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2,251 Newest Publications about the topic biochemistry


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Coelimination and Survival in Gene Network Evolution: Dismantling the RA-Signaling in a Chordate

01-Sep-2016 | Josep Martí-Solans; Olga V. Belyaeva; Nuria P. Torres-Aguila; Natalia Y. Kedishvili; Ricard Albalat; Cristian Cañestro, Molecular Biology and Evolution, 2016

The bloom of genomics is revealing gene loss as a pervasive evolutionary force generating genetic diversity that shapes the evolution of species. Outside bacteria and yeast, however, the understanding of the process of gene loss remains elusive, especially in the evolution of animal species. ...


Purification and analysis of endogenous human RNA exosome complexes [METHOD]

01-Sep-2016 | Michal Domanski; Paula Upla; William J. Rice; Kelly R. Molloy; Natalia E. Ketaren; David L. Stokes; Torben Heick Jen ..., RNA, 2016

As a result of its importance in key RNA metabolic processes, the ribonucleolytic RNA exosome complex has been the focus of intense study for almost two decades. Research on exosome subunit assembly, cofactor and substrate interaction, enzymatic catalysis and structure have largely been conducted ...


Renal simplicity denervation reduces blood pressure and renal injuries in an obesity‐induced hypertension dog model

25-Aug-2016 | Zhihui Zhang, Kan Yang, Lixiong Zeng, Xiaoyan Wang, Fenglin Jiang, Shan Tu, Qishun Liang, Zhijie Shen, Clinical and Experimental Pharmacology and Physiology, 2016

Abstract This study aimed to investigate the effects of renal sympathetic denervation (RDN) on blood pressure, renal function, and renal tissue pathological changes in obesity‐induced hypertensive dogs. Thirty‐two beagle dogs (10‐12 months) were randomized to the control (n=10) and model ...


Kinetic and thermodynamic framework for P4-P6 RNA reveals tertiary motif modularity and modulation of the folding preferred pathway [Biochemistry]

23-Aug-2016 | Namita Bisaria; Max Greenfeld; Charles Limouse; Dmitri S. Pavlichin; Hideo Mabuchi; Daniel Herschlag, Proceedings of the National Academy of Sciences current issue, 2016

The past decade has seen a wealth of 3D structural information about complex structured RNAs and identification of functional intermediates. Nevertheless, developing a complete and predictive understanding of the folding and function of these RNAs in biology will require connection of individual ...


Peroxidation of polyunsaturated fatty acids by lipoxygenases drives ferroptosis [Biochemistry]

23-Aug-2016 | Wan Seok Yang; Katherine J. Kim; Michael M. Gaschler; Milesh Patel; Mikhail S. Shchepinov; Brent R. Stockwell, Proceedings of the National Academy of Sciences current issue, 2016

Ferroptosis is form of regulated nonapoptotic cell death that is involved in diverse disease contexts. Small molecules that inhibit glutathione peroxidase 4 (GPX4), a phospholipid peroxidase, cause lethal accumulation of lipid peroxides and induce ferroptotic cell death. Although ferroptosis has ...


Crystallographic snapshots of sulfur insertion by lipoyl synthase [Biochemistry]

23-Aug-2016 | Martin I. McLaughlin; Nicholas D. Lanz; Peter J. Goldman; Kyung-Hoon Lee; Squire J. Booker; Catherine L. Drennan, Proceedings of the National Academy of Sciences current issue, 2016

Lipoyl synthase (LipA) catalyzes the insertion of two sulfur atoms at the unactivated C6 and C8 positions of a protein-bound octanoyl chain to produce the lipoyl cofactor. To activate its substrate for sulfur insertion, LipA uses a [4Fe-4S] cluster and S-adenosylmethionine (AdoMet) radical ...


Assembly scaffold NifEN: A structural and functional homolog of the nitrogenase catalytic component [Biochemistry]

23-Aug-2016 | Aaron W. Fay; Michael A. Blank; Johannes G. Rebelein; Chi Chung Lee; Markus W. Ribbe; Britt Hedman; Keith O. Hodgson ..., Proceedings of the National Academy of Sciences current issue, 2016

NifEN is a biosynthetic scaffold for the cofactor of Mo-nitrogenase (designated the M-cluster). Previous studies have revealed the sequence and structural homology between NifEN and NifDK, the catalytic component of nitrogenase. However, direct proof for the functional homology between the two ...


Coiled-coil destabilizing residues in the group A Streptococcus M1 protein are required for functional interaction [Biochemistry]

23-Aug-2016 | Chelsea M. Stewart; Cosmo Z. Buffalo; J. Andrés Valderrama; Anna Henningham; Jason N. Cole; Victor Nizet; Partho Ghosh, Proceedings of the National Academy of Sciences current issue, 2016

The sequences of M proteins, the major surface-associated virulence factors of the widespread bacterial pathogen group A Streptococcus, are antigenically variable but have in common a strong propensity to form coiled coils. Paradoxically, these sequences are also replete with coiled-coil ...


Enhancing student retention of prerequisite knowledge through pre‐class activities and in‐class reinforcement

18-Aug-2016 | Ann T.S. Taylor, Eric L. Olofson, Walter R.P. Novak, Biochemistry and Molecular Biology Education, 2016

Abstract To foster the connection between biochemistry and the supporting prerequisite concepts, a collection of activities that explicitly link general and organic chemistry concepts to biochemistry ideas was written and either assigned as pre‐class work or as recitation activities. We ...


A User‐Friendly Means to Scale from the Biochemistry of Photosynthesis to Whole Crop Canopies and Production in Time and Space – Development of Java WIMOVAC

16-Aug-2016 | Qingfeng Song, Dairui Chen, Stephen P Long, Xin‐Guang Zhu, Plant, Cell & Environment, 2016

Abstract Windows Intuitive Model of Vegetation response to Atmosphere and Climate Change (WIMOVAC) has been used widely as a generic modular mechanistically‐rich model of plant production. It can predict the responses of leaf and canopy carbon balance, as well as production in different ...


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