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33,581 Newest Publications about the topic genes

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Decreased A-to-I RNA editing as a source of keratinocytes' dsRNA in psoriasis [ARTICLE]

01-Jun-2018 | Lea Shallev; Eli Kopel; Ariel Feiglin; Gil S. Leichner; Dror Avni; Yechezkel Sidi; Eli Eisenberg; Aviv Barzilai; Ere ..., RNA, 2018

Recognition of dsRNA molecules activates the MDA5–MAVS pathway and plays a critical role in stimulating type-I interferon responses in psoriasis. However, the source of the dsRNA accumulation in psoriatic keratinocytes remains largely unknown. A-to-I RNA editing is a common co- or ...

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Balance between MAT2A intron detention and splicing is determined cotranscriptionally [REPORT]

01-Jun-2018 | Kathryn E. Pendleton; Sung-Kyun Park; Olga V. Hunter; Stefan M. Bresson; Nicholas K. Conrad, RNA, 2018

Transcriptome analysis of human cells has revealed that intron retention controls the expression of a large number of genes with diverse cellular functions. Detained introns (DI) constitute a subgroup of transcripts with retained introns that are not exported to the cytoplasm but instead remain ...

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Pathogens constancy, harbinger of nosocomial infection cum identification of resistant genes and drug designing

20-May-2018 | Author(s): Sana Farooq Ahmad, Ibrar Khan, Abdul Wadood, Sadiq Azam, Noor Rehman, Muhammad Waqas, Kashif ..., Computational Biology and Chemistry, 2018

Publication date: June 2018 Source:Computational Biology and Chemistry, Volume 74 Author(s): Sana Farooq Ahmad, Ibrar Khan, Abdul Wadood, Sadiq Azam, Noor Rehman, Muhammad Waqas, Kashif Bashir, Asaf Ali Khan Hospitals are the most prominent places for the growth and spread ...

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An efficient strategy for identifying cancer-related key genes based on graph entropy

20-May-2018 | Author(s): Wei Zhang, Shu-Lin Wang, Computational Biology and Chemistry, 2018

Publication date: June 2018 Source:Computational Biology and Chemistry, Volume 74 Author(s): Wei Zhang, Shu-Lin Wang Gene networks are beneficial to identify functional genes that are highly relevant to clinical outcomes. Most of the current methods require information about the ...

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Mutation screening using formalin-fixed paraffin-embedded tissues: a stratified approach according to DNA quality

16-May-2018 | Francesco Cucco; Alexandra Clipson; Hannah Kennedy; Joe Sneath Thompson; Ming Wang; Sharon Barrans; Moniek van Hoppe ..., Laboratory Investigation, 2018

DNA samples from formalin-fixed paraffin-embedded tissues are highly degraded with variable quality, and this imposes a big challenge for targeted sequencing due to false positives, largely caused by PCR errors and cytosine deamination. To eliminate false positives, a common practice is to ...

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Genomic adaptation to drought in wild barley is driven by edaphic natural selection at the Tabigha Evolution Slope [Evolution]

15-May-2018 | Xiaolei Wang; Zhong-Hua Chen; Chongyi Yang; Xuelei Zhang; Gulei Jin; Guang Chen; Yuanyuan Wang; Paul Holford; Eviata ..., Proceedings of the National Academy of Sciences current issue, 2018

Microsite evolution involving ecological divergence due to geological, edaphic, or climatic conditions requires adaptive complexes to environmental stresses. The higher drought tolerance of wild barley populations inhabiting Terra Rossa soil at the Tabigha Evolution Slope has been described, but ...

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Insulin promoter in human pancreatic {beta} cells contacts diabetes susceptibility loci and regulates genes affecting insulin metabolism [Cell Biology]

15-May-2018 | Xing Jian; Gary Felsenfeld, Proceedings of the National Academy of Sciences current issue, 2018

We show that in a human pancreatic β cell line the human insulin gene promoter on chromosome 11 physically contacts sites on other chromosomes. Many of these contacted sites contain type 1 or type 2 diabetes susceptibility loci. We find that insulin gene expression can affect expression of ...

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Gene regulatory network architecture in different developmental contexts influences the genetic basis of morphological evolution

03-May-2018 | Sebastian Kittelmann; Alexandra D. Buffry; Franziska A. Franke; Isabel Almudi; Marianne Yoth; Gonzalo Sabaris; Juan ..., PLoS Genetics, 2018

by Sebastian Kittelmann, Alexandra D. Buffry, Franziska A. Franke, Isabel Almudi, Marianne Yoth, Gonzalo Sabaris, Juan Pablo Couso, Maria D. S. Nunes, Nicolás Frankel, José Luis Gómez-Skarmeta, Jose Pueyo-Marques, Saad Arif, Alistair P. McGregor Convergent phenotypic evolution is often caused ...

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HNRNPA1 promotes recognition of splice site decoys by U2AF2 in vivo [RESEARCH]

01-May-2018 | Howard, J. M., Lin, H., Wallace, A. J., Kim, G., Draper, J. M., Haeussler, M., Katzman, S., Toloue, M., Liu, Y., San ..., Genome Research, 2018

Alternative pre-mRNA splicing plays a major role in expanding the transcript output of human genes. This process is regulated, in part, by the interplay of trans-acting RNA binding proteins (RBPs) with myriad cis-regulatory elements scattered throughout pre-mRNAs. These molecular recognition ...

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Detecting epistasis within chromatin regulatory circuitry reveals CAND2 as a novel susceptibility gene for obesity

01-May-2018 | Shan-Shan Dong; Shi Yao; Yi-Xiao Chen; Yan Guo; Yu-Jie Zhang; Hui-Min Niu; Ruo-Han Hao; Hui Shen; Qing Tian; Hong-We ..., International Journal of Obesity, 2018

Genome-wide association studies have identified many susceptibility loci for obesity. However, missing heritability problem is still challenging and ignorance of genetic interactions is believed to be an important cause. Current methods for detecting interactions usually do not consider ...

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