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21,131 Newest Publications of Oxford University Press

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Visualizing structure-mediated interactions in supercoiled DNA molecules

19-Apr-2018 | Scott S, Xu Z, Kouzine F, et al., Nucleic Acids Research, 2018

Abstract We directly visualize the topology-mediated interactions between an unwinding site on a supercoiled DNA plasmid and a specific probe molecule designed to bind to this site, as a function of DNA supercoiling and temperature. The visualization relies on containing the DNA molecules within ...

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Crystal structures of thrombin in complex with chemically modified thrombin DNA aptamers reveal the origins of enhanced affinity

19-Apr-2018 | Dolot R, Lam C, Sierant M, et al., Nucleic Acids Research, 2018

Abstract Thrombin-binding aptamer (TBA) is a DNA 15-mer of sequence 5′-GGT TGG TGT GGT TGG-3′ that folds into a G-quadruplex structure linked by two T-T loops located on one side and a T-G-T loop on the other. These loops are critical for post-SELEX modification to improve TBA target affinity. ...

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Dissecting the sources of gene expression variation in a pan-cancer analysis identifies novel regulatory mutations

17-Apr-2018 | Sharma A, Jiang C, De S., Nucleic Acids Research, 2018

Abstract Although the catalog of cancer-associated mutations in protein-coding regions is nearly complete for all major cancer types, an assessment of regulatory changes in cancer genomes and their clinical significance remain largely preliminary. Adopting bottom-up approach, we quantify the ...

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Multiple RPAs make WRN syndrome protein a superhelicase

14-Apr-2018 | Lee M, Shin S, Uhm H, et al., Nucleic Acids Research, 2018

Abstract RPA is known to stimulate the helicase activity of Werner syndrome protein (WRN), but the exact stimulation mechanism is not understood. We use single-molecule FRET and magnetic tweezers to investigate the helicase activity of WRN and its stimulation by RPA. We show that WRN alone is a ...

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Brooding and glochidia release in Margaritifera auricularia (Spengler, 1793) (Unionoida: Margaritiferidae)

27-Mar-2018 | Soler J, Wantzen K, Jugé P, et al., Journal of Molluscan Studies, 2018

Abstract We describe the gill anatomy of Margaritifera auricularia, including a histological analysis of the marsupium, its brooding capacity and the length of the maturation process, providing information on the hitherto unknown reproductive strategy of French populations. Ova and developing ...

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RNA-splicing factor SART3 regulates translesion DNA synthesis

24-Mar-2018 | Huang M, Zhou B, Gong J, et al., Nucleic Acids Research, 2018

Abstract Translesion DNA synthesis (TLS) is one mode of DNA damage tolerance that uses specialized DNA polymerases to replicate damaged DNA. DNA polymerase η (Polη) is well known to facilitate TLS across ultraviolet (UV) irradiation and mutations in POLH are implicated in skin carcinogenesis. ...

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Genetic variants in autism-related CNTNAP2 impair axonal growth of cortical neurons

21-Mar-2018 | Canali G, Garcia M, Hivert B, et al., Human Molecular Genetics, 2018

Abstract The CNTNAP2 gene, coding for the cell adhesion glycoprotein Caspr2, is thought to be one of the major susceptibility genes for autism spectrum disorder (ASD). A large number of rare heterozygous missense CNTNAP2 variants have been identified in ASD patients. However, most of them are ...

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Molecular partners of hNOT/ALG3, the human counterpart of the Drosophila NOT and yeast ALG3 gene, suggest its involvement in distinct cellular processes relevant to congenital disorders of glycosylation, cancer, neurodegeneration and a variety of further pathologies

14-Mar-2018 | Hacker B, Schultheiß C, Döring M, et al., Human Molecular Genetics, 2018

Abstract This study provides first insights into the involvement of hNOT/ALG3, the human counterpart of the Drosophila Neighbour of TID and yeast ALG3 gene, in various putative molecular networks. HNOT/ALG3 encodes two translated transcripts encoding precursor proteins differing in their ...

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The IL-4/STAT6/PPARγ signaling axis is driving the expansion of the RXR heterodimer cistrome, providing complex ligand responsiveness in macrophages

28-Feb-2018 | Daniel B, Nagy G, Horvath A, et al., Nucleic Acids Research, 2018

Abstract Retinoid X receptor (RXR) is an obligate heterodimeric partner of several nuclear receptors (NRs), and as such a central component of NR signaling regulating the immune and metabolic phenotype of macrophages. Importantly, the binding motifs of RXR heterodimers are enriched in the ...

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A regulatory RNA is involved in RNA duplex formation and biofilm regulation in Sulfolobus acidocaldarius

26-Feb-2018 | Orell A, Tripp V, Aliaga-Tobar V, et al., Nucleic Acids Research, 2018

Abstract Non-coding RNAs (ncRNA) are involved in essential biological processes in all three domains of life. The regulatory potential of ncRNAs in Archaea is, however, not fully explored. In this study, RNA-seq analyses identified a set of 29 ncRNA transcripts in the hyperthermophilic archaeon ...

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