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2,899 Newest Publications of Cold Spring Harbor Laboratory Press
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GPAT2, a mitochondrial outer membrane protein, in piRNA biogenesis in germline stem cells [ARTICLES]
01-06-2013 | Yusuke Shiromoto; Satomi Kuramochi-Miyagawa; Akito Daiba; Shinichiro Chuma; Ami Katanaya; Akiko Katsumata; Ken Nishi ..., RNA, 2013
piRNA (PIWI-interacting RNA) is a germ cell–specific small RNA in which biogenesis PIWI (P-element wimpy testis) family proteins play crucial roles. MILI (mouse Piwi-like), one of the three mouse PIWI family members, is indispensable for piRNA production, DNA methylation of retrotransposons ...
Identification of purple sea urchin telomerase RNA using a next-generation sequencing based approach [METHOD]
01-06-2013 | Yang Li; Joshua D. Podlevsky; Manja Marz; Xiaodong Qi; Steve Hoffmann; Peter F. Stadler; Julian J.-L. Chen, RNA, 2013
Telomerase is a ribonucleoprotein (RNP) enzyme essential for telomere maintenance and chromosome stability. While the catalytic telomerase reverse transcriptase (TERT) protein is well conserved across eukaryotes, telomerase RNA (TR) is extensively divergent in size, sequence, and structure. ...
Escherichia coli rimM and yjeQ null strains accumulate immature 30S subunits of similar structure and protein complement [ARTICLES]
01-06-2013 | Vivian Leong; Meredith Kent; Ahmad Jomaa; Joaquin Ortega, RNA, 2013
Assembly of the Escherichia coli 30S ribosomal subunits proceeds through multiple parallel pathways. The protein factors RimM, YjeQ, RbfA, and Era work in conjunction to assist at the late stages of the maturation process of the small subunit. However, it is unclear how the functional ...
RNA recognition by the DNA end-binding Ku heterodimer [ARTICLES]
01-06-2013 | Andrew B. Dalby; Karen J. Goodrich; Jennifer S. Pfingsten; Thomas R. Cech, RNA, 2013
Most nucleic acid-binding proteins selectively bind either DNA or RNA, but not both nucleic acids. The Saccharomyces cerevisiae Ku heterodimer is unusual in that it has two very different biologically relevant binding modes: (1) Ku is a sequence-nonspecific double-stranded DNA end-binding ...
The rRNA methyltransferase Bud23 shows functional interaction with components of the SSU processome and RNase MRP [ARTICLES]
01-06-2013 | Richa Sardana; Joshua P. White; Arlen W. Johnson, RNA, 2013
Bud23 is responsible for the conserved methylation of G1575 of 18S rRNA, in the P-site of the small subunit of the ribosome. bud23 mutants have severely reduced small subunit levels and show a general failure in cleavage at site A2 during rRNA processing. Site A2 is the primary cleavage site ...
Post-retrieval late process contributes to persistence of reactivated fear memory [BRIEF COMMUNICATIONS]
01-06-2013 | Daisuke Nakayama; Yoshiko Yamasaki; Norio Matsuki; Hiroshi Nomura, Learning & Memory, 2013
Several studies have demonstrated the mechanisms involved in memory persistence after learning. However, little is known about memory persistence after retrieval. In this study, a protein synthesis inhibitor, anisomycin, was infused into the basolateral amygdala of mice 9.5 h after retrieval ...
microRNAs are ligands of Toll-like receptors [MINI-REVIEW]
01-06-2013 | Xi Chen; Hongwei Liang; Junfeng Zhang; Ke Zen; Chen-Yu Zhang, RNA, 2013
It has long been known that microRNAs (miRNAs) can regulate target gene expression at the post-transcriptional level. Recent studies, however, have revealed that miRNAs can also be transported from donor cells to recipient cells, in which these RNAs function in a novel manner as ligands of ...
Hippocampus and medial prefrontal cortex contributions to trace and contextual fear memory expression over time [RESEARCH]
01-06-2013 | Christopher L. Beeman; Philip S. Bauer; Jamie L. Pierson; Jennifer J. Quinn, Learning & Memory, 2013
Previous work has shown that damage to the dorsal hippocampus (DH) occurring at recent, but not remote, timepoints following acquisition produces a deficit in trace conditioned fear memory expression. The opposite pattern has been observed with lesions to the medial prefrontal cortex (mPFC). ...
Fabrication of 14 different RNA nanoparticles for specific tumor targeting without accumulation in normal organs [ARTICLES]
01-06-2013 | Yi Shu; Farzin Haque; Dan Shu; Wei Li; Zhenqi Zhu; Malak Kotb; Yuri Lyubchenko; Peixuan Guo, RNA, 2013
Due to structural flexibility, RNase sensitivity, and serum instability, RNA nanoparticles with concrete shapes for in vivo application remain challenging to construct. Here we report the construction of 14 RNA nanoparticles with solid shapes for targeting cancers specifically. These RNA ...
NR2A- and NR2B-containing NMDA receptors in the prelimbic medial prefrontal cortex differentially mediate trace, delay, and contextual fear conditioning [BRIEF COMMUNICATIONS]
01-06-2013 | Marieke R. Gilmartin; Janine L. Kwapis; Fred J. Helmstetter, Learning & Memory, 2013
Activation of N-methyl-D-aspartate receptors (NMDAR) in the prelimbic medial prefrontal cortex (PL mPFC) is necessary for the acquisition of both trace and contextual fear memories, but it is not known how specific NR2 subunits support each association. The NR2B subunit confers unique ...
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