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142 Newest Publications about the topic adult stem cells


Single Lgr5- or Lgr6-expressing taste stem/progenitor cells generate taste bud cells ex vivo [Developmental Biology]

18-11-2014 | Wenwen Ren; Brian C. Lewandowski; Jaime Watson; Eitaro Aihara; Ken Iwatsuki; Alexander A. Bachmanov; Robert F. Margo ..., Proceedings of the National Academy of Sciences current issue, 2014

Leucine-rich repeat-containing G protein-coupled receptor 5 (Lgr5) and its homologs (e.g., Lgr6) mark adult stem cells in multiple tissues. Recently, we and others have shown that Lgr5 marks adult taste stem/progenitor cells in posterior tongue. However, the regenerative potential of ...


Gender‐Linked Stem Cell Alterations in Stroke and Postpartum Depression

15-11-2014 | Mibel M. Pabón, Xun‐Ming Ji, Jamie Winderbaum Fernandez, Cesar V. Borlongan, CNS Neuroscience & Therapeutics, 2014

Summary Stroke is a significant unmet clinical need. The current stroke treatment of tissue plasminogen activator is limited to the very acute 4.5h after disease onset which benefits only less than 3% of ischemic stroke patients. Our overarching hypothesis advances the notion that gender, ...


PGC-1{beta} promotes enterocyte lifespan and tumorigenesis in the intestine [Medical Sciences]

21-10-2014 | Elena Bellafante; Annalisa Morgano; Lorena Salvatore; Stefania Murzilli; Giuseppe Di Tullio; Andria D’Orazio; Doming ..., Proceedings of the National Academy of Sciences current issue, 2014

The mucosa of the small intestine is renewed completely every 3–5 d throughout the entire lifetime by small populations of adult stem cells that are believed to reside in the bottom of the crypts and to migrate and differentiate into all the different populations of intestinal cells. When the ...


Bifunctional ectodermal stem cells around the nail display dual fate homeostasis and adaptive wounding response toward nail regeneration [Cell Biology]

21-10-2014 | Yvonne Leung; Eve Kandyba; Yi-Bu Chen; Seth Ruffins; Cheng-Ming Chuong; Krzysztof Kobielak, Proceedings of the National Academy of Sciences current issue, 2014

Regulation of adult stem cells (SCs) is fundamental for organ maintenance and tissue regeneration. On the body surface, different ectodermal organs exhibit distinctive modes of regeneration and the dynamics of their SC homeostasis remain to be unraveled. A slow cycling characteristic has been ...


Wnts Enhance Neurotrophin-Induced Neuronal Differentiation in Adult Bone-Marrow-Derived Mesenchymal Stem Cells via Canonical and Noncanonical Signaling Pathways

29-08-2014 | Hung-Li Tsai et al., PLoS ONE, 2014

by Hung-Li Tsai, Wing-Ping Deng, Wen-Fu Thomas Lai, Wen-Ta Chiu, Charn-Bing Yang, Yu-Hui Tsai, Shiaw-Min Hwang, Perry F. Renshaw Wnts were previously shown to regulate the neurogenesis of neural stem or progenitor cells. Here, we explored the underlying molecular mechanisms through which Wnt ...


Bone morphogenetic protein‐2, ‐6, and ‐7 differently regulate osteogenic differentiation of human periodontal ligament stem cells

13-07-2013 | Sema S. Hakki, Buket Bozkurt, Erdogan E. Hakki, Seyit Ali Kayis, Gizem Turac, Irem Yilmaz, Erdal Karaoz, Journal of Biomedical Materials Research Part B: Applied Biomaterials, 2013

Abstract The utility of adult stem cells for bone regeneration may be an attractive alternative in the treatment of extensive injury, congenital malformations, or diseases causing large bone defects. To create an environment that is supportive of bone formation, signals from molecules such as ...


Character comparison of abdomen‐derived and eyelid‐derived mesenchymal stem cells

22-05-2013 | S.‐H. Kim, S. H. Bang, S. A. Park, S. Y. Kang, K. D. Park, I. U. Oh, S. H. Yoo, H. Kim, C.‐H. Kim, S. Y. Baek, Cell Proliferation, 2013

Abstract Objectives While most human adipose tissues, such as those located in the abdomen, hip and thigh, are of mesodermal origin, adipose tissues located in the face are of ectodermal origin. The present study has compared stem cell‐related features of abdomen‐derived adult stem cells ...


How stem cells speak with host immune cells in inflammatory brain diseases

30-04-2013 | Stefano Pluchino, Chiara Cossetti, Glia, 2013

Advances in stem cell biology have raised great expectations that diseases and injuries of the central nervous system (CNS) may be ameliorated by the development of non‐hematopoietic stem cell medicines. Yet, the application of adult stem cells as CNS therapeutics is challenging and the ...


Dental follicle progenitor cells responses to Porphyromonas gingivalis LPS

08-04-2013 | Kyriaki Chatzivasileiou, Cornelia A. Lux, Gustav Steinhoff, Hermann Lang, Journal of Cellular and Molecular Medicine, 2013

Abstract Periodontitis is a bacterially induced chronic inflammatory disease. Dental follicle progenitor cells (DFPCs) have been proposed as biological graft for periodontal regenerative therapies. The potential impact of bacterial toxins on DFPCs properties is still poorly understood. The aim ...


Expression of Oct4 in human embryonic stem cells is dependent on nanotopographical configuration

07-04-2013 | Acta Biomaterialia, 2013

May 2013 Publication year: 2013Source:Acta Biomaterialia, Volume 9, Issue 5 The fate of adult stem cells can be influenced by physical cues, including nanotopography. However, the response of human embryonic stem cells (hESCs) to dimensionally well-defined nanotopography is unknown. ...


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