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2,602 Newest Publications about the topic biochemistry


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Toward dynamic structural biology: Two decades of single-molecule Förster resonance energy transfer

19-Jan-2018 | Eitan Lerner; Thorben Cordes; Antonino Ingargiola; Yazan Alhadid; SangYoon Chung; Xavier Michalet; Shimon Weiss, Science , 2018

Classical structural biology can only provide static snapshots of biomacromolecules. Single-molecule Förster resonance energy transfer (smFRET) paved the way for studying dynamics in macromolecular structures under biologically relevant conditions. Since its first implementation in 1996, smFRET ...


Atomic mutagenesis of stop codon nucleotides reveals the chemical prerequisites for release factor-mediated peptide release [Biochemistry]

16-Jan-2018 | Thomas Philipp Hoernes; Nina Clementi; Michael Andreas Juen; Xinying Shi; Klaus Faserl; Jessica Willi; Catherina Gas ..., Proceedings of the National Academy of Sciences current issue, 2018

Termination of protein synthesis is triggered by the recognition of a stop codon at the ribosomal A site and is mediated by class I release factors (RFs). Whereas in bacteria, RF1 and RF2 promote termination at UAA/UAG and UAA/UGA stop codons, respectively, eukaryotes only depend on one RF (eRF1) ...


Grade distribution digests: A novel tool to enhance teaching and student learning in laboratory practicals

29-Dec-2017 | Peter G. Arthur, Reza Zareie, Paul Kirkwood, Martha Ludwig, Paul V. Attwood, Biochemistry and Molecular Biology Education, 2017

Abstract Assessment is a central component of course curriculums and is used to certify student learning, but it can also be used as a tool to improve teaching and learning. Many laboratory courses are structured such that there is only a grade for a particular laboratory, which limits the ...


Update on research and application of problem‐based learning in medical science education

29-Dec-2017 | Chuifeng Fan, Biying Jiang, Xiuying Shi, Enhua Wang, Qingchang Li, Biochemistry and Molecular Biology Education, 2017

Abstract Problem‐based learning (PBL) is a unique form of pedagogy dedicated to developing students' self‐learning and clinical practice skills. After several decades of development, although applications vary, PBL has been recognized all over the world and implemented by many medical schools. ...


Safety evaluation of subchronic feeding of nisI transformed Lactobacillus plantarum in Sprague‐Dawley rats

27-Dec-2017 | Haiyan Liu, Xiaoyun He, Wentao Xu, Kunlun Huang, Jianwei Zhang, Journal of Food Safety, 2017

Abstract The nisI gene was inserted into Lp (Lactobacillus plantarum) genome and obtained Lp590 (L.plantarum 590). The nisI gene can help Lp590 tolerate higher concentration of nisin. Although Lp was generally recognized as safe, the safety of the nisI transformed Lp is unknown. In this ...


Small laccase from streptomyces coelicolor—an ideal model protein/enzyme for undergraduate laboratory experience

23-Dec-2017 | Ryan Cook, Drew Hannon, Jonathan N. Southard, Sudipta Majumdar, Biochemistry and Molecular Biology Education, 2017

Abstract A one semester undergraduate biochemistry laboratory experience is described for an understanding of recombinant technology from gene cloning to protein characterization. An integrated experimental design includes three sequential modules: molecular cloning, protein expression and ...


Stem cell education for medical students at Tongji University: Primary cell culture and directional differentiation of rat bone marrow mesenchymal stem cells

23-Dec-2017 | Caixia Jin, Haibin Tian, Jiao Li, Song Jia, Siguang Li, Guo‐Tong Xu, Lei Xu, Lixia Lu, Biochemistry and Molecular Biology Education, 2017

Abstract Stem cells are cells that can self‐renew and differentiate into a variety of cell types under certain conditions. Stem cells have great potential in regenerative medicine and cell therapy for the treatment of certain diseases. To deliver knowledge about this frontier in science and ...


Aminoglycoside interactions and impacts on the eukaryotic ribosome [Biochemistry]

19-Dec-2017 | Irina Prokhorova; Roger B. Altman; Muminjon Djumagulov; Jaya P. Shrestha; Alexandre Urzhumtsev; Angelica Ferguson; C ..., Proceedings of the National Academy of Sciences current issue, 2017

Aminoglycosides are chemically diverse, broad-spectrum antibiotics that target functional centers within the bacterial ribosome to impact all four principle stages (initiation, elongation, termination, and recycling) of the translation mechanism. The propensity of aminoglycosides to induce ...


Structural insights into how GTP-dependent conformational changes in a metallochaperone UreG facilitate urease maturation [Biochemistry]

19-Dec-2017 | Man Hon Yuen; Yu Hang Fong; Yap Shing Nim; Pak Ho Lau; Kam-Bo Wong, Proceedings of the National Academy of Sciences current issue, 2017

The ability of metallochaperones to allosterically regulate the binding/release of metal ions and to switch protein-binding partners along the metal delivery pathway is essential to the metallation of the metalloenzymes. Urease, catalyzing the hydrolysis of urea into ammonia and carbon dioxide, ...


Conserved salt-bridge competition triggered by phosphorylation regulates the protein interactome [Biochemistry]

19-Dec-2017 | John J. Skinner; Sheng Wang; Jiyoung Lee; Colin Ong; Ruth Sommese; Sivaraj Sivaramakrishnan; Wolfgang Koelmel; Maria ..., Proceedings of the National Academy of Sciences current issue, 2017

Phosphorylation is a major regulator of protein interactions; however, the mechanisms by which regulation occurs are not well understood. Here we identify a salt-bridge competition or “theft” mechanism that enables a phospho-triggered swap of protein partners by Raf Kinase Inhibitory Protein ...


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