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749 Newest Publications about the topic anxiety

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Early Parkinson's disease symptoms in {alpha}-synuclein transgenic monkeys

15-Apr-2015 | Yuyu Niu; Xiangyu Guo; Yongchang Chen; Chuan-En Wang; Jinquan Gao; Weili Yang; Yu Kang; Wei Si; Hong Wang; Shang-Hsu ..., Human Molecular Genetics, 2015

Parkinson's disease (PD) is an age-dependent neurodegenerative disease that can be caused by genetic mutations in α-synuclein (α-syn) or duplication of wild-type α-syn; PD is characterized by the deposition of α-syn aggregates, indicating a gain of toxicity from accumulation of α-syn. Although ...

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MicroRNA hsa‐miR‐4717‐5p regulates RGS2 and may be a risk factor for anxiety‐related traits

02-Apr-2015 | Leif Hommers, Annette Raab, Alexandra Bohl, Heike Weber, Claus‐Jürgen Scholz, Angelika Erhardt, Elisabeth Binder, Vo ..., American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, 2015

Regulator of G‐protein Signaling 2 (RGS2) is a key regulator of G‐protein‐coupled signaling pathways involved in fear and anxiety. Data from rodent models and genetic analysis of anxiety‐related traits and disorders in humans suggest down‐regulation of RGS2 expression to be a risk factor for ...

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Genetic Analyses Benefit From Using Less Heterogeneous Phenotypes: An Illustration With the Hospital Anxiety and Depression Scale (HADS)

01-Apr-2015 | Charles A. Laurin, Jouke‐Jan Hottenga, Gonneke Willemsen, Dorret I. Boomsma, Gitta H. Lubke, Genetic Epidemiology, 2015

ABSTRACT Phenotypic heterogeneity of depression has been cited as one of the causes of the limited success to detect genetic variants in genome‐wide studies. The 7‐item Hospital Anxiety and Depression Scale (HADS‐D) was developed to detect depression in individuals with physical health ...

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Is it true that essential tremor affects sleep? A comparison between young essential tremor patients and normal controls

01-Apr-2015 | Yildizhan Sengul, Hakan Sengul, Sleep and Biological Rhythms, 2015

Abstract Essential tremor (ET) is the most common movement disorder and cause of functional disability. ET is known as a monosymptomatic, pure motor system disease. This interpretation of ET has been questioned in the last decade. Non‐motor symptoms have added to the definition of the disease. ...

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Regional inactivations of primate ventral prefrontal cortex reveal two distinct mechanisms underlying negative bias in decision making [Psychological and Cognitive Sciences]

31-Mar-2015 | Hannah F. Clarke; Nicole K. Horst; Angela C. Roberts, Proceedings of the National Academy of Sciences current issue, 2015

Dysregulation of the orbitofrontal and ventrolateral prefrontal cortices is implicated in anxiety and mood disorders, but the specific contributions of each region are unknown, including how they gate the impact of threat on decision making. To address this, the effects of GABAergic inactivation ...

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Blood transcriptomic markers for major depression: from animal models to clinical settings

30-Mar-2015 | Eva E. Redei, Neha S. Mehta, Annals of the New York Academy of Sciences, 2015

Depression is a heterogeneous disorder and, similar to other spectrum disorders, its manifestation varies by age of onset, severity, comorbidity, treatment responsiveness, and other factors. A laboratory blood test based on specific biomarkers for major depressive disorder (MDD) and its ...

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Positive effects of the traditional Chinese medicine MLC901 in cognitive tasks

30-Mar-2015 | T. Lorivel, C. Gandin, J. Veyssière, M. Lazdunski, C. Heurteaux, Journal of Neuroscience Research, 2015

MLC901 (NurAiDII) is used as a treatment for stroke patients. It has been shown that MLC901 improves motor and cognitive recovery in ischemic and traumatic brain‐injured rodents. The present study seeks to delineate cognitive effects induced by MLC901 in normal, noninjured mice. To this end, the ...

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d‐amino acid oxidase knockout (Dao−/−) mice show enhanced short‐term memory performance and heightened anxiety, but no sleep or circadian rhythm disruption

27-Mar-2015 | David Pritchett, Sibah Hasan, Shu K. E. Tam, Sandra J. Engle, Nicholas J. Brandon, Trevor Sharp, Russell G. Foster, ..., European Journal of Neuroscience, 2015

Abstract d‐amino acid oxidase (DAO, DAAO) is an enzyme that degrades d‐serine, the primary endogenous co‐agonist of the synaptic N‐methyl‐d‐aspartate receptor. Convergent evidence implicates DAO in the pathophysiology and potential treatment of schizophrenia. To better understand the ...

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Psychopathological manifestations of joint hypermobility and joint hypermobility syndrome/ Ehlers–Danlos syndrome, hypermobility type: The link between connective tissue and psychological distress revised

26-Mar-2015 | Lorenzo Sinibaldi, Gianluca Ursini, Marco Castori, American Journal of Medical Genetics Part C: Seminars in Medical Genetics, 2015

Psychological distress is a known feature of generalized joint hypermobility (gJHM), as well as of its most common syndromic presentation, namely Ehlers–Danlos syndrome, hypermobility type (a.k.a. joint hypermobility syndrome — JHS/EDS‐HT), and significantly contributes to the quality of life ...

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Caregivers of patients with disorder of consciousness: burden, quality of life and social support

24-Mar-2015 | A. M. Giovannetti, V. Covelli, D. Sattin, M. Leonardi, Acta Neurologica Scandinavica, 2015

Objective To evaluate quality of life (QoL) and its predictors, psychological burden and level of perceived social support in caregivers of patients with disorder of consciousness. Materials & Methods World Health Organization Quality of Life‐Bref (WHOQOL‐BREF), State Trait Anxiety ...

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