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1,899 Newest Publications about the topic biochemistry


Structure of LacY with an {alpha}-substituted galactoside: Connecting the binding site to the protonation site [Biochemistry]

21-Jul-2015 | Hemant Kumar; Janet S. Finer-Moore; H. Ronald Kaback; Robert M. Stroud, Proceedings of the National Academy of Sciences current issue, 2015

The X-ray crystal structure of a conformationally constrained mutant of the Escherichia coli lactose permease (the LacY double-Trp mutant Gly-46→Trp/Gly-262→Trp) with bound p-nitrophenyl-α-d-galactopyranoside (α-NPG), a high-affinity lactose analog, is described. With the exception of Glu-126 ...


Sex hormone-dependent tRNA halves enhance cell proliferation in breast and prostate cancers [Biochemistry]

21-Jul-2015 | Shozo Honda; Phillipe Loher; Megumi Shigematsu; Juan P. Palazzo; Ryusuke Suzuki; Issei Imoto; Isidore Rigoutsos; Yoh ..., Proceedings of the National Academy of Sciences current issue, 2015

Sex hormones and their receptors play critical roles in the development and progression of the breast and prostate cancers. Here we report that a novel type of transfer RNA (tRNA)-derived small RNA, termed Sex HOrmone-dependent TRNA-derived RNAs (SHOT-RNAs), are specifically and abundantly ...


Skip residues modulate the structural properties of the myosin rod and guide thick filament assembly [Biochemistry]

21-Jul-2015 | Keenan C. Taylor; Massimo Buvoli; Elif Nihal Korkmaz; Ada Buvoli; Yuqing Zheng; Nathan T. Heinze; Qiang Cui; Leslie ..., Proceedings of the National Academy of Sciences current issue, 2015

The rod of sarcomeric myosins directs thick filament assembly and is characterized by the insertion of four skip residues that introduce discontinuities in the coiled-coil heptad repeats. We report here that the regions surrounding the first three skip residues share high structural similarity ...


Structure and mechanism of the ATPase that powers viral genome packaging [Biochemistry]

21-Jul-2015 | Brendan J. Hilbert; Janelle A. Hayes; Nicholas P. Stone; Caroline M. Duffy; Banumathi Sankaran; Brian A. Kelch, Proceedings of the National Academy of Sciences current issue, 2015

Many viruses package their genomes into procapsids using an ATPase machine that is among the most powerful known biological motors. However, how this motor couples ATP hydrolysis to DNA translocation is still unknown. Here, we introduce a model system with unique properties for studying motor ...


Mitochondrial diseases caused by toxic compound accumulation: from etiopathology to therapeutic approaches

21-Jul-2015 | Ivano Di Meo, Costanza Lamperti, Valeria Tiranti, EMBO Molecular Medicine, 2015

Abstract Mitochondrial disorders are a group of highly invalidating human conditions for which effective treatment is currently unavailable and characterized by faulty energy supply due to defective oxidative phosphorylation (OXPHOS). Given the complexity of mitochondrial genetics and ...


A semester‐long project‐oriented biochemistry laboratory based on Helicobacter pylori urease

14-Jul-2015 | Kate R. Farnham, Danielle H. Dube, Biochemistry and Molecular Biology Education, 2015

Abstract Here we present the development of a 13 week project‐oriented biochemistry laboratory designed to introduce students to foundational biochemical techniques and then enable students to perform original research projects once they have mastered these techniques. In particular, we ...


The comparative toxicity of a reduced, crude comfrey (Symphytum officinale) alkaloid extract and the pure, comfrey‐derived pyrrolizidine alkaloids, lycopsamine and intermedine in chicks (Gallus gallus domesticus)

14-Jul-2015 | Ammon W. Brown, Bryan L. Stegelmeier, Steven M. Colegate, Dale R. Gardner, Kip E. Panter, Edward L. Knoppel, Jeffery ..., Journal of Applied Toxicology, 2015

Abstract Comfrey (Symphytum officinale), a commonly used herb, contains dehydropyrrolizidine alkaloids that, as a group of bioactive metabolites, are potentially hepatotoxic, pneumotoxic, genotoxic and carcinogenic. Consequently, regulatory agencies and international health organizations have ...


A national comparison of biochemistry and molecular biology capstone experiences

14-Jul-2015 | Ann Aguanno, Pamela Mertz, Debra Martin, Ellis Bell, Biochemistry and Molecular Biology Education, 2015

Abstract Recognizing the increasingly integrative nature of the molecular life sciences, the American Society for Biochemistry and Molecular Biology (ASBMB) recommends that Biochemistry and Molecular Biology (BMB) programs develop curricula based on concepts, content, topics, and expected ...


Mapping the binding interface of ERK and transcriptional repressor Capicua using photocrosslinking [Biochemistry]

14-Jul-2015 | Alan S. Futran; Saw Kyin; Stanislav Y. Shvartsman; A. James Link, Proceedings of the National Academy of Sciences current issue, 2015

Extracellular signal-regulated kinase (ERK) coordinates cellular responses to a range of stimuli by phosphorylating its numerous substrates. One of these substrates, Capicua (Cic), is a transcriptional repressor that was first identified in Drosophila and has been implicated in a number of human ...


Role of RAG1 autoubiquitination in V(D)J recombination [Biochemistry]

14-Jul-2015 | Samarendra K. Singh; Martin Gellert, Proceedings of the National Academy of Sciences current issue, 2015

The variable domains of Ig and T-cell receptor genes in vertebrates are assembled from gene fragments by the V(D)J recombination process. The RAG1–RAG2 recombinase (RAG1/2) initiates this recombination by cutting DNA at the borders of recombination signal sequences (RSS) and their neighboring ...


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