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2,271 Newest Publications about the topic biochemistry

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Marine Drugs, Vol. 14, Pages 171: Marine Microbiological Enzymes: Studies with Multiple Strategies and Prospects

22-Sep-2016 | Wang, Yan ; Song, Qinghao ; Zhang, Xiao-Hua, Marine Drugs, 2016

Marine microorganisms produce a series of promising enzymes that have been widely used or are potentially valuable for our daily life. Both classic and newly developed biochemistry technologies have been broadly used to study marine and terrestrial microbiological enzymes. In this brief review, ...

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Anabolic Effect of Insulin Therapy on the Bone: Osteoprotegerin and Osteocalcin Up‐Regulation in Streptozotocin‐Induced Diabetic Rats

21-Sep-2016 | Raul Hernandes Bortolin, Francisco Paulo Freire Neto, Carlos Alberto Arcaro Filho, João Felipe Bezerra, Flávio Santo ..., Basic & Clinical Pharmacology & Toxicology, 2016

Abstract Type 1 diabetes mellitus (T1DM) is associated with several skeletal alterations, particularly in conditions of poor glycaemic control. Insulin therapy is the major conservative treatment for T1DM; however, the effects of this hormone on bone markers of T1DM rats are limited, and the ...

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WD40 domain of Apc1 is critical for the coactivator-induced allosteric transition that stimulates APC/C catalytic activity [Biochemistry]

20-Sep-2016 | Qiuhong Li; Leifu Chang; Shintaro Aibara; Jing Yang; Ziguo Zhang; David Barford, Proceedings of the National Academy of Sciences current issue, 2016

The anaphase-promoting complex/cyclosome (APC/C) is a large multimeric cullin–RING E3 ubiquitin ligase that orchestrates cell-cycle progression by targeting cell-cycle regulatory proteins for destruction via the ubiquitin proteasome system. The APC/C assembly comprises two scaffolding ...

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Structure of Bor1 supports an elevator transport mechanism for SLC4 anion exchangers [Biochemistry]

20-Sep-2016 | Bryan H. Thurtle-Schmidt; Robert M. Stroud, Proceedings of the National Academy of Sciences current issue, 2016

Boron is essential for plant growth because of its incorporation into plant cell walls; however, in excess it is toxic to plants. Boron transport and homeostasis in plants is regulated in part by the borate efflux transporter Bor1, a member of the solute carrier (SLC) 4 transporter family with ...

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DNA and RNA topoisomerase activities of Top3{beta} are promoted by mediator protein Tudor domain-containing protein 3 [Biochemistry]

20-Sep-2016 | Grace Ee-Lu Siaw; I-Fen Liu; Po-Yen Lin; Michael D. Been; Tao-shih Hsieh, Proceedings of the National Academy of Sciences current issue, 2016

Topoisomerase 3β (Top3β) can associate with the mediator protein Tudor domain-containing protein 3 (TDRD3) to participate in two gene expression processes of transcription and translation. Despite the apparent importance of TDRD3 in binding with Top3β and directing it to cellular compartments ...

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Structural mechanism for the recognition and ubiquitination of a single nucleosome residue by Rad6-Bre1 [Biochemistry]

20-Sep-2016 | Laura D. Gallego; Medini Ghodgaonkar Steger; Anton A. Polyansky; Tobias Schubert; Bojan Zagrovic; Ning Zheng; Tim Cl ..., Proceedings of the National Academy of Sciences current issue, 2016

Cotranscriptional ubiquitination of histone H2B is key to gene regulation. The yeast E3 ubiquitin ligase Bre1 (human RNF20/40) pairs with the E2 ubiquitin conjugating enzyme Rad6 to monoubiquitinate H2B at Lys123. How this single lysine residue on the nucleosome core particle (NCP) is targeted by ...

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Feasibility of the functional expression of the human organic anion transporting polypeptide 1B1 (OATP1B1) and its genetic variant 521T/C in the mouse liver

18-Sep-2016 | Author(s): Yoon-Jee Chae, Kyeong-Ryoon Lee, Jong-Hwa Lee, Wooin Lee, Dae-Duk Kim, Suk-Jae Chung, Han-Joo ..., European Journal of Pharmaceutical Science, 2016

Publication date: 1 January 2017 Source:European Journal of Pharmaceutical Sciences, Volume 96 Author(s): Yoon-Jee Chae, Kyeong-Ryoon Lee, Jong-Hwa Lee, Wooin Lee, Dae-Duk Kim, Suk-Jae Chung, Han-Joo Maeng The objective of this study was to examine the feasibility of ...

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Anatomy of the {beta}-branching enzyme of polyketide biosynthesis and its interaction with an acyl-ACP substrate [Biochemistry]

13-Sep-2016 | Finn P. Maloney; Lena Gerwick; William H. Gerwick; David H. Sherman; Janet L. Smith, Proceedings of the National Academy of Sciences current issue, 2016

Alkyl branching at the β position of a polyketide intermediate is an important variation on canonical polyketide natural product biosynthesis. The branching enzyme, 3-hydroxy-3-methylglutaryl synthase (HMGS), catalyzes the aldol addition of an acyl donor to a β-keto-polyketide intermediate ...

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Cutting back on the carbs [Biochemistry]

13-Sep-2016 | Vivian H. Trang; Peter D. Senter, Proceedings of the National Academy of Sciences current issue, 2016

Glycans are essential components in maintaining many important biological processes within the body, and can be found in forms ranging from simple monomers to complex polymeric assemblies. On the cell surface, oligosaccharides are presented and recognized by an array of carbohydrate-binding ...

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Conserved methionine dictates substrate preference in Nramp-family divalent metal transporters [Biochemistry]

13-Sep-2016 | Aaron T. Bozzi; Lukas B. Bane; Wilhelm A. Weihofen; Anne L. McCabe; Abhishek Singharoy; Christophe J. Chipot; Klaus ..., Proceedings of the National Academy of Sciences current issue, 2016

Natural resistance-associated macrophage protein (Nramp) family transporters catalyze uptake of essential divalent transition metals like iron and manganese. To discriminate against abundant competitors, the Nramp metal-binding site should favor softer transition metals, which interact either ...

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