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2,183 Newest Publications about the topic biochemistry


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Linking Inflammation and Parkinson Disease: Hypochlorous Acid Generates Parkinsonian Poisons

01-Jun-2016 | Thomas M. Jeitner; Mike Kalogiannis; Boris F. Krasnikov; Irving Gomlin; Morgan R. Peltier; Graham R. Moran, Toxicological Sciences, 2016

Inflammation is a common feature of Parkinson Disease and other neurodegenerative disorders. Hypochlorous acid (HOCl) is a reactive oxygen species formed by neutrophils and other myeloperoxidase-containing cells during inflammation. HOCl chlorinates the amine and catechol moieties of dopamine to ...


Teaching biochemistry online at Oregon State University

27-May-2016 | Kevin Ahern, Biochemistry and Molecular Biology Education, 2016

Abstract A strategy for growing online biochemistry courses is presented based on successes in ecampus at Oregon State University. Four free drawing cards were key to the effort—YouTube videos, iTunes U online free course content, an Open Educational Resource textbook—Biochemistry Free and ...


Direct and essential function for Hrd3 in ER-associated degradation [Biochemistry]

24-May-2016 | Nidhi Vashistha; Sonya E. Neal; Amanjot Singh; Sarah M. Carroll; Randolph Y. Hampton, Proceedings of the National Academy of Sciences current issue, 2016

The HRD (HMG-CoA reductase degradation) pathway is a conserved route of endoplasmic reticulum-associated degradation (ERAD), by which misfolded ER proteins are ubiquitinated and degraded. ERAD substrates are ubiquitinated by the action of the Hrd1 RING-H2 E3 ligase. Hrd1 is always present in a ...


Interactions of a fungal lytic polysaccharide monooxygenase with {beta}-glucan substrates and cellobiose dehydrogenase [Biochemistry]

24-May-2016 | Gaston Courtade; Reinhard Wimmer; Åsmund K. Røhr; Marita Preims; Alfons K. G. Felice; Maria Dimarogona; Gustav Vaaje ..., Proceedings of the National Academy of Sciences current issue, 2016

Lytic polysaccharide monooxygenases (LPMOs) are copper-dependent enzymes that catalyze oxidative cleavage of glycosidic bonds using molecular oxygen and an external electron donor. We have used NMR and isothermal titration calorimetry (ITC) to study the interactions of a broad-specificity fungal ...


Endogenous B-ring oxysterols inhibit the Hedgehog component Smoothened in a manner distinct from cyclopamine or side-chain oxysterols [Biochemistry]

24-May-2016 | Navdar Sever; Randall K. Mann; Libin Xu; William J. Snell; Carmen I. Hernandez-Lara; Ned A. Porter; Philip A. Beachy, Proceedings of the National Academy of Sciences current issue, 2016

Cellular lipids are speculated to act as key intermediates in Hedgehog signal transduction, but their precise identity and function remain enigmatic. In an effort to identify such lipids, we pursued a Hedgehog pathway inhibitory activity that is particularly abundant in flagellar lipids of ...


Ectopic expression of ceramide synthase 2 in neurons suppresses neurodegeneration induced by ceramide synthase 1 deficiency [Biochemistry]

24-May-2016 | Stefka D. Spassieva; Xiaojie Ji; Ye Liu; Kenneth Gable; Jacek Bielawski; Teresa M. Dunn; Erhard Bieberich; Lihong Zhao, Proceedings of the National Academy of Sciences current issue, 2016

Sphingolipids exhibit extreme functional and chemical diversity that is in part determined by their hydrophobic moiety, ceramide. In mammals, the fatty acyl chain length variation of ceramides is determined by six (dihydro)ceramide synthase (CerS) isoforms. Previously, we and others showed that ...


Students' knowledge of, and attitudes towards biotechnology revisited, 1995–2014: Changes in agriculture biotechnology but not in medical biotechnology

18-May-2016 | Shao‐Yen Chen, Yih‐Ru Chu, Chen‐Yung Lin, Tzen‐Yuh Chiang, Biochemistry and Molecular Biology Education, 2016

Abstract Modern biotechnology is one of the most important scientific and technological revolutions in the 21st century, with an increasing and measurable impact on society. Development of biotechnology curriculum has become important to high school bioscience classrooms. This study has ...


Laboratory course on Streptomyces genetics and secondary metabolism

18-May-2016 | Vilja Siitonen, Kaj Räty, Mikko Metsä‐Ketelä, Biochemistry and Molecular Biology Education, 2016

Abstract The “Streptomyces genetics and secondary metabolism” laboratory course gives an introduction to the versatile soil dwelling Gram‐positive bacteria Streptomyces and their secondary metabolism. The course combines genetic modification of Streptomyces; growing of the strain and ...


Electron tomography reveals the fibril structure and lipid interactions in amyloid deposits [Biochemistry]

17-May-2016 | Marius Kollmer; Katrin Meinhardt; Christian Haupt; Falk Liberta; Melanie Wulff; Julia Linder; Lisa Handl; Liesa Hein ..., Proceedings of the National Academy of Sciences current issue, 2016

Electron tomography is an increasingly powerful method to study the detailed architecture of macromolecular complexes or cellular structures. Applied to amyloid deposits formed in a cell culture model of systemic amyloid A amyloidosis, we could determine the structural morphology of the fibrils ...


Control of serotonin transporter phosphorylation by conformational state [Biochemistry]

17-May-2016 | Yuan-Wei Zhang; Benjamin E. Turk; Gary Rudnick, Proceedings of the National Academy of Sciences current issue, 2016

Serotonin transporter (SERT) is responsible for reuptake and recycling of 5-hydroxytryptamine (5-HT; serotonin) after its exocytotic release during neurotransmission. Mutations in human SERT are associated with psychiatric disorders and autism. Some of these mutations affect the regulation of ...


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