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2,402 Newest Publications about the topic biochemistry

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Marine Drugs, Vol. 15, Pages 45: Propylene Glycol Alginate Sodium Sulfate Alleviates  Cerulein‐Induced Acute Pancreatitis by Modulating  the MEK/ERK Pathway in Mice

17-Feb-2017 | Zhang, Hui ; Li, Yueyue ; Li, Linqiang ; Liu, Hua ; Hu, Liangkai ; Dai, Ying ; Chen, Jianqing ; Xu, Shuqi ; Chen, We ..., Marine Drugs, 2017

Previousstudieshavefocusedontheeffectsofpropyleneglycolalginatesodiumsulfate (PSS) against thrombosis, but the anti‐inflammatory potential is unknown. Therefore, we specificallyfocusedontheprotectiveeffectsofPSSoncerulein‐inducedacutepancreatitis(AP) ...

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An investigative graduate laboratory course for teaching modern DNA techniques

16-Feb-2017 | Alexandre de Lencastre, A. Thomas Torello, Lani C. Keller, Biochemistry and Molecular Biology Education, 2017

Abstract This graduate‐level DNA methods laboratory course is designed to model a discovery‐based research project and engages students in both traditional DNA analysis methods and modern recombinant DNA cloning techniques. In the first part of the course, students clone the Drosophila ...

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Binding, sliding, and function of cohesin during transcriptional activation [Biochemistry]

14-Feb-2017 | Melinda S. Borrie; John S. Campor; Hansa Joshi; Marc R. Gartenberg, Proceedings of the National Academy of Sciences current issue, 2017

The ring-shaped cohesin complex orchestrates long-range DNA interactions to mediate sister chromatid cohesion and other aspects of chromosome structure and function. In the yeast Saccharomyces cerevisiae, the complex binds discrete sites along chromosomes, including positions within and around ...

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Profile of Bruce M. Alberts, 2016 Lasker-Koshland Special Achievement Award in Medical Science Awardee [Profiles]

14-Feb-2017 | Shirley M. Tilghman, Proceedings of the National Academy of Sciences current issue, 2017

On September 23, 2016, Bruce M. Alberts was presented with the Lasker-Koshland Special Achievement Award in Medical Science, which honored him for “fundamental discoveries in DNA replication and protein biochemistry; for visionary leadership in directing national and international scientific ...

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Formation of a repressive complex in the mammalian circadian clock is mediated by the secondary pocket of CRY1 [Biochemistry]

14-Feb-2017 | Alicia K. Michael; Jennifer L. Fribourgh; Yogarany Chelliah; Colby R. Sandate; Greg L. Hura; Dina Schneidman-Duhovny ..., Proceedings of the National Academy of Sciences current issue, 2017

The basic helix–loop–helix PAS domain (bHLH-PAS) transcription factor CLOCK:BMAL1 (brain and muscle Arnt-like protein 1) sits at the core of the mammalian circadian transcription/translation feedback loop. Precise control of CLOCK:BMAL1 activity by coactivators and repressors establishes the ...

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Mechanistic insights into caspase-9 activation by the structure of the apoptosome holoenzyme [Biochemistry]

14-Feb-2017 | Yini Li; Mengying Zhou; Qi Hu; Xiao-chen Bai; Weiyun Huang; Sjors H. W. Scheres; Yigong Shi, Proceedings of the National Academy of Sciences current issue, 2017

Mammalian intrinsic apoptosis requires activation of the initiator caspase-9, which then cleaves and activates the effector caspases to execute cell killing. The heptameric Apaf-1 apoptosome is indispensable for caspase-9 activation by together forming a holoenzyme. The molecular mechanism of ...

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Hydroxyl regioisomerization of anthracycline catalyzed by a four-enzyme cascade [Biochemistry]

14-Feb-2017 | Zhuan Zhang; Yu-Kang Gong; Qiang Zhou; Yu Hu; Hong-Min Ma; Yong-Sheng Chen; Yasuhiro Igarashi; Lifeng Pan; Gong-Li Tang, Proceedings of the National Academy of Sciences current issue, 2017

Ranking among the most effective anticancer drugs, anthracyclines represent an important family of aromatic polyketides generated by type II polyketide synthases (PKSs). After formation of polyketide cores, the post-PKS tailoring modifications endow the scaffold with various structural ...

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Comprehensive understanding of acetohydroxyacid synthase inhibition by different herbicide families [Biochemistry]

14-Feb-2017 | Mario D. Garcia; Amanda Nouwens; Thierry G. Lonhienne; Luke W. Guddat, Proceedings of the National Academy of Sciences current issue, 2017

Five commercial herbicide families inhibit acetohydroxyacid synthase (AHAS, E.C. 2.2.1.6), which is the first enzyme in the branched-chain amino acid biosynthesis pathway. The popularity of these herbicides is due to their low application rates, high crop vs. weed selectivity, and low toxicity in ...

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Nucleotide-dependent switch in proteasome assembly mediated by the Nas6 chaperone [Biochemistry]

14-Feb-2017 | Frances Li; Geng Tian; Deanna Langager; Vladyslava Sokolova; Daniel Finley; Soyeon Park, Proceedings of the National Academy of Sciences current issue, 2017

The proteasome is assembled via the nine-subunit lid, nine-subunit base, and 28-subunit core particle (CP). Previous work has shown that the chaperones Rpn14, Nas6, Hsm3, and Nas2 each bind a specific ATPase subunit of the base and antagonize base–CP interaction. Here, we show that the Nas6 ...

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Dissecting the proton transport pathway in electrogenic Na+/H+ antiporters [Biochemistry]

14-Feb-2017 | Povilas Uzdavinys; Mathieu Coinçon; Emmanuel Nji; Mama Ndi; Iven Winkelmann; Christoph von Ballmoos; David Drew, Proceedings of the National Academy of Sciences current issue, 2017

Sodium/proton exchangers of the SLC9 family mediate the transport of protons in exchange for sodium to help regulate intracellular pH, sodium levels, and cell volume. In electrogenic Na+/H+ antiporters, it has been assumed that two ion-binding aspartate residues transport the two protons that are ...

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