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Early rearing history influences oxytocin receptor epigenetic regulation in rhesus macaques [Neuroscience]

31-Oct-2017 | Maggie Baker; Stephen G. Lindell; Carlos A. Driscoll; Zhifeng Zhou; Qiaoping Yuan; Melanie L. Schwandt; Isaac Miller ..., Proceedings of the National Academy of Sciences current issue, 2017

Adaptations to stress can occur through epigenetic processes and may be a conduit for informing offspring of environmental challenge. We employed ChIP-sequencing for H3K4me3 to examine effects of early maternal deprivation (peer-rearing, PR) in archived rhesus macaque hippocampal samples (male, n ...


Why Are the Correlations between mRNA and Protein Levels so Low among the 275 Predicted Protein-Coding Genes on Human Chromosome 18?

27-Oct-2017 | Ekaterina V. Poverennaya; Ekaterina V. Ilgisonis; Elena A. Ponomarenko; Arthur T. Kopylov; Victor G. Zgoda; Sergey P ..., Journal of Proteome Research, 2017

In this work targeted (selected reaction monitoring, SRM, PASSEL: PASS00697) and panoramic (shotgun LC–MS/MS, PRIDE: PXD00244) mass-spectrometric methods as well as transcriptomic analysis of the same samples using RNA-Seq and PCR methods (SRA experiment IDs: SRX341198, SRX267708, SRX395473, ...


Comparative genomics of geographically distant Fusarium fujikuroi isolates revealed two distinct pathotypes correlating with secondary metabolite profiles

26-Oct-2017 | Eva-Maria Niehaus; Hee-Kyoung Kim; Martin Münsterkötter; Slavica Janevska; Birgit Arndt; Svetlana A. Kalinina; Petra ..., PLoS Pathogens, 2017

by Eva-Maria Niehaus, Hee-Kyoung Kim, Martin Münsterkötter, Slavica Janevska, Birgit Arndt, Svetlana A. Kalinina, Petra M. Houterman, Il-Pyung Ahn, Ilaria Alberti, Stefano Tonti, Da-Woon Kim, Christian M. K. Sieber, Hans-Ulrich Humpf, Sung-Hwan Yun, Ulrich Güldener, Bettina Tudzynski Fusarium ...


Pharmacokinetics and Pharmacodynamics of the Triterpenoid Ursolic Acid in Regulating the Antioxidant, Anti-inflammatory, and Epigenetic Gene Responses in Rat Leukocytes

25-Oct-2017 | Chengyue Zhang; Chao Wang; Wenji Li; Renyi Wu; Yue Guo; David Cheng; Yuqing Yang; Ioannis P. Androulakis; Ah-Ng Kong, Molecular Pharmaceutics, 2017

The triterpenoid ursolic acid (UA) has been proposed as a potential cancer chemopreventive agent in many preclinical and clinical studies. In the present work, we aimed to characterize the pharmacokinetics (PK) of UA and to quantitatively assess the antioxidative and anti-inflammatory effects of ...


Functional convergence of histone methyltransferases EHMT1 and KMT2C involved in intellectual disability and autism spectrum disorder

25-Oct-2017 | Tom S. Koemans; Tjitske Kleefstra; Melissa C. Chubak; Max H. Stone; Margot R. F. Reijnders; Sonja de Munnik; Marjole ..., PLoS Genetics, 2017

by Tom S. Koemans, Tjitske Kleefstra, Melissa C. Chubak, Max H. Stone, Margot R. F. Reijnders, Sonja de Munnik, Marjolein H. Willemsen, Michaela Fenckova, Connie T. R. M. Stumpel, Levinus A. Bok, Margarita Sifuentes Saenz, Kyna A. Byerly, Linda B. Baughn, Alexander P. A. Stegmann, Rolph Pfundt, ...


Genetic modifiers of muscular dystrophy act on sarcolemmal resealing and recovery from injury

24-Oct-2017 | Mattia Quattrocelli; Joanna Capote; Joyce C. Ohiri; James L. Warner; Andy H. Vo; Judy U. Earley; Michele Hadhazy; Al ..., PLoS Genetics, 2017

by Mattia Quattrocelli, Joanna Capote, Joyce C. Ohiri, James L. Warner, Andy H. Vo, Judy U. Earley, Michele Hadhazy, Alexis R. Demonbreun, Melissa J. Spencer, Elizabeth M. McNally Genetic disruption of the dystrophin complex produces muscular dystrophy characterized by a fragile muscle plasma ...


Molecular typing and occurrence of beta‐lactam resistance genes of Shigella sonnei strains isolated during 1983‐2014 in the São Paulo State in Brazil

23-Oct-2017 | Amanda Ap. Seribelli, Miliane R. Frazão, Marta I. Cazentini Medeiros, Eliana G. Stehling, Juliana P. Falcão, Microbiology and Immunology, 2017

ABSTRACT Shigella sonnei is generally associated with dysentery in developed countries; but it has recently emerged in developing countries. Specifically, in Brazil there are few published studies that molecularly characterized this species. The aims of this study were to analyze the efficacy ...


The importance of propolis in alleviating the negative physiological effects of heat stress in quail chicks

20-Oct-2017 | Gamal M. K. Mehaisen; Rania M. Ibrahim; Adel A. Desoky; Hosam M. Safaa; Osama A. El-Sayed; Ahmed O. Abass, PLoS ONE, 2017

by Gamal M. K. Mehaisen, Rania M. Ibrahim, Adel A. Desoky, Hosam M. Safaa, Osama A. El-Sayed, Ahmed O. Abass Heat stress is one of the most detrimental confrontations in tropical and subtropical regions of the world, causing considerable economic losses in poultry production. Propolis, a ...


Mycobacterium tuberculosis infection modulates adipose tissue biology

17-Oct-2017 | Macarena Beigier-Bompadre; Georgina N. Montagna; Anja A. Kühl; Laura Lozza; January Weiner III; Andreas Kupz; Alexis ..., PLoS Pathogens, 2017

by Macarena Beigier-Bompadre, Georgina N. Montagna, Anja A. Kühl, Laura Lozza, January Weiner III, Andreas Kupz, Alexis Vogelzang, Hans-Joachim Mollenkopf, Delia Löwe, Silke Bandermann, Anca Dorhoi, Volker Brinkmann, Kai Matuschewski, Stefan H. E. Kaufmann Mycobacterium tuberculosis (Mtb) ...


Molecular mechanisms and structural features of cardiomyopathy-causing troponin T mutants in the tropomyosin overlap region [Biochemistry]

17-Oct-2017 | Binnu Gangadharan; Margaret S. Sunitha; Souhrid Mukherjee; Ritu Roy Chowdhury; Farah Haque; Narendrakumar Sekar; Ram ..., Proceedings of the National Academy of Sciences current issue, 2017

Point mutations in genes encoding sarcomeric proteins are the leading cause of inherited primary cardiomyopathies. Among them are mutations in the TNNT2 gene that encodes cardiac troponin T (TnT). These mutations are clustered in the tropomyosin (Tm) binding region of TnT, TNT1 (residues 80–180). ...


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