01-06-2013 | Paolo Innocenti; Stephen F. Chenoweth, Molecular Biology and Evolution, 2013

Change in gene expression is a major facilitator of phenotypic evolution. Understanding the evolutionary potential of gene expression requires taking into account complex systems of regulatory networks, the structure of which could potentially bias evolutionary trajectories. We analyzed the ...

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07-05-2013 | Yutaro Hoshi, Yasuo Uchida, Masanori Tachikawa, Takashi Inoue, Sumio Ohtsuki, Tetsuya Terasaki, Journal of Pharmaceutical Sciences, 2013

Abstract The purpose of this study was to determine the protein amounts of blood–brain barrier (BBB) permeability‐related transporters, receptors, and tight junction proteins in Sprague Dawley and Wistar rats and common marmoset, and also to investigate inter‐species and inter‐strain ...

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05-05-2013 | Author(s): Chao Zheng , Qianqian Guo , Zhongming Wu , Lei Sun , Zhengpu Zhang , Chaoxing Li , Xinge Zhang, European Journal of Pharmaceutical Science, 2013

Publication date: Available online 3 May 2013Source:European Journal of Pharmaceutical Sciences Author(s): Chao Zheng , Qianqian Guo , Zhongming Wu , Lei Sun , Zhengpu Zhang , Chaoxing Li , Xinge Zhang Nasal drug delivery system has been a very promising route for delivery of ...

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04-05-2013 | Dudley W. Lamming, Lan Ye, Michael C. Astle, Joseph A. Baur, David M. Sabatini, David E. Harrison, Aging Cell, 2013

Summary Rapamycin, an inhibitor of the mechanistic target of rapamycin (mTOR) signaling pathway, extends the lifespan of yeast, worms, flies, and mice. Interventions that promote longevity are often correlated with increased insulin sensitivity, and it therefore is surprising that chronic ...

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03-05-2013 | Milagros Rocha, Nadezda Apostolova, Jose Raul Herance, Susana Rovira‐Llopis, Antonio Hernandez‐Mijares, Victor M. Victor, Medicinal Research Reviews, 2013

Abstract There is abundant evidence to suggest that mitochondrial dysfunction is a main cause of insulin resistance and related cardiometabolic comorbidities. On the other hand, insulin resistance is one of the main characteristics of type 2 diabetes, obesity, and metabolic syndrome. ...

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03-05-2013 | Horng-Yih Ou et al., PLoS ONE, 2013

by Horng-Yih Ou, Chih-Yuan Wang, Yi-Ching Yang, Ming-Fong Chen, Chih-Jen Chang Background Fatty infiltration of the pancreas has been shown to interfere with insulin secretion. Both insulin sensitivity and secretion are important in the pathogenesis of diabetes and prediabetes. However, ...

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02-05-2013 | Yeyi Gu, Joshua D. Lambert, Molecular Nutrition & Food Research, 2013

Cocoa (Theobroma cacao L., Sterculiaceae) is a widely consumed food ingredient. Although typically found in high‐fat, high‐sugar foods such as chocolate, cocoa is rich in polyphenols, methylxanthines, and monounsaturated fatty acids. There is increasing evidence that moderate consumption of ...

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01-05-2013 | Teresia Wangensteen, Lars Retterstøl, Olaug K. Rødningen, Jøran Hjelmesæth, Pål Aukrust, Bente Halvorsen, American Journal of Medical Genetics Part A, 2013

Abstract Genetic studies have provided novel insights of appetite regulation and pathophysiology of obesity. The adipose tissue is an active endocrine organ secreting several hormones contributing to insulin resistance and the development of the comorbidities of obesity, such as type 2 ...

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30-04-2013 | Beyhan Tüysüz, Saliha Yılmaz, Ece Gül, Luis Kolb, Kaya Bilguvar, Olcay Evliyaoğlu, Murat Günel, American Journal of Medical Genetics Part A, 2013

Abstract Spondyloepimetaphyseal dysplasia (SEMD), Pakistani type, is a skeletal dysplasia characterized by platyspondyly, delayed epiphyseal ossification, mild metaphyseal abnormalities, short stature, and short and bowed legs, and is caused by mutations in PAPSS2. In a single Turkish ...

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29-04-2013 | David Blum; Luc Buée, Expert Review of Neurotherapeutics, 2013

Expert Review of Neurotherapeutics , May 2013, Vol. 13, No. 5, Pages 461-463.

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