30-04-2013 | Stefano Pluchino, Chiara Cossetti, Glia, 2013

Advances in stem cell biology have raised great expectations that diseases and injuries of the central nervous system (CNS) may be ameliorated by the development of non‐hematopoietic stem cell medicines. Yet, the application of adult stem cells as CNS therapeutics is challenging and the ...

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08-04-2013 | Kyriaki Chatzivasileiou, Cornelia A. Lux, Gustav Steinhoff, Hermann Lang, Journal of Cellular and Molecular Medicine, 2013

Abstract Periodontitis is a bacterially induced chronic inflammatory disease. Dental follicle progenitor cells (DFPCs) have been proposed as biological graft for periodontal regenerative therapies. The potential impact of bacterial toxins on DFPCs properties is still poorly understood. ...

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07-04-2013 | Acta Biomaterialia, 2013

May 2013 Publication year: 2013Source:Acta Biomaterialia, Volume 9, Issue 5 The fate of adult stem cells can be influenced by physical cues, including nanotopography. However, the response of human embryonic stem cells (hESCs) to dimensionally well-defined nanotopography is ...

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14-03-2013 | Juliana L. Carvalho, Vinicius B. A. Braga, Marcos B. Melo, Ana Carolina D. A. Campos, Maira S. Oliveira, Dawidson A. ..., Journal of Cellular and Molecular Medicine, 2013

Abstract Cardiovascular diseases are the number one cause of death globally and are projected to remain the single leading cause of death. Treatment options abounds, although efficacy is limited. Recent studies attribute discrete and ephemeral benefits to adult stem cell therapies, ...

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05-03-2013 | Alessandra Insinga; Angelo Cicalese; Mario Faretta; Barbara Gallo; Luisa Albano; Simona Ronzoni; Laura Furia; Andrea ..., Proceedings of the National Academy of Sciences current issue, 2013

DNA damage leads to a halt in proliferation owing to apoptosis or senescence, which prevents transmission of DNA alterations. This cellular response depends on the tumor suppressor p53 and functions as a powerful barrier to tumor development. Adult stem cells are resistant to DNA ...

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01-02-2013 | Xinhong Lim; Roel Nusse, CSH Perspectives, 2013

The skin and its appendages constitute the largest organ of the body. Its stratified epithelia offer protection from environmental stresses such as dehydration, irradiation, mechanical trauma, and pathogenic infection, whereas its appendages, like hair and sebaceous glands, help regulate ...

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01-01-2013 | Prue N. Plummer; Ruth Freeman; Ryan J. Taft; Jelena Vider; Michael Sax; Brittany A. Umer; Dingcheng Gao; Christopher ..., Cancer Research, 2013

Bone marrow–derived endothelial progenitor cells (EPC) contribute to the angiogenesis-dependent growth of tumors in mice and humans. EPCs regulate the angiogenic switch via paracrine secretion of proangiogenic growth factors and by direct luminal incorporation into sprouting nascent vessels. ...

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28-12-2012 | Pauline Po Yee Lui, Journal of Cellular and Molecular Medicine, 2012

Abstract Tendon stem cells are multi‐potent adult stem cells with broad differentiation plasticity that render them of great importance in cell‐based therapies for the repair of tendons. We called them tendon‐derived stem cells (TDSCs) to indicate the tissue origin from which the stem ...

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24-12-2012 | Vaibhav Mundra; Ivan C. Gerling; Ram I. Mahato, Molecular Pharmaceutics, 2012

Mesenchymal stem cells (MSCs) are multipotent adult stem cells which have self-renewal capacity and differentiation potential into several mesenchymal lineages including bones, cartilages, adipose tissues and tendons. MSCs may repair tissue injuries and prevent immune cell activation and ...

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22-12-2012 | M. Rezai Rad, G.E. Wise, H. Brooks, M.B. Flanagan, S. Yao, Cell Proliferation, 2012

Abstract Objectives Adult stem cells (ASCs) remain in a slowly cycling/quiescent state under normal physiological conditions, but they can be awakened from this by certain factors, such as injury signals. Previously, our group has shown that dental follicle stem cells (DFSCs) appear to ...

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