My watch list
my.bionity.com  
Login  

2,426 Newest Publications about the topic biochemistry

rss

You can refine your search further. Select from the filter options on the left to narrow down your results.

Structure of human IFIT1 with capped RNA reveals adaptable mRNA binding and mechanisms for sensing N1 and N2 ribose 2'-O methylations [Biochemistry]

14-Mar-2017 | Yazan M. Abbas; Beatrice Theres Laudenbach; Saúl Martínez-Montero; Regina Cencic; Matthias Habjan; Andreas Pichlmair ..., Proceedings of the National Academy of Sciences current issue, 2017

IFIT1 (IFN-induced protein with tetratricopeptide repeats-1) is an effector of the host innate immune antiviral response that prevents propagation of virus infection by selectively inhibiting translation of viral mRNA. It relies on its ability to compete with the translation initiation factor ...

more

Specific phospholipid binding to Na,K-ATPase at two distinct sites [Biochemistry]

14-Mar-2017 | Michael Habeck; Einat Kapri-Pardes; Michal Sharon; Steven J. D. Karlish, Proceedings of the National Academy of Sciences current issue, 2017

Membrane protein function can be affected by the physical state of the lipid bilayer and specific lipid–protein interactions. For Na,K-ATPase, bilayer properties can modulate pump activity, and, as observed in crystal structures, several lipids are bound within the transmembrane domain. ...

more

Genome-wide transcription-coupled repair in Escherichia coli is mediated by the Mfd translocase [Biochemistry]

14-Mar-2017 | Ogun Adebali; Yi-Ying Chiou; Jinchuan Hu; Aziz Sancar; Christopher P. Selby, Proceedings of the National Academy of Sciences current issue, 2017

We used high-throughput sequencing of short, cyclobutane pyrimidine dimer-containing ssDNA oligos generated during repair of UV-induced damage to study that process at both mechanistic and systemic levels in Escherichia coli. Numerous important insights on DNA repair were obtained, bringing ...

more

Rps3/uS3 promotes mRNA binding at the 40S ribosome entry channel and stabilizes preinitiation complexes at start codons [Biochemistry]

14-Mar-2017 | Jinsheng Dong; Colin Echeverría Aitken; Anil Thakur; Byung-Sik Shin; Jon R. Lorsch; Alan G. Hinnebusch, Proceedings of the National Academy of Sciences current issue, 2017

The eukaryotic 43S preinitiation complex (PIC) bearing Met-tRNAiMet in a ternary complex (TC) with eukaryotic initiation factor (eIF)2-GTP scans the mRNA leader for an AUG codon in favorable “Kozak” context. AUG recognition provokes rearrangement from an open PIC conformation with TC bound in a ...

more

Bioinformatic analysis of riboswitch structures uncovers variant classes with altered ligand specificity [Biochemistry]

14-Mar-2017 | Zasha Weinberg; James W. Nelson; Christina E. Lünse; Madeline E. Sherlock; Ronald R. Breaker, Proceedings of the National Academy of Sciences current issue, 2017

Riboswitches are RNAs that form complex, folded structures that selectively bind small molecules or ions. As with certain groups of protein enzymes and receptors, some riboswitch classes have evolved to change their ligand specificity. We developed a procedure to systematically analyze known ...

more

Exploring protein structure and dynamics through a project‐oriented biochemistry laboratory module

13-Mar-2017 | James M. Lipchock, Patrick S. Ginther, Bonnie B. Douglas, Kelly E. Bird, J. Patrick Loria, Biochemistry and Molecular Biology Education, 2017

Abstract Here, we present a 10‐week project‐oriented laboratory module designed to provide a course‐based undergraduate research experience in biochemistry that emphasizes the importance of biomolecular structure and dynamics in enzyme function. This module explores the impact of mutagenesis ...

more

Crystal structure of Aquifex aeolicus {sigma}N bound to promoter DNA and the structure of {sigma}N-holoenzyme [Biochemistry]

07-Mar-2017 | Elizabeth A. Campbell; Shreya Kamath; Kanagalaghatta R. Rajashankar; Mengyu Wu; Seth A. Darst, Proceedings of the National Academy of Sciences current issue, 2017

The bacterial σ factors confer promoter specificity to the RNA polymerase (RNAP). One alternative σ factor, σN, is unique in its structure and functional mechanism, forming transcriptionally inactive promoter complexes that require activation by specialized AAA+ ATPases. We report a 3.4-Å ...

more

Distinct C-mannosylation of netrin receptor thrombospondin type 1 repeats by mammalian DPY19L1 and DPY19L3 [Biochemistry]

07-Mar-2017 | Aleksandra Shcherbakova; Birgit Tiemann; Falk F. R. Buettner; Hans Bakker, Proceedings of the National Academy of Sciences current issue, 2017

Thrombospondin type 1 repeats (TSRs) occur in diverse proteins involved in adhesion and signaling. The two extracellular TSRs of the netrin receptor UNC5A contain WxxWxxWxxC motifs that can be C-mannosylated on all tryptophans. A single C-mannosyltransferase (dumpy-19, DPY-19), modifying the ...

more

Two-metal versus one-metal mechanisms of lysine adenylylation by ATP-dependent and NAD+-dependent polynucleotide ligases [Biochemistry]

07-Mar-2017 | Mihaela-Carmen Unciuleac; Yehuda Goldgur; Stewart Shuman, Proceedings of the National Academy of Sciences current issue, 2017

Polynucleotide ligases comprise a ubiquitous superfamily of nucleic acid repair enzymes that join 3′-OH and 5′-PO4 DNA or RNA ends. Ligases react with ATP or NAD+ and a divalent cation cofactor to form a covalent enzyme-(lysine-Nζ)–adenylate intermediate. Here, we report crystal structures of the ...

more

Chemistry at the protein-mineral interface in L-ferritin assists the assembly of a functional ({mu}3-oxo)Tris[({mu}2-peroxo)] triiron(III) cluster [Biochemistry]

07-Mar-2017 | Cecilia Pozzi; Silvia Ciambellotti; Caterina Bernacchioni; Flavio Di Pisa; Stefano Mangani; Paola Turano, Proceedings of the National Academy of Sciences current issue, 2017

X-ray structures of homopolymeric L-ferritin obtained by freezing protein crystals at increasing exposure times to a ferrous solution showed the progressive formation of a triiron cluster on the inner cage surface of each subunit. After 60 min exposure, a fully assembled ...

more

Page 1 From 243
Subscribe to e-mail updates relating to your search

You will receive via e-mail the latest search results matching your search criteria. This service is free of charge and can be cancelled at any time.

Your browser is not current. Microsoft Internet Explorer 6.0 does not support some functions on Chemie.DE