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1,961 Newest Publications about the topic biochemistry


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Safe and bodywide muscle transduction in young adult Duchenne muscular dystrophy dogs with adeno-associated virus

15-Oct-2015 | Yongping Yue; Xiufang Pan; Chady H. Hakim; Kasun Kodippili; Keqing Zhang; Jin-Hong Shin; Hsiao T. Yang; Thomas McDon ..., Human Molecular Genetics, 2015

The ultimate goal of muscular dystrophy gene therapy is to treat all muscles in the body. Global gene delivery was demonstrated in dystrophic mice more than a decade ago using adeno-associated virus (AAV). However, translation to affected large mammals has been challenging. The only reported ...


Amniotic fluid biochemistry in isolated polyhydramnios: A series of 464 cases

02-Oct-2015 | Bichr Allaf, Sophie Dreux, Thomas Schmitz, Isabelle Czerkiewicz, Claudine Le Vaillant, Alexandra Benachi, Véronique ..., Prenatal Diagnosis, 2015

Abstract Objective To report amniotic fluid biochemistry in a large series of 464 cases of isolated polyhydramnios in order to analyze both the outcome and the benefit of amniotic fluid biochemistry. Methods This retrospective cohort (2008‐2012) included polyhydramnios cases for which ...


[Developmental Biology] Size Scaling of Microtubule Assemblies in Early Xenopus Embryos

01-Oct-2015 | Timothy J. Mitchison; Keisuke Ishihara; Phuong Nguyen; Martin Wühr, CSH Perspectives, 2015

The first 12 cleavage divisions in Xenopus embryos provide a natural experiment in size scaling, as cell radius decreases ~16-fold with little change in biochemistry. Analyzing both natural cleavage and egg extract partitioned into droplets revealed that mitotic spindle size scales with cell ...


Environmental roles of microbial amino acid racemases

30-Sep-2015 | Sara B. Hernández, Felipe Cava, Environmental Microbiology, 2015

Abstract Enzymes catalysing the stereo‐chemical inter‐conversion of amino acids are known as amino acid racemases. In bacteria, these enzymes are fundamental to synthesize the D‐Ala and D‐Glu that are critical components of the peptidoglycan. In addition to this structural function in cell ...


Structure of subcomplex I{beta} of mammalian respiratory complex I leads to new supernumerary subunit assignments [Biochemistry]

29-Sep-2015 | Jiapeng Zhu; Martin S. King; Minmin Yu; Liron Klipcan; Andrew G. W. Leslie; Judy Hirst, Proceedings of the National Academy of Sciences current issue, 2015

Mitochondrial complex I (proton-pumping NADH:ubiquinone oxidoreductase) is an essential respiratory enzyme. Mammalian complex I contains 45 subunits: 14 conserved “core” subunits and 31 “supernumerary” subunits. The structure of Bos taurus complex I, determined to 5-Å resolution by electron ...


Development of a histone deacetylase 6 inhibitor and its biological effects [Biochemistry]

29-Sep-2015 | Ju-Hee Lee; Yuanshan Yao; Adaickapillai Mahendran; Lang Ngo; Gisela Venta-Perez; Megan L. Choy; Ronald Breslow; Paul ..., Proceedings of the National Academy of Sciences current issue, 2015

We report the development of a potent, selective histone deacetylase 6 (HDAC6) inhibitor. This HDAC6 inhibitor blocks growth of normal and transformed cells but does not induce death of normal cells. The HDAC6 inhibitor alone is as effective as paclitaxel in anticancer activity in tumor-bearing ...


Crystal structure reveals specific recognition of a G-quadruplex RNA by a {beta}-turn in the RGG motif of FMRP [Biochemistry]

29-Sep-2015 | Nikita Vasilyev; Anna Polonskaia; Jennifer C. Darnell; Robert B. Darnell; Dinshaw J. Patel; Alexander Serganov, Proceedings of the National Academy of Sciences current issue, 2015

Fragile X Mental Retardation Protein (FMRP) is a regulatory RNA binding protein that plays a central role in the development of several human disorders including Fragile X Syndrome (FXS) and autism. FMRP uses an arginine-glycine-rich (RGG) motif for specific interactions with guanine ...


The Sec2 translocase of the chloroplast inner envelope contains a unique and dedicated SECE2 component

25-Sep-2015 | Yubing Li, Rajneesh Singhal, Isaiah W. Taylor, Patrick H. McMinn, Xien Yu Chua, Kenneth Cline, Donna E. Fernandez, The Plant Journal, 2015

Summary Biogenesis of chloroplasts involves a series of protein trafficking events. Nuclear‐encoded proteins are imported into the organelle and then secondarily trafficked to various chloroplast locations by systems that are directly homologous to bacterial systems. Although the ...


Loop recognition and copper-mediated disulfide reduction underpin metal site assembly of CuA in human cytochrome oxidase [Biochemistry]

22-Sep-2015 | Marcos N. Morgada; Luciano A. Abriata; Chiara Cefaro; Karolina Gajda; Lucia Banci; Alejandro J. Vila, Proceedings of the National Academy of Sciences current issue, 2015

Maturation of cytochrome oxidases is a complex process requiring assembly of several subunits and adequate uptake of the metal cofactors. Two orthologous Sco proteins (Sco1 and Sco2) are essential for the correct assembly of the dicopper CuA site in the human oxidase, but their function is not ...


Biochemical isolation of Argonaute protein complexes by Ago-APP [Biochemistry]

22-Sep-2015 | Judith Hauptmann; Daniel Schraivogel; Astrid Bruckmann; Sudhir Manickavel; Leonhard Jakob; Norbert Eichner; Janina P ..., Proceedings of the National Academy of Sciences current issue, 2015

During microRNA (miRNA)-guided gene silencing, Argonaute (Ago) proteins interact with a member of the TNRC6/GW protein family. Here we used a short GW protein-derived peptide fused to GST and demonstrate that it binds to Ago proteins with high affinity. This allows for the simultaneous isolation ...


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