13-09-2011 | Helene Myrvang, Nature Clinical Practice Cardiovascular Medicine, 2011

Timing of alteplase for acute stroke Nature Reviews Cardiology 7, 416 (2010). doi:10.1038/nrcardio.2010.89 Author: Helene Myrvang Intravenous alteplase (recombinant tissue plasminogen activator) is restricted for use within 3 h from stroke onset by marketing authorizations. Some ...

more

13-09-2011 | Christian Biertümpfel; Ye Zhao; Yuji Kondo; Santiago Ramón-Maiques; Mark Gregory; Jae Young Lee; Chikahide Masutani; ..., Nature, 2011

Structure and mechanism of human DNA polymerase η Nature 465, 1044 (2010). doi:10.1038/nature09196 Authors: Christian Biertümpfel, Ye Zhao, Yuji Kondo, Santiago Ramón-Maiques, Mark Gregory, Jae Young Lee, Chikahide Masutani, Alan R. Lehmann, Fumio Hanaoka & Wei Yang The variant form ...

more

13-09-2011 | Albert-László Barabási; Natali Gulbahce; Joseph Loscalzo, Nature Reviews Genetics, 2011

Network medicine: a network-based approach to human disease Nature Reviews Genetics 12, 56 (2011). doi:10.1038/nrg2918 Authors: Albert-László Barabási, Natali Gulbahce & Joseph Loscalzo Given the functional interdependencies between the molecular components in a human cell, a ...

more

13-09-2011 | Hengyao Niu; Woo-Hyun Chung; Zhu Zhu; Youngho Kwon; Weixing Zhao; Peter Chi; Rohit Prakash; Changhyun Seong; Dongqin ..., Nature, 2011

Mechanism of the ATP-dependent DNA end-resection machinery from Saccharomyces cerevisiae Nature 467, 108 (2010). doi:10.1038/nature09318 Authors: Hengyao Niu, Woo-Hyun Chung, Zhu Zhu, Youngho Kwon, Weixing Zhao, Peter Chi, Rohit Prakash, Changhyun Seong, Dongqing Liu, Lucy Lu, ...

more

13-09-2011 | Arianne Heinrichs, Nature Reviews Molecular Cell Biology, 2011

Small RNAs: Dispensable Dicer Nature Reviews Molecular Cell Biology 11, 461 (2010). doi:10.1038/nrm2932 Author: Arianne Heinrichs Two groups identify an alternative miRNA biogenesis pathway.

more

13-09-2011 | Chris Murgatroyd; Alexandre V Patchev; Yonghe Wu; Vincenzo Micale; Yvonne Bockmühl; Dieter Fischer; Florian Holsboer ..., Nature Neuroscience, 2011

Dynamic DNA methylation programs persistent adverse effects of early-life stress Nature Neuroscience 13, 649 (2010). doi:10.1038/nn0510-649e Author: Chris Murgatroyd, Alexandre V Patchev, Yonghe Wu, Vincenzo Micale, Yvonne Bockmühl, Dieter Fischer, Florian Holsboer, Carsten T Wotjak, ...

more

13-09-2011 | H-O Jin; S-K Seo; Y-S Kim; S-H Woo; K-H Lee; J-Y Yi; S-J Lee; T-B Choe; J-H Lee; S An; S-I Hong; I-C Park, Oncogene, 2011

TXNIP potentiates Redd1-induced mTOR suppression through stabilization of Redd1 Oncogene 30, 3792 (1 September 2011). doi:10.1038/onc.2011.102 Authors: H-O Jin, S-K Seo, Y-S Kim, S-H Woo, K-H Lee, J-Y Yi, S-J Lee, T-B Choe, J-H Lee, S An, S-I Hong & ...

more

13-09-2011 | Nature Reviews Drug Discovery, 2011

In this issue Nature Reviews Drug Discovery 9, 341 (2010). doi:10.1038/nrd3167 Traditionally, signalling through seven-transmembrane receptors (7TMRs) — which are one of the largest classes of drug targets — was thought to be mediated solely via G proteins. Recently, however, it has ...

more

13-09-2011 | Nature Reviews Genetics, 2011

From the editors Nature Reviews Genetics 12, 1 (2011). doi:10.1038/nrg2935 “There are sciences and the applications of science, bound together as the fruit of the tree which bears it.”

more

13-09-2011 | Nature Reviews Drug Discovery, 2011

News in brief Nature Reviews Drug Discovery 9, 583 (2010). doi:10.1038/nrd3239 Regulatory decision suggests high bar for obesity drugsThe US FDA's Endocrinologic and Metabolic Drugs Advisory Committee voted 10–6 against the use of Vivus' investigational product Qnexa for the treatment ...

more