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162 Newest Publications about the topic adult stem cells

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[Research Article] NAD+ repletion improves mitochondrial and stem cell function and enhances life span in mice

17-Jun-2016 | Hongbo Zhang; Dongryeol Ryu; Yibo Wu; Karim Gariani; Xu Wang; Peiling Luan; Davide D’Amico; Eduardo R. Ropelle; Matt ..., Science , 2016

Adult stem cells (SCs) are essential for tissue maintenance and regeneration yet are susceptible to senescence during aging. We demonstrate the importance of the amount of the oxidized form of cellular nicotinamide adenine dinucleotide (NAD+) and its effect on mitochondrial activity as a pivotal ...

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T Cell Fate at the Single-Cell Level

11-May-2016 | Veit R. Buchholz; Ton N.M. Schumacher; Dirk H. Busch, Annual Review of Immunology, 2016

T cell responses display two key characteristics. First, a small population of epitope-specific naive T cells expands by several orders of magnitude. Second, the T cells within this proliferating population take on diverse functional and phenotypic properties that determine their ability to exert ...

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Secreted microvesicular miR‐31 inhibits osteogenic differentiation of mesenchymal stem cells

05-May-2016 | Sylvia Weilner, Elisabeth Schraml, Matthias Wieser, Paul Messner, Karl Schneider, Klemens Wassermann, Lucia Micutkov ..., Aging Cell, 2016

Summary Damage to cells and tissues is one of the driving forces of aging and age‐related diseases. Various repair systems are in place to counteract this functional decline. In particular, the property of adult stem cells to self‐renew and differentiate is essential for tissue homeostasis and ...

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High throughput approaches for controlled stem cell differentiation

09-Apr-2016 | Author(s): Hwan D. Kim, Eunjee A. Lee, Young Hwan Choi, Young Hyeon An, Rachel H. Koh, Seunghyun L. Kim, ..., Acta Biomaterialia, 2016

Publication date: 1 April 2016 Source:Acta Biomaterialia, Volume 34 Author(s): Hwan D. Kim, Eunjee A. Lee, Young Hwan Choi, Young Hyeon An, Rachel H. Koh, Seunghyun L. Kim, Nathaniel S. Hwang Stem cells have unique ability to undergo self-renewal indefinitely in culture and ...

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Modification of Tet1 and histone methylation dynamics in dairy goat male germline stem cells

14-Mar-2016 | Liming Zheng, Yuanxin Zhai, Na Li, Chongyang Wu, Haijing Zhu, Zhuying Wei, Chunling Bai, Guangpeng Li, Jinlian Hua, Cell Proliferation, 2016

Abstract Objectives Tet (ten‐eleven translocation) protein 1 is a key enzyme for DNA demethylation, which modulates DNA methylation and gene transcription. DNA methylation and histone methylation are critical elements in self‐renewal of male germline stem cells (mGSCs) and spermatogenesis. ...

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The effects of proliferation and DNA damage on hematopoietic stem cell function determine ageing

27-Jan-2016 | Satish Khurana, Developmental Dynamics, 2016

Abstract In most of the mammalian tissues, homeostasis as well as injury repair depends upon a small number of resident adult stem cells. The decline in tissue/organ function in aged organisms has been directly linked with poorly functioning stem cells. Altered function of hematopoietic stem ...

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Targeted Deletion of p53 in Lgr5-Expressing Intestinal Stem Cells Promotes Colon Tumorigenesis in a Preclinical Model of Colitis-Associated Cancer

15-Dec-2015 | Laurie A. Davidson; Evelyn S. Callaway; Eunjoo Kim; Brad R. Weeks; Yang-Yi Fan; Clinton D. Allred; Robert S. Chapkin, Cancer Research, 2015

p53 has been shown to mediate cancer stem–like cell function by suppressing pluripotency and cellular dedifferentiation. However, there have been no studies to date that have addressed the specific effects of p53 loss in colonic adult stem cells. In this study, we investigated the consequences of ...

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Cell surface glycan engineering of neural stem cells augments neurotropism and improves recovery in a murine model of multiple sclerosis

01-Dec-2015 | Jasmeen S Merzaban; Jaime Imitola; Sarah C Starossom; Bing Zhu; Yue Wang; Jack Lee; Amal J Ali; Marta Olah; Ayman F ..., Glycobiology , 2015

Neural stem cell (NSC)-based therapies offer potential for neural repair in central nervous system (CNS) inflammatory and degenerative disorders. Typically, these conditions present with multifocal CNS lesions making it impractical to inject NSCs locally, thus mandating optimization of vascular ...

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LPS-Stimulated Human Skin-Derived Stem Cells Enhance Neo-Vascularization during Dermal Regeneration

13-Nov-2015 | Tobias Kisch et al., PLoS ONE, 2015

by Tobias Kisch, Caroline Weber, Daniel H. Rapoport, Charli Kruse, Sandra Schumann, Felix H. Stang, Frank Siemers, Anna E. Matthießen High numbers of adult stem cells are still required to improve the formation of new vessels in scaffolds to accelerate dermal regeneration. Recent data indicate ...

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Suppression of IGF‐I signals in neural stem cells enhances neurogenesis and olfactory function during aging

29-Jul-2015 | Zayna Chaker, Saba Aïd, Hugues Berry, Martin Holzenberger, Aging Cell, 2015

Summary Downregulation of insulin‐like growth factor (IGF) pathways prolongs lifespan in various species, including mammals. Still, the cellular mechanisms by which IGF signaling controls the aging trajectory of individual organs are largely unknown. Here, we asked whether suppression of IGF‐I ...

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