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2,283 Newest Publications of Elsevier
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Activity-based protein profiling: an enabling technology in chemical biology research
10-02-2012 | Nan Li, Herman S Overkleeft, Bogdan I Florea, Current Opinion in Chemical Biology, 2012
Activity-based protein profiling (ABPP) is one of the main driving forces in chemical biology and one of the most visible areas where organic chemistry contributes to chemical biology research. In recent years, ABPP research has gradually made the transfer from the relatively easy target ...
Beta type Ti–Mo alloys with changeable Young’s modulus for spinal fixation applications
10-02-2012 | Xingfeng Zhao, Mitsuo Niinomi, Masaaki Nakai, Junko Hieda, Acta Biomaterialia, 2012
To develop a novel biomedical titanium alloy with a changeable Young’s modulus via deformation-induced ω phase transformation for the spinal rods in the spinal fixation devices, a series of metastable β type binary Ti–(15–18)Mo alloys were prepared. In this study, the microstructures, Young’s ...
Assessing embryonic stem cell response to surface chemistry using plasma polymer gradients
10-02-2012 | Frances J. Harding, Lauren R. Clements, Robert D. Short, Helmut Thissen, Nicolas H. Voelcker, Acta Biomaterialia, 2012
The control of cell-material interactions is the key to a broad range of biomedical interactions. Gradient surfaces have recently been established as tools allowing the high-throughput screening and optimisation of these interactions. In this report, we show that plasma polymer gradients can ...
An in situ cross-linking hybrid hydrogel for controlled release of proteins
10-02-2012 | Hila Epstein-Barash, Cristina Stefanescu, Daniel S. Kohane, Acta Biomaterialia, 2012
There is a clear need for methods of providing safe controlled release of therapeutic proteins, either to achieve and maintain high local protein concentrations, or for sustained systemic delivery. Here we have developed a protein delivery system combining in situ cross-linkable ...
Enzymatically crosslinked gelatin-phenol hydrogels with broader stiffness range for osteogenic differentiation of human mesenchymal stem cells
10-02-2012 | Li-Shan Wang, Du Chan, Joo Eun Chung, Motoichi Kurisawa, Acta Biomaterialia, 2012
An injectable hydrogel system, composed of gelatin-hydroxyphenylpropionic acid (Gtn-HPA) conjugates chemically crosslinked by an enzyme-mediated oxidation reaction, has been designed as a biodegradable scaffold for tissue engineering. In light of the role of substrate stiffness on cell ...
Alignment of Multi-Layered Muscle Cells within 3D Hydrogel Macrochannels
10-02-2012 | Stephanie L. Hume, Sarah M. Hoyt, John S. Walker, Balaji V. Sridhar, John F. Ashley, ..., Acta Biomaterialia, 2012
This work describes the development and testing of poly(ethylene glycol) (PEG) hydrogels with independently-controlled dimensions of wide and deep macrochannels for their ability to promote alignment of skeletal myoblasts and myoblast differentiation. A UV-photopatterned thiol-ene mold was ...
Antibody conjugated Pegylated Cerium oxide nanoparticles for specific targeting of Aβ aggregates modulate neuronal survival pathways
10-02-2012 | Annamaria Cimini, Barbara D’Angelo, Soumen Das, Roberta Gentile, Elisabetta Benedetti, ..., Acta Biomaterialia, 2012
Oxidative stress has been found to be associated in progression of neurodegenerative diseases such as Alzheimer’s, Parkinson’s, Lou Gehrig’s, etc. In the recent years, cerium oxide nanoparticles (CNPs) were studied as potent antioxidant agents able to exert neuroprotective effects. This work ...
Self-Assembling Glucagon-Like Peptide 1-Mimetic Peptide Amphiphiles for Enhanced Activity and Proliferation of Insulin-Secreting Cells
10-02-2012 | Saahir Khan, Shantanu Sur, Christina J. Newcomb, Elizabeth A. Appelt, Samuel I. Stupp, Acta Biomaterialia, 2012
Current treatment for type 1 diabetes mellitus requires daily insulin injections that fail to produce physiological glycemic control. Islet cell transplantation has been proposed as a permanent cure but is limited by loss of β-cell viability and function. These limitations could potentially ...
Neuroprotective Effect of Undecylenic Acid Extracted fromRicinusCommunisL.through Inhibition of μ-Calpain
09-02-2012 | Eunyoung Lee, Ji-Eun Eom, Hye-Lin Kim, Da-Hye Kang, Kyu-Yeon Jun, ..., European Journal of Pharmaceutical Science, 2012
The key neuropathological features of Alzheimer’s disease are abnormal deposition of Aβ plaques and insoluble Aβ peptides in extracellular brain and intracellular neurofibril tangles induced by abnormal tau hyperphosphorylation. μ-Calpain is one of the factors that bridge these Aβ- and ...
Recent advances in bioinorganic chemistry of bismuth
08-02-2012 | Hongyan Li, Hongzhe Sun, Current Opinion in Chemical Biology, 2012
Bismuth has been used in medicine for over two centuries for the treatment of various diseases, in particular for gastrointestinal disorders, owing to its antimicrobial activity. Recent structural characterization of bismuth drugs provides an insight into assembly and pharmacokinetic pathway ...
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