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5,724 Newest Publications of American Chemical Society Publications
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Metabolomics as a Potential New Approach for Investigating Human Reproductive Disorders
17-05-2013 | Frédérique Courant; Jean-Philippe Antignac; Fabrice Monteau; Bruno Le Bizec, Journal of Proteome Research, 2013
Metabolomics has been emerging for several years as a global chemical phenotyping approach offering fascinating descriptive capabilities for addressing life complexity. It facilitates the understanding of the mechanisms of biological and biochemical processes in complex systems and promises ...
Antitumor Activity of Tumor-Targeted RNA Replicase-Based Plasmid That Expresses Interleukin-2 in a Murine Melanoma Model
17-05-2013 | B. Leticia Rodriguez; Jorge M. Blando; Dharmika S. P. Lansakara-P; Yuriko Kiguchi; John DiGiovanni; Zhengrong Cui, Molecular Pharmaceutics, 2013
Double-stranded RNA (dsRNA) has multiple antitumor mechanisms that may be used to control tumor growth. Previously we have shown that treatment of solid tumors with a plasmid that encodes Sindbis viral RNA replicase complex, pSIN-β, significantly inhibited the growth of tumors in mice. In the ...
Systemic Responses of Mice to Dextran Sulfate Sodium-Induced Acute Ulcerative Colitis Using 1H NMR Spectroscopy
17-05-2013 | Fangcong Dong; Lulu Zhang; Fuhua Hao; Huiru Tang; Yulan Wang, Journal of Proteome Research, 2013
The interplay between genetic mutation and environmental factors is believed to contribute to the etiology of inflammatory bowel disease (IBD). While focused attention has been paid to the aforementioned research, time-specific and organ-specific metabolic changes associated with IBD are ...
Understanding the Biological Context of NS5A–Host Interactions in HCV Infection: A Network-Based Approach
17-05-2013 | Lokesh P. Tripathi; Hiroto Kambara; Yi-An Chen; Yorihiro Nishimura; Kohji Moriishi; Toru Okamoto; Eiji Morita; Takay ..., Journal of Proteome Research, 2013
Hepatitis C virus (HCV) is a major cause of chronic liver disease. HCV NS5A protein plays an important role in HCV infection through its interactions with other HCV proteins and host factors. In an attempt to further our understanding of the biological context of protein interactions between ...
Intracellular Drug Delivery Nanocarriers of Glutathione-Responsive Degradable Block Copolymers Having Pendant Disulfide Linkages
17-05-2013 | Behnoush Khorsand; Gabriel Lapointe; Christopher Brett; Jung Kwon Oh, Biomacromolecules, 2013
Self-assembled micelles of amphiphilic block copolymers (ABPs) with stimuli-responsive degradation (SRD) properties have a great promise as nanotherapeutics exhibiting enhanced release of encapsulated therapeutics into targeted cells. Here, thiol-responsive degradable micelles based on a new ...
Ab Initio Molecular Dynamics of Na+ and Mg2+ Countercations at the Backbone of RNA in Water Solution
17-05-2013 | Stefan Kolev; Petko St. Petkov; Miroslav Rangelov; Georgi N. Vayssilov, ACS Chemical Biology, 2013
The interactions between sodium or magnesium ions and phosphate groups of the RNA backbone represented as dinucleotide fragments in water solution have been studied using ab initio Born–Oppenheimer molecular dynamics. All systems have been simulated at 300 and 320 K. Sodium ions have mobility ...
An Immunocytochemical-Derived Correlate for Evaluating the Bridging of Heteromeric Mu-Delta Opioid Protomers by Bivalent Ligands
17-05-2013 | Ajay S. Yekkirala; Alexander E Kalyuzhny; Philip S. Portoghese, ACS Chemical Biology, 2013
Bivalent ligands that contain two pharmacophores linked by a spacer are promising tools to investigate the pharmacology of opioid receptor heteromers. Evidence for occupation of neighboring protomers by two phamacophores of a single bivalent ligand (bridging) has relied mainly on ...
Thiol-ene Enabled Detection of Thiophosphorylated Kinase Substrates
17-05-2013 | Kathleen C. A. Garber; Erin E. Carlson, ACS Chemical Biology, 2013
Protein phosphorylation is a ubiquitous posttranslational modification that regulates cell signaling in both prokaryotes and eukaryotes. Although the study of phosphorylation has made great progress, several major hurdles remain, including the difficulty of the assignment of endogenous ...
Reversal of Multidrug Resistance by Mitochondrial Targeted Self-Assembled Nanocarrier Based on Stearylamine
16-05-2013 | Zhiwen Zhang; Zeying Liu; Li Ma; Shijun Jiang; Yixin Wang; Haijun Yu; Qi Yin; Jingbin Cui; Yaping Li, Molecular Pharmaceutics, 2013
Multidrug resistance (MDR) remains one of the major challenges for successful chemotherapy. Herein, we tried to develope a mitochondria targeted teniposide loaded self-assembled nanocarrier based on stearylamine (SA-TSN) to reverse MDR of breast cancer. SA-TSN was nanometer-sized spherical ...
The Influence of Maltotriose-Modified Poly(propylene imine) Dendrimers on the Chronic Lymphocytic Leukemia Cells in Vitro: Dense Shell G4 PPI
16-05-2013 | Ida Franiak-Pietryga; Ewelina Ziółkowska; Barbara Ziemba; Dietmar Appelhans; Brigitte Voit; Michał Szewczyk; Joanna ..., Molecular Pharmaceutics, 2013
Chronic lymphocytic leukemia (CLL) is the most common leukemia in Europe and North America. For many years scientists and doctors have been working on introducing the most effective therapy into CLL as prognosis of survival time and the course of the disease differ among patients, which might ...
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