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1,501 Newest Publications about the topic alzheimer's disease

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Oral administration of Pantoea agglomerans-derived lipopolysaccharide prevents metabolic dysfunction and Alzheimer’s disease-related memory loss in senescence-accelerated prone 8 (SAMP8) mice fed a high-fat diet

01-Jun-2018 | Yutaro Kobayashi; Hiroyuki Inagawa; Chie Kohchi; Kimiko Kazumura; Hiroshi Tsuchiya; Toshiyuki Miwa; Katsuichiro Okaz ..., PLoS ONE, 2018

by Yutaro Kobayashi, Hiroyuki Inagawa, Chie Kohchi, Kimiko Kazumura, Hiroshi Tsuchiya, Toshiyuki Miwa, Katsuichiro Okazaki, Gen-Ichiro Soma The pathogenesis of Alzheimer’s disease (AD) remains unclear, but an imbalance between the production and clearance of amyloid-β (Aβ) peptides is known to ...

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A molecular network of the aging human brain provides insights into the pathology and cognitive decline of Alzheimer’s disease

25-May-2018 | Sara Mostafavi; Chris Gaiteri; Sarah E. Sullivan; Charles C. White; Shinya Tasaki; Jishu Xu; Mariko Taga; Hans-Ulric ..., Nature Neuroscience, 2018

There is a need for new therapeutic targets with which to prevent Alzheimer’s disease (AD), a major contributor to aging-related cognitive decline. Here we report the construction and validation of a molecular network of the aging human frontal cortex. Using RNA sequence data from 478 ...

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Design of optimal nonlinear network controllers for Alzheimer's disease

24-May-2018 | Lazaro M. Sanchez-Rodriguez; Yasser Iturria-Medina; Erica A. Baines; Sabela C. Mallo; Mehdy Dousty; Roberto C. Soter ..., PLoS Computational Biology, 2018

by Lazaro M. Sanchez-Rodriguez, Yasser Iturria-Medina, Erica A. Baines, Sabela C. Mallo, Mehdy Dousty, Roberto C. Sotero, on behalf of The Alzheimer’s Disease Neuroimaging Initiative Brain stimulation can modulate the activity of neural circuits impaired by Alzheimer’s disease (AD), having ...

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Computational insights into β-site amyloid precursor protein enzyme 1 (BACE1) inhibition by tanshinones and salvianolic acids from Salvia miltiorrhiza via molecular docking simulations

20-May-2018 | Author(s): Ting Yu, Pradeep Paudel, Su Hui Seong, Jeong Ah Kim, Hyun Ah Jung, Jae Sue Choi, Computational Biology and Chemistry, 2018

Publication date: Available online 13 April 2018 Source:Computational Biology and Chemistry Author(s): Ting Yu, Pradeep Paudel, Su Hui Seong, Jeong Ah Kim, Hyun Ah Jung, Jae Sue Choi The rhizome of Salvia miltiorrhiza has emerged as a rich source of natural therapeutic agents, ...

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Combined QSAR, molecular docking and molecular dynamics study on new Acetylcholinesterase and Butyrylcholinesterase inhibitors

20-May-2018 | Author(s): Ismail Daoud, Nadjib Melkemi, Toufik Salah, Said Ghalem, Computational Biology and Chemistry, 2018

Publication date: June 2018 Source:Computational Biology and Chemistry, Volume 74 Author(s): Ismail Daoud, Nadjib Melkemi, Toufik Salah, Said Ghalem Background and purpose This work deals with several molecular modeling methods used to discover new therapeutic agents for treating ...

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Changes in functional and structural brain connectome along the Alzheimer’s disease continuum

09-May-2018 | Massimo Filippi; Silvia Basaia; Elisa Canu; Francesca Imperiale; Giuseppe Magnani; Monica Falautano; Giancarlo Comi; ..., Molecular Psychiatry, 2018

The aim of this study was two-fold: (i) to investigate structural and functional brain network architecture in patients with Alzheimer’s disease (AD) and amnestic mild cognitive impairment (aMCI), stratified in converters (c-aMCI) and non-converters (nc-aMCI) to AD; and to assess the relationship ...

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Development of comorbidities in men with prostate cancer treated with androgen deprivation therapy: an Australian population-based cohort study

02-May-2018 | Huah Shin Ng; Bogda Koczwara; David Roder; Agnes Vitry, Prostate Cancer and Prostatic Diseases, 2018

The increasing use of androgen deprivation therapy has prompted further evaluation of its potential adverse effects as the treatment may exacerbate or increase the risk of developing new comorbid diseases. This study aims to assess the patterns of comorbidities among Australian men with prostate ...

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Changes in cerebral metabolic activity in men undergoing androgen deprivation therapy for non-metastatic prostate cancer

27-Apr-2018 | M. M. Cherrier; D. J. Cross; C. S. Higano; S. Minoshima, Prostate Cancer and Prostatic Diseases, 2018

Androgen deprivation therapy (ADT) is a common treatment option for men with biochemical relapse from prostate cancer. ADT is associated with changes in mood, cognition, and quality of life, and most recently with increased risk for Alzheimer’s disease (AD). This study examined changes in brain ...

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Human brain arousal in the resting state: a genome-wide association study

27-Apr-2018 | Philippe Jawinski; Holger Kirsten; Christian Sander; Janek Spada; Christine Ulke; Jue Huang; Ralph Burkhardt; Markus ..., Molecular Psychiatry, 2018

Arousal affects cognition, emotion, and behavior and has been implicated in the etiology of psychiatric disorders. Although environmental conditions substantially contribute to the level of arousal, stable interindividual characteristics are well-established and a genetic basis has been ...

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In vitro and in silico evaluation of Centaurea saligna (K.Koch) Wagenitz—An endemic folk medicinal plant

15-Apr-2018 | Author(s): Gokhan Zengin, Gizem Bulut, Adriano Mollica, Carene Marie Nancy Picot-Allain, Mohamad Fawzi Mah ..., Computational Biology and Chemistry, 2018

Publication date: Available online 13 February 2018 Source:Computational Biology and Chemistry Author(s): Gokhan Zengin, Gizem Bulut, Adriano Mollica, Carene Marie Nancy Picot-Allain, Mohamad Fawzi Mahomoodally Centaurea saligna (K.Koch) Wagenitz is an endemic plant used in ...

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