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25,495 Newest Publications about the topic expression
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Gene Coexpression Networks Reveal Key Drivers of Phenotypic Divergence in Lake Whitefish
01-06-2013 | Marie Filteau; Scott A. Pavey; Jérôme St-Cyr; Louis Bernatchez, Molecular Biology and Evolution, 2013
A functional understanding of processes involved in adaptive divergence is one of the awaiting opportunities afforded by high-throughput transcriptomic technologies. Functional analysis of coexpressed genes has succeeded in the biomedical field in identifying key drivers of disease pathways. ...
Expression Divergence between Escherichia coli and Salmonella enterica serovar Typhimurium Reflects Their Lifestyles
01-06-2013 | Pieter Meysman; Aminael Sánchez-Rodríguez; Qiang Fu; Kathleen Marchal; Kristof Engelen, Molecular Biology and Evolution, 2013
Escherichia coli K12 is a commensal bacteria and one of the best-studied model organisms. Salmonella enterica serovar Typhimurium, on the other hand, is a facultative intracellular pathogen. These two prokaryotic species can be considered related phylogenetically, and they share a large ...
Interspecific Divergence of Transcription Networks along Lines of Genetic Variance in Drosophila: Dimensionality, Evolvability, and Constraint
01-06-2013 | Paolo Innocenti; Stephen F. Chenoweth, Molecular Biology and Evolution, 2013
Change in gene expression is a major facilitator of phenotypic evolution. Understanding the evolutionary potential of gene expression requires taking into account complex systems of regulatory networks, the structure of which could potentially bias evolutionary trajectories. We analyzed the ...
Estimating Selection on Synonymous Codon Usage from Noisy Experimental Data
01-06-2013 | Edward W.J. Wallace; Edoardo M. Airoldi; D. Allan Drummond, Molecular Biology and Evolution, 2013
A key goal in molecular evolution is to extract mechanistic insights from signatures of selection. A case study is codon usage, where despite many recent advances and hypotheses, two longstanding problems remain: the relative contribution of selection and mutation in determining codon ...
Inhibition of galectin-3 reduces atherosclerosis in apolipoprotein E-deficient mice
01-06-2013 | Alison C MacKinnon; Xiaojun Liu; Patrick WF Hadoke; Mark R Miller; David E Newby; Tariq Sethi, Glycobiology , 2013
Atherosclerosis is a major risk factor for cardiovascular disease (CVD) and stroke. Galectin-3 is a carbohydrate-binding lectin implicated in the pathophysiology of CVD and is highly expressed within atherosclerotic lesions in mice and humans. The object of this present study was to use ...
Advanced mass spectrometry and chemical analyses reveal the presence of terminal disialyl motif on mouse B-cell glycoproteins
01-06-2013 | Shui-Hua Wang; Chih-Ming Tsai; Kuo-I Lin; Kay-Hooi Khoo, Glycobiology , 2013
The occurrence of a terminal disialyl motif on mammalian O-glycans is increasingly being identified through recent mass spectrometry (MS)-based glycomic profiling. In most cases, it is carried on simple core 1 structures in which both the galactose and N-acetyl galactosamine can be ...
Overexpression of Sulf2 in idiopathic pulmonary fibrosis
01-06-2013 | Xinping Yue; Jingning Lu; Linda Auduong; Mark D Sides; Joseph A Lasky, Glycobiology , 2013
Previously, we have shown that heparan sulfate (HS) 6-O-endosulfatase 1 (Sulf1) is a transforming growth factor-β1 (TGF-β1)-responsive gene in normal human lung fibroblasts and functions as a negative feedback regulator of TGF-β1 and that TGF-β1 induces the expression of Sulf1 as well as ...
Expression of Shiga toxin 2e glycosphingolipid receptors of primary porcine brain endothelial cells and toxin-mediated breakdown of the blood–brain barrier
01-06-2013 | Iris Meisen; Regina Rosenbrück; Hans-Joachim Galla; Sabine Hüwel; Ivan U Kouzel; Michael Mormann; Helge Karch; Johan ..., Glycobiology , 2013
Shiga toxin (Stx) 2e, released by certain Stx-producing Escherichia coli, is presently the best characterized virulence factor responsible for pig edema disease, which is characterized by hemorrhagic lesions, neurological disorders and often fatal outcomes. Although Stx2e-mediated brain ...
An efficient method for selectively imaging and quantifying in situ the expression of sialylated glycoproteins on living cells
01-06-2013 | Ying Zhang; Jiangbei Yuan; Jingjing Song; Zhongfu Wang; Linjuan Huang, Glycobiology , 2013
A simple and efficient method for selectively imaging and monitoring in situ the expression of sialylated glycoproteins on living cells has been developed. Treating living cells by mild periodate oxidation to selectively generate aldehydes on sialylated glycoproteins, followed by direct ...
Identification of microRNA and bioinformatics target gene analysis in beef cattle intramuscular fat and subcutaneous fat
15-05-2013 | Haiyang Wang; Yue Zheng; Genlin Wang; Huixia Li, Molecular BioSystems, 2013
microRNA (miRNA) are endogenous non-coding RNA that has been proposed play important roles in the formation of body fat. However, the differential expression of miRNA and the role of these miRNA in bovine intramuscular and subcutaneous fat tissue are still unknown. In this study, profile of ...
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