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33,555 Newest Publications about the topic genes


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Negative supercoiling of DNA by gyrase is inhibited in Salmonella enterica serovar Typhimurium during adaptation to acid stress

20-Jan-2018 | Aoife M Colgan, Heather J Quinn, Stefani C Kary, Lesley A. Mitchenall, Anthony Maxwell, Andrew DS Cameron, Charles J ..., Molecular Microbiology, 2018

Summary DNA in intracellular Salmonella enterica serovar Typhimurium relaxes during growth in the acidified (pH 4 to 5) macrophage vacuole and DNA relaxation correlates with upregulation of Salmonella genes involved in adaptation to the macrophage environment. Bacterial ATP levels did not ...


Viruses, Vol. 10, Pages 46: Distinct Effects of Type I and III Interferons on Enteric Viruses

20-Jan-2018 | Ingle, Harshad ; Peterson, Stefan T.; Baldridge, Megan T., Viruses, 2018

Viruses, Vol. 10, Pages 46: Distinct Effects of Type I and III Interferons on Enteric Viruses Viruses doi: 10.3390/v10010046 Authors: Harshad Ingle Stefan Peterson Megan Baldridge Interferons (IFNs) are key host cytokines in the innate immune response to viral infection, and ...


Arsenite‐induced histone H3 modification and its effects on EGR1 and FOS expression in HeLa cells

19-Jan-2018 | Toshihide Suzuki, Hiroshi Watanabe, Kayoko Kita, Taro Honma, Takafumi Ochi, Journal of Applied Toxicology, 2018

Abstract It is evident that trivalent arsenicals do not have mutagenicity, but they are human carcinogens. Recently, epigenetic modification has been considered as one of the important causes of arsenical carcinogenicity. Here we examined global histone H3 modification by trivalent inorganic ...


Three‐generation family with novel contiguous gene deletion on chromosome 2p22 associated with thoracic aortic aneurysm syndrome

19-Jan-2018 | Bianca Quiñones‐Pérez, Grace E. VanNoy, Meghan C. Towne, Yiping Shen, Michael N. Singh, Pankaj B. Agrawal, Sharon E. ..., American Journal of Medical Genetics Part A, 2018

Latent transforming growth factor binding proteins (LTBP) are a family of extracellular matrix glycoproteins that play an important role in the regulation of transforming growth factor beta (TGF‐ß) activation. Dysregulation of the TGF‐ß pathway has been implicated in the pathogenesis of ...


Eukaryotic phytoplankton community spatiotemporal dynamics as identified through gene expression within a eutrophic estuary

19-Jan-2018 | Weida Gong, Hans Paerl, Adrian Marchetti, Environmental Microbiology, 2018

Summary Over the span of a year, we investigated the interactions between biotic and abiotic factors within the eutrophic Neuse River Estuary (NRE). Through metatranscriptomic sequencing in combination with water quality measurements, we show that there are different metabolic strategies ...


Ethanolamine is a Valuable Nutrient Source that Impacts Clostridium difficile Pathogenesis

19-Jan-2018 | Kathryn L. Nawrocki, Daniela Wetzel, Joshua B. Jones, Emily C. Woods, Shonna M. McBride, Environmental Microbiology, 2018

SUMMARY Clostridium (Clostridioides) difficile is a gastrointestinal pathogen that colonizes the intestinal tract of mammals and can cause severe diarrheal disease. Although C. difficile growth is confined to the intestinal tract, our understanding of the specific metabolites and host factors ...


Antibiogram and genetic diversity of Salmonella enterica with zoonotic potential isolated from morbid native chickens and pigeons in Egypt

19-Jan-2018 | E. Abdeen, W. Elmonir, I. I. A. Suelam, W. S. Mousa, Journal of Applied Microbiology, 2018

Abstract Aims This study investigated the possible role of Fayoumi chickens and pigeons in the transmission of multidrug resistant (MDR) Salmonella with zoonotic potential. Methods and Results Morbid Fayoumi chickens (70) and pigeons (30) were examined to detect the prevalence and ...


Multiplexed gene synthesis in emulsions for exploring protein functional landscapes

19-Jan-2018 | Calin Plesa; Angus M. Sidore; Nathan B. Lubock; Di Zhang; Sriram Kosuri, Science , 2018

Improving our ability to construct and functionally characterize DNA sequences would broadly accelerate progress in biology. Here, we introduce DropSynth, a scalable, low-cost method to build thousands of defined gene-length constructs in a pooled (multiplexed) manner. DropSynth uses a library of ...


Avoiding interferon avoidance

19-Jan-2018 | Stella Hurtley; Caroline Ash, Science , 2018

Vaccines Interferon (IFN) expression is a mammal's first response to viral infection. Many viruses have thus evolved mechanisms to evade IFN. Du et al. developed a method to systematically ablate IFN evasion genes from live, attenuated influenza virus (see the Perspective by Teijaro and Burton). A


Allocation of distinct organ fates from a precursor field requires a shift in expression and function of gene regulatory networks

19-Jan-2018 | Sneha Palliyil; Jinjin Zhu; Luke R. Baker; Sarah D. Neuman; Arash Bashirullah; Justin P. Kumar, PLoS Genetics, 2018

by Sneha Palliyil, Jinjin Zhu, Luke R. Baker, Sarah D. Neuman, Arash Bashirullah, Justin P. Kumar A common occurrence in metazoan development is the rise of multiple tissues/organs from a single uniform precursor field. One example is the anterior forebrain of vertebrates, which produces the ...


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