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153 Newest Publications about the topic adult stem cells


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Suppression of IGF‐I signals in neural stem cells enhances neurogenesis and olfactory function during aging

29-Jul-2015 | Zayna Chaker, Saba Aïd, Hugues Berry, Martin Holzenberger, Aging Cell, 2015

Summary Downregulation of insulin‐like growth factor (IGF) pathways prolongs lifespan in various species, including mammals. Still, the cellular mechanisms by which IGF signaling controls the aging trajectory of individual organs are largely unknown. Here, we asked whether suppression of IGF‐I ...


DNA methylation differs between sister chromatids, and this difference correlates with the degree of differentiation potential

26-Jun-2015 | E.L. Patkin, N.A. Grudinina, L.K. Sasina, E.M. Noniashvili, L.I. Pavlinova, I.O. Suchkova, M.E. Kustova, G.A. Sofronov, Molecular Reproduction and Development, 2015

Abstract Sister chromatids may be distinguished and discretely segregated in asymmetrically dividing embryonic and adult stem cells. In preimplantation mouse embryos, for example, sister chromatids differ in chromatin characteristics (Patkin et al., 1994) and in methylation levels of sister ...


Q&A: Hans Clevers

14-May-2015 | Eric Bender, Nature, 2015

Q&A: Hans Clevers Nature. doi:10.1038/521S15a Author: Eric Bender In 2009, Hans Clevers and Toshiro Sato (then a postdoc in Clevers' lab) demonstrated a powerful new model to study development and disease: a three-dimensional ...


Induction of insulin‐producing cells from umbilical cord blood‐derived stromal cells by activation of the c‐Met/HGF axis

24-Apr-2015 | Bo Sun, Rui Liu, Zhong‐Dang Xiao, Development, Growth & Differentiation, 2015

Efficient and effective therapies are required for diabetes mellitus. The use of adult stem cells for treating diabetes represents a major focus of current research. We have attempted to differentiate adult stem cells produced from umbilical cord blood‐derived stromal cells into ...


The extracellular matrix compartment of neural stem and glial progenitor cells

22-Apr-2015 | Andreas Faissner, Jacqueline Reinhard, Glia, 2015

Neuroepithelial and radial GLIA stem cells generate the majority of the cellular constituents of the central nervous system. Following precisely timed phases of neurogenesis and gliogenesis the stem cells recede, with the exception of adult neural stem cells that persist in two generally ...


Culturing Adult Stem Cells from Mouse Small Intestinal Crypts

01-Apr-2015 | Hamilton, K. E., Crissey, M. A. S., Lynch, J. P., Rustgi, A. K., CSH Protocols, 2015

In recent years, the study of primary cells in culture has evolved from an extraphysiological, two-dimensional platform to novel, three-dimensional platforms in which the addition of matrix components and/or supporting cells provide an ex vivo niche. Such studies have provided the basis on which ...


[Report] A mitochondrial UPR-mediated metabolic checkpoint regulates hematopoietic stem cell aging

20-Mar-2015 | Mary Mohrin; Jiyung Shin; Yufei Liu; Katharine Brown; Hanzhi Luo; Yannan Xi; Cole M. Haynes; Danica Chen, Science , 2015

Deterioration of adult stem cells accounts for much of aging-associated compromised tissue maintenance. How stem cells maintain metabolic homeostasis remains elusive. Here, we identified a regulatory branch of the mitochondrial unfolded protein response (UPRmt), which is mediated by the interplay ...


H3K4me1 marks DNA regions hypomethylated during aging in human stem and differentiated cells [RESEARCH]

01-Jan-2015 | Fernandez, A. F., Bayon, G. F., Urdinguio, R. G., Torano, E. G., Garcia, M. G., Carella, A., Petrus-Reurer, S., Ferr ..., Genome Research, 2015

In differentiated cells, aging is associated with hypermethylation of DNA regions enriched in repressive histone post-translational modifications. However, the chromatin marks associated with changes in DNA methylation in adult stem cells during lifetime are still largely unknown. Here, DNA ...


Comparison of osteogenic differentiation potential of human adult stem cells loaded on bioceramic‐coated electrospun poly (L‐lactide) nanofibres

11-Dec-2014 | A. Ardeshirylajimi, M. Mossahebi‐Mohammadi, S. Vakilian, L. Langroudi, E. Seyedjafari, A. Atashi, M. Soleimani, Cell Proliferation, 2014

Abstract Objectives To compare potential of four types of stem cell in tissue engineering and regenerative medicine applications, osteogenic capacity of newly introduced mesenchymal stem cells (MSCs) derived from buccal fat pads (BFP) (an adipose‐encapsulated mass of the oral cavity), was ...


Identification of nucleoside analogues as inducers of neuronal differentiation in a human reporter cell line and adult stem cells

02-Dec-2014 | Katharina Raasch, Edith Malecki, Maria Siemann, Malayko Montilla Martinez, Jürgen J. Heinisch, Janine Müller, Lidia ..., Chemical Biology & Drug Design, 2014

Abstract Nucleoside analogues (NSAs) were among the first chemotherapeutic agents and could also be useful for manipulation of cell fate. To investigate the potential of NSAs for induction of neuronal differentiation, we developed a novel phenotypic assay based on a human neuron‐committed ...


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