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27 Newest Publications about the topic hemophilia


Polymorphisms in the F8 Gene and MHC-II Variants as Risk Factors for the Development of Inhibitory Anti-Factor VIII Antibodies during the Treatment of Hemophilia A: A Computational Assessment

16-05-2013 | Gouri Shankar Pandey et al., PLoS Computational Biology, 2013

by Gouri Shankar Pandey, Chen Yanover, Tom E. Howard, Zuben E. Sauna The development of neutralizing anti-drug-antibodies to the Factor VIII protein-therapeutic is currently the most significant impediment to the effective management of hemophilia A. Common non-synonymous single nucleotide ...


A genome-wide association study of resistance to HIV infection in highly exposed uninfected individuals with hemophilia A

01-05-2013 | Jérôme Lane; Paul J. McLaren; Lucy Dorrell; Kevin V. Shianna; Amanda Stemke; Kimberly Pelak; Stephen Moore; Johannes ..., Human Molecular Genetics, 2013

Human genetic variation contributes to differences in susceptibility to HIV-1 infection. To search for novel host resistance factors, we performed a genome-wide association study (GWAS) in hemophilia patients highly exposed to potentially contaminated factor VIII infusions. Individuals with ...


Anti‐inflammatory/regulatory cytokine microenvironment mediated by IL‐4 and IL‐10 coordinates the immune response in hemophilia A patients infected chronically with Hepatitis C virus

16-04-2013 | João Paulo Pimentel, Daniel Gonçalves Chaves, Ana Ruth Silva Araújo, Erbênia Maria Martins de Araújo, Liziara da Sil ..., Journal of Medical Virology, 2013

Abstract In the past decades patients with hemophilia were infected commonly by hepatitis C virus (HCV) and a significant number of patients are infected chronically. Focusing on the role of the immune system for controlling and or maintaining HCV infection, the leukocyte and cytokine profiles ...


The clot thickens for long-lasting drugs that stop hemophilia short

06-02-2013 | Alisa Opar, Nature Medicine, 2013

Nature Medicine 19, 121 (2013). doi:10.1038/nm0213-121 Author: Alisa Opar


Domain organization of membrane‐bound factor VIII

17-01-2013 | Svetla Stoilova‐McPhie, Gillian C. Lynch, Steven Ludtke, B. Montgomery Pettitt, Biopolymers, 2013

Abstract Factor VIII (FVIII) is the blood coagulation protein when defective or deficient causes for hemophilia A, a severe hereditary bleeding disorder. Activated FVIII (FVIIIa) is the co‐factor to the serine protease Factor IXa (FIXa) within the membrane‐bound Tenase complex, responsible for ...


Gene Therapy for Hemophilia: Addressing the Coming Challenges of Affordability and Accessibility

01-01-2013 | Mark W Skinner, Molecular Therapy, 2013

Gene Therapy for Hemophilia: Addressing the Coming Challenges of Affordability and Accessibility Molecular Therapy 21, 1 (January 2013). doi:10.1038/mt.2012.272 Author: Mark W Skinner


The CDC Hemophilia A Mutation Project (CHAMP) Mutation List: a New Online Resource

26-12-2012 | Amanda B. Payne, Connie H. Miller, Fiona M. Kelly, J. Michael Soucie, W. Craig Hooper, Human Mutation, 2012

ABSTRACT Genotyping efforts in hemophilia A (HA) populations in many countries have identified large numbers of unique mutations in the Factor VIII gene (F8). To assist HA researchers conducting genotyping analyses, we have developed a listing of F8 mutations including those listed in existing ...


Pharmaceuticals, Vol. 5, Pages 1372-1392: The Liver as a Target Organ for Gene Therapy: State of the Art, Challenges, and Future Perspectives

10-12-2012 | Jacobs, Frank ; Gordts, Stephanie C.; Muthuramu, Ilayaraja ; De Geest, Bart, Pharmaceuticals, 2012

The liver is a target for gene therapy of inborn errors of metabolism, of hemophilia, and of acquired diseases such as liver cancer and hepatitis. The ideal gene transfer strategy should deliver the transgene DNA to parenchymal liver cells with accuracy and precision in the absence of side ...


Development and Characterization of Recombinant Ovine Coagulation Factor VIII

09-11-2012 | Philip M. Zakas et al., PLoS ONE, 2012

by Philip M. Zakas, Bagirath Gangadharan, Graca Almeida-Porada, Christopher D. Porada, H. Trent Spencer, Christopher B. Doering Animal models of the bleeding disorder, hemophilia A, have been an integral component of the biopharmaceutical development process and have facilitated the ...


Leopold: The “Bleeder Prince” and Public Knowledge about Hemophilia in Victorian Britain

01-07-2012 | Alan R. Rushton, Journal of the History of Medicine and Allied Sciences, 2012

Hemophilia is a rare bleeding disorder inherited by males born of unaffected female carriers of the trait. British physicians became knowledgeable about this hereditary disease early in the nineteenth century as they investigated families transmitting the character through several generations. ...


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