13-09-2011 | Volker Diehl, Nature Clinical Practice Oncology, 2011

Hematology: Are macrophages the bad guys in Hodgkin lymphoma? Nature Reviews Clinical Oncology 7, 301 (2010). doi:10.1038/nrclinonc.2010.71 Author: Volker Diehl Prognostic models for patients with Hodgkin lymphoma are imperfect and do not allow a precise individualized therapy. A ...

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13-09-2011 | Mark Ratner, Nature Biotechnology, 2011

Roche plans for more convenient-to-use Herceptin and Rituxan Nature Biotechnology 28, 298 (2010). doi:10.1038/nbt0410-298 Author: Mark Ratner

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13-09-2011 | Nature Reviews Drug Discovery, 2011

Learning from failure Nature Reviews Drug Discovery 9, 499 (2010). doi:10.1038/nrd3222 The launch of a new initiative to share data from failed clinical trials of investigational drugs for Alzheimer's disease provides both a promising opportunity to improve drug development in this ...

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13-09-2011 | Isobel Franks, Nature Clinical Practice Gastroenterology & Hepatology, 2011

Clostridium difficile: Hypoxia-inducible factor protects intestinal mucosa from Clostridium difficile induced injury Nature Reviews Gastroenterology & Hepatology 7, 476 (2010). doi:10.1038/nrgastro.2010.127 Author: Isobel Franks Hypoxia-inducible factor (HIF) signaling protects the ...

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13-09-2011 | Hongbo Jia; Nathalie L. Rochefort; Xiaowei Chen; Arthur Konnerth, Nature, 2011

Dendritic organization of sensory input to cortical neurons in vivo Nature 464, 1307 (2010). doi:10.1038/nature08947 Authors: Hongbo Jia, Nathalie L. Rochefort, Xiaowei Chen & Arthur Konnerth In sensory cortex regions, neurons are tuned to specific stimulus features. For example, in ...

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13-09-2011 | Katrina Ray, Nature Clinical Practice Rheumatology, 2011

Rheumatoid arthritis: Anti-TNF therapy for RA hinders function and survival of dendritic cells Nature Reviews Rheumatology 6, 383 (2010). doi:10.1038/nrrheum.2010.93 Author: Katrina Ray New research shows that blockade of tumor necrosis factor (TNF) leads to impaired dendritic cell ...

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13-09-2011 | Laurence Zitvogel; Guido Kroemer, Nature Medicine, 2011

Targeting dendritic cell metabolism in cancer Nature Medicine 16, 858 (2010). doi:10.1038/nm0810-858 Authors: Laurence Zitvogel & Guido Kroemer Cancers can compromise the capacity of the host immune system to recognize tumor antigens. Recent findings now show that increased ...

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13-09-2011 | Nature Reviews Genetics, 2011

In Brief Nature Reviews Genetics 11, 596 (2010). doi:10.1038/nrg2856 Genome evolutionGenomic signatures of germline gene expressionMcVicker, G. & Green, P.Genome Res.4 Aug 2010 (doi:10.1101/gr.106666.110)Features that influence genome evolution, such as nucleotide substitutions, ...

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13-09-2011 | Chen Varol; Ehud Zigmond; Steffen Jung, Nature Reviews Immunology, 2011

Securing the immune tightrope: mononuclear phagocytes in the intestinal lamina propria Nature Reviews Immunology 10, 415 (2010). doi:10.1038/nri2778 Authors: Chen Varol, Ehud Zigmond & Steffen Jung The intestinal landscape comprises the host's own tissue and immune cells, as ...

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13-09-2011 | Michael N. Silver, Nature Photonics, 2011

The real issues with rare earths Nature Photonics 5, 127 (2011). doi:10.1038/nphoton.2011.26 Author: Michael N. Silver

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