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153 Newest Publications about the topic cyclophosphamide
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Enhancing the sensitivity of the comet assay as a genotoxicity test, by combining it with bacterial repair enzyme FPG
01-05-2013 | Amaya Azqueta; Leire Arbillaga; Adela López de Cerain; Andrew Collins, Mutagenesis, 2013
The alkaline comet assay, when employed as a genotoxicity test, has relatively low sensitivity because it fails to detect—at non-cytotoxic concentrations—known genotoxins that do not induce breaks or alkali-labile sites. We demonstrate that this limitation is overcome by incorporating in the ...
The first antibody therapy for cancer: a personal experience
08-04-2013 | Antonio J Grillo-López, Expert Review of Anticancer Therapy, 2013
More than 100years ago, Paul Ehrlich proposed that antibodies could be used for therapeutic purposes. Little progress was achieved until Köhler and Milstein developed hybridoma technology in the 1970s. In 1997, rituximab, the first antibody for the treatment of cancer, was approved. Its ...
Dual control of Shuanghuang Shengbai granule on upstream and downstream signal modulators of CyclinD-CDK4/6 signaling pathway of cell cycle in Lewis-bearing mice with cyclophosphamide-induced myelosuppression
27-03-2013 | Gu X, Xu Z, Zhu LY, Wang L, Li K, Pei Q, OncoTargets and Therapy, 2013
Gu X, Xu Z, Zhu LY, Wang L, Li K, Pei Q
Protective Effects of Total Flavonoids from Epimedium on the Male Mouse Reproductive System Against Cyclophosphamide‐Induced Oxidative Injury by Up‐Regulating the Expressions of SOD3 and GPX1
12-03-2013 | Ding Yuan, Hongwu Wang, Haibo He, Liangliang Jia, Yumin He, Ting Wang, Xiao Zeng, Yuzhou Li, Shouchao Li, Changcheng ..., Phytotherapy Research, 2013
Total flavonoids of Epimedium (TFE) is the main active composition of Epimedium that has been used to treat male reproductive problems. The present aim was to investigate the protective effects of TFE on male mice reproductive system against cyclophosphamide (CP)‐induced oxidative injury. ...
Neutrophil and Eosinophil Granulocytes as Key Players in a Mouse Model of Chemical-Induced Asthma
01-02-2013 | Vanessa De Vooght; Stijn Smulders; Steven Haenen; Jochen Belmans; Ghislain Opdenakker; Erik Verbeken; Benoit Nemery; ..., Toxicological Sciences, 2013
Diisocyanates are an important cause of chemical-induced occupational asthma. This type of immunologically mediated asthma is often characterized by a predominant granulocytic inflammation in the airways, rather than an infiltration by lymphocytes. We sought to determine the contribution of ...
Polo-like Kinase 1: A Potential Therapeutic Option in Combination with Conventional Chemotherapy for the Management of Patients with Triple-Negative Breast Cancer
15-01-2013 | Virginie Maire; Fariba Némati; Marion Richardson; Anne Vincent-Salomon; Bruno Tesson; Guillem Rigaill; Eléonore Grav ..., Cancer Research, 2013
Breast cancers are composed of molecularly distinct subtypes with different clinical outcomes and responses to therapy. To discover potential therapeutic targets for the poor prognosis-associated triple-negative breast cancer (TNBC), gene expression profiling was carried out on a cohort of ...
Human cardiotoxic drugs delivered by soaking and microinjection induce cardiovascular toxicity in zebrafish
11-01-2013 | Jun‐Jing Zhu, Yi‐Qiao Xu, Jian‐Hui He, Hang‐Ping Yu, Chang‐Jiang Huang, Ji‐Min Gao, Qiao‐Xiang Dong, Yao‐Xian Xuan, ..., Journal of Applied Toxicology, 2013
ABSTRACT Cardiovascular toxicity is a major challenge for the pharmaceutical industry and predictive screening models to identify and eliminate pharmaceuticals with the potential to cause cardiovascular toxicity in humans are urgently needed. In this study, taking advantage of the ...
The Role of Mesothelin in Tumor Progression and Targeted Therapy
01-01-2013 | Tang, Zhewei; Qian, Min; Ho, Mitchell, Anti-Cancer Agents in Medicinal Chemistry , 2013
Abstract: Mesothelin, a glycosylphosphatidylinositol (GPI) anchored cell surface protein, is a potential target for antibody-based cancer therapy due to its high expression in mesothelioma, ovarian cancer, pancreatic cancer, cholangiocarcinoma and other cancers. The SS1P immunotoxin ...
Involvement of Interleukin-6-Regulated Nitric Oxide Synthase in Hemorrhagic Cystitis and Impaired Bladder Contractions in Young Rats Induced by Acrolein, a Urinary Metabolite of Cyclophosphamide
01-01-2013 | Ching-Chia Wang; Te-I Weng; En-Ting Wu; Mei-Hwan Wu; Rong-Sen Yang; Shing-Hwa Liu, Toxicological Sciences, 2013
Hemorrhagic cystitis is a common complication in children receiving cyclophosphamide, a chemotherapeutic alkylating agent. Acrolein is a urinary metabolite from cyclophosphamide and can induce hemorrhagic cystitis. Here, we investigated the effects and mechanisms of acrolein by intravesical ...
Automatic analysis of the micronucleus test in primary human lymphocytes using image analysis
01-01-2013 | W. Frieauff; H. J. Martus; W. Suter; A. Elhajouji, Mutagenesis, 2013
The in vitro micronucleus test (MNT) is a well-established test for early screening of new chemical entities in industrial toxicology. For assessing the clastogenic or aneugenic potential of a test compound, micronucleus induction in cells has been shown repeatedly to be a sensitive and a ...
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