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2,554 Newest Publications about the topic biochemistry

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PAF1 complex component Leo1 helps recruit Drosophila Myc to promoters [Biochemistry]

31-Oct-2017 | Jennifer M. Gerlach; Michael Furrer; Maria Gallant; Dirk Birkel; Apoorva Baluapuri; Elmar Wolf; Peter Gallant, Proceedings of the National Academy of Sciences current issue, 2017

The Myc oncogene is a transcription factor with a powerful grip on cellular growth and proliferation. The physical interaction of Myc with the E-box DNA motif has been extensively characterized, but it is less clear whether this sequence-specific interaction is sufficient for Myc’s binding to its ...

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Mechanistic principles underlying regulation of the actin cytoskeleton by phosphoinositides [Biochemistry]

24-Oct-2017 | Yosuke Senju; Maria Kalimeri; Essi V. Koskela; Pentti Somerharju; Hongxia Zhao; Ilpo Vattulainen; Pekka Lappalainen, Proceedings of the National Academy of Sciences current issue, 2017

The actin cytoskeleton powers membrane deformation during many cellular processes, such as migration, morphogenesis, and endocytosis. Membrane phosphoinositides, especially phosphatidylinositol 4,5-bisphosphate [PI(4,5)P2], regulate the activities of many actin-binding proteins (ABPs), including ...

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p,p′-Methoxyl-diphenyl diselenide-loaded polymeric nanocapsules as a novel approach to inflammatory pain treatment: Behavioral, biochemistry and molecular evidence

14-Oct-2017 | Author(s): Marcel Henrique Marcondes Sari, Vanessa Angonesi Zborowski, Luana Mota Ferreira, Natália Silva Ja ..., European Journal of Pharmaceutical Science, 2017

Publication date: 1 January 2018 Source:European Journal of Pharmaceutical Sciences, Volume 111 Author(s): Marcel Henrique Marcondes Sari, Vanessa Angonesi Zborowski, Luana Mota Ferreira, Natália Silva Jardim, Allanna Valentini Barbieri, Letícia Cruz, Cristina Wayne Nogueira ...

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Sending and Receiving Hedgehog Signals

06-Oct-2017 | Kostadin Petrov; Bradley M. Wierbowski; Adrian Salic, Annual Review of Cell and Developmental Biology, 2017

Communication between cells pervades the development and physiology of metazoans. In animals, this process is carried out by a relatively small number of signaling pathways, each consisting of a chain of biochemical events through which extracellular stimuli control the behavior of target cells. ...

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Sending and Receiving Hedgehog Signals

06-Oct-2017 | Kostadin Petrov; Bradley M. Wierbowski; Adrian Salic, Annual Review of Cell and Developmental Biology, 2017

Communication between cells pervades the development and physiology of metazoans. In animals, this process is carried out by a relatively small number of signaling pathways, each consisting of a chain of biochemical events through which extracellular stimuli control the behavior of target cells. ...

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How does nitrogenase spring its trap?

06-Oct-2017 | Caroline Ash; Jesse Smith; Jake Yeston, Science , 2017

Biochemistry It's a bit of a chemical mystery why, after eons of evolution to optimize efficiency, nitrogenase enzymes still make hydrogen as a by-product when they make ammonia. Recent work suggests that this step is key to binding the nitrogen molecule in the active site. Khadka et al. attached

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Evolutionary diversification of protein-protein interactions by interface add-ons [Biochemistry]

03-Oct-2017 | Maximilian G. Plach; Florian Semmelmann; Florian Busch; Markus Busch; Leonhard Heizinger; Vicki H. Wysocki; Rainer M ..., Proceedings of the National Academy of Sciences current issue, 2017

Cells contain a multitude of protein complexes whose subunits interact with high specificity. However, the number of different protein folds and interface geometries found in nature is limited. This raises the question of how protein–protein interaction specificity is achieved on the structural ...

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Mechanisms for restraining cAMP-dependent protein kinase revealed by subunit quantitation and cross-linking approaches [Biochemistry]

26-Sep-2017 | Ryan Walker-Gray; Florian Stengel; Matthew G. Gold, Proceedings of the National Academy of Sciences current issue, 2017

Protein phosphorylation by cyclic AMP-dependent protein kinase (PKA) underlies key cellular processes, including sympathetic stimulation of heart cells, and potentiation of synaptic strength in neurons. Unrestrained PKA activity is pathological, and an enduring challenge is to understand how the ...

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Structures of the peptide-modifying radical SAM enzyme SuiB elucidate the basis of substrate recognition [Biochemistry]

26-Sep-2017 | Katherine M. Davis; Kelsey R. Schramma; William A. Hansen; John P. Bacik; Sagar D. Khare; Mohammad R. Seyedsayamdost ..., Proceedings of the National Academy of Sciences current issue, 2017

Posttranslational modification of ribosomally synthesized peptides provides an elegant means for the production of biologically active molecules known as RiPPs (ribosomally synthesized and posttranslationally modified peptides). Although the leader sequence of the precursor peptide is often ...

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Molecular mechanism of water reorientational slowing down in concentrated ionic solutions [Biochemistry]

19-Sep-2017 | Qiang Zhang; TianMin Wu; Chen Chen; Shaul Mukamel; Wei Zhuang, Proceedings of the National Academy of Sciences current issue, 2017

Water dynamics in concentrated ionic solutions plays an important role in a number of material and energy conversion processes such as the charge transfer at the electrolyte–electrode interface in aqueous rechargeable ion batteries. One long-standing puzzle is that all electrolytes, regardless of ...

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