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1,067 Newest Publications of RSC Publishing
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Multivalency Amplifies the Selection and Affinity of Bradykinin-Derived Peptide for Lipid Nanovesicles
15-05-2013 | Hubert Yin, Molecular BioSystems, 2013
The trimer of a Bradykinin derivative displayed more than five-fold increase in binding affinity for phosphatidylserine-enriched nanovesicles as compared to its monomeric precursor. The nanovesicle selection is directly correlated to multivalency, which amplified the electrostatic attraction. ...
Identification of microRNA and bioinformatics target gene analysis in beef cattle intramuscular fat and subcutaneous fat
15-05-2013 | Haiyang Wang; Yue Zheng; Genlin Wang; Huixia Li, Molecular BioSystems, 2013
microRNA (miRNA) are endogenous non-coding RNA that has been proposed play important roles in the formation of body fat. However, the differential expression of miRNA and the role of these miRNA in bovine intramuscular and subcutaneous fat tissue are still unknown. In this study, profile of ...
Mass Spectrometry–based Identification and Characterisation of Lysine and Arginine Methylation in the Human Proteome
15-05-2013 | Michael Bremang; Alessandro Cuomo; Anna Maria Agresta; Magdalena Stugiewicz; Valeria Spadotto; Tiziana Bonaldi, Molecular BioSystems, 2013
Protein methylation is a post-translational modification (PTM) by which a variable number of methyl groups is transferred to lysine and arginine residues within proteins. Despite increased interest in this modification due to its reversible nature and its emerging role in a diverse set of ...
Structural comparison of biological networks based on dominant vertices
15-05-2013 | Beatriz Luna; Edgardo Galan-Vasquez; Edgardo Ugalde; Agustino Martinez-Antonio, Molecular BioSystems, 2013
It is a current practice to organize biological data in a network structure where vertices represent biological components and arrows represent their interactions. A great diversity of graph theoretical notions, such as clustering coefficient, network motifs, centrality, degree distribution, ...
The intrinsically disordered C-terminal region of Arabidopsis thaliana TCP8 transcription factor acts both as a transactivation and self-assembly domain
15-05-2013 | Isabel Valsecchi; Emilie Guittard-Crilat; Regis Maldiney; Yvette Habricot; Sabrina Lignon; Régine Lebrun; Emile Migi ..., Molecular BioSystems, 2013
TCPs are plant specific transcription factors with non-canonical basic helix-loop-helix domains. While Arabidopsis thaliana has 24 TCPs involved in cell proliferation and differentiation, their mode of action has not been fully elucidated. Using bioinformatic tools, we demonstrate that TCP ...
Digital and analogical reality in proteomics investigation
08-05-2013 | Andrea Urbani; Massimo Castagnola; Mauro Fasano; Luca Bini; Alessandra Modesti; Anna Maria Timperio; Paola Roncada, Molecular BioSystems, 2013
Are protein functions continuous or discretized? Proteomics investigations are starting to address this non-trivial awesome question focusing upon determining the nature of biological molecular relationships. In the following editorial we present a number of experimental studies published in ...
Comparative analyses of stress-responsive genes in Arabidopsis thaliana: insight from genomic data mining, functional enrichment, pathway analysis and phenomics
08-05-2013 | Mahantesha Naika; Khader Shameer; Ramanathan Sowdhamini, Molecular BioSystems, 2013
Biotic and abiotic stresses adversely affect agriculture by reducing crop growth and productivity worldwide. To investigate the abiotic stress-responsive genes in Arabidopsis thaliana, we compiled a dataset of stress signals and differentially upregulated genes (
Exploring higher-order EGFR oligomerisation and phosphorylation—a combined experimental and theoretical approach
08-05-2013 | Noga Kozer; Dipak Barua; Suzanne Orchard; Eduoard C. Nice; Antony W. Burgess; William S. Hlavacek; Andrew H. A. Clayton, Molecular BioSystems, 2013
The epidermal growth factor receptor (EGFR) kinase is generally considered to be activated by either ligand-induced dimerisation or a ligand-induced conformational change within pre-formed dimers. Ligand-induced higher-order EGFR oligomerisation or clustering has been reported but it is not ...
Transport of nucleosides in vcCNT facilitated by sodium gradients from Molecular Dynamics Simulations
08-05-2013 | Zhiwei Feng; Tingjun Hou; Youyong Li, Molecular BioSystems, 2013
Nucleosides are required for DNA and RNA synthesis, and the nucleoside adenosine has a function in a variety of signaling processes. Nucleosides require a specialized class of integral membrane proteins, known as nucleoside transporters (NTs), for specific transport across cell membranes. NTs ...
In silico investigation and targeting of amyloid [small beta] oligomers of different size.
01-05-2013 | Ida Autiero; Michele Saviano; Emma Langella, Molecular BioSystems, 2013
Aggregation of Amyloid β (Aβ) peptide into fibrils has been implicated in the pathogenesis of Alzheimer's disease (AD). As a result, in recent years, substantial efforts have been expended in the study of the mechanism of aggregation of the Aβ peptide as well as of its inhibition by potential ...
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