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692 Newest Publications about the topic anxiety

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Addition of an NK1 receptor antagonist to an SSRI did not enhance the antidepressant effects of SSRI monotherapy: results from a randomized clinical trial in patients with major depressive disorder

20-10-2014 | William A. Ball, Duane B. Snavely, Richard J. Hargreaves, Armin Szegedi, Christopher Lines, Scott A. Reines, Human Psychopharmacology: Clinical and Experimental, 2014

Objective Aprepitant is a neurokinin 1 receptor antagonist approved for prevention of chemotherapy‐induced and post‐operative nausea and vomiting. Early studies demonstrated promising antidepressant activity as monotherapy, although this was unsupported by subsequent phase 3 trials. This phase ...

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Sleep disturbances and excessive daytime sleepiness in migraine: A comparison between comorbidities and disability

20-10-2014 | Yıldızhan Sengul, Hakan S Sengul, Bahadir Bakim, Sevda K Yucekaya, Selma Yucel, Mucella Akgun, Sleep and Biological Rhythms, 2014

Abstract Many studies have investigated the association between headache and sleep disorders, but few have focused on migraine. The goal of this study was to evaluate sleep disturbance and excessive daytime sleepiness (EDS) in relation to migraine disability. 120 migraine patients who were ...

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Genetics of sudden cardiac death in the young

13-10-2014 | J.B. Saenen, E.M. Van Craenenbroeck, D. Proost, F. Marchau, L. Van Laer, C.J. Vrints, B.L. Loeys, Clinical Genetics, 2014

Abstract Sudden cardiac death (SCD) has an enormous impact on those who are left behind, evoking strong feelings of anxiety and incomprehension because such a dramatic event was not anticipated. Moreover, over the last decade a prominent genetic contribution to the pathogenesis of SCD has been ...

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Benefits and burdens of newborn screening: public understanding and decision-making

13-10-2014 | Stuart G Nicholls; Brenda J Wilson; Holly Etchegary; Jamie C Brehaut; Beth K Potter; Robin Hayeems; Pranesh Chakrabo ..., Personalized Medicine, 2014

In this article we review the literature regarding the public understanding of the potential benefits and burdens of expanded newborn bloodspot screening. We draw attention to broadened notions of benefit that go beyond early identification of asymptomatic individuals and interventions to reduce ...

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Long‐term Psychosocial and Behavioral Adjustment in Individuals Receiving Genetic Test Results in Lynch Syndrome

09-10-2014 | MJ Esplen, J Wong, M Aronson, Kate Butler, H Rothenmund, K Semotiuk, L Madlensky, C Way, E Dicks, J Green, S Gallinger, Clinical Genetics, 2014

Abstract A cross‐sectional study of 155 participants who underwent genetic testing for Lynch Syndrome (LS) examined long‐term psychosocial and behavioral outcomes. Participants completed standardized measures of perceived risk, psychosocial functioning, knowledge, and a questionnaire of ...

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Questioning the association between bisphosphonates and atypical femoral fractures

07-10-2014 | Michael Pazianas, Se‐min Kim, Tony Yuen, Li Sun, Sol Epstein, Mone Zaidi, Annals of the New York Academy of Sciences, 2014

Bisphosphonates are the first‐line treatment for osteoporosis. Structurally, they are stable analogues of pyrophosphate and therefore exhibit a high affinity for bone mineral. They reduce bone loss by attenuating the ability of the osteoclast to resorb bone, decreasing activation frequency, and ...

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A case‐control study of brain structure and behavioral characteristics in 47,XXX Syndrome

07-10-2014 | Rhoshel K. Lenroot, Jonathan D. Blumenthal, Gregory L. Wallace, Liv S. Clasen, Nancy Raitano Lee, Jay N. Giedd, Genes, Brain and Behavior, 2014

Abstract Trisomy X, the presence of an extra X chromosome in females (47,XXX), is a relatively common but under‐recognized chromosomal disorder associated with characteristic cognitive and behavioral features of varying severity. The objective of this study was to determine whether there were ...

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Central V1b receptor antagonism in lactating rats: Impairment of maternal care but not of maternal aggression

06-10-2014 | Doris S Bayerl, Stefanie M Klampfl, Oliver J Bosch, Journal of Neuroendocrinology, 2014

Abstract Maternal behaviour in rodents is mediated by the central oxytocin and vasopressin systems, among others. The role of vasopressin, acting via the V1a receptor (V1aR), on maternal care and maternal aggression has recently been described. However, a potential involvement of the V1b ...

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Reduced sensitivity to both positive and negative reinforcement in mice over‐expressing the 5‐hydroxytryptamine transporter

04-10-2014 | Samantha J. Line, Chris Barkus, Nancy Rawlings, Katie Jennings, Stephen McHugh, Trevor Sharp, David M. Bannerman, European Journal of Neuroscience, 2014

Abstract The 5‐hydroxytryptamine (5‐HT) transporter (5‐HTT) is believed to play a key role in both normal and pathological psychological states. Much previous data suggest that the s allele of the polymorphic regulatory region of the 5‐HTT gene promoter is associated with reduced 5‐HTT ...

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Use of antidepressant medication and suicidal ideation—the Northern Finland Birth Cohort 1966

03-10-2014 | Ina Rissanen, Erika Jääskeläinen, Matti Isohanni, Hannu Koponen, Matti Joukamaa, Antti Alaräisänen, Jouko Miettunen, Human Psychopharmacology: Clinical and Experimental, 2014

Objective The aim was to study the association between use of antidepressant medication and suicidal ideation in different diagnostic groups in a large population‐based cohort. Methods Information on prescribed drugs within the Northern Finland Birth Cohort 1966 was collected at the age ...

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