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1,926 Newest Publications about the topic biochemistry

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The transcriptome of Euglena gracilis reveals unexpected metabolic capabilities for carbohydrate and natural product biochemistry

19-Aug-2015 | Ellis O'Neill; Martin Trick; Lionel Hill; Martin Rejzek; Renata Dursi; Chris Hamilton; Paul Zimba; Bernard Henrissat ..., Molecular BioSystems, 2015

Euglena gracilis is a highly complex alga belonging to the green plant line that shows characteristics of both plants and animals, while in evolutionary terms it is most closely related to the protozoan parasites Trypanosoma and Leishmania. This well-studied organism has long been known as a rich ...

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Creative template-dependent synthesis by human polymerase mu [Biochemistry]

18-Aug-2015 | Andrea F. Moon; Rajendrakumar A. Gosavi; Thomas A. Kunkel; Lars C. Pedersen; Katarzyna Bebenek, Proceedings of the National Academy of Sciences current issue, 2015

Among the many proteins used to repair DNA double-strand breaks by nonhomologous end joining (NHEJ) are two related family X DNA polymerases, Pol λ and Pol µ. Which of these two polymerases is preferentially used for filling DNA gaps during NHEJ partly depends on sequence complementarity at the ...

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Consecutive radical S-adenosylmethionine methylations form the ethyl side chain in thienamycin biosynthesis [Biochemistry]

18-Aug-2015 | Daniel R. Marous; Evan P. Lloyd; Andrew R. Buller; Kristos A. Moshos; Tyler L. Grove; Anthony J. Blaszczyk; Squire J ..., Proceedings of the National Academy of Sciences current issue, 2015

Despite their broad anti-infective utility, the biosynthesis of the paradigm carbapenem antibiotic, thienamycin, remains largely unknown. Apart from the first two steps shared with a simple carbapenem, the pathway sharply diverges to the more structurally complex members of this class of β-lactam ...

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SufB intein of Mycobacterium tuberculosis as a sensor for oxidative and nitrosative stresses [Biochemistry]

18-Aug-2015 | Natalya I. Topilina; Cathleen M. Green; Pradeepa Jayachandran; Danielle S. Kelley; Matthew J. Stanger; Carol Lyn Pia ..., Proceedings of the National Academy of Sciences current issue, 2015

Inteins are mobile genetic elements that self-splice at the protein level. Mycobacteria have inteins inserted into several important genes, including those corresponding to the iron-sulfur cluster assembly protein SufB. Curiously, the SufB inteins are found primarily in mycobacterial species that ...

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C-S bond cleavage by a polyketide synthase domain [Biochemistry]

18-Aug-2015 | Ming Ma; Jeremy R. Lohman; Tao Liu; Ben Shen, Proceedings of the National Academy of Sciences current issue, 2015

Leinamycin (LNM) is a sulfur-containing antitumor antibiotic featuring an unusual 1,3-dioxo-1,2-dithiolane moiety that is spiro-fused to a thiazole-containing 18-membered lactam ring. The 1,3-dioxo-1,2-dithiolane moiety is essential for LNM’s antitumor activity, by virtue of its ability to ...

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Essential role for polymerase specialization in cellular nonhomologous end joining [Biochemistry]

18-Aug-2015 | John M. Pryor; Crystal A. Waters; Ana Aza; Kenjiro Asagoshi; Christina Strom; Piotr A. Mieczkowski; Luis Blanco; Dal ..., Proceedings of the National Academy of Sciences current issue, 2015

Nonhomologous end joining (NHEJ) repairs chromosome breaks and must remain effective in the face of extensive diversity in broken end structures. We show here that this flexibility is often reliant on the ability to direct DNA synthesis across strand breaks, and that polymerase (Pol) μ and Pol λ ...

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Enzymes and bioproducts produced by the ascomycete fungus Paecilomyces variotii

14-Aug-2015 | I. Herrera Bravo de Laguna, F. J. Toledo Marante, R. Mioso, Journal of Applied Microbiology, 2015

Summary Due its innate ability to produce extracellular enzymes which can provide eco‐friendly solutions for a variety of biotechnological applications, Paecilomyces variotii is a potential source of industrial bioproducts. In this review, we report biotechnological records on the biochemistry ...

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Taming Cell Penetrating Peptides: Never Too Old To Teach Old Dogs New Tricks

14-Aug-2015 | Qianyu Zhang; Huile Gao; Qin He, Molecular Pharmaceutics, 2015

Cell penetrating peptides (CPPs) have received substantial attention due to their intrinsic property to cross plasma membranes or even as helpers to facilitate the cellular entry of drug molecules, macromolecules, and nanoparticles. Although CPPs and CPP-like peptides provided versatile platforms ...

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Divergent evolution of an atypical S-adenosyl-l-methionine-dependent monooxygenase involved in anthracycline biosynthesis [Biochemistry]

11-Aug-2015 | Thadée Grocholski; Pedro Dinis; Laila Niiranen; Jarmo Niemi; Mikko Metsä-Ketelä, Proceedings of the National Academy of Sciences current issue, 2015

Bacterial secondary metabolic pathways are responsible for the biosynthesis of thousands of bioactive natural products. Many enzymes residing in these pathways have evolved to catalyze unusual chemical transformations, which is facilitated by an evolutionary pressure promoting chemical diversity. ...

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Inactive conformation enhances binding function in physiological conditions [Biochemistry]

11-Aug-2015 | Olga Yakovenko; Veronika Tchesnokova; Evgeni V. Sokurenko; Wendy E. Thomas, Proceedings of the National Academy of Sciences current issue, 2015

Many receptors display conformational flexibility, in which the binding pocket has an open inactive conformation in the absence of ligand and a tight active conformation when bound to ligand. Here we study the bacterial adhesin FimH to address the role of the inactive conformation of the pocket ...

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