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157 Newest Publications about the topic adult stem cells

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The effects of proliferation and DNA damage on hematopoietic stem cell function determine ageing

27-Jan-2016 | Satish Khurana, Developmental Dynamics, 2016

Abstract In most of the mammalian tissues, homeostasis as well as injury repair depends upon a small number of resident adult stem cells. The decline in tissue/organ function in aged organisms has been directly linked with poorly functioning stem cells. Altered function of hematopoietic stem ...

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Targeted Deletion of p53 in Lgr5-Expressing Intestinal Stem Cells Promotes Colon Tumorigenesis in a Preclinical Model of Colitis-Associated Cancer

15-Dec-2015 | Laurie A. Davidson; Evelyn S. Callaway; Eunjoo Kim; Brad R. Weeks; Yang-Yi Fan; Clinton D. Allred; Robert S. Chapkin, Cancer Research, 2015

p53 has been shown to mediate cancer stem–like cell function by suppressing pluripotency and cellular dedifferentiation. However, there have been no studies to date that have addressed the specific effects of p53 loss in colonic adult stem cells. In this study, we investigated the consequences of ...

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Cell surface glycan engineering of neural stem cells augments neurotropism and improves recovery in a murine model of multiple sclerosis

01-Dec-2015 | Jasmeen S Merzaban; Jaime Imitola; Sarah C Starossom; Bing Zhu; Yue Wang; Jack Lee; Amal J Ali; Marta Olah; Ayman F ..., Glycobiology , 2015

Neural stem cell (NSC)-based therapies offer potential for neural repair in central nervous system (CNS) inflammatory and degenerative disorders. Typically, these conditions present with multifocal CNS lesions making it impractical to inject NSCs locally, thus mandating optimization of vascular ...

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LPS-Stimulated Human Skin-Derived Stem Cells Enhance Neo-Vascularization during Dermal Regeneration

13-Nov-2015 | Tobias Kisch et al., PLoS ONE, 2015

by Tobias Kisch, Caroline Weber, Daniel H. Rapoport, Charli Kruse, Sandra Schumann, Felix H. Stang, Frank Siemers, Anna E. Matthießen High numbers of adult stem cells are still required to improve the formation of new vessels in scaffolds to accelerate dermal regeneration. Recent data indicate ...

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Suppression of IGF‐I signals in neural stem cells enhances neurogenesis and olfactory function during aging

29-Jul-2015 | Zayna Chaker, Saba Aïd, Hugues Berry, Martin Holzenberger, Aging Cell, 2015

Summary Downregulation of insulin‐like growth factor (IGF) pathways prolongs lifespan in various species, including mammals. Still, the cellular mechanisms by which IGF signaling controls the aging trajectory of individual organs are largely unknown. Here, we asked whether suppression of IGF‐I ...

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DNA methylation differs between sister chromatids, and this difference correlates with the degree of differentiation potential

26-Jun-2015 | E.L. Patkin, N.A. Grudinina, L.K. Sasina, E.M. Noniashvili, L.I. Pavlinova, I.O. Suchkova, M.E. Kustova, G.A. Sofronov, Molecular Reproduction and Development, 2015

Abstract Sister chromatids may be distinguished and discretely segregated in asymmetrically dividing embryonic and adult stem cells. In preimplantation mouse embryos, for example, sister chromatids differ in chromatin characteristics (Patkin et al., 1994) and in methylation levels of sister ...

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Q&A: Hans Clevers

14-May-2015 | Eric Bender, Nature, 2015

Q&A: Hans Clevers Nature. doi:10.1038/521S15a Author: Eric Bender In 2009, Hans Clevers and Toshiro Sato (then a postdoc in Clevers' lab) demonstrated a powerful new model to study development and disease: a three-dimensional ...

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Induction of insulin‐producing cells from umbilical cord blood‐derived stromal cells by activation of the c‐Met/HGF axis

24-Apr-2015 | Bo Sun, Rui Liu, Zhong‐Dang Xiao, Development, Growth & Differentiation, 2015

Efficient and effective therapies are required for diabetes mellitus. The use of adult stem cells for treating diabetes represents a major focus of current research. We have attempted to differentiate adult stem cells produced from umbilical cord blood‐derived stromal cells into ...

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The extracellular matrix compartment of neural stem and glial progenitor cells

22-Apr-2015 | Andreas Faissner, Jacqueline Reinhard, Glia, 2015

Neuroepithelial and radial GLIA stem cells generate the majority of the cellular constituents of the central nervous system. Following precisely timed phases of neurogenesis and gliogenesis the stem cells recede, with the exception of adult neural stem cells that persist in two generally ...

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Culturing Adult Stem Cells from Mouse Small Intestinal Crypts

01-Apr-2015 | Hamilton, K. E., Crissey, M. A. S., Lynch, J. P., Rustgi, A. K., CSH Protocols, 2015

In recent years, the study of primary cells in culture has evolved from an extraphysiological, two-dimensional platform to novel, three-dimensional platforms in which the addition of matrix components and/or supporting cells provide an ex vivo niche. Such studies have provided the basis on which ...

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