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1,668 Newest Publications about the topic biochemistry

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Development and analysis of an instrument to assess student understanding of GOB chemistry knowledge relevant to clinical nursing practice

22-11-2014 | Corina E. Brown, Richard M. Hyslop, Jack Barbera, Biochemistry and Molecular Biology Education, 2014

Abstract The General, Organic, and Biological Chemistry Knowledge Assessment (GOB‐CKA) is a multiple‐choice instrument designed to assess students' understanding of the chemistry topics deemed important to clinical nursing practice. This manuscript describes the development process of the ...

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Molecular determinants of caspase-9 activation by the Apaf-1 apoptosome [Biochemistry]

18-11-2014 | Qi Hu; Di Wu; Wen Chen; Zhen Yan; Chuangye Yan; Tianxi He; Qionglin Liang; Yigong Shi, Proceedings of the National Academy of Sciences current issue, 2014

Autocatalytic activation of an initiator caspase triggers the onset of apoptosis. In dying cells, caspase-9 activation is mediated by a multimeric adaptor complex known as the Apaf-1 apoptosome. The molecular mechanism by which caspase-9 is activated by the Apaf-1 apoptosome remains largely ...

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Differential gradients of interaction affinities drive efficient targeting and recycling in the GET pathway [Biochemistry]

18-11-2014 | Michael E. Rome; Un Seng Chio; Meera Rao; Harry Gristick; Shu-ou Shan, Proceedings of the National Academy of Sciences current issue, 2014

Efficient and accurate localization of membrane proteins requires a complex cascade of interactions between protein machineries. This requirement is exemplified in the guided entry of tail-anchored (TA) protein (GET) pathway, where the central targeting factor Get3 must sequentially interact with ...

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c-Abl tyrosine kinase promotes adipocyte differentiation by targeting PPAR-gamma 2 [Biochemistry]

18-11-2014 | Rom Keshet; Zina Bryansker Kraitshtein; Matan Shanzer; Julia Adler; Nina Reuven; Yosef Shaul, Proceedings of the National Academy of Sciences current issue, 2014

Adipocyte differentiation, or adipogenesis, is a complex and highly regulated process. A recent proteomic analysis has predicted that the nonreceptor tyrosine kinase Abelson murine leukemia viral oncogene (c-Abl) is a putative key regulator of adipogenesis, but the underlying mechanism remained ...

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Correction for Vestergaard et al., Critical roles of isoleucine-364 and adjacent residues in a hydrophobic gate control of phospholipid transport by the mammalian P4-ATPase ATP8A2 [Correction]

18-11-2014 | Proceedings of the National Academy of Sciences current issue, 2014

BIOCHEMISTRY Correction for “Critical roles of isoleucine-364 and adjacent residues in a hydrophobic gate control of phospholipid transport by the mammalian P4-ATPase ATP8A2,” by Anna L. Vestergaard, Jonathan A. Coleman, Thomas Lemmin, Stine A. Mikkelsen, Laurie L. Molday, Bente Vilsen, Robert S. ...

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Liat1, an arginyltransferase-binding protein whose evolution among primates involved changes in the numbers of its 10-residue repeats [Biochemistry]

18-11-2014 | Christopher S. Brower; Connor E. Rosen; Richard H. Jones; Brandon C. Wadas; Konstantin I. Piatkov; Alexander Varshavsky, Proceedings of the National Academy of Sciences current issue, 2014

The arginyltransferase Ate1 is a component of the N-end rule pathway, which recognizes proteins containing N-terminal degradation signals called N-degrons, polyubiquitylates these proteins, and thereby causes their degradation by the proteasome. At least six isoforms of mouse Ate1 are produced ...

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Molecular insights into DNA interference by CRISPR-associated nuclease-helicase Cas3 [Biochemistry]

18-11-2014 | Bei Gong; Minsang Shin; Jiali Sun; Che-Hun Jung; Edward L. Bolt; John van der Oost; Jeong-Sun Kim, Proceedings of the National Academy of Sciences current issue, 2014

Mobile genetic elements in bacteria are neutralized by a system based on clustered regularly interspaced short palindromic repeats (CRISPRs) and CRISPR-associated (Cas) proteins. Type I CRISPR-Cas systems use a “Cascade” ribonucleoprotein complex to guide RNA specifically to complementary ...

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A laboratory exercise for visible gel filtration chromatography using fluorescent proteins

17-11-2014 | Wenqiang Zhang, Yibin Cao, Lishan Xu, Jufang Gong, Meihao Sun, Biochemistry and Molecular Biology Education, 2014

Abstract Gel filtration chromatography (GFC) separates molecules according to size and is one of the most widely used methods for protein purification. Here, red fluorescent protein (RFP), green fluorescent protein (GFP), yellow fluorescent protein (YFP), cyan fluorescent protein (CFP), and/or ...

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Ultraviolet Index and Location are Important Determinants of Vitamin D Status in People with Human Immunodeficiency Virus (HIV)

14-11-2014 | Karen M Klassen, Christopher K Fairley, Michael G Kimlin, Mark Kelly, Tim RH Read, Jennifer Broom, Darren B Russell, ..., Photochemistry and Photobiology, 2014

Abstract This study aimed to document the vitamin D status of HIV‐infected individuals across a wide latitude range in one country and to examine associated risk factors for low vitamin D. Using data from patients attending four HIV specialist clinics across a wide latitude range in Australia, ...

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Simulating an investigative study of clinical cancer samples: Use of tissue slides and PCR‐based promoter‐hypermethylation analysis

14-11-2014 | Yuan Yuan Chew, Cheen Fei Chin, Foong May Yeong, Biochemistry and Molecular Biology Education, 2014

Abstract Topics on the molecular basis underlying cancer are quite popular among students. Also, excellent textbooks abound that provide interesting materials for discussion during lectures and tutorials about major events leading to cancer formation and progression. However, much less is ...

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