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2,367 Newest Publications about the topic biochemistry

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[Report] Macrocyclic bis-thioureas catalyze stereospecific glycosylation reactions

13-Jan-2017 | Yongho Park; Kaid C. Harper; Nadine Kuhl; Eugene E. Kwan; Richard Y. Liu; Eric N. Jacobsen, Science , 2017

Carbohydrates are involved in nearly all aspects of biochemistry, but their complex chemical structures present long-standing practical challenges to their synthesis. In particular, stereochemical outcomes in glycosylation reactions are highly dependent on the steric and electronic properties of ...

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Weighted Protein Interaction Network Analysis of Frontotemporal Dementia

12-Jan-2017 | Raffaele Ferrari; Ruth C. Lovering; John Hardy; Patrick A. Lewis; Claudia Manzoni, Journal of Proteome Research, 2017

The genetic analysis of complex disorders has undoubtedly led to the identification of a wealth of associations between genes and specific traits. However, moving from genetics to biochemistry one gene at a time has, to date, rather proved inefficient and under-powered to comprehensively explain ...

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Structure of phosphorylated UBL domain and insights into PINK1-orchestrated parkin activation [Biochemistry]

10-Jan-2017 | Jacob D. Aguirre; Karen M. Dunkerley; Pascal Mercier; Gary S. Shaw, Proceedings of the National Academy of Sciences current issue, 2017

Mutations in PARK2 and PARK6 genes are responsible for the majority of hereditary Parkinson’s disease cases. These genes encode the E3 ubiquitin ligase parkin and the protein kinase PTEN-induced kinase 1 (PINK1), respectively. Together, parkin and PINK1 regulate the mitophagy pathway, which ...

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Arginine substitution of a cysteine in transmembrane helix M8 converts Na+,K+-ATPase to an electroneutral pump similar to H+,K+-ATPase [Biochemistry]

10-Jan-2017 | Rikke Holm; Jaanki Khandelwal; Anja P. Einholm; Jens P. Andersen; Pablo Artigas; Bente Vilsen, Proceedings of the National Academy of Sciences current issue, 2017

Na+,K+-ATPase and H+,K+-ATPase are electrogenic and nonelectrogenic ion pumps, respectively. The underlying structural basis for this difference has not been established, and it has not been revealed how the H+,K+-ATPase avoids binding of Na+ at the site corresponding to the Na+-specific site of ...

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Ohr plays a central role in bacterial responses against fatty acid hydroperoxides and peroxynitrite [Biochemistry]

10-Jan-2017 | Thiago G. P. Alegria; Diogo A. Meireles; José R. R. Cussiol; Martín Hugo; Madia Trujillo; Marcos Antonio de Oliveira ..., Proceedings of the National Academy of Sciences current issue, 2017

Organic hydroperoxide resistance (Ohr) enzymes are unique Cys-based, lipoyl-dependent peroxidases. Here, we investigated the involvement of Ohr in bacterial responses toward distinct hydroperoxides. In silico results indicated that fatty acid (but not cholesterol) hydroperoxides docked well into ...

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Promoting active learning of graduate student by deep reading in biochemistry and microbiology pharmacy curriculum

06-Jan-2017 | Ren Peng, Biochemistry and Molecular Biology Education, 2017

Abstract To promote graduate students' active learning, deep reading of high quality papers was done by graduate students enrolled in biochemistry and microbiology pharmacy curriculum offered by college of life science, Jiangxi Normal University from 2013 to 2015. The number of graduate ...

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Proteome-pI: proteome isoelectric point database

04-Jan-2017 | Lukasz P. Kozlowski, Nucleic Acids Research, 2017

Proteome-pI is an online database containing information about predicted isoelectric points for 5029 proteomes calculated using 18 methods. The isoelectric point, the pH at which a particular molecule carries no net electrical charge, is an important parameter for many analytical biochemistry and ...

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Triazoles inhibit cholesterol export from lysosomes by binding to NPC1 [Biochemistry]

03-Jan-2017 | Michael N. Trinh; Feiran Lu; Xiaochun Li; Akash Das; Qiren Liang; Jef K. De Brabander; Michael S. Brown; Joseph L. G ..., Proceedings of the National Academy of Sciences current issue, 2017

Niemann–Pick C1 (NPC1), a membrane protein of lysosomes, is required for the export of cholesterol derived from receptor-mediated endocytosis of LDL. Lysosomal cholesterol export is reportedly inhibited by itraconazole, a triazole that is used as an antifungal drug [Xu et al. (2010) Proc Natl ...

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Mouse models of Casc3 reveal developmental functions distinct from other components of the exon junction complex [REPORT]

01-Jan-2017 | Hanqian Mao; Hannah E. Brown; Debra L. Silver, RNA, 2017

The exon junction complex (EJC) is a multiprotein complex integral to mRNA metabolism. Biochemistry and genetic studies have concluded that the EJC is composed of four core proteins, MAGOH, EIF4A3, RBM8A, and CASC3. Yet recent studies in Drosophila indicate divergent physiological functions for ...

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Stability of Cross-Feeding Polymorphisms in Microbial Communities

30-Dec-2016 | Ivana Gudelj; Margie Kinnersley; Peter Rashkov; Karen Schmidt; Frank Rosenzweig, PLoS Computational Biology, 2016

by Ivana Gudelj, Margie Kinnersley, Peter Rashkov, Karen Schmidt, Frank Rosenzweig Cross-feeding, a relationship wherein one organism consumes metabolites excreted by another, is a ubiquitous feature of natural and clinically-relevant microbial communities and could be a key factor promoting ...

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