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1,473 Newest Publications about the topic alzheimer's disease


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Nuclear and membrane estrogen receptor antagonists induce similar mTORC2 activation‐reversible changes in synaptic protein expression and actin polymerization in the mouse hippocampus

20-Jan-2018 | Fang‐Zhou Xing, Yan‐Gang Zhao, Yuan‐Yuan Zhang, Li He, Ji‐Kai Zhao, Meng‐Ying Liu, Yan Liu, Ji‐Qiang Zhang, CNS Neuroscience & Therapeutics, 2018

Summary Aims Estrogens play pivotal roles in hippocampal synaptic plasticity through nuclear receptors (nERs; including ERα and ERβ) and the membrane receptor (mER; also called GPR30), but the underlying mechanism and the contributions of nERs and mER remain unclear. Mammalian target of ...


The Protective Effect of Antarctic Krill Oil on Cognitive Function by Inhibiting Oxidative Stress in the Brain of Senescence‐Accelerated Prone Mouse Strain 8 (SAMP8) Mice

19-Jan-2018 | Qian Li, Fengjuan Wu, Min Wen, Teruyoshi Yanagita, Changhu Xue, Tiantian Zhang, Yuming Wang, Journal of Food Science, 2018

Abstract Alzheimer's disease (AD) is a common neurodegenerative disorder, and oxidative stress plays a vital role in its progression. Antarctic krill oil (AKO) is rich in polyunsaturated fatty acids, which has various biological activities, such as improving insulin sensitivity, alleviating ...


Isoflurane anesthesia in aged mice and effects of A1 adenosine receptors on cognitive impairment

18-Jan-2018 | Chun‐Long Zuo, Chun‐Man Wang, Jin Liu, Ting Shen, Jiang‐Ping Zhou, Xin‐Rui Hao, Yi‐Zhao Pan, Hua‐Cheng Liu, Qing‐Qua ..., CNS Neuroscience & Therapeutics, 2018

Summary Aims Isoflurane may not only accelerate the process of Alzheimer's disease (AD), but increase the risk of incidence of postoperative cognitive dysfunction (POCD). However, the underlying mechanisms remain unknown. This study was designed to investigate whether isoflurane contributed ...


Characterization of a 3xTg‐AD mouse model of Alzheimer's disease with the senescence accelerated mouse prone 8 (SAMP8) background

17-Jan-2018 | Jessica Virgili, Meryem Lebbadi, Cyntia Tremblay, Isabelle St‐Amour, Caroline Pierrisnard, Audrey Faucher‐Genest, Vi ..., Synapse, 2018

Abstract No model fully recapitulates the neuropathology of Alzheimer's disease (AD). Although the triple‐transgenic mouse model of AD (3xTg‐AD) expresses Aβ plaques and tau‐laden neurofibrillary tangles, as well as synaptic and behavioral deficits, it does not display frank neuronal loss. ...


The prodrug of 7,8-dihydroxyflavone development and therapeutic efficacy for treating Alzheimer’s disease [Chemistry]

16-Jan-2018 | Chun Chen; Zhihao Wang; Zhentao Zhang; Xia Liu; Seong Su Kang; Ying Zhang; Keqiang Ye, Proceedings of the National Academy of Sciences current issue, 2018

The BDNF mimetic compound 7,8-dihydroxyflavone (7,8-DHF), a potent small molecular TrkB agonist, displays prominent therapeutic efficacy against Alzheimer’s disease (AD). However, 7,8-DHF has only modest oral bioavailability and a moderate pharmacokinetic (PK) profile. To alleviate these ...


β-Ecdysterone protects SH-SY5Y cells against β-amyloid-induced apoptosis via c-Jun N-terminal kinase- and Akt-associated complementary pathways

12-Jan-2018 | Tianjiao Xu; Chengu Niu; Xiaojie Zhang; Miaoxian Dong, Laboratory Investigation, 2018

Recently, the significantly higher incidence of Alzheimer’s disease (AD) in women than in men has been attributed to the loss of neuroprotective estrogen after menopause. Does phytoestrogen have the ability to protect against amyloid-β (Aβ) toxicity? The aim of this study was to evaluate ...


A long‐lived aβ oligomer resistant to fibrillization

10-Jan-2018 | Mimi Nick, Yibing Wu, Nathan W. Schmidt, Stanley B. Prusiner, Jan Stöhr, William F. DeGrado, Biopolymers, 2018

Abstract The hydrophobic Aβ peptide is highly aggregation prone; it first forms soluble oligomers, which then convert into the amyloid fibrils found in the cerebral plaques of Alzheimer's disease. It is generally understood that as the peptide concentration of Aβ increases, the fibrillization ...


Loss of kallikrein‐related peptidase 7 exacerbates amyloid pathology in Alzheimer's disease model mice

08-Jan-2018 | Kiwami Kidana, Takuya Tatebe, Kaori Ito, Norikazu Hara, Akiyoshi Kakita, Takashi Saito, Sho Takatori, Yasuyoshi Ouch ..., EMBO Molecular Medicine, 2018

Abstract Deposition of amyloid‐β (Aβ) as senile plaques is one of the pathological hallmarks in the brains of Alzheimer's disease (AD) patients. In addition, glial activation has been found in AD brains, although the precise pathological role of astrocytes remains unclear. Here, we identified ...


TSPO regulation in reactive gliotic diseases

06-Jan-2018 | Adam M. McNeela, Charles Bernick, Rochelle M. Hines, Dustin J. Hines, Journal of Neuroscience Research, 2018

Abstract The brain is the most metabolically active organ in the body. This high metabolic demand is apparent in that 60% of the brain is comprised of mitochondria‐enriched cells. A disruption of the brain's ability to meet this immense metabolic demand is central to the pathogenesis of a ...


Enriched physical environment reverses spatial cognitive impairment of socially isolated APPswe/PS1dE9 transgenic mice before amyloidosis onset

23-Dec-2017 | Min Cao, Pan‐Pan Hu, Yan‐Li Zhang, Yi‐Xin Yan, Christopher B. Shields, Yi‐Ping Zhang, Gang Hu, Ming Xiao, CNS Neuroscience & Therapeutics, 2017

Summary Aims Social isolation increases the onset of Alzheimer's disease (AD). Environmental enrichment, a complicated social and physical construct, plays beneficial effects on brain plasticity and function. This study was designed to determine whether physical enrichment can reduce the ...


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