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A neuronal MAP kinase constrains growth of a C. elegans sensory dendrite throughout the life of the organism

07-Jun-2018 | Ian G. McLachlan; Isabel Beets; Mario de Bono; Maxwell G. Heiman, PLoS Genetics, 2018

by Ian G. McLachlan, Isabel Beets, Mario de Bono, Maxwell G. Heiman Neurons develop elaborate morphologies that provide a model for understanding cellular architecture. By studying C. elegans sensory dendrites, we previously identified genes that act to promote the extension of ciliated sensory ...

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A mutational co-occurrence network in gastric cancer based on an association index

06-Jun-2018 | Sungjin Park; Seungyoon Nam, International Journal of Data Mining and Bioinformatics, 2018

A mutational co-occurrence network in gastric cancer based on an association indexSungjin Park; Seungyoon NamInternational Journal of Data Mining and Bioinformatics, Vol. 20, No. 1 (2018) pp. 67 - 76Gastric cancer (GC) is one of the most lethal, as well as one of the heterogeneous, cancer types. ...

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Gene-gene interaction analysis for quantitative trait using cluster-based multifactor dimensionality reduction method

06-Jun-2018 | Youjung Lee; Hyein Kim; Taesung Park; Mira Park, International Journal of Data Mining and Bioinformatics, 2018

Gene-gene interaction analysis for quantitative trait using cluster-based multifactor dimensionality reduction methodYoujung Lee; Hyein Kim; Taesung Park; Mira ParkInternational Journal of Data Mining and Bioinformatics, Vol. 20, No. 1 (2018) pp. 1 - 11With recent advances in high-throughput ...

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Viruses, Vol. 10, Pages 308: The E. coli Global Regulator DksA Reduces Transcription during T4 Infection

06-Jun-2018 | Patterson-West, Jennifer ; James, Tamara D.; Fernández-Coll, Llorenç ; Iben, James R.; Moon, Kyung ; Knipling, Les ..., Viruses, 2018

Viruses, Vol. 10, Pages 308: The E. coli Global Regulator DksA Reduces Transcription during T4 Infection Viruses doi: 10.3390/v10060308 Authors: Jennifer Patterson-West Tamara D. James Llorenç Fernández-Coll James R. Iben Kyung Moon Leslie Knipling Michael Cashel Deborah M. ...

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Systematic prediction of genes functionally linked to CRISPR-Cas systems by gene neighborhood analysis [Biophysics and Computational Biology]

05-Jun-2018 | Sergey A. Shmakov; Kira S. Makarova; Yuri I. Wolf; Konstantin V. Severinov; Eugene V. Koonin, Proceedings of the National Academy of Sciences current issue, 2018

The CRISPR-Cas systems that mediate adaptive immunity in bacteria and archaea encompass a small set of core cas genes that are essential in diverse systems belonging to the same subtype, type, or class. However, a much greater number of genes only sporadically co-occur with CRISPR-Cas, and for ...

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Mutations in a subfamily of abscisic acid receptor genes promote rice growth and productivity [Plant Biology]

05-Jun-2018 | Chunbo Miao; Lihong Xiao; Kai Hua; Changsong Zou; Yang Zhao; Ray A. Bressan; Jian-Kang Zhu, Proceedings of the National Academy of Sciences current issue, 2018

Climate change is challenging plant agriculture and our ability to manage food security. Crop growth and yield are controlled by several phytohormones and their overlapping signal networks. We report here an unexpected aspect of the abscisic acid (ABA) signal network that directly impacts rice ...

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CAGE-seq analysis of Epstein-Barr virus lytic gene transcription: 3 kinetic classes from 2 mechanisms

04-Jun-2018 | Reza Djavadian; Mitchell Hayes; Eric Johannsen, PLoS Pathogens, 2018

by Reza Djavadian, Mitchell Hayes, Eric Johannsen Epstein-Barr virus (EBV) lytic replication proceeds through an ordered cascade of gene expression that integrates lytic DNA amplification and late gene transcription. We and others previously demonstrated that 6 EBV proteins that have orthologs ...

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Functional analysis of African Xanthomonas oryzae pv. oryzae TALomes reveals a new susceptibility gene in bacterial leaf blight of rice

04-Jun-2018 | Tuan T. Tran; Alvaro L. Pérez-Quintero; Issa Wonni; Sara C. D. Carpenter; Yanhua Yu; Li Wang; Jan E. Leach; Valérie ..., PLoS Pathogens, 2018

by Tuan T. Tran, Alvaro L. Pérez-Quintero, Issa Wonni, Sara C. D. Carpenter, Yanhua Yu, Li Wang, Jan E. Leach, Valérie Verdier, Sébastien Cunnac, Adam J. Bogdanove, Ralf Koebnik, Mathilde Hutin, Boris Szurek Most Xanthomonas species translocate Transcription Activator-Like (TAL) effectors into ...

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Defects in intracellular trafficking of fungal cell wall synthases lead to aberrant host immune recognition

04-Jun-2018 | Shannon K. Esher; Kyla S. Ost; Maria A. Kohlbrenner; Kaila M. Pianalto; Calla L. Telzrow; Althea Campuzano; Connie B ..., PLoS Pathogens, 2018

by Shannon K. Esher, Kyla S. Ost, Maria A. Kohlbrenner, Kaila M. Pianalto, Calla L. Telzrow, Althea Campuzano, Connie B. Nichols, Carol Munro, Floyd L. Wormley Jr., J. Andrew Alspaugh The human fungal pathogen, Cryptococcus neoformans, dramatically alters its cell wall, both in size and ...

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Isolation of a natural DNA virus of Drosophila melanogaster, and characterisation of host resistance and immune responses

04-Jun-2018 | William H. Palmer; Nathan C. Medd; Philippa M. Beard; Darren J. Obbard, PLoS Pathogens, 2018

by William H. Palmer, Nathan C. Medd, Philippa M. Beard, Darren J. Obbard Drosophila melanogaster has played a key role in our understanding of invertebrate immunity. However, both functional and evolutionary studies of host-virus interaction in Drosophila have been limited by a dearth of ...

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