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146 Newest Publications about the topic adult stem cells


[Report] A mitochondrial UPR-mediated metabolic checkpoint regulates hematopoietic stem cell aging

20-Mar-2015 | Mary Mohrin; Jiyung Shin; Yufei Liu; Katharine Brown; Hanzhi Luo; Yannan Xi; Cole M. Haynes; Danica Chen, Science , 2015

Deterioration of adult stem cells accounts for much of aging-associated compromised tissue maintenance. How stem cells maintain metabolic homeostasis remains elusive. Here, we identified a regulatory branch of the mitochondrial unfolded protein response (UPRmt), which is mediated by the interplay ...


H3K4me1 marks DNA regions hypomethylated during aging in human stem and differentiated cells [RESEARCH]

01-Jan-2015 | Fernandez, A. F., Bayon, G. F., Urdinguio, R. G., Torano, E. G., Garcia, M. G., Carella, A., Petrus-Reurer, S., Ferr ..., Genome Research, 2015

In differentiated cells, aging is associated with hypermethylation of DNA regions enriched in repressive histone post-translational modifications. However, the chromatin marks associated with changes in DNA methylation in adult stem cells during lifetime are still largely unknown. Here, DNA ...


Comparison of osteogenic differentiation potential of human adult stem cells loaded on bioceramic‐coated electrospun poly (L‐lactide) nanofibres

11-Dec-2014 | A. Ardeshirylajimi, M. Mossahebi‐Mohammadi, S. Vakilian, L. Langroudi, E. Seyedjafari, A. Atashi, M. Soleimani, Cell Proliferation, 2014

Abstract Objectives To compare potential of four types of stem cell in tissue engineering and regenerative medicine applications, osteogenic capacity of newly introduced mesenchymal stem cells (MSCs) derived from buccal fat pads (BFP) (an adipose‐encapsulated mass of the oral cavity), was ...


Identification of nucleoside analogues as inducers of neuronal differentiation in a human reporter cell line and adult stem cells

02-Dec-2014 | Katharina Raasch, Edith Malecki, Maria Siemann, Malayko Montilla Martinez, Jürgen J. Heinisch, Janine Müller, Lidia ..., Chemical Biology & Drug Design, 2014

Abstract Nucleoside analogues (NSAs) were among the first chemotherapeutic agents and could also be useful for manipulation of cell fate. To investigate the potential of NSAs for induction of neuronal differentiation, we developed a novel phenotypic assay based on a human neuron‐committed ...


Single Lgr5- or Lgr6-expressing taste stem/progenitor cells generate taste bud cells ex vivo [Developmental Biology]

18-Nov-2014 | Wenwen Ren; Brian C. Lewandowski; Jaime Watson; Eitaro Aihara; Ken Iwatsuki; Alexander A. Bachmanov; Robert F. Margo ..., Proceedings of the National Academy of Sciences current issue, 2014

Leucine-rich repeat-containing G protein-coupled receptor 5 (Lgr5) and its homologs (e.g., Lgr6) mark adult stem cells in multiple tissues. Recently, we and others have shown that Lgr5 marks adult taste stem/progenitor cells in posterior tongue. However, the regenerative potential of ...


Gender‐Linked Stem Cell Alterations in Stroke and Postpartum Depression

15-Nov-2014 | Mibel M. Pabón, Xun‐Ming Ji, Jamie Winderbaum Fernandez, Cesar V. Borlongan, CNS Neuroscience & Therapeutics, 2014

Summary Stroke is a significant unmet clinical need. The current stroke treatment of tissue plasminogen activator is limited to the very acute 4.5h after disease onset which benefits only less than 3% of ischemic stroke patients. Our overarching hypothesis advances the notion that gender, ...


PGC-1{beta} promotes enterocyte lifespan and tumorigenesis in the intestine [Medical Sciences]

21-Oct-2014 | Elena Bellafante; Annalisa Morgano; Lorena Salvatore; Stefania Murzilli; Giuseppe Di Tullio; Andria D’Orazio; Doming ..., Proceedings of the National Academy of Sciences current issue, 2014

The mucosa of the small intestine is renewed completely every 3–5 d throughout the entire lifetime by small populations of adult stem cells that are believed to reside in the bottom of the crypts and to migrate and differentiate into all the different populations of intestinal cells. When the ...


Bifunctional ectodermal stem cells around the nail display dual fate homeostasis and adaptive wounding response toward nail regeneration [Cell Biology]

21-Oct-2014 | Yvonne Leung; Eve Kandyba; Yi-Bu Chen; Seth Ruffins; Cheng-Ming Chuong; Krzysztof Kobielak, Proceedings of the National Academy of Sciences current issue, 2014

Regulation of adult stem cells (SCs) is fundamental for organ maintenance and tissue regeneration. On the body surface, different ectodermal organs exhibit distinctive modes of regeneration and the dynamics of their SC homeostasis remain to be unraveled. A slow cycling characteristic has been ...


Wnts Enhance Neurotrophin-Induced Neuronal Differentiation in Adult Bone-Marrow-Derived Mesenchymal Stem Cells via Canonical and Noncanonical Signaling Pathways

29-Aug-2014 | Hung-Li Tsai et al., PLoS ONE, 2014

by Hung-Li Tsai, Wing-Ping Deng, Wen-Fu Thomas Lai, Wen-Ta Chiu, Charn-Bing Yang, Yu-Hui Tsai, Shiaw-Min Hwang, Perry F. Renshaw Wnts were previously shown to regulate the neurogenesis of neural stem or progenitor cells. Here, we explored the underlying molecular mechanisms through which Wnt ...


Bone morphogenetic protein‐2, ‐6, and ‐7 differently regulate osteogenic differentiation of human periodontal ligament stem cells

13-Jul-2013 | Sema S. Hakki, Buket Bozkurt, Erdogan E. Hakki, Seyit Ali Kayis, Gizem Turac, Irem Yilmaz, Erdal Karaoz, Journal of Biomedical Materials Research Part B: Applied Biomaterials, 2013

Abstract The utility of adult stem cells for bone regeneration may be an attractive alternative in the treatment of extensive injury, congenital malformations, or diseases causing large bone defects. To create an environment that is supportive of bone formation, signals from molecules such as ...


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