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2,327 Newest Publications about the topic biochemistry

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Biochemistry: A fast way to convert carbon

24-Nov-2016 | Nature, 2016

Biochemistry: A fast way to convert carbon Nature 539, 7630 (2016). doi:10.1038/539471a Researchers have come up with a biochemical pathway that converts carbon dioxide into useful organic compounds more efficiently than plants can.A team led ...

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Biochemistry: Catalyst clicks drugs together

24-Nov-2016 | Nature, 2016

Biochemistry: Catalyst clicks drugs together Nature 539, 7630 (2016). doi:10.1038/539470d A new type of catalyst assembles cancer drugs from benign components, and can work inside laboratory animals.Some drug molecules can be split into ...

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Using yeast to determine the functional consequences of mutations in the human p53 tumor suppressor gene: An introductory course‐based undergraduate research experience in molecular and cell biology

22-Nov-2016 | Daria S. Hekmat‐Scafe, Sara E. Brownell, Patricia Chandler Seawell, Shyamala Malladi, Jamie F. Conklin Imam, Veena S ..., Biochemistry and Molecular Biology Education, 2016

Abstract The opportunity to engage in scientific research is an important, but often neglected, component of undergraduate training in biology. We describe the curriculum for an innovative, course‐based undergraduate research experience (CURE) appropriate for a large, introductory cell and ...

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Control of transcriptional pausing by biased thermal fluctuations on repetitive genomic sequences [Biochemistry]

22-Nov-2016 | Masahiko Imashimizu; Ariel Afek; Hiroki Takahashi; Lucyna Lubkowska; David B. Lukatsky, Proceedings of the National Academy of Sciences current issue, 2016

In the process of transcription elongation, RNA polymerase (RNAP) pauses at highly nonrandom positions across genomic DNA, broadly regulating transcription; however, molecular mechanisms responsible for the recognition of such pausing positions remain poorly understood. Here, using a combination ...

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Distinct regions that control ion selectivity and calcium-dependent activation in the bestrophin ion channel [Biochemistry]

22-Nov-2016 | George Vaisey; Alexandria N. Miller; Stephen B. Long, Proceedings of the National Academy of Sciences current issue, 2016

Cytoplasmic calcium (Ca2+) activates the bestrophin anion channel, allowing chloride ions to flow down their electrochemical gradient. Mutations in bestrophin 1 (BEST1) cause macular degenerative disorders. Previously, we determined an X-ray structure of chicken BEST1 that revealed the ...

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Cross-linking reveals laminin coiled-coil architecture [Biochemistry]

22-Nov-2016 | Gad Armony; Etai Jacob; Toot Moran; Yishai Levin; Tevie Mehlman; Yaakov Levy; Deborah Fass, Proceedings of the National Academy of Sciences current issue, 2016

Laminin, an ∼800-kDa heterotrimeric protein, is a major functional component of the extracellular matrix, contributing to tissue development and maintenance. The unique architecture of laminin is not currently amenable to determination at high resolution, as its flexible and narrow segments ...

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Phylogenetic and Functional Classification of the Photolyase/Cryptochrome Family

19-Nov-2016 | Nuri Ozturk, Photochemistry and Photobiology, 2016

Abstract The Photolyase/Cryptochrome (PHR/CRY) family is a large group of proteins with similar structure and but very diverge functions such as in DNA repair, circadian clock resetting, and regulation of transcription. As a result of advances in the biochemistry of the CRY/PHR family and ...

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Blog construction as an effective tool in biochemistry active learning

15-Nov-2016 | Estêvão Cubas Rolim, Julia Martins de Oliveira, Luana T. Dalvi, Daniel C. Moreira, Natasha Garcia Caldas, Felipe Fer ..., Biochemistry and Molecular Biology Education, 2016

Abstract To boost active learning in undergraduate students, they were given the task of preparing blogs on topics of clinical biochemistry. This “experiment” lasted for 12 teaching‐semesters (from 2008 to 2013), and included a survey on the blogs' usefulness at the end of each semester. The ...

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Drosophila IRBP bZIP heterodimer binds P-element DNA and affects hybrid dysgenesis [Biochemistry]

15-Nov-2016 | Malik Joseph Francis; Siobhan Roche; Michael Jeffrey Cho; Eileen Beall; Bosun Min; Ronaldo Paolo Panganiban; Donald ..., Proceedings of the National Academy of Sciences current issue, 2016

In Drosophila, P-element transposition causes mutagenesis and genome instability during hybrid dysgenesis. The P-element 31-bp terminal inverted repeats (TIRs) contain sequences essential for transposase cleavage and have been implicated in DNA repair via protein–DNA interactions with cellular ...

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Structural basis for DNA recognition by STAT6 [Biochemistry]

15-Nov-2016 | Jing Li; Jose Pindado Rodriguez; Fengfeng Niu; Mengchen Pu; Jinan Wang; Li-Wei Hung; Qiang Shao; Yanping Zhu; Wei Di ..., Proceedings of the National Academy of Sciences current issue, 2016

STAT6 participates in classical IL-4/IL-13 signaling and stimulator of interferon genes-mediated antiviral innate immune responses. Aberrations in STAT6-mediated signaling are linked to development of asthma and diseases of the immune system. In addition, STAT6 remains constitutively active in ...

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