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2,221 Newest Publications about the topic biochemistry

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Gpr161 anchoring of PKA consolidates GPCR and cAMP signaling [Biochemistry]

12-Jul-2016 | Verena A. Bachmann; Johanna E. Mayrhofer; Ronit Ilouz; Philipp Tschaikner; Philipp Raffeiner; Ruth Röck; Mathieu Cou ..., Proceedings of the National Academy of Sciences current issue, 2016

Scaffolding proteins organize the information flow from activated G protein-coupled receptors (GPCRs) to intracellular effector cascades both spatially and temporally. By this means, signaling scaffolds, such as A-kinase anchoring proteins (AKAPs), compartmentalize kinase activity and ensure ...

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Structural basis of viral RNA-dependent RNA polymerase catalysis and translocation [Biochemistry]

12-Jul-2016 | Bo Shu; Peng Gong, Proceedings of the National Academy of Sciences current issue, 2016

Viral RNA-dependent RNA polymerases (RdRPs) play essential roles in viral genome replication and transcription. We previously reported several structural states of the poliovirus RdRP nucleotide addition cycle (NAC) that revealed a unique palm domain-based active site closure mechanism and ...

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Cardiac myosin light chain is phosphorylated by Ca2+/calmodulin-dependent and -independent kinase activities [Biochemistry]

05-Jul-2016 | Audrey N. Chang; Pravin Mahajan; Stefan Knapp; Hannah Barton; H. Lee Sweeney; Kristine E. Kamm; James T. Stull, Proceedings of the National Academy of Sciences current issue, 2016

The well-known, muscle-specific smooth muscle myosin light chain kinase (MLCK) (smMLCK) and skeletal muscle MLCK (skMLCK) are dedicated protein kinases regulated by an autoregulatory segment C terminus of the catalytic core that blocks myosin regulatory light chain (RLC) binding and ...

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The neurofibromin recruitment factor Spred1 binds to the GAP related domain without affecting Ras inactivation [Biochemistry]

05-Jul-2016 | Theresia Dunzendorfer-Matt; Ellen L. Mercado; Karl Maly; Frank McCormick; Klaus Scheffzek, Proceedings of the National Academy of Sciences current issue, 2016

Neurofibromatosis type 1 (NF1) and Legius syndrome are related diseases with partially overlapping symptoms caused by alterations of the tumor suppressor genes NF1 (encoding the protein neurofibromin) and SPRED1 (encoding sprouty-related, EVH1 domain-containing protein 1, Spred1), respectively. ...

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Selective small molecule inhibitor of the Mycobacterium tuberculosis fumarate hydratase reveals an allosteric regulatory site [Biochemistry]

05-Jul-2016 | Monica Kasbekar; Gerhard Fischer; Bryan T. Mott; Adam Yasgar; Marko Hyvönen; Helena I. M. Boshoff; Chris Abell; Clif ..., Proceedings of the National Academy of Sciences current issue, 2016

Enzymes in essential metabolic pathways are attractive targets for the treatment of bacterial diseases, but in many cases, the presence of homologous human enzymes makes them impractical candidates for drug development. Fumarate hydratase, an essential enzyme in the tricarboxylic acid (TCA) ...

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Role and structural mechanism of WASP-triggered conformational changes in branched actin filament nucleation by Arp2/3 complex [Biochemistry]

05-Jul-2016 | Max Rodnick-Smith; Qing Luan; Su-Ling Liu; Brad J. Nolen, Proceedings of the National Academy of Sciences current issue, 2016

The Arp2/3 (Actin-related proteins 2/3) complex is activated by WASP (Wiskott–Aldrich syndrome protein) family proteins to nucleate branched actin filaments that are important for cellular motility. WASP recruits actin monomers to the complex and stimulates movement of Arp2 and Arp3 into a ...

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Computational modelling of atherosclerosis

01-Jul-2016 | Andrew Parton; Victoria McGilligan; Maurice O’Kane; Francina R. Baldrick; Steven Watterson, Briefings in Bioinformatics, 2016

Atherosclerosis is one of the principle pathologies of cardiovascular disease with blood cholesterol a significant risk factor. The World Health Organization estimates that approximately 2.5 million deaths occur annually because of the risk from elevated cholesterol, with 39% of adults worldwide ...

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Promiscuous or discriminating: Has the favored mRNA target of Fragile X Mental Retardation Protein been overlooked? [Biochemistry]

28-Jun-2016 | Aoife C. McMahon; Michael Rosbash, Proceedings of the National Academy of Sciences current issue, 2016

Fragile X syndrome (FXS), the most common heritable cause of intellectual disability, is caused by the loss of the RNA-binding protein Fragile X Mental Retardation Protein (FMRP). FMRP is thought to bind neuronal mRNA transcripts, traffic them to synapses, and regulate their translation (1). ...

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Structure of a phleboviral envelope glycoprotein reveals a consolidated model of membrane fusion [Biochemistry]

28-Jun-2016 | Steinar Halldorsson; Anna-Janina Behrens; Karl Harlos; Juha T. Huiskonen; Richard M. Elliott; Max Crispin; Benjamin ..., Proceedings of the National Academy of Sciences current issue, 2016

An emergent viral pathogen termed severe fever with thrombocytopenia syndrome virus (SFTSV) is responsible for thousands of clinical cases and associated fatalities in China, Japan, and South Korea. Akin to other phleboviruses, SFTSV relies on a viral glycoprotein, Gc, to catalyze the merger of ...

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Chemical properties of lipids strongly affect the kinetics of the membrane-induced aggregation of {alpha}-synuclein [Biochemistry]

28-Jun-2016 | Céline Galvagnion; James W. P. Brown; Myriam M. Ouberai; Patrick Flagmeier; Michele Vendruscolo; Alexander K. Buell; ..., Proceedings of the National Academy of Sciences current issue, 2016

Intracellular α-synuclein deposits, known as Lewy bodies, have been linked to a range of neurodegenerative disorders, including Parkinson’s disease. α-Synuclein binds to synthetic and biological lipids, and this interaction has been shown to play a crucial role for both α-synuclein’s native ...

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