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176 Newest Publications about the topic adult stem cells


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EMT programs promote basal mammary stem cell and tumor-initiating cell stemness by inducing primary ciliogenesis and Hedgehog signaling [Cell Biology]

05-Dec-2017 | Vincent J. Guen; Tony E. Chavarria; Cornelia Kröger; Xin Ye; Robert A. Weinberg; Jacqueline A. Lees, Proceedings of the National Academy of Sciences current issue, 2017

Tissue regeneration relies on adult stem cells (SCs) that possess the ability to self-renew and produce differentiating progeny. In an analogous manner, the development of certain carcinomas depends on a small subset of tumor cells, called “tumor-initiating cells” (TICs), with SC-like properties. ...


Staufen1 inhibits MyoD translation to actively maintain muscle stem cell quiescence [Cell Biology]

24-Oct-2017 | Antoine de Morrée; Cindy T. J. van Velthoven; Qiang Gan; Jayesh S. Salvi; Julian D. D. Klein; Igor Akimenko; Marco Q ..., Proceedings of the National Academy of Sciences current issue, 2017

Tissue regeneration depends on the timely activation of adult stem cells. In skeletal muscle, the adult stem cells maintain a quiescent state and proliferate upon injury. We show that muscle stem cells (MuSCs) use direct translational repression to maintain the quiescent state. High-resolution ...


Organ Culture of the Xenopus Tadpole Intestine

01-Oct-2017 | Ishizuya-Oka, A., CSH Protocols, 2017

During Xenopus metamorphosis, most tadpole organs remodel from the larval to adult form to prepare for adaptation to terrestrial life. Organ culture serves as an important tool for studying larval-to-adult organ remodeling independent of the effects of other parts of the body. Here, I introduce a ...


The bio in the ink: cartilage regeneration with bioprintable hydrogels and articular cartilage-derived progenitor cells

06-Aug-2017 | Author(s): Riccardo Levato, William R. Webb, Iris A. Otto, Anneloes Mensinga, Yadan Zhang, Mattie van Ri ..., Acta Biomaterialia, 2017

Publication date: Available online 4 August 2017 Source:Acta Biomaterialia Author(s): Riccardo Levato, William R. Webb, Iris A. Otto, Anneloes Mensinga, Yadan Zhang, Mattie van Rijen, René van Weeren, Ilyas M. Khan, Jos Malda Cell-laden hydrogels are the primary building ...


Thermally Triggered Hydrogel Injection Into Bovine Intervertebral Disc Tissue Explants Induces Differentiation Of Mesenchymal Stem Cells And Restores Mechanical Function.

12-Mar-2017 | Author(s): A.A. Thorpe, G Dougill, L. Vickers, ND. Reeves, C. Sammon, G. Cooper, C.L. Le Maitre, Acta Biomaterialia, 2017

Publication date: Available online 8 March 2017 Source:Acta Biomaterialia Author(s): A.A. Thorpe, G Dougill, L. Vickers, ND. Reeves, C. Sammon, G. Cooper, C.L. Le Maitre We previously reported a synthetic Laponite® crosslinked pNIPAM-co-DMAc (L-pNIPAM-co-DMAc) hydrogel which ...


VEGF165 induces differentiation of hair follicle stem cells into endothelial cells and plays a role in in vivo angiogenesis

28-Feb-2017 | Renfu Quan, Weibin Du, Xuan Zheng, Shichao Xu, Qiang Li, Xing Ji, Ximei Wu, Rongxue Shao, Disheng Yang, Journal of Cellular and Molecular Medicine, 2017

Abstract Within the vascular endothelial growth factor (VEGF) family of five subtypes, VEGF165 secreted by endothelial cells has been identified to be the most active and widely distributed factor that plays a vital role in courses of angiogenesis, vascularization and mesenchymal cell ...


[In Depth] Congress votes on sweeping biomedical bill

02-Dec-2016 | Jocelyn Kaiser; Jeffrey Mervis; Kelly Servick, Science , 2016

Congress this week began voting on a sweeping biomedical innovation bill that includes nearly $5 billion in dedicated funding for a trio of major research initiatives at the National Institutes of Health (NIH). The bill also includes measures to speed the approval of new drugs and medical devices ...


Chitosan/poly‐octanoic acid 2‐thiophen‐3‐yl‐ethyl ester blends as a scaffold to maintain myoblasts regeneration potential in vitro

05-Sep-2016 | Cristina Padilla, Andrea Ramos, Natalia González, Mauricio Isaacs, Flavia Zacconi, Hugo C. Olguín, Loreto M. Valenzuela, Journal of Biomedical Materials Research Part A, 2016

Abstract Satellite cells are a small cell population that function as muscle‐specific adult stem cells. When muscle damage occurs, these cells are able to activate, proliferate and ultimately fuse with each other in order to form new myofibers or fuse with existing ones. For tissue engineering ...


Culture and establishment of self-renewing human and mouse adult liver and pancreas 3D organoids and their genetic manipulation

01-Sep-2016 | Laura Broutier; Amanda Andersson-Rolf; Christopher J Hindley; Sylvia F Boj; Hans Clevers; Bon-Kyoung Koo; Meritxell Huch, Nature Protocols, 2016

Nature Protocols 11, 1724 (2016). doi:10.1038/nprot.2016.097 Authors: Laura Broutier, Amanda Andersson-Rolf, Christopher J Hindley, Sylvia F Boj, Hans Clevers, Bon-Kyoung Koo & Meritxell Huch Adult somatic tissues have proven difficult to expand in vitro, largely because of the ...


The rate of protein synthesis in hematopoietic stem cells is limited partly by 4E-BPs [Research Communications]

01-Aug-2016 | Robert A.J. Signer; Le Qi; Zhiyu Zhao; David Thompson; Alla A. Sigova; Zi Peng Fan; George N. DeMartino; Richard A. ..., Genes & Development, 2016

Adult stem cells must limit their rate of protein synthesis, but the underlying mechanisms remain largely unexplored. Differences in protein synthesis among hematopoietic stem cells (HSCs) and progenitor cells did not correlate with differences in proteasome activity, total RNA content, mRNA ...


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