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3,429 Newest Publications about the topic antibodies
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Highly efficient production of anti-HER2 scFv antibody variant for targeting breast cancer cells
03-05-2011 | Silvia Sommaruga, Alessio Lombardi, Agnese Salvadè, Serena Mazzucchelli, Fabio Corsi, Patrizia Galeffi, Paolo Tortor ..., Applied Microbiology and Biotechnology, 2011
The human epidermal growth factor receptor 2 (HER2) is a transmembrane tyrosine kinase receptor overexpressed in 30% of human breast cancers. One of the mechanisms by which tumor cell proliferation can be inhibited consists in hampering HER2 dimerization by targeting its extracellular domain ...
Development of Biotechnology Products in Pre-filled Syringes: Technical Considerations and Approaches
03-05-2011 | Advait Badkar, Amanda Wolf, Leigh Bohack, Parag Kolhe, AAPS PharmSciTech, 2011
A monoclonal antibody (mAb) product development case study is presented to address some of the issues faced during developing a pre-filled syringe (PFS) product for a biotherapeutic. In particular, issues involving incompatibility with silicone oil and a stability-based approach for selection ...
Evidence for erythrocyte-binding antigen 175 as a component of a ligand-blocking blood-stage malaria vaccine [Microbiology]
03-05-2011 | Jiang, Lubin; Gaur, Deepak; Mu, Jianbing; Zhou, Hong; Long, Carole A.; Miller, Louis H., Proceedings of the National Academy of Sciences current issue, 2011
The ligands that pathogens use to invade their target cells have often proven to be good targets for vaccine development. However, Plasmodium falciparum has redundant ligands that mediate invasion of erythrocytes. The first requirement for the development of a successful ligand-blocking ...
Immune escape from HIV-specific antibody-dependent cellular cytotoxicity (ADCC) pressure [Immunology]
03-05-2011 | Chung, Amy W.; Isitman, Gamze; Navis, Marjon; Kramski, Marit; Center, Rob J.; Kent, Stephen J.; Stratov, Ivan, Proceedings of the National Academy of Sciences current issue, 2011
Effective immunity to HIV is poorly understood. In particular, a role for antibody-dependent cellular cytotoxicity (ADCC) in controlling HIV is controversial. We hypothesized that significant pressure from HIV-specific ADCC would result in immune-escape variants. A series of ADCC epitopes in ...
Targeted therapies: Resistance—SRC in the middle
03-05-2011 | M. Teresa Villanueva, Nature Clinical Practice Oncology, 2011
Targeted therapies: Resistance—SRC in the middle Nature Reviews Clinical Oncology 8, 317 (2011). doi:10.1038/nrclinonc.2011.56 Author: M. Teresa Villanueva The monoclonal antibody trastuzumab—which targets the tyrosine kinase receptor (TKR) HER2—is an example of a ...
Process and economic evaluation for monoclonal antibody purification using a membrane‐only process
02-05-2011 | Varadaraju, Hemanthram; Schneiderman, Steven; Zhang, Lifeng; Fong, Hao; Menkhaus, Todd J., Biotechnology Progress, 2011
Abstract In recent years, the market for therapeutic monoclonal antibodies (mAb) has grown exponentially, and with this there has been a desire to reduce the costs associated with production and purification of these high‐value biological products. A typical mAb purification process ...
Development of a mathematical model for evaluating the dynamics of normal and apoptotic Chinese hamster ovary cells
02-05-2011 | Naderi, Saeideh; Meshram, Mukesh; Wei, Catherine; McConkey, Brendan; Ingalls, Brian; Budman, Hector; Scharer, Jeno, Biotechnology Progress, 2011
Abstract A metabolic flux based methodology was developed for modeling the metabolism of a Chinese hamster ovary cell line. The elimination of insignificant fluxes resulted in a simplified metabolic network which was the basis for modeling the significant metabolites. Employing kinetic ...
Rheumatoid arthritis: Rituximab-induced changes in type 1 IFN response correlate with outcome
02-05-2011 | Shreeya Nanda, Nature Clinical Practice Rheumatology, 2011
Rheumatoid arthritis: Rituximab-induced changes in type 1 IFN response correlate with outcome Nature Reviews Rheumatology 7, 253 (2011). doi:10.1038/nrrheum.2011.46 Author: Shreeya Nanda Treatment with rituximab, an anti-CD20 monoclonal antibody, leads to depletion of ...
CCN2 is not required for skin development
01-05-2011 | Shangxi Liu, Andrew Leask, Journal of Cell Communication and Signaling, 2011
Mice lacking the pro-adhesive matricellular protein connective tissue growth factor (CTGF/CCN2) display an embryonic lethal phenotype due to defects in bone and cartilage. However, the specific role of CCN2 in skin development is unknown. Here, we generated mice deleted for CCN2 in the entire ...
Evidence of protection against clinical and chronic hepatitis B infection 20 years after infant vaccination in a high endemicity region
01-05-2011 | Y. Poovorawan, V. Chongsrisawat, A. Theamboonlers, G. Leroux-Roels, S. Kuriyakose, M. Leyssen, J.-M. Jacquet; Y. Poo ..., Journal of Viral Hepatitis, 2011
Summary. Vaccination against hepatitis B virus (HBV) immediately after birth prevents neonatal infection by vertical transmission from HBV carrier mothers. There is an ongoing debate whether infant vaccination is sufficient to protect against infection when exposed to HBV later in life. We ...
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