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2,432 Newest Publications about the topic biochemistry


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Heavy metals? No problem for this snail

14-Apr-2017 | Julia Fahrenkamp-Uppenbrink, Science , 2017

Biochemistry![Figure][1] The common periwinkle uses metallothioneins to cope with environmental heavy metals. CREDIT: ANDREY NEKRASOV/ALAMY STOCK PHOTO Snails and slugs can accumulate and detoxify heavy metals with the help of metallothioneins, small sulphur-rich proteins that can bind ions


Distinct recognition of complement iC3b by integrins {alpha}X{beta}2 and {alpha}M{beta}2 [Biochemistry]

28-Mar-2017 | Shutong Xu; Jianchuan Wang; Jia-Huai Wang; Timothy A. Springer, Proceedings of the National Academy of Sciences current issue, 2017

Recognition by the leukocyte integrins αXβ2 and αMβ2 of complement iC3b-opsonized targets is essential for effector functions including phagocytosis. The integrin-binding sites on iC3b remain incompletely characterized. Here, we describe negative-stain electron microscopy and biochemical studies ...


Persistence of the mitochondrial permeability transition in the absence of subunit c of human ATP synthase [Biochemistry]

28-Mar-2017 | Jiuya He; Holly C. Ford; Joe Carroll; Shujing Ding; Ian M. Fearnley; John E. Walker, Proceedings of the National Academy of Sciences current issue, 2017

The permeability transition in human mitochondria refers to the opening of a nonspecific channel, known as the permeability transition pore (PTP), in the inner membrane. Opening can be triggered by calcium ions, leading to swelling of the organelle, disruption of the inner membrane, and ATP ...


Better understanding of homologous recombination through a 12‐week laboratory course for undergraduates majoring in biotechnology

17-Mar-2017 | Ming Li, Xiaodong Shen, Yan Zhao, Xiaomei Hu, Fuquan Hu, Xiancai Rao, Biochemistry and Molecular Biology Education, 2017

Abstract Homologous recombination, a central concept in biology, is defined as the exchange of DNA strands between two similar or identical nucleotide sequences. Unfortunately, undergraduate students majoring in biotechnology often experience difficulties in understanding the molecular basis ...


Structure of human IFIT1 with capped RNA reveals adaptable mRNA binding and mechanisms for sensing N1 and N2 ribose 2'-O methylations [Biochemistry]

14-Mar-2017 | Yazan M. Abbas; Beatrice Theres Laudenbach; Saúl Martínez-Montero; Regina Cencic; Matthias Habjan; Andreas Pichlmair ..., Proceedings of the National Academy of Sciences current issue, 2017

IFIT1 (IFN-induced protein with tetratricopeptide repeats-1) is an effector of the host innate immune antiviral response that prevents propagation of virus infection by selectively inhibiting translation of viral mRNA. It relies on its ability to compete with the translation initiation factor ...


Specific phospholipid binding to Na,K-ATPase at two distinct sites [Biochemistry]

14-Mar-2017 | Michael Habeck; Einat Kapri-Pardes; Michal Sharon; Steven J. D. Karlish, Proceedings of the National Academy of Sciences current issue, 2017

Membrane protein function can be affected by the physical state of the lipid bilayer and specific lipid–protein interactions. For Na,K-ATPase, bilayer properties can modulate pump activity, and, as observed in crystal structures, several lipids are bound within the transmembrane domain. ...


Genome-wide transcription-coupled repair in Escherichia coli is mediated by the Mfd translocase [Biochemistry]

14-Mar-2017 | Ogun Adebali; Yi-Ying Chiou; Jinchuan Hu; Aziz Sancar; Christopher P. Selby, Proceedings of the National Academy of Sciences current issue, 2017

We used high-throughput sequencing of short, cyclobutane pyrimidine dimer-containing ssDNA oligos generated during repair of UV-induced damage to study that process at both mechanistic and systemic levels in Escherichia coli. Numerous important insights on DNA repair were obtained, bringing ...


Rps3/uS3 promotes mRNA binding at the 40S ribosome entry channel and stabilizes preinitiation complexes at start codons [Biochemistry]

14-Mar-2017 | Jinsheng Dong; Colin Echeverría Aitken; Anil Thakur; Byung-Sik Shin; Jon R. Lorsch; Alan G. Hinnebusch, Proceedings of the National Academy of Sciences current issue, 2017

The eukaryotic 43S preinitiation complex (PIC) bearing Met-tRNAiMet in a ternary complex (TC) with eukaryotic initiation factor (eIF)2-GTP scans the mRNA leader for an AUG codon in favorable “Kozak” context. AUG recognition provokes rearrangement from an open PIC conformation with TC bound in a ...


Bioinformatic analysis of riboswitch structures uncovers variant classes with altered ligand specificity [Biochemistry]

14-Mar-2017 | Zasha Weinberg; James W. Nelson; Christina E. Lünse; Madeline E. Sherlock; Ronald R. Breaker, Proceedings of the National Academy of Sciences current issue, 2017

Riboswitches are RNAs that form complex, folded structures that selectively bind small molecules or ions. As with certain groups of protein enzymes and receptors, some riboswitch classes have evolved to change their ligand specificity. We developed a procedure to systematically analyze known ...


Voltage-sensitive rhodol with enhanced two-photon brightness [Biochemistry]

14-Mar-2017 | Rishikesh U. Kulkarni; Daniel J. Kramer; Narges Pourmandi; Kaveh Karbasi; Helen S. Bateup; Evan W. Miller, Proceedings of the National Academy of Sciences current issue, 2017

We have designed, synthesized, and applied a rhodol-based chromophore to a molecular wire-based platform for voltage sensing to achieve fast, sensitive, and bright voltage sensing using two-photon (2P) illumination. Rhodol VoltageFluor-5 (RVF5) is a voltage-sensitive dye with improved 2P ...


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