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Mitochondrial DNA, nuclear context, and the risk for carcinogenesis

14-Jan-2018 | Brett A. Kaufman, Martin Picard, Neal Sondheimer, Environmental and Molecular Mutagenesis, 2018

The inheritance of mitochondrial DNA (mtDNA) from mother to child is complicated by differences in the stability of the mitochondrial genome. Although the germ line mtDNA is protected through the minimization of replication between generations, sequence variation can occur either through ...



13-Jan-2018 | Journal of Clinical Pharmacy and Therapeutics, 2018

‘Influence of genetic variants of IDH1, IDH2, TET2 and DNMT3A on cytarabine cytotoxicity in different populations’ by Y. Wang & J. K. Lamba1 The above article from the Journal of Clinical Pharmacy and Therapeutics, published online on 21 November 2017 in Wiley Online Library ...


Kbtbd2 inhibits the cytotoxic activity of immortalized NK cells through down‐regulating mTOR signaling in a mouse hepatocellular carcinoma model

13-Jan-2018 | Kai Dai, Yabing Huang, Zubing Chen, Xiaomei Sun, Lihua Yang, Yingan Jiang, European Journal of Immunology, 2018

Abstract Natural killer cell (NK cell)‐based immunotherapy is a promising therapeutic strategy for hepatocellular carcinoma (HCC). However, the molecular mechanisms underlying the regulation of NK cell function in the tumor sites are not completely elucidated. In this study, we identified the ...


Dietary Factors Modulate Colonic Tumorigenesis Through the Interaction of Gut Microbiota and Host Chloride Channels

13-Jan-2018 | Yong Zhang, Chao Kang, Xiao‐lan Wang, Min Zhou, Meng‐ting Chen, Xiao‐hui Zhu, Kai Liu, Bin Wang, Qian‐yong Zhang, Ju ..., Molecular Nutrition & Food Research, 2018

Scope : In recent decades, the association between diet, gut microbiota and the risk of colorectal cancer (CRC) has been established. Gut microbiota and associated metabolites, such as bile acids and butyrate, are now known to play a key role in CRC development. The aim of this study was to ...


Enhanced chondrogenesis of mesenchymal stem cells over silk fibroin/chitosan‐chondroitin sulfate three dimensional scaffold in dynamic culture condition

13-Jan-2018 | Parinita Agrawal, Krishna Pramanik, Varshini Vishwanath, Amit Biswas, Akalabya Bissoyi, Pradeep Kumar Patra, Journal of Biomedical Materials Research Part B: Applied Biomaterials, 2018

Abstract Chondroitin sulfate (Ch) is one of the main structural components of cartilage tissue, therefore, its presence in tissue engineered scaffold is expected to enhance cartilage regeneration. Previously, silk fibroin/chitosan (SF/CS) blend was proven to be a potential biomaterial for ...


Optimized paired‐sgRNA/Cas9 cloning and expression cassette triggers high‐efficiency multiplex genome editing in kiwifruit

13-Jan-2018 | Zupeng Wang, Shuaibin Wang, Dawei Li, Qiong Zhang, Li Li, Caihong Zhong, Yifei Liu, Hongwen Huang, Plant Biotechnology Journal, 2018

Abstract Kiwifruit is an important fruit crop; however, technologies for its functional genomic and molecular improvement are limited. The clustered regulatory interspaced short palindromic repeats (CRISPR)/CRISPR‐associated protein (Cas) system has been successfully applied to genetic ...


Verification of DNA Motifs in Arabidopsis using CRISPR/Cas9 Mediated Mutagenesis

13-Jan-2018 | Chenlong Li, Chen Chen, Huhui Chen, Suikang Wang, Xuemei Chen, Yuhai Cui, Plant Biotechnology Journal, 2018

Abstract Transcription factors (TFs) and chromatin‐modifying factors (CMFs) access chromatin by recognizing specific DNA motifs in their target genes. Chromatin Immunoprecipitation followed by next generation sequencing (ChIP‐seq) has been widely used to discover the potential DNA binding ...


Modification of chrysanthemum odour and taste with chrysanthemol synthase induces strong dual resistance against cotton aphids

13-Jan-2018 | Hao Hu, Jinjin Li, Thierry Delatte, Jacques Vervoort, Liping Gao, Francel Verstappen, Wei Xiong, Jianping Gan, Maart ..., Plant Biotechnology Journal, 2018

Abstract Aphids are pests of chrysanthemum that employ plant volatiles to select host plants and ingest cell contents to probe host quality before engaging in prolonged feeding and reproduction. Changes in volatile and non‐volatile metabolite profiles can disrupt aphid‐plant interactions and ...


Recent advances in metabolic engineering of Yarrowia lipolytica for lipid overproduction

13-Jan-2018 | Si‐Yu Zeng, Hu‐Hu Liu, Tian‐Qiong Shi, Ping Song, Lu‐Jing Ren, He Huang, Xiao‐Jun Ji, European Journal of Lipid Science and Technology, 2018

Abstract The non‐conventional yeast Yarrowia lipolytica has been receiving growing attention due to its excellent lipid accumulation capacity. Microbial lipid has attracted widespread interest due to their broad applications as dietary supplements, cosmetic additives, oleochemicals and ...


Specific labelling of myonuclei by an antibody against Pericentriolar material 1 (PCM1) on skeletal muscle tissue sections

13-Jan-2018 | I. M. Winje, M. Bengtsen, E. Eftestøl, I. Juvkam, J. C. Bruusgaard, K. Gundersen, Acta Physiologica, 2018

Abstract Aim Skeletal muscle is a heterogeneous tissue containing several different cell types and only about 40 – 50% of the cell nuclei within the tissue belong to myofibres. Existing technology, attempting to distinguish myonuclei from other nuclei at the light microscopy level, has led ...


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