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1,622 Newest Publications about the topic biochemistry


Structural basis of cellular dNTP regulation by SAMHD1 [Biochemistry]

14-10-2014 | Xiaoyun Ji; Chenxiang Tang; Qi Zhao; Wei Wang; Yong Xiong, Proceedings of the National Academy of Sciences current issue, 2014

The sterile alpha motif and HD domain-containing protein 1 (SAMHD1), a dNTPase, prevents the infection of nondividing cells by retroviruses, including HIV, by depleting the cellular dNTP pool available for viral reverse transcription. SAMHD1 is a major regulator of cellular dNTP levels in ...


Hyperactivation of BDNF‐TrkB Signaling Cascades in Human Hypothalamic Hamartoma (HH): A Potential Mechanism Contributing to Epileptogenesis

13-10-2014 | Suzan Semaan, Jie Wu, Yan Gan, Yu Jin, Guo‐Hui Li, John F. Kerrigan, Yong‐Chang Chang, Yao Huang, CNS Neuroscience & Therapeutics, 2014

Summary Aims Although compelling evidence suggests that human hypothalamic hamartoma (HH) is intrinsically epileptogenic for gelastic seizures, the molecular mechanisms responsible for epileptogenesis within HH remain to be elucidated. The aim of this study was to test the hypothesis that ...


‘Riff-raff’ charge draws ire

09-10-2014 | ;, Nature, 2014

‘Riff-raff’ charge draws ire Nature 514, 7521 (2014). doi:10.1038/514143e When Steven McKnight, president of the American Society for Biochemistry and Molecular Biology (ASBMB), publicly complained in the society's September newsletter about ...


A β1‐6/β1‐3 galactosidase from Bifidobacterium animalis subsp. lactis Bl‐04 gives insight into sub‐specificities of β‐galactoside catabolism within Bifidobacterium

07-10-2014 | Alexander Holm Viborg, Folmer Fredslund, Takane Katayama, Stinne Kirketerp Nielsen, Birte Svensson, Motomitsu Kitaok ..., Molecular Microbiology, 2014

Summary The Bifidobacterium genus harbours several health promoting members of the gut microbiota. Bifidobacteria display metabolic specialization by preferentially utilizing dietary or host derived β‐galactosides. This study investigates the biochemistry and structure of a glycoside hydrolase ...


Basis for substrate recognition and distinction by matrix metalloproteinases [Biochemistry]

07-10-2014 | Boris I. Ratnikov; Piotr Cieplak; Kosi Gramatikoff; James Pierce; Alexey Eroshkin; Yoshinobu Igarashi; Marat Kazanov ..., Proceedings of the National Academy of Sciences current issue, 2014

Genomic sequencing and structural genomics produced a vast amount of sequence and structural data, creating an opportunity for structure–function analysis in silico [Radivojac P, et al. (2013) Nat Methods 10(3):221–227]. Unfortunately, only a few large experimental datasets exist to serve as ...


Single-molecule investigation of G-quadruplex folds of the human telomere sequence in a protein nanocavity [Biochemistry]

07-10-2014 | Na An; Aaron M. Fleming; Eric G. Middleton; Cynthia J. Burrows, Proceedings of the National Academy of Sciences current issue, 2014

Human telomeric DNA consists of tandem repeats of the sequence 5′-TTAGGG-3′ that can fold into various G-quadruplexes, including the hybrid, basket, and propeller folds. In this report, we demonstrate use of the α-hemolysin ion channel to analyze these subtle topological changes at a nanometer ...


Ribosome-induced tuning of GTP hydrolysis by a translational GTPase [Biochemistry]

07-10-2014 | Cristina Maracci; Frank Peske; Ev Dannies; Corinna Pohl; Marina V. Rodnina, Proceedings of the National Academy of Sciences current issue, 2014

GTP hydrolysis by elongation factor Tu (EF-Tu), a translational GTPase that delivers aminoacyl-tRNAs to the ribosome, plays a crucial role in decoding and translational fidelity. The basic reaction mechanism and the way the ribosome contributes to catalysis are a matter of debate. Here we use ...


Pharmacologic rescue of an enzyme-trafficking defect in primary hyperoxaluria 1 [Biochemistry]

07-10-2014 | Non Miyata; Janos Steffen; Meghan E. Johnson; Sonia Fargue; Christopher J. Danpure; Carla M. Koehler, Proceedings of the National Academy of Sciences current issue, 2014

Primary hyperoxaluria 1 (PH1; Online Mendelian Inheritance in Man no. 259900), a typically lethal biochemical disorder, may be caused by the AGTP11LG170R allele in which the alanine:glyoxylate aminotransferase (AGT) enzyme is mistargeted from peroxisomes to mitochondria. AGT contains a C-terminal ...


Mesoscopic Model and Free Energy Landscape for Protein-DNA Binding Sites: Analysis of Cyanobacterial Promoters

02-10-2014 | Rafael Tapia-Rojo et al., PLoS Computational Biology, 2014

by Rafael Tapia-Rojo, Juan José Mazo, José Ángel Hernández, María Luisa Peleato, María F. Fillat, Fernando Falo The identification of protein binding sites in promoter sequences is a key problem to understand and control regulation in biochemistry and biotechnological processes. We use a ...


Predicting leaf wax n‐alkane 2H/1H ratios: controlled water source and humidity experiments with hydroponically grown trees confirm predictions of Craig‐Gordon model


Abstract The extent to which both water source and atmospheric humidity affect δ2H values of terrestrial plant leaf waxes will affect interpretations of δ2H variation of leaf waxes as a proxy for hydrologic conditions. To elucidate the effects of these parameters, we conducted a long‐term ...


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