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168 Newest Publications about the topic adult stem cells
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Chitosan/poly‐octanoic acid 2‐thiophen‐3‐yl‐ethyl ester blends as a scaffold to maintain myoblasts regeneration potential in vitro
05-Sep-2016 | Cristina Padilla, Andrea Ramos, Natalia González, Mauricio Isaacs, Flavia Zacconi, Hugo C. Olguín, Loreto M. Valenzuela, Journal of Biomedical Materials Research Part A, 2016
Abstract Satellite cells are a small cell population that function as muscle‐specific adult stem cells. When muscle damage occurs, these cells are able to activate, proliferate and ultimately fuse with each other in order to form new myofibers or fuse with existing ones. For tissue engineering ...
Culture and establishment of self-renewing human and mouse adult liver and pancreas 3D organoids and their genetic manipulation
01-Sep-2016 | Laura Broutier; Amanda Andersson-Rolf; Christopher J Hindley; Sylvia F Boj; Hans Clevers; Bon-Kyoung Koo; Meritxell Huch, Nature Protocols, 2016
Nature Protocols 11, 1724 (2016). doi:10.1038/nprot.2016.097 Authors: Laura Broutier, Amanda Andersson-Rolf, Christopher J Hindley, Sylvia F Boj, Hans Clevers, Bon-Kyoung Koo & Meritxell Huch Adult somatic tissues have proven difficult to expand in vitro, largely because of the ...
The rate of protein synthesis in hematopoietic stem cells is limited partly by 4E-BPs [Research Communications]
01-Aug-2016 | Robert A.J. Signer; Le Qi; Zhiyu Zhao; David Thompson; Alla A. Sigova; Zi Peng Fan; George N. DeMartino; Richard A. ..., Genes & Development, 2016
Adult stem cells must limit their rate of protein synthesis, but the underlying mechanisms remain largely unexplored. Differences in protein synthesis among hematopoietic stem cells (HSCs) and progenitor cells did not correlate with differences in proteasome activity, total RNA content, mRNA ...
Keeping stem cells under control: New insights into the mechanisms that limit niche‐stem cell signaling within the reproductive system
20-Jul-2016 | Mayu Inaba, Yukiko M. Yamashita, Michael Buszczak, Molecular Reproduction and Development, 2016
SUMMARY Adult stem cells reside in specialized microenvironments, called niches, that maintain stem cells in an undifferentiated and self‐renewing state. Defining and understanding the mechanisms that restrict niche signaling exclusively to stem cells is crucial to determine how stem cells ...
In situ characterization of the mTORC1 during adipogenesis of human adult stem cells on chip [Applied Biological Sciences]
19-Jul-2016 | Xuanye Wu; Nils Schneider; Alina Platen; Indranil Mitra; Matthias Blazek; Roland Zengerle; Roland Schüle; Matthias Meier, Proceedings of the National Academy of Sciences current issue, 2016
Mammalian target of rapamycin (mTOR) is a central kinase integrating nutrient, energy, and metabolite signals. The kinase forms two distinct complexes: mTORC1 and mTORC2. mTORC1 plays an essential but undefined regulatory function for regeneration of adipose tissue. Analysis of mTOR in general is ...
[Report] Return to quiescence of mouse neural stem cells by degradation of a proactivation protein
15-Jul-2016 | Noelia Urbán; Debbie L. C. van den Berg; Antoine Forget; Jimena Andersen; Jeroen A. A. Demmers; Charles Hunt; Olivie ..., Science , 2016
Quiescence is essential for long-term maintenance of adult stem cells. Niche signals regulate the transit of stem cells from dormant to activated states. Here, we show that the E3-ubiquitin ligase Huwe1 (HECT, UBA, and WWE domain–containing 1) is required for proliferating stem cells of the adult ...
[Research Article] NAD+ repletion improves mitochondrial and stem cell function and enhances life span in mice
17-Jun-2016 | Hongbo Zhang; Dongryeol Ryu; Yibo Wu; Karim Gariani; Xu Wang; Peiling Luan; Davide D’Amico; Eduardo R. Ropelle; Matt ..., Science , 2016
Adult stem cells (SCs) are essential for tissue maintenance and regeneration yet are susceptible to senescence during aging. We demonstrate the importance of the amount of the oxidized form of cellular nicotinamide adenine dinucleotide (NAD+) and its effect on mitochondrial activity as a pivotal ...
T Cell Fate at the Single-Cell Level
11-May-2016 | Veit R. Buchholz; Ton N.M. Schumacher; Dirk H. Busch, Annual Review of Immunology, 2016
T cell responses display two key characteristics. First, a small population of epitope-specific naive T cells expands by several orders of magnitude. Second, the T cells within this proliferating population take on diverse functional and phenotypic properties that determine their ability to exert ...
Secreted microvesicular miR‐31 inhibits osteogenic differentiation of mesenchymal stem cells
05-May-2016 | Sylvia Weilner, Elisabeth Schraml, Matthias Wieser, Paul Messner, Karl Schneider, Klemens Wassermann, Lucia Micutkov ..., Aging Cell, 2016
Summary Damage to cells and tissues is one of the driving forces of aging and age‐related diseases. Various repair systems are in place to counteract this functional decline. In particular, the property of adult stem cells to self‐renew and differentiate is essential for tissue homeostasis and ...
High throughput approaches for controlled stem cell differentiation
09-Apr-2016 | Author(s): Hwan D. Kim, Eunjee A. Lee, Young Hwan Choi, Young Hyeon An, Rachel H. Koh, Seunghyun L. Kim, ..., Acta Biomaterialia, 2016
Publication date: 1 April 2016 Source:Acta Biomaterialia, Volume 34 Author(s): Hwan D. Kim, Eunjee A. Lee, Young Hwan Choi, Young Hyeon An, Rachel H. Koh, Seunghyun L. Kim, Nathaniel S. Hwang Stem cells have unique ability to undergo self-renewal indefinitely in culture and ...
