al., PLoS ONE, 2013
by Fazal Shirazi, Dimitrios P. Kontoyiannis The incidence of mucormycosis has increased drastically in immunocompromised patients. Also the array of targets whose inhibition results in Mucorales death is limited. Recently, researchers identified mitochondria as important regulators of ...
Reversal of Multidrug Resistance by Mitochondrial Targeted Self-Assembled Nanocarrier Based on Stearylamine
16-05-2013 | Zhiwen Zhang; Zeying Liu; Li Ma; Shijun Jiang; Yixin Wang; Haijun Yu; Qi Yin; Jingbin Cui; Yaping Li, Molecular Pharmaceutics, 2013
Multidrug resistance (MDR) remains one of the major challenges for successful chemotherapy. Herein, we tried to develope a mitochondria targeted teniposide loaded self-assembled nanocarrier based on stearylamine (SA-TSN) to reverse MDR of breast cancer. SA-TSN was nanometer-sized spherical ...
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