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10,853 Newest Publications in proceedings of the national academy of sciences current issue
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Self-assembled, aptamer-tethered DNA nanotrains for targeted transport of molecular drugs in cancer theranostics [Applied Biological Sciences]
14-05-2013 | Guizhi Zhu; Jing Zheng; Erqun Song; Michael Donovan; Kejing Zhang; Chen Liu; Weihong Tan, Proceedings of the National Academy of Sciences current issue, 2013
Nanotechnology has allowed the construction of various nanostructures for applications, including biomedicine. However, a simple target-specific, economical, and biocompatible drug delivery platform with high maximum tolerated doses is still in demand. Here, we report aptamer-tethered DNA ...
Blood meal-induced changes to antennal transcriptome profiles reveal shifts in odor sensitivities in Anopheles gambiae [Neuroscience]
14-05-2013 | David C. Rinker; R. Jason Pitts; Xiaofan Zhou; Eunho Suh; Antonis Rokas; Laurence J. Zwiebel, Proceedings of the National Academy of Sciences current issue, 2013
Olfactory-driven behaviors are central to the lifecycle of the malaria vector mosquito Anopheles gambiae and are initiated by peripheral signaling in the antenna and other olfactory tissues. To continue gaining insight into the relationship between gene expression and olfaction, we have ...
Structures of the phage Sf6 large terminase provide new insights into DNA translocation and cleavage [Biochemistry]
14-05-2013 | Haiyan Zhao; Theodore E. Christensen; Yvonne N. Kamau; Liang Tang, Proceedings of the National Academy of Sciences current issue, 2013
Many DNA viruses use powerful molecular motors to cleave concatemeric viral DNA into genome-length units and package them into preformed procapsid powered by ATP hydrolysis. Here we report the structures of the DNA-packaging motor gp2 of bacteriophage Sf6, which reveal a unique clade of ...
Gene silencing in adipose tissue macrophages regulates whole-body metabolism in obese mice [Physiology]
14-05-2013 | Myriam Aouadi; Michaela Tencerova; Pranitha Vangala; Joseph C. Yawe; Sarah M. Nicoloro; Shinya U. Amano; Jessica L. ..., Proceedings of the National Academy of Sciences current issue, 2013
Adipose tissue (AT) inflammation and infiltration by macrophages is associated with insulin resistance and type 2 diabetes in obese humans, offering a potential target for therapeutics. However, whether AT macrophages (ATMs) directly contribute to systemic glucose intolerance has not been ...
Viscosity of {alpha}-pinene secondary organic material and implications for particle growth and reactivity [Earth, Atmospheric, and Planetary Sciences]
14-05-2013 | Lindsay Renbaum-Wolff; James W. Grayson; Adam P. Bateman; Mikinori Kuwata; Mathieu Sellier; Benjamin J. Murray; John ..., Proceedings of the National Academy of Sciences current issue, 2013
Particles composed of secondary organic material (SOM) are abundant in the lower troposphere. The viscosity of these particles is a fundamental property that is presently poorly quantified yet required for accurate modeling of their formation, growth, evaporation, and environmental impacts. ...
Targeted resequencing implicates the familial Mediterranean fever gene MEFV and the toll-like receptor 4 gene TLR4 in Behcet disease [Genetics]
14-05-2013 | Yohei Kirino; Qing Zhou; Yoshiaki Ishigatsubo; Nobuhisa Mizuki; Ilknur Tugal-Tutkun; Emire Seyahi; Yilmaz Özyazgan; ..., Proceedings of the National Academy of Sciences current issue, 2013
Genome-wide association studies (GWAS) are a powerful means of identifying genes with disease-associated common variants, but they are not well-suited to detecting genes with disease-associated rare and low-frequency variants. In the current study of Behçet disease (BD), nonsynonymous ...
Limits to upward movement of subalpine forests in a warming climate [Ecology]
14-05-2013 | Daniel C. Donato, Proceedings of the National Academy of Sciences current issue, 2013
Rapid changes to the earth’s climate are well underway, already influencing biological systems across the globe. Among the key impacts are potential shifts in the geographic range of many species or ecosystems, often predicted to move either poleward or upward in response to warmer conditions ...
Anomalous heat transport and condensation in convection of cryogenic helium [Physics]
14-05-2013 | Pavel Urban; David Schmoranzer; Pavel Hanzelka; Katepalli R. Sreenivasan; Ladislav Skrbek, Proceedings of the National Academy of Sciences current issue, 2013
When a hot body A is thermally connected to a cold body B, the textbook knowledge is that heat flows from A to B. Here, we describe the opposite case in which heat flows from a colder but constantly heated body B to a hotter but constantly cooled body A...
Neural predictors of individual differences in response to math tutoring in primary-grade school children [Neuroscience]
14-05-2013 | Kaustubh Supekar; Anna G. Swigart; Caitlin Tenison; Dietsje D. Jolles; Miriam Rosenberg-Lee; Lynn Fuchs; Vinod Menon, Proceedings of the National Academy of Sciences current issue, 2013
Now, more than ever, the ability to acquire mathematical skills efficiently is critical for academic and professional success, yet little is known about the behavioral and neural mechanisms that drive some children to acquire these skills faster than others. Here we investigate the behavioral ...
Diversity, host switching and evolution of Plasmodium vivax infecting African great apes [Evolution]
14-05-2013 | Franck Prugnolle; Virginie Rougeron; Pierre Becquart; Antoine Berry; Boris Makanga; Nil Rahola; Céline Arnathau; Bar ..., Proceedings of the National Academy of Sciences current issue, 2013
Plasmodium vivax is considered to be absent from Central and West Africa because of the protective effect of Duffy negativity. However, there are reports of persons returning from these areas infected with this parasite and observations suggesting the existence of transmission. Among the ...
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