04-05-2013 | Andreas M. Grabrucker, Developmental Neurobiology, 2013

Abstract The establishment and maintenance of synaptic contacts as well as synaptic plasticity are crucial factors for normal brain function. The functional properties of a synapse are largely dependent on the molecular setup of synaptic proteins. Multidomain proteins of the ProSAP/Shank ...

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03-05-2013 | Yun Song, Xu Chen, Li‐Yan Wang, Wei Gao, Mei‐Jia Zhu, CNS Neuroscience & Therapeutics, 2013

Summary Background and purpose Alzheimer's disease (AD) is a progressive neurodegenerative disorder, and Aβ‐induced neuronal damage is the major pathology of AD. There is increasing evidence that neuroinflammation induced by Aβ is also involved in the pathogenesis of AD. Fasudil is a ...

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02-05-2013 | Yash B. Joshi, Jin Chu, Domenico Praticò, Aging Cell, 2013

Summary Emerging evidence suggests that dysregulation stress hormones, such as glucocorticoids, in aged persons put them at a higher risk to develop Alzheimer's disease (AD). However, the mechanisms underlying such vulnerability remain to be unraveled. Pharmacologic inhibition of ...

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01-05-2013 | Ida Autiero; Michele Saviano; Emma Langella, Molecular BioSystems, 2013

Aggregation of Amyloid β (Aβ) peptide into fibrils has been implicated in the pathogenesis of Alzheimer's disease (AD). As a result, in recent years, substantial efforts have been expended in the study of the mechanism of aggregation of the Aβ peptide as well as of its inhibition by potential ...

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01-05-2013 | Md. Mahiuddin Ahmed; A. Ranjitha Dhanasekaran; Suhong Tong; Frances K. Wiseman; Elizabeth M.C. Fisher; Victor L.J. T ..., Human Molecular Genetics, 2013

Tc1 mouse model of Down syndrome (DS) is functionally trisomic for ~120 human chromosome 21 (HSA21) classical protein-coding genes. Tc1 mice display features relevant to the DS phenotype, including abnormalities in learning and memory and synaptic plasticity. To determine the molecular basis ...

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27-04-2013 | Anja Hafner, Gordana Glavan, Nataša Obermajer, Marko Živin, Reinhard Schliebs, Janko Kos, Aging Cell, 2013

Summary γ‐Enolase is a neurotrophic‐like factor promoting growth, differentiation, survival and regeneration of neurons. Its neurotrophic activity is regulated by cysteine protease cathepsin X which cleaves the C‐terminal end of the molecule. We have investigated the expression and ...

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26-04-2013 | Xiao‐Jie Liu, Li Yuan, Dong Yang, Wei‐Na Han, Qing‐Shan Li, Wei Yang, Qing‐song Liu, Jin‐Shun Qi, Synapse, 2013

ABSTRACT Alzheimer's disease (AD), the most prevalent neurodegenerative disease in the elderly, leads to progressive loss of memory and cognitive deficits. Amyloid‐β protein (Aβ) in the brain is thought to be the main cause of memory loss in AD. Melatonin, an indole hormone secreted by ...

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25-04-2013 | Dmitry Lim, Anand Iyer, Virginia Ronco, Ambra A. Grolla, Pier Luigi Canonico, Eleonora Aronica, Armando A. Genazzani, Glia, 2013

The amyloid hypothesis of Alzheimer's disease (AD) suggests that soluble amyloid β (Aβ) is an initiator of a cascade of events eventually leading to neurodegeneration. Recently, we reported that Aβ deranged Ca2+ homeostasis specifically in hippocampal astrocytes by targeting key elements of ...

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24-04-2013 | Tatsuya Kikuchi, Toshimitsu Okamura, Ming‐Rong Zhang, Toshiaki Irie, Journal of Labelled Compounds and Radiopharmaceuticals, 2013

Imaging acetylcholinesterase (AChE) is valuable not only for diagnosing and understanding dementia but also for monitoring the effects of cholinesterase inhibitors used as antidementia drugs and for determining the appropriate clinical dosage of newly developed cholinesterase inhibitors. ...

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24-04-2013 | N. Scott Mason, Chester A. Mathis, William E. Klunk, Journal of Labelled Compounds and Radiopharmaceuticals, 2013

The development of positron emission tomography (PET) radioligands for the non‐invasive imaging of amyloid‐β plaque burden has been the focus of intense research efforts over the last decade. A variety of structural backbones have been investigated and several radiolabeled molecules have ...

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