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726 Newest Publications about the topic anxiety


Mal de debarquement syndrome: new insights

27-Feb-2015 | Yoon‐Hee Cha, Annals of the New York Academy of Sciences, 2015

Mal de Debarquement Syndrome (MdDS) is an enigmatic neurotological disorder with high morbidity, psychosocial burden, and few treatment options. Fortunately, there has been recent growth in scientific interest in understanding the biological basis of and in treating MdDS. Recent studies using ...


Oxytocin involves in the regulation of social behaviors in medial amygdala‐lesioned mice via inhibiting ERK signaling pathway

24-Feb-2015 | Yu Wang, Shanshan Zhao, Zhe Wu, Yu Feng, Chuansheng Zhao, Chaodong Zhang, Clinical and Experimental Pharmacology and Physiology, 2015

Abstract The neuropeptide oxytocin (OXT) has been implicated in the pathophysiology of behavioral deficits among patients with autism spectrum disorder (ASD). However, the molecular mechanisms underlying its role in ASD remain unclear. In the present study, a murine model with ASD‐like ...


Brain 5-HT deficiency increases stress vulnerability and impairs antidepressant responses following psychosocial stress [Neuroscience]

24-Feb-2015 | Benjamin D. Sachs; Jason R. Ni; Marc G. Caron, Proceedings of the National Academy of Sciences current issue, 2015

Brain serotonin (5-HT) deficiency and exposure to psychosocial stress have both been implicated in the etiology of depression and anxiety disorders, but whether 5-HT deficiency influences susceptibility to depression- and anxiety-like phenotypes induced by psychosocial stress has not been ...


The “Good Cop, Bad Cop” Effect in the RT-Based Concealed Information Test: Exploring the Effect of Emotional Expressions Displayed by a Virtual Investigator

20-Feb-2015 | Mihai Varga et al., PLoS ONE, 2015

by Mihai Varga, George Visu-Petra, Mircea Miclea, Laura Visu-Petra Concealing the possession of relevant information represents a complex cognitive process, shaped by contextual demands and individual differences in cognitive and socio-emotional functioning. The Reaction Time-based Concealed ...


Adenosine A2b receptors control A1 receptor‐mediated inhibition of synaptic transmission in the mouse hippocampus

19-Feb-2015 | Francisco Q. Gonçalves, Johny Pires, Anna Pliassova, Rui Beleza, Cristina Lemos, Joana M. Marques, Ricardo J. Rodrig ..., European Journal of Neuroscience, 2015

Abstract Adenosine is a neuromodulator mostly acting through A1 (inhibitory) and A2A (excitatory) receptors in the brain. A2B receptors (A2BR) are Gs/q‐protein‐coupled receptors with low expression in the brain. As A2BR function is largely unknown, we have now explored their role in the mouse ...


Including a subject‐paced trial may make the PASAT more acceptable for MS patients

18-Feb-2015 | O. Bosnes, O.‐P. Dahl, O. Almkvist, Acta Neurologica Scandinavica, 2015

The Paced Auditory Serial Addition Test (PASAT) is regularly used in the evaluation of cognition in multiple sclerosis (MS). However, the test may impose frustration, distress, and anxiety in patients, which may result in refusal to participate by many patients. Objectives In this study, ...


Programming the brain and behaviour by early life stress: A focus on neuroactive steroids

16-Feb-2015 | Paula J Brunton, Journal of Neuroendocrinology, 2015

Abstract Animal studies have amply demonstrated that stress exposure during pregnancy or in early post‐natal life can adversely influence brain development and have long‐term ‘programming’ effects on future brain function and behaviour. Furthermore, a growing body of evidence from human ...


Affective Neural Responses Modulated by Serotonin Transporter Genotype in Clinical Anxiety and Depression

12-Feb-2015 | Desmond J. Oathes et al., PLoS ONE, 2015

by Desmond J. Oathes, Lori M. Hilt, Jack B. Nitschke Serotonin transporter gene variants are known to interact with stressful life experiences to increase chances of developing affective symptoms, and these same variants have been shown to influence amygdala reactivity to affective stimuli in ...


Low-dose exposure to bisphenol A and replacement bisphenol S induces precocious hypothalamic neurogenesis in embryonic zebrafish [Environmental Sciences]

03-Feb-2015 | Cassandra D. Kinch; Kingsley Ibhazehiebo; Joo-Hyun Jeong; Hamid R. Habibi; Deborah M. Kurrasch, Proceedings of the National Academy of Sciences current issue, 2015

Bisphenol A (BPA), a ubiquitous endocrine disruptor that is present in many household products, has been linked to obesity, cancer, and, most relevant here, childhood neurological disorders such as anxiety and hyperactivity. However, how BPA exposure translates into these neurodevelopmental ...


Giant ankyrin-G stabilizes somatodendritic GABAergic synapses through opposing endocytosis of GABAA receptors [Neuroscience]

27-Jan-2015 | Wei Chou Tseng; Paul M. Jenkins; Masashi Tanaka; Richard Mooney; Vann Bennett, Proceedings of the National Academy of Sciences current issue, 2015

GABAA-receptor-based interneuron circuitry is essential for higher order function of the human nervous system and is implicated in schizophrenia, depression, anxiety disorders, and autism. Here we demonstrate that giant ankyrin-G (480-kDa ankyrin-G) promotes stability of somatodendritic GABAergic ...


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