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2,544 Newest Publications about the topic biochemistry

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A Life in Bacillus subtilis Signal Transduction

08-Sep-2017 | James A. Hoch, Annual Review of Microbiology, 2017

This is a tale of how technology drove the discovery of the molecular basis for signal transduction in the initiation of sporulation in Bacillus subtilis and in bacterial two-component systems. It progresses from genetics to cloning and sequencing to biochemistry to structural biology to an ...

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Cellular cap-binding protein, eIF4E, promotes picornavirus genome restructuring and translation [Biochemistry]

05-Sep-2017 | Brian C. Avanzino; Gabriele Fuchs; Christopher S. Fraser, Proceedings of the National Academy of Sciences current issue, 2017

Picornaviruses use internal ribosome entry sites (IRESs) to translate their genomes into protein. A typical feature of these IRESs is their ability to bind directly to the eukaryotic initiation factor (eIF) 4G component of the eIF4F cap-binding complex. Remarkably, the hepatitis A virus (HAV) ...

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[Biochemistry] Toward the Atomic Structure of PrPSc

01-Sep-2017 | Jose A. Rodriguez; Lin Jiang; David S. Eisenberg, CSH Perspectives, 2017

In this review, we detail our current knowledge of PrPSc structure on the basis of structural and computational studies. We discuss the progress toward an atomic resolution description of PrPSc and results from the broader field of amyloid studies that may further inform our knowledge of this ...

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Intentionally flawed manuscripts as means for teaching students to critically evaluate scientific papers

31-Aug-2017 | Jaroslav Ferenc, Filip Červenák, Erik Birčák, Katarína Juríková, Ivana Goffová, Peter Gorilák, Barbora Huraiová, Jan ..., Biochemistry and Molecular Biology Education, 2017

As future scientists, university students need to learn how to avoid making errors in their own manuscripts, as well as how to identify flaws in papers published by their peers. Here we describe a novel approach on how to promote students' ability to critically evaluate scientific articles. The ...

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Songs about cancer, gene expression, and the biochemistry of photosynthesis

31-Aug-2017 | Richard H. Heineman, Biochemistry and Molecular Biology Education, 2017

Abstract These three biology songs can be used for educational purposes to teach about biochemical concepts. They touch on three different topics: (1) cancer progression and germ cells, (2) gene expression, promoters, and repressors, and (3) electronegativity and the biochemical basis of ...

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Lucky kindlin: A cloverleaf at the integrin tail [Biochemistry]

29-Aug-2017 | Patricia Kammerer; Jonas Aretz; Reinhard Fässler, Proceedings of the National Academy of Sciences current issue, 2017

In a paper published in PNAS, Li et al. (1) solve the long-awaited crystal structure of kindlin-2, which plays a central role in integrin activation, clustering, and signaling (2, 3). Integrins are a large family of heterodimeric adhesion molecules composed of α- and β-subunits and expressed on ...

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Elucidating crosstalk mechanisms between phosphorylation and O-GlcNAcylation [Biochemistry]

29-Aug-2017 | Aneika C. Leney; Dris El Atmioui; Wei Wu; Huib Ovaa; Albert J. R. Heck, Proceedings of the National Academy of Sciences current issue, 2017

Proteins can be modified by multiple posttranslational modifications (PTMs), creating a PTM code that controls the function of proteins in space and time. Unraveling this complex PTM code is one of the great challenges in molecular biology. Here, using mass spectrometry-based assays, we focus on ...

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Structural basis of kindlin-mediated integrin recognition and activation [Biochemistry]

29-Aug-2017 | Huadong Li; Yi Deng; Kang Sun; Haibin Yang; Jie Liu; Meiling Wang; Zhang Zhang; Jirong Lin; Chuanyue Wu; Zhiyi Wei; ..., Proceedings of the National Academy of Sciences current issue, 2017

Kindlins and talins are integrin-binding proteins that are critically involved in integrin activation, an essential process for many fundamental cellular activities including cell-matrix adhesion, migration, and proliferation. As FERM-domain–containing proteins, talins and kindlins, respectively, ...

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Browning in apples: Exploring the biochemical basis of an easily‐observable phenotype

26-Aug-2017 | Charles E. Deutch, Biochemistry and Molecular Biology Education, 2017

Abstract Many fruits and vegetables undergo browning when they are cut and the tissue is exposed to the air. This is due to the activity of the enzyme polyphenol oxidase (PPO, EC 1.14.18.1) with endogenous substrates. In this laboratory experiment, students prepare slices of different ...

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Phosphorylation of serine96 of histidine-rich calcium-binding protein by the Fam20C kinase functions to prevent cardiac arrhythmia [Biochemistry]

22-Aug-2017 | Adam J. Pollak; Kobra Haghighi; Swati Kunduri; Demetrios A. Arvanitis; Philip A. Bidwell; Guan-Sheng Liu; Vivek P. S ..., Proceedings of the National Academy of Sciences current issue, 2017

Precise Ca cycling through the sarcoplasmic reticulum (SR), a Ca storage organelle, is critical for proper cardiac muscle function. This cycling initially involves SR release of Ca via the ryanodine receptor, which is regulated by its interacting proteins junctin and triadin. The ...

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