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712 Newest Publications about the topic anxiety

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Functional characterization of FABP3, 5 and 7 gene variants identified in schizophrenia and autism spectrum disorder and mouse behavioral studies

15-Dec-2014 | Chie Shimamoto; Tetsuo Ohnishi; Motoko Maekawa; Akiko Watanabe; Hisako Ohba; Ryoichi Arai; Yoshimi Iwayama; Yasuko H ..., Human Molecular Genetics, 2014

Disturbances of lipid metabolism have been implicated in psychiatric illnesses. We previously reported an association between the gene for fatty acid binding protein 7 (FABP7) and schizophrenia. Furthermore, we identified and reported several rare non-synonymous polymorphisms of the ...

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Psychological characteristics of patients with myotonic dystrophy type 1

11-Dec-2014 | J. A. Bertrand, S. Jean, L. Laberge, C. Gagnon, J. Mathieu, J. F. Gagnon, L. Richer, Acta Neurologica Scandinavica, 2014

Objectives Myotonic dystrophy type 1 (DM1) is the most common adult‐onset muscular dystrophy. It is associated with motor symptoms but patients also display non‐motor symptoms such as particular personality traits. Studies have reported mixed results about personality characteristics which may ...

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The GAD65 knock out mouse – a model for GABAergic processes in fear‐ and stress‐induced psychopathology

02-Dec-2014 | Iris Müller, Gürsel Çalışkan, Oliver Stork, Genes, Brain and Behavior, 2014

Abstract The GABA synthetic enzyme glutamic acid decarboxylase (GAD)65 is critically involved in the activity‐dependent regulation of GABAergic inhibition in the central nervous system. It is also required for the maturation of the GABAergic system during adolescence, a phase that is critical ...

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Pharmacological enhancement of mGluR5 facilitates contextual fear memory extinction [BRIEF COMMUNICATIONS]

01-Dec-2014 | Ferzin Sethna; Hongbing Wang, Learning & Memory, 2014

Behavioral exposure therapy, which involves extinction of the previously acquired fear, has been used to treat anxiety-related symptoms such as post-traumatic stress disorder. It has been hypothesized that proextinction pharmacotherapeutics may enhance the efficacy of exposure therapy. Systemic ...

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Subjective sleep characteristics in primary insomnia versus insomnia with comorbid anxiety or mood disorder

28-Nov-2014 | Merijn Laar, Dirk Pevernagie, Petra Mierlo, Sebastiaan Overeem, Sleep and Biological Rhythms, 2014

Abstract We assessed subjective sleep measures in a cohort of 146 patients with chronic insomnia and hypothesized that these measures may differ depending on the presence as well as the type of comorbid psychiatric disorders. All patients were consecutively referred to a third line sleep ...

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Angelman syndrome in adulthood

26-Nov-2014 | Anna M. Larson, Julianna E. Shinnick, Elias A. Shaaya, Elizabeth A. Thiele, Ronald L. Thibert, American Journal of Medical Genetics Part A, 2014

Angelman syndrome (AS) is a neurogenetic disorder. The goal of this study was to investigate the primary health issues affecting adults with AS and to further characterize the natural history and genotype–phenotype correlations. Standardized phone interviews with caregivers for 110 adolescents ...

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A Network View on Psychiatric Disorders: Network Clusters of Symptoms as Elementary Syndromes of Psychopathology

26-Nov-2014 | Rutger Goekoop et al., PLoS ONE, 2014

by Rutger Goekoop, Jaap G. Goekoop Introduction The vast number of psychopathological syndromes that can be observed in clinical practice can be described in terms of a limited number of elementary syndromes that are differentially expressed. Previous attempts to identify elementary syndromes ...

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Cholesterol levels in Fragile X syndrome

25-Nov-2014 | Elizabeth Berry‐Kravis, Rebecca Levin, Haroon Shah, Shaguna Mathur, Jennifer C. Darnell, Bichun Ouyang, American Journal of Medical Genetics Part A, 2014

Fragile X syndrome (FXS) is associated with intellectual disability and behavioral dysfunction, including anxiety, ADHD symptoms, and autistic features. Although individuals with FXS are largely considered healthy and lifespan is not thought to be reduced, very little is known about the ...

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Immune mediated disorders in women with a fragile X expansion and FXTAS

14-Nov-2014 | Isha Jalnapurkar, Nuva Rafika, Flora Tassone, Randi Hagerman, American Journal of Medical Genetics Part A, 2014

Premutation alleles in fragile X mental retardation 1 (FMR1) can cause the late‐onset neurodegenerative disorder, fragile X‐associated tremor ataxia syndrome (FXTAS) and/or the fragile X‐associated primary ovarian insufficiency in approximately 20% of heterozygotes. Heterozygotes of the FMR1 ...

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Of ‘Disgrace’ and ‘Pain’ – Corticolimbic Interaction Patterns for Disorder-Relevant and Emotional Words in Social Phobia

14-Nov-2014 | Inga Laeger et al., PLoS ONE, 2014

by Inga Laeger, Christian Dobel, Britta Radenz, Harald Kugel, Kati Keuper, Annuschka Eden, Volker Arolt, Pienie Zwitserlood, Udo Dannlowski, Peter Zwanzger Limbic hyperactivation and an impaired functional interplay between the amygdala and the prefrontal cortex are discussed to go along with, ...

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