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20,495 Newest Publications about the topic genes
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Thirdhand smoke causes DNA damage in human cells
01-07-2013 | Bo Hang; Altaf H. Sarker; Christopher Havel; Saikat Saha; Tapas K. Hazra; Suzaynn Schick; Peyton Jacob III; Virender ..., Mutagenesis, 2013
Exposure to thirdhand smoke (THS) is a newly described health risk. Evidence supports its widespread presence in indoor environments. However, its genotoxic potential, a critical aspect in risk assessment, is virtually untested. An important characteristic of THS is its ability to undergo ...
Sensitivity of the Pig-a assay for detecting gene mutation in rats exposed acutely to strong clastogens
01-07-2013 | Javed A. Bhalli; Joseph G. Shaddock; Mason G. Pearce; Vasily N. Dobrovolsky, Mutagenesis, 2013
Clastogens are potential human carcinogens whose detection by genotoxicity assays is important for safety assessment. Although some endogenous genes are sensitive to the mutagenicity of clastogens, many genes that are used as reporters for in vivo mutation (e.g. transgenes) are not. In this ...
Otitis media in the Tgif knockout mouse implicates TGF{beta} signalling in chronic middle ear inflammatory disease
01-07-2013 | Hilda Tateossian; Susan Morse; Andrew Parker; Philomena Mburu; Nick Warr; Abraham Acevedo-Arozena; Michael Cheeseman ..., Human Molecular Genetics, 2013
Otitis media with effusion (OME) is the most common cause of hearing loss in children and tympanostomy to alleviate the condition remains the commonest surgical intervention in children in the developed world. Chronic and recurrent forms of OM are known to have a very significant genetic ...
Heterochromatinization induced by GAA-repeat hyperexpansion in Friedreich's ataxia can be reduced upon HDAC inhibition by vitamin B3
01-07-2013 | Ping K. Chan; Raul Torres; Cihangir Yandim; Pui P. Law; Sanjay Khadayate; Marta Mauri; Crina Grosan; Nadine Chapman- ..., Human Molecular Genetics, 2013
Large intronic expansions of the triplet-repeat sequence (GAA.TTC) cause transcriptional repression of the Frataxin gene (FXN) leading to Friedreich's ataxia (FRDA). We previously found that GAA-triplet expansions stimulate heterochromatinization in vivo in transgenic mice. We report here ...
Increased genome instability in human DNA segments with self-chains: homology-induced structural variations via replicative mechanisms
01-07-2013 | Weichen Zhou; Feng Zhang; Xiaoli Chen; Yiping Shen; James R. Lupski; Li Jin, Human Molecular Genetics, 2013
Environmental factors including ionizing radiation and chemical agents have been known to be able to induce DNA rearrangements and cause genomic structural variations (SVs); however, the roles of intrinsic characteristics of the human genome, such as regional genome architecture, in SV ...
Glycosaminoglycans in the blood of hereditary multiple exostoses patients: Half reduction of heparan sulfate to chondroitin sulfate ratio and the possible diagnostic application
01-07-2013 | Md. Ferdous Anower-E-Khuda; Kazu Matsumoto; Hiroko Habuchi; Hiroyuki Morita; Takashi Yokochi; Katsuji Shimizu; Koji ..., Glycobiology , 2013
Hereditary multiple exostoses (HME) is an autosomal dominant skeletal disorder with wide variation in clinical phenotype and is caused by heterogeneous germline mutations in two of the Ext genes, EXT-1 and EXT-2, which encode ubiquitously expressed glycosyltransferases involved in the ...
The role of nonsense-mediated decay in neuronal ceroid lipofuscinosis
01-07-2013 | Jake N. Miller; Chun-Hung Chan; David A. Pearce, Human Molecular Genetics, 2013
Neuronal ceroid lipofuscinosis (NCL), commonly referred to as Batten disease, is a group of autosomal recessive neurodegenerative diseases of childhood characterized by seizures, blindness, motor and cognitive decline and premature death. Currently, there are over 400 known mutations in 14 ...
A newly isolated Chlorella sp. from desert sand crusts exhibits a unique resistance to excess light intensity
16-06-2013 | Haim Treves, Hagai Raanan, Omri Finkel, Simon M. Berkowicz, Nir Keren, Yoram Shotland, Aaron Kaplan, FEMS Microbiology Ecology, 2013
Abstract We recently isolated a small green alga from a biological sand crust (BSC) in the NW Negev, Israel. Based on its 18S rDNA and rbcL genes it is a close relative of Chlorella sorokiniana and of certain strains of C. vulgaris and C. variabilis, but differs substantially in many ...
ING5 Is a Tip60 Cofactor That Acetylates p53 in Response to DNA Damage
15-06-2013 | Nansong Liu; Jiadong Wang; Jifeng Wang; Rukai Wang; Zhongle Liu; Yao Yu; Hong Lu, Cancer Research, 2013
Posttranslational modification of p53 is a critical event in regulating the expression of its target genes. p53 is acetylated at lysine 120 (K120) by acetyltranferases Tip60 (KAT5) and hMOF (KAT8) in response to DNA damage. Identification of cofactors for these two enzymes will shed light on ...
DDB2 Suppresses Epithelial-to-Mesenchymal Transition in Colon Cancer
15-06-2013 | Nilotpal Roy; Prashant V. Bommi; Uppoor G. Bhat; Shaumick Bhattacharjee; Indira Elangovan; Jing Li; Krushna C. Patra ..., Cancer Research, 2013
Colon cancer is one of the deadliest cancers worldwide because of its metastasis to other essential organs. Metastasis of colon cancer involves a complex set of events, including epithelial-to-mesenchymal transition (EMT) that increases invasiveness of the tumor cells. Here, we show that the ...
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