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2,077 Newest Publications about the topic biochemistry

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The Incidence of Superficial Scald in “Wujiuxiang” Pears (Pyrus Pyrifolia Cv. Wujiuxiang) during and after Controlled Atmosphere Storage

04-Feb-2016 | Limei Li, Yufeng Xia, Cailing Xu, Jingang He, Junfeng Guan, Journal of Food Quality, 2016

Abstract This work is aimed to assess the effect of the low temperature controlled atmosphere (CA) storage on reducing the incidence of fruit superficial scald in “Wujiuxiang” pears (Pyrus pyrifolia cv. Wujiuxiang). We set up four low temperature CA storage conditions with pCO2 0.03 kPa, 1 ...

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Transition state for the NSD2-catalyzed methylation of histone H3 lysine 36 [Biochemistry]

02-Feb-2016 | Myles B. Poulin; Jessica L. Schneck; Rosalie E. Matico; Patrick J. McDevitt; Michael J. Huddleston; Wangfang Hou; Ne ..., Proceedings of the National Academy of Sciences current issue, 2016

Nuclear receptor SET domain containing protein 2 (NSD2) catalyzes the methylation of histone H3 lysine 36 (H3K36). It is a determinant in Wolf–Hirschhorn syndrome and is overexpressed in human multiple myeloma. Despite the relevance of NSD2 to cancer, there are no potent, selective inhibitors of ...

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Intrinsic regulation of FIC-domain AMP-transferases by oligomerization and automodification [Biochemistry]

02-Feb-2016 | Frédéric V. Stanger; Björn M. Burmann; Alexander Harms; Hugo Aragão; Adam Mazur; Timothy Sharpe; Christoph Dehio; Se ..., Proceedings of the National Academy of Sciences current issue, 2016

Filamentation induced by cyclic AMP (FIC)-domain enzymes catalyze adenylylation or other posttranslational modifications of target proteins to control their function. Recently, we have shown that Fic enzymes are autoinhibited by an α-helix (αinh) that partly obstructs the active site. For the ...

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Programmable polyproteams built using twin peptide superglues [Biochemistry]

02-Feb-2016 | Gianluca Veggiani; Tomohiko Nakamura; Michael D. Brenner; Raphaël V. Gayet; Jun Yan; Carol V. Robinson; Mark Howarth, Proceedings of the National Academy of Sciences current issue, 2016

Programmed connection of amino acids or nucleotides into chains introduced a revolution in control of biological function. Reacting proteins together is more complex because of the number of reactive groups and delicate stability. Here we achieved sequence-programmed irreversible connection of ...

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Constant molecular aging rates vs. the exponential acceleration of mortality [Biochemistry]

02-Feb-2016 | Caleb E. Finch; Eileen M. Crimmins, Proceedings of the National Academy of Sciences current issue, 2016

Laëtitia Gorisse, Philippe Gillery, and their coworkers (1) at the University of Reims elegantly document carbamylation as a biochemical change of aging in long-lived proteins that accumulates progressively across the life span. In human skin samples, the main carbamylation product, homocitruline ...

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Correction for Sohl et al., Probing the structural and molecular basis of nucleotide selectivity by human mitochondrial DNA polymerase {gamma} [Correction]

02-Feb-2016 | Proceedings of the National Academy of Sciences current issue, 2016

BIOCHEMISTRY Correction for “Probing the structural and molecular basis of nucleotide selectivity by human mitochondrial DNA polymerase γ,” by Christal D. Sohl, Michal R. Szymanski, Andrea C. Mislak, Christie K. Shumate, Sheida Amiralaei, Raymond F. Schinazi, Karen S. Anderson, and Y. Whitney ...

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Nicastrin guards Alzheimer’s gate [Biochemistry]

02-Feb-2016 | Siniša Urban, Proceedings of the National Academy of Sciences current issue, 2016

Alzheimer’s disease is characterized by protein deposits of amyloid-β as plaques in the brain (1). The suite of enzymes that produce amyloid-β by cutting it out of the amyloid-β precursor protein (APP) have long been considered to be prime targets for therapeutic intervention. Converting this ...

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Nicastrin functions to sterically hinder {gamma}-secretase-substrate interactions driven by substrate transmembrane domain [Biochemistry]

02-Feb-2016 | David M. Bolduc; Daniel R. Montagna; Yongli Gu; Dennis J. Selkoe; Michael S. Wolfe, Proceedings of the National Academy of Sciences current issue, 2016

γ-Secretase is an intramembrane-cleaving protease that processes many type-I integral membrane proteins within the lipid bilayer, an event preceded by shedding of most of the substrate’s ectodomain by α- or β-secretases. The mechanism by which γ-secretase selectively recognizes and recruits ...

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Structure of NDP-forming Acetyl-CoA synthetase ACD1 reveals a large rearrangement for phosphoryl transfer [Biochemistry]

02-Feb-2016 | Renato H.-J. Weiße; Annette Faust; Marcel Schmidt; Peter Schönheit; Axel J. Scheidig, Proceedings of the National Academy of Sciences current issue, 2016

The NDP-forming acyl-CoA synthetases (ACDs) catalyze the conversion of various CoA thioesters to the corresponding acids, conserving their chemical energy in form of ATP. The ACDs are the major energy-conserving enzymes in sugar and peptide fermentation of hyperthermophilic archaea. They are ...

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N‐Acetyl Cysteine does not prevent liver toxicity from chronic low dose plus sub‐acute high dose paracetamol exposure in young or old mice

28-Jan-2016 | Alice‐Elizabeth Kane, Aniko Huizer‐Pajkos, John Mach, Catriona McKenzie, Sarah‐Jayne Mitchell, Rafael de Cabo, Brett ..., Fundamental & Clinical Pharmacology, 2016

Abstract Paracetamol is an analgesic commonly used by people of all ages, which is well documented to cause severe hepatotoxicity with acute over‐exposures. The risk of hepatotoxicity from non‐acute paracetamol exposures is less extensively studied, and this is the exposure most common in ...

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