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1,790 Newest Publications about the topic biochemistry

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Antioxidant icariside II combined with insulin restores erectile function in streptozotocin‐induced type 1 diabetic rats

17-Mar-2015 | Lin Wang, Yongde Xu, Huixi Li, Hongen Lei, Ruili Guan, Zhezhu Gao, Zhongcheng Xin, Journal of Cellular and Molecular Medicine, 2015

Abstract Erectile dysfunction (ED) worsens in patients with diabetes mellitus (DM) despite good control of blood glucose level with insulin. Recent studies imply that diabetic vascular stresses (e.g. oxidative stress) persist in spite of glucose normalization, which is defined as metabolic ...

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Plasmodium falciparum chloroquine resistance transporter is a H+-coupled polyspecific nutrient and drug exporter [Biochemistry]

17-Mar-2015 | Narinobu Juge; Sawako Moriyama; Takaaki Miyaji; Mamiyo Kawakami; Haruka Iwai; Tomoya Fukui; Nathan Nelson; Hiroshi O ..., Proceedings of the National Academy of Sciences current issue, 2015

Extrusion of chloroquine (CQ) from digestive vacuoles through the Plasmodium falciparum CQ resistance transporter (PfCRT) is essential to establish CQ resistance of the malaria parasite. However, the physiological relevance of PfCRT and how CQ-resistant PfCRT gains the ability to transport CQ ...

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Cleavage of amyloid precursor protein by an archaeal presenilin homologue PSH [Biochemistry]

17-Mar-2015 | Shangyu Dang; Shenjie Wu; Jiawei Wang; Hongbo Li; Min Huang; Wei He; Yue-Ming Li; Catherine C. L. Wong; Yigong Shi, Proceedings of the National Academy of Sciences current issue, 2015

Aberrant cleavage of amyloid precursor protein (APP) by γ-secretase contributes to the development of Alzheimer’s disease. More than 200 disease-derived mutations have been identified in presenilin (the catalytic subunit of γ-secretase), making modulation of γ-secretase activity a potentially ...

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Myosin VI deafness mutation prevents the initiation of processive runs on actin [Biochemistry]

17-Mar-2015 | Olena Pylypenko; Lin Song; Ai Shima; Zhaohui Yang; Anne M. Houdusse; H. Lee Sweeney, Proceedings of the National Academy of Sciences current issue, 2015

Mutations in the reverse-direction myosin, myosin VI, are associated with deafness in humans and mice. A myosin VI deafness mutation, D179Y, which is in the transducer of the motor, uncoupled the release of the ATP hydrolysis product, inorganic phosphate (Pi), from dependency on actin binding and ...

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Rationally designed fluorogenic protease reporter visualizes spatiotemporal dynamics of apoptosis in vivo [Biochemistry]

17-Mar-2015 | Tsz-Leung To; Beverly J. Piggott; Kalpana Makhijani; Dan Yu; Yuh Nung Jan; Xiaokun Shu, Proceedings of the National Academy of Sciences current issue, 2015

Fluorescence resonance energy transfer-based reporters have been widely used in imaging cell signaling; however, their in vivo application has been handicapped because of poor signal. Although fluorogenic reporters overcome this problem, no such reporter of proteases has been demonstrated for in ...

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OGP Functionalized Phenylalanine-Based Poly(ester urea) for Enhancing Osteoinductive Potential of Human Mesenchymal Stem Cells

12-Mar-2015 | Gina M. Policastro; Fei Lin; Laura A. Smith Callahan; Andrew Esterle; Matthew Graham; Kimberly Sloan Stakleff; Matth ..., Biomacromolecules, 2015

Amino acid-based poly(ester urea)s (PEU) are high modulus, resorbable polymers with many potential uses, including the surgical repair of bone defects. In vitro and in vivo studies have previously shown that phenylalanine-based PEUs have nontoxic hydrolytic byproducts and tunable degradation ...

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Genome‐guided investigation of plant natural product biosynthesis

11-Mar-2015 | Franziska Kellner, Jeongwoon Kim, Bernardo J. Clavijo, John P. Hamilton, Kevin L. Childs, Brieanne Vaillancourt, Jas ..., The Plant Journal, 2015

Summary The medicinal plant Madagascar periwinkle, Catharanthus roseus (L.) G. Don, produces hundreds of biologically active monoterpene‐derived indole alkaloid (MIA) metabolites and is the sole source of the potent, expensive anti‐cancer compounds vinblastine and vincristine. Access to a ...

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Selective molecular transport through the protein shell of a bacterial microcompartment organelle [Biochemistry]

10-Mar-2015 | Chiranjit Chowdhury; Sunny Chun; Allan Pang; Michael R. Sawaya; Sharmistha Sinha; Todd O. Yeates; Thomas A. Bobik, Proceedings of the National Academy of Sciences current issue, 2015

Bacterial microcompartments are widespread prokaryotic organelles that have important and diverse roles ranging from carbon fixation to enteric pathogenesis. Current models for microcompartment function propose that their outer protein shell is selectively permeable to small molecules, but ...

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Rational design of a split-Cas9 enzyme complex [Biochemistry]

10-Mar-2015 | Addison V. Wright; Samuel H. Sternberg; David W. Taylor; Brett T. Staahl; Jorge A. Bardales; Jack E. Kornfeld; Jenni ..., Proceedings of the National Academy of Sciences current issue, 2015

Cas9, an RNA-guided DNA endonuclease found in clustered regularly interspaced short palindromic repeats (CRISPR) bacterial immune systems, is a versatile tool for genome editing, transcriptional regulation, and cellular imaging applications. Structures of Streptococcus pyogenes Cas9 alone or ...

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Integrating bio‐inorganic and analytical chemistry into an undergraduate biochemistry laboratory

06-Mar-2015 | Daniel J. Erasmus, Sharon E. Brewer, Bruno Cinel, Biochemistry and Molecular Biology Education, 2015

Abstract Undergraduate laboratories expose students to a wide variety of topics and techniques in a limited amount of time. This can be a challenge and lead to less exposure to concepts and activities in bio‐inorganic chemistry and analytical chemistry that are closely‐related to biochemistry. ...

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