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2,514 Newest Publications about the topic biochemistry

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pLoc-mPlant: predict subcellular localization of multi-location plant proteins by incorporating the optimal GO information into general PseAAC

19-Jul-2017 | Xiang Cheng; Xuan Xiao; Kuo-Chen Chou, Molecular BioSystems, 2017

One of the fundamental goals in cellular biochemistry is to identify the functions of proteins in the context of compartments that organize them in the cellular environment. To realize this, it is indispensable to develop an automated method for fast and accurate identification of the subcellular ...

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Undergraduate research as curriculum

11-Jul-2017 | Erin L. Dolan, Biochemistry and Molecular Biology Education, 2017

Abstract To date, national interests, policies, and calls for transformation of undergraduate education have been the main drivers of research integration into the undergraduate curriculum, briefly described here. The New Horizons in Biochemistry and Molecular Biology Education conference at ...

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TraR directly regulates transcription initiation by mimicking the combined effects of the global regulators DksA and ppGpp [Biochemistry]

11-Jul-2017 | Saumya Gopalkrishnan; Wilma Ross; Albert Y. Chen; Richard L. Gourse, Proceedings of the National Academy of Sciences current issue, 2017

The Escherichia coli F element-encoded protein TraR is a distant homolog of the chromosome-encoded transcription factor DksA. Here we address the mechanism by which TraR acts as a global regulator, inhibiting some promoters and activating others. We show that TraR regulates transcription directly ...

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Nucleotide-dependent farnesyl switch orchestrates polymerization and membrane binding of human guanylate-binding protein 1 [Biochemistry]

11-Jul-2017 | Sergii Shydlovskyi; Anke Y. Zienert; Semra Ince; Christine Dovengerds; Annika Hohendahl; Julia M. Dargazanli; Ailisa ..., Proceedings of the National Academy of Sciences current issue, 2017

Dynamin-like proteins (DLPs) mediate various membrane fusion and fission processes within the cell, which often require the polymerization of DLPs. An IFN-inducible family of DLPs, the guanylate-binding proteins (GBPs), is involved in antimicrobial and antiviral responses within the cell. Human ...

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Structure of human nSMase2 reveals an interdomain allosteric activation mechanism for ceramide generation [Biochemistry]

11-Jul-2017 | Michael V. Airola; Prajna Shanbhogue; Achraf A. Shamseddine; Kip E. Guja; Can E. Senkal; Rohan Maini; Nana Bartke; B ..., Proceedings of the National Academy of Sciences current issue, 2017

Neutral sphingomyelinase 2 (nSMase2, product of the SMPD3 gene) is a key enzyme for ceramide generation that is involved in regulating cellular stress responses and exosome-mediated intercellular communication. nSMase2 is activated by diverse stimuli, including the anionic phospholipid ...

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CRISPR-Cas9 conformational activation as elucidated from enhanced molecular simulations [Biochemistry]

11-Jul-2017 | Giulia Palermo; Yinglong Miao; Ross C. Walker; Martin Jinek; J. Andrew McCammon, Proceedings of the National Academy of Sciences current issue, 2017

CRISPR-Cas9 has become a facile genome editing technology, yet the structural and mechanistic features underlying its function are unclear. Here, we perform extensive molecular simulations in an enhanced sampling regime, using a Gaussian-accelerated molecular dynamics (GaMD) methodology, which ...

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Creating 3D physical models to probe student understanding of macromolecular structure

06-Jul-2017 | A. Kat Cooper, M. T. Oliver‐Hoyo, Biochemistry and Molecular Biology Education, 2017

The high degree of complexity of macromolecular structure is extremely difficult for students to process. Students struggle to translate the simplified two‐dimensional representations commonly used in biochemistry instruction to three‐dimensional aspects crucial in understanding ...

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The Ca2+/CaM2 binding transcription factor TGA3 elevates LCD expression and H2S production to bolster Cr6+ tolerance in Arabidopsis

03-Jul-2017 | Huihui Fang, Zhiqiang Liu, Yanping Long, Yali Liang, Zhuping Jin, Liping Zhang, Danmei Liu, Hua Li, Jixian Zhai, Yan ..., The Plant Journal, 2017

Summary Heavy metals (HMs) contamination on agricultural lands not only reduces crop yield but also causes human health concerns. As a plant gasotransmitter, hydrogen sulfide (H2S) can trigger various defense responses and help reduce HMs accumulation in plants; however, little is known about ...

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Varying iron release from transferrin and lactoferrin proteins. A laboratory experiment

03-Jul-2017 | Fernando Carmona, Ana González, Manu Sánchez, Natividad Gálvez, Rafael Cuesta, Mercè Capdevila, Jose M. Dominguez‐Vera, Biochemistry and Molecular Biology Education, 2017

Abstract Iron metabolism is an important subject of study for undergraduate students of chemistry and biochemistry. Relevant laboratory exercises are scarce in the literature but would be very helpful in assisting students grasp key concepts. The experiment described here deals with different ...

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Biosynthesis of isonitrile lipopeptides by conserved nonribosomal peptide synthetase gene clusters in Actinobacteria [Biochemistry]

03-Jul-2017 | Nicholas C. Harris; Michio Sato; Nicolaus A. Herman; Frederick Twigg; Wenlong Cai; Joyce Liu; Xuejun Zhu; Jordan Dow ..., Proceedings of the National Academy of Sciences current issue, 2017

A putative lipopeptide biosynthetic gene cluster is conserved in many species of Actinobacteria, including Mycobacterium tuberculosis and M. marinum, but the specific function of the encoding proteins has been elusive. Using both in vivo heterologous reconstitution and in vitro biochemical ...

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