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941 Newest Publications about the topic anxiety

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Duloxetine in elderly major depression disorder: effectiveness and drug plasma level evaluation

12-Jul-2016 | Chiara Rovera, Massimo Carlo Mauri, Elena Bertin, Chiara Di Pace, Silvia Paletta, Alessandra Reggiori, Ilaria France ..., Human Psychopharmacology: Clinical and Experimental, 2016

Objective The aim of this open‐label naturalistic study was to assess clinical outcomes and the predictive value of duloxetine plasma levels in major depressive disorder in the elderly. Methods This naturalistic, open‐label design involved 35 outpatients aged between 65 and 87 years. ...

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Conditioning- and time-dependent increases in context fear and generalization [RESEARCH]

01-Jul-2016 | Andrew M. Poulos; Nehali Mehta; Bryan Lu; Dorsa Amir; Briana Livingston; Anthony Santarelli; Irina Zhuravka; Michael ..., Learning & Memory, 2016

A prominent feature of fear memories and anxiety disorders is that they endure across extended periods of time. Here, we examine how the severity of the initial fear experience influences incubation, generalization, and sensitization of contextual fear memories across time. Adult rats were ...

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Cannabinoids reverse the effects of early stress on neurocognitive performance in adulthood [RESEARCH]

01-Jul-2016 | Shirley Alteba; Nachshon Korem; Irit Akirav, Learning & Memory, 2016

Early life stress (ES) significantly increases predisposition to psychopathologies. Cannabinoids may cause cognitive deficits and exacerbate the effects of ES. Nevertheless, the endocannabinoid system has been suggested as a therapeutic target for the treatment of stress- and anxiety-related ...

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[In Depth] ‘Brexit’ casts pall on future of U.K. science

01-Jul-2016 | Daniel Clery, Science , 2016

Days after the United Kingdom's momentous vote in favor of leaving the European Union, the U.K. science community is seething with anxiety. No one knows whether U.K. science will struggle or thrive when the divorce goes ahead. Neither the U.K. government nor the European Commission had thought ...

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Recording Hyperpolarization-Activated Cyclic Nucleotide-Gated Channel Currents (Ih) in Neurons

01-Jul-2016 | Shah, M. M., CSH Protocols, 2016

Hyperpolarization-activated cyclic nucleotide–gated (HCN) channels are voltage-gated ion channels that play a crucial role in many physiological processes such as memory formation and spatial navigation. Alterations in expression and function of HCN channels have also been associated with ...

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When Neutral Turns Significant: Brain dynamics of rapidly formed associations between neutral stimuli and emotional contexts

23-Jun-2016 | Carlos Ventura‐Bort, Andreas Löw, Julia Wendt, Florin Dolcos, Alfons O. Hamm, Mathias Weymar, European Journal of Neuroscience, 2016

Abstract The ability to associate neutral stimuli with motivationally relevant outcomes is an important survival strategy. In the present study, we used event‐related potentials (ERPs) to investigate brain dynamics of associative emotional learning when participants were confronted with ...

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Psychophysiological Associations with Gastrointestinal Symptomatology in Autism Spectrum Disorder

20-Jun-2016 | Bradley J. Ferguson, Sarah Marler, Lily L. Altstein, Evon Batey Lee, Jill Akers, Kristin Sohl, Aaron McLaughlin, Kai ..., Autism Research, 2016

Autism spectrum disorder (ASD) is often accompanied by gastrointestinal disturbances, which also may impact behavior. Alterations in autonomic nervous system functioning are also frequently observed in ASD. The relationship between these findings in ASD is not known. We examined the relationship ...

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Neuroendocrine Regulation of Anxiety: Beyond the HPA Axis

18-Jun-2016 | Amanda P. Borrow, Alexis M. Stranahan, Deborah Suchecki, Roberto Yunes, Journal of Neuroendocrinology, 2016

Abstract The central nervous system regulates and responds to endocrine signals, and this reciprocal relationship determines emotional processing and behavioural anxiety. While the hypothalamic‐pituitary‐adrenal axis (HPA) remains the best‐characterised system for this relationship, other ...

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Crystal Genetics, Inc.

14-Jun-2016 | Bahram G Kermani, Personalized Medicine, 2016

Crystal Genetics, Inc. is an early-stage genetic test company, focused on achieving the highest possible clinical-grade accuracy and comprehensiveness for detecting germline (e.g., in hereditary cancer) and somatic (e.g., in early cancer detection) mutations. Crystal's mission is to significantly ...

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A de novo microtriplication at 4q21.21‐q21.22 in a patient with a vascular malignant hemangioma, elongated sigmoid colon, developmental delay, and absence of speech

11-Jun-2016 | Igor N. Lebedev, Lyudmila P. Nazarenko, Nikolay A. Skryabin, Nadezhda P. Babushkina, Anna A. Kashevarova, American Journal of Medical Genetics Part A, 2016

The widespread application of array comparative genomic hybridization (aCGH) has provided new insights into the clinical significance of copy number variations (CNVs) in the human genome. Many microdeletion syndromes have recently been linked to corresponding reciprocal microduplication ...

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