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689 Newest Publications about the topic anxiety

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Genetics of sudden cardiac death in the young

13-10-2014 | J.B. Saenen, E.M. Van Craenenbroeck, D. Proost, F. Marchau, L. Van Laer, C.J. Vrints, B.L. Loeys, Clinical Genetics, 2014

Abstract Sudden cardiac death (SCD) has an enormous impact on those who are left behind, evoking strong feelings of anxiety and incomprehension because such a dramatic event was not anticipated. Moreover, over the last decade a prominent genetic contribution to the pathogenesis of SCD has been ...

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Benefits and burdens of newborn screening: public understanding and decision-making

13-10-2014 | Stuart G Nicholls; Brenda J Wilson; Holly Etchegary; Jamie C Brehaut; Beth K Potter; Robin Hayeems; Pranesh Chakrabo ..., Personalized Medicine, 2014

In this article we review the literature regarding the public understanding of the potential benefits and burdens of expanded newborn bloodspot screening. We draw attention to broadened notions of benefit that go beyond early identification of asymptomatic individuals and interventions to reduce ...

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Long‐term Psychosocial and Behavioral Adjustment in Individuals Receiving Genetic Test Results in Lynch Syndrome

09-10-2014 | MJ Esplen, J Wong, M Aronson, Kate Butler, H Rothenmund, K Semotiuk, L Madlensky, C Way, E Dicks, J Green, S Gallinger, Clinical Genetics, 2014

Abstract A cross‐sectional study of 155 participants who underwent genetic testing for Lynch Syndrome (LS) examined long‐term psychosocial and behavioral outcomes. Participants completed standardized measures of perceived risk, psychosocial functioning, knowledge, and a questionnaire of ...

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Questioning the association between bisphosphonates and atypical femoral fractures

07-10-2014 | Michael Pazianas, Se‐min Kim, Tony Yuen, Li Sun, Sol Epstein, Mone Zaidi, Annals of the New York Academy of Sciences, 2014

Bisphosphonates are the first‐line treatment for osteoporosis. Structurally, they are stable analogues of pyrophosphate and therefore exhibit a high affinity for bone mineral. They reduce bone loss by attenuating the ability of the osteoclast to resorb bone, decreasing activation frequency, and ...

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A case‐control study of brain structure and behavioral characteristics in 47,XXX Syndrome

07-10-2014 | Rhoshel K. Lenroot, Jonathan D. Blumenthal, Gregory L. Wallace, Liv S. Clasen, Nancy Raitano Lee, Jay N. Giedd, Genes, Brain and Behavior, 2014

Abstract Trisomy X, the presence of an extra X chromosome in females (47,XXX), is a relatively common but under‐recognized chromosomal disorder associated with characteristic cognitive and behavioral features of varying severity. The objective of this study was to determine whether there were ...

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Central V1b receptor antagonism in lactating rats: Impairment of maternal care but not of maternal aggression

06-10-2014 | Doris S Bayerl, Stefanie M Klampfl, Oliver J Bosch, Journal of Neuroendocrinology, 2014

Abstract Maternal behaviour in rodents is mediated by the central oxytocin and vasopressin systems, among others. The role of vasopressin, acting via the V1a receptor (V1aR), on maternal care and maternal aggression has recently been described. However, a potential involvement of the V1b ...

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Reduced sensitivity to both positive and negative reinforcement in mice over‐expressing the 5‐hydroxytryptamine transporter

04-10-2014 | Samantha J. Line, Chris Barkus, Nancy Rawlings, Katie Jennings, Stephen McHugh, Trevor Sharp, David M. Bannerman, European Journal of Neuroscience, 2014

Abstract The 5‐hydroxytryptamine (5‐HT) transporter (5‐HTT) is believed to play a key role in both normal and pathological psychological states. Much previous data suggest that the s allele of the polymorphic regulatory region of the 5‐HTT gene promoter is associated with reduced 5‐HTT ...

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Use of antidepressant medication and suicidal ideation—the Northern Finland Birth Cohort 1966

03-10-2014 | Ina Rissanen, Erika Jääskeläinen, Matti Isohanni, Hannu Koponen, Matti Joukamaa, Antti Alaräisänen, Jouko Miettunen, Human Psychopharmacology: Clinical and Experimental, 2014

Objective The aim was to study the association between use of antidepressant medication and suicidal ideation in different diagnostic groups in a large population‐based cohort. Methods Information on prescribed drugs within the Northern Finland Birth Cohort 1966 was collected at the age ...

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How well do clinicians and patients agree on depression treatment outcomes? Implications for personalized medicine

02-10-2014 | Boadie W. Dunlop, Bhrett McCabe, James M. Eudicone, John J. Sheehan, Ross A. Baker, Human Psychopharmacology: Clinical and Experimental, 2014

Objective In order to inform outcomes assessments in personalized medicine research, we evaluated the level of agreement between self‐reported (SR) and clinician‐rated (CR) measures of depression severity before and after treatment with an antidepressant medication. Methods We pooled ...

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Learning and behavioral deficits associated with the absence of the fragile X mental retardation protein: what a fly and mouse model can teach us [REVIEWS]

01-10-2014 | Ana Rita Santos; Alexandros K. Kanellopoulos; Claudia Bagni, Learning & Memory, 2014

The Fragile X syndrome (FXS) is the most frequent form of inherited mental disability and is considered a monogenic cause of autism spectrum disorder. FXS is caused by a triplet expansion that inhibits the expression of the FMR1 gene. The gene product, the Fragile X Mental Retardation Protein ...

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