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1,429 Newest Publications about the topic biochemistry
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Editors' Choice
15-05-2013 | Science , 2013
Biomedicine: The Benefits of Sequestration | Education: Motivation + Skill = Success | Animal Behavior: A Social Shake-up by Song | Chemistry: Brushing Away Toxicity | Chemistry: Mimicking Rodlike Viruses | Biomedicine: Peptide Prevention | Biochemistry: Attacked by Radicals
A new member of the 4-methylideneimidazole-5-one-containing aminomutase family from the enediyne kedarcidin biosynthetic pathway [Biochemistry]
14-05-2013 | Sheng-Xiong Huang; Jeremy R. Lohman; Tingting Huang; Ben Shen, Proceedings of the National Academy of Sciences current issue, 2013
4-Methylideneimidazole-5-one (MIO)-containing aminomutases catalyze the conversion of l-α-amino acids to β-amino acids with either an (R) or an (S) configuration. l-Phenylalanine and l-tyrosine are the only two natural substrates identified to date. The enediyne chromophore of the ...
Structure-kinetic relationship study of CDK8/CycC specific compounds [Biochemistry]
14-05-2013 | Elisabeth V. Schneider; Jark Böttcher; Robert Huber; Klaus Maskos; Lars Neumann, Proceedings of the National Academy of Sciences current issue, 2013
In contrast with the very well explored concept of structure–activity relationship, similar studies are missing for the dependency between binding kinetics and compound structure of a protein ligand complex, the structure–kinetic relationship. Here, we present a structure–kinetic relationship ...
Effects of raftilose on serum biochemistry and liver morphology in rats fed with normal or high‐fat diet
08-05-2013 | Inês Correia‐Sá, Hugo de‐Sousa‐Lopes, Maria J. Martins, Isabel Azevedo, Eduardo Moura, Maria A. Vieira‐Coelho, Molecular Nutrition & Food Research, 2013
Non‐alcoholic fatty liver disease is the leading cause of chronic liver injury in developed countries. Oligofructose (OFS) is a prebiotic with proven benefits for health. The aim of the study is to evaluate the effect of 10% OFS on hepatic morphology and lipid metabolism in Wistar Kyoto ...
Microbial canthaxanthin: Perspectives on biochemistry and biotechnological production
08-05-2013 | Seyed Mohammad Taghi Gharibzahedi, Seyed Hadi Razavi, Seyed Mohammad Mousavi, Engineering in Life Sciences, 2013
Canthaxanthin (CX) as a high‐value carotenoid is widely used in medical, pharmaceutical, cosmetic, chemical, and food industries. In this review, recent developments in the biotechnological production of CX associated with comprehensive insights on CX biosynthesis pathways to improve CX ...
Problem‐solving test: Digestion of a plasmid with restriction endonucleases
08-05-2013 | József Szeberényi, Biochemistry and Molecular Biology Education, 2013
Terms to be familiar with before you start to solve the test: plasmid, restriction endonuclease, agarose gel electrophoresis, ethidium bromide staining, autoradiography, Coomassie staining, Southern blotting, linear and circular DNA, superhelical DNA, exonuclease, modification methylase, ...
The potential and promise of mefenamic acid
08-05-2013 | Nevio Cimolai, Expert Review of Clinical Pharmacology, 2013
Clinical use of mefenamic acid has generally declined in an era where other NSAID use has flourished. While having modes of action and general toxicities similar to other NSAIDs, mefenamic acid, as a member of the fenamates, nevertheless possesses some unique in vitro effects that have the ...
[Perspective] Biochemistry: As Good as Chocolate
08-05-2013 | Krzysztof Palczewski, Philip D. Kiser, Science , 2013
Structural details of how ligands bind to serotonin receptors should guide the development of pharmaceuticals with fewer side effects. [Also see Reports by Wang et al. and Wacker et al.]
Structures of complexes comprised of Fischerella transcription factor HetR with Anabaena DNA targets [Biochemistry]
07-05-2013 | Youngchang Kim; Zi Ye; Grazyna Joachimiak; Patrick Videau; Jasmine Young; Kathryn Hurd; Sean M. Callahan; Piotr Gorn ..., Proceedings of the National Academy of Sciences current issue, 2013
HetR is an essential regulator of heterocyst development in cyanobacteria. Many mutations in HetR render Anabaena incapable of nitrogen fixation. The protein binds to a DNA palindrome upstream of hetP and other genes. We have determined the crystal structures of HetR complexed with ...
Identification and characterization of a previously undescribed family of sequence-specific DNA-binding domains [Biochemistry]
07-05-2013 | Matthew B. Lohse; Aaron D. Hernday; Polly M. Fordyce; Liron Noiman; Trevor R. Sorrells; Victor Hanson-Smith; Clariss ..., Proceedings of the National Academy of Sciences current issue, 2013
Sequence-specific DNA-binding proteins are among the most important classes of gene regulatory proteins, controlling changes in transcription that underlie many aspects of biology. In this work, we identify a transcriptional regulator from the human fungal pathogen Candida albicans that binds ...
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