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1,877 Newest Publications about the topic biochemistry

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Connecting biology and organic chemistry introductory laboratory courses through a collaborative research project

03-Jul-2015 | Ariana L. Boltax, Stephanie Armanious, Melissa S. Kosinski‐Collins, Jason K. Pontrello, Biochemistry and Molecular Biology Education, 2015

Abstract Modern research often requires collaboration of experts in fields, such as math, chemistry, biology, physics, and computer science to develop unique solutions to common problems. Traditional introductory undergraduate laboratory curricula in the sciences often do not emphasize ...

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Discovering the first tyrosine kinase [Biochemistry]

30-Jun-2015 | Tony Hunter, Proceedings of the National Academy of Sciences current issue, 2015

In the middle of the 20th century, animal tumor viruses were heralded as possible models for understanding human cancer. By the mid-1970s, the molecular basis by which tumor viruses transform cells into a malignant state was beginning to emerge as the first viral genomic sequences were reported ...

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Mediation of donor-acceptor distance in an enzymatic methyl transfer reaction [Biochemistry]

30-Jun-2015 | Jianyu Zhang; Heather J. Kulik; Todd J. Martinez; Judith P. Klinman, Proceedings of the National Academy of Sciences current issue, 2015

Enzymatic methyl transfer, catalyzed by catechol-O-methyltransferase (COMT), is investigated using binding isotope effects (BIEs), time-resolved fluorescence lifetimes, Stokes shifts, and extended graphics processing unit (GPU)-based quantum mechanics/molecular mechanics (QM/MM) approaches. The ...

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A universal entropy-driven mechanism for thioredoxin-target recognition [Biochemistry]

30-Jun-2015 | Prakash B. Palde; Kate S. Carroll, Proceedings of the National Academy of Sciences current issue, 2015

Cysteine residues in cytosolic proteins are maintained in their reduced state, but can undergo oxidation owing to posttranslational modification during redox signaling or under conditions of oxidative stress. In large part, the reduction of oxidized protein cysteines is mediated by a small 12-kDa ...

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Computational prediction and biochemical characterization of novel RNA aptamers to Rift Valley fever virus nucleocapsid protein

28-Jun-2015 | Author(s): Mary Ellenbecker , Jeremy St. Goddard , Alec Sundet , Jean-Marc Lanchy , Douglas Raiford , J.Stephen ..., Computational Biology and Chemistry, 2015

Publication date: Available online 22 June 2015 Source:Computational Biology and Chemistry Author(s): Mary Ellenbecker , Jeremy St. Goddard , Alec Sundet , Jean-Marc Lanchy , Douglas Raiford , J.Stephen Lodmell Rift Valley fever virus (RVFV) is a potent human and livestock pathogen ...

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Circulating irisin levels are associated with lipid and uric acid metabolism in a Chinese population

26-Jun-2015 | Shanshan Tang, Rong Zhang, Feng Jiang, Jie Wang, Miao Chen, Danfeng Peng, Jing Yan, Shiyun Wang, Yuqian Bao, Cheng H ..., Clinical and Experimental Pharmacology and Physiology, 2015

Abstract Irisin is a novel hormone secreted by skeletal muscle after exercise, which may ameliorate insulin resistance. In this study, we aimed to explore the relationship between circulating irisin levels and type 2 diabetes (T2DM) as well as related metabolic traits in a Chinese population. ...

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Accumulation and toxicity of intravenously‐injected functionalized graphene oxide in mice

23-Jun-2015 | Kai‐Ping Wen, Ying‐Chieh Chen, Chia‐Hui Chuang, Hwan‐You Chang, Chi‐Young Lee, Nyan‐Hwa Tai, Journal of Applied Toxicology, 2015

Abstract Graphene and its functionalized derivatives have recently emerged as interesting nanomaterials with promising applications in biomedicine. In this study, the long‐term in vivo biodistribution of intravenously injected nanographene oxide (NGO) functionalized with poly sodium ...

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Empirical inference of circuitry and plasticity in a kinase signaling network [Biochemistry]

23-Jun-2015 | Edmund H. Wilkes; Camille Terfve; John G. Gribben; Julio Saez-Rodriguez; Pedro Rodriguez Cutillas, Proceedings of the National Academy of Sciences current issue, 2015

Our understanding of physiology and disease is hampered by the difficulty of measuring the circuitry and plasticity of signaling networks that regulate cell biology, and how these relate to phenotypes. Here, using mass spectrometry-based phosphoproteomics, we systematically characterized the ...

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Regulation by a chaperone improves substrate selectivity during cotranslational protein targeting [Biochemistry]

23-Jun-2015 | Aileen Ariosa; Jae Ho Lee; Shuai Wang; Ishu Saraogi; Shu-ou Shan, Proceedings of the National Academy of Sciences current issue, 2015

The ribosome exit site is a crowded environment where numerous factors contact nascent polypeptides to influence their folding, localization, and quality control. Timely and accurate selection of nascent polypeptides into the correct pathway is essential for proper protein biogenesis. To ...

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Cytochrome cbb3 of Thioalkalivibrio is a Na+-pumping cytochrome oxidase [Biochemistry]

23-Jun-2015 | Maria S. Muntyan; Dmitry A. Cherepanov; Anssi M. Malinen; Dmitry A. Bloch; Dimitry Y. Sorokin; Inna I. Severina; Tat ..., Proceedings of the National Academy of Sciences current issue, 2015

Cytochrome c oxidases (Coxs) are the basic energy transducers in the respiratory chain of the majority of aerobic organisms. Coxs studied to date are redox-driven proton-pumping enzymes belonging to one of three subfamilies: A-, B-, and C-type oxidases. The C-type oxidases (cbb3 cytochromes), ...

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