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2,930 Newest Publications in nucleic acids research
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matching the following criteria
EBP1 and DRBP76/NF90 binding proteins are included in the major histocompatibility complex class II RNA operon
01-09-2011 | Corso, C., Pisapia, L., Citro, A., Cicatiello, V., Barba, P., Cigliano, L., Abrescia, P., Maffei, A., Manco, G., Del ..., Nucleic Acids Research, 2011
Major histocompatibility complex class II mRNAs encode heterodimeric proteins involved in the presentation of exogenous antigens during an immune response. Their 3'UTRs bind a protein complex in which we identified two factors: EBP1, an ErbB3 receptor-binding protein and DRBP76, a ...
Functional conservation in human and Drosophila of Metazoan ADAR2 involved in RNA editing: loss of ADAR1 in insects
01-09-2011 | Keegan, L. P., McGurk, L., Palavicini, J. P., Brindle, J., Paro, S., Li, X., Rosenthal, J. J. C., O'Connell, M. A., Nucleic Acids Research, 2011
Flies with mutations in the single Drosophila Adar gene encoding an RNA editing enzyme involved in editing 4% of all transcripts have severe locomotion defects and develop age-dependent neurodegeneration. Vertebrates have two ADAR-editing enzymes that are catalytically active; ADAR1 and ...
The in vitro loose dimer structure and rearrangements of the HIV-2 leader RNA
01-09-2011 | Purzycka, K. J., Pachulska-Wieczorek, K., Adamiak, R. W., Nucleic Acids Research, 2011
RNA dimerization is an essential step in the retroviral life cycle. Dimerization and encapsidation signals, closely linked in HIV-2, are located in the leader RNA region. The SL1 motif and nucleocapsid protein are considered important for both processes. In this study, we show the structure ...
Characterization of extracellular circulating microRNA
01-09-2011 | Turchinovich, A., Weiz, L., Langheinz, A., Burwinkel, B., Nucleic Acids Research, 2011
MicroRNAs (miRNAs), a class of post-transcriptional gene expression regulators, have recently been detected in human body fluids, including peripheral blood plasma as extracellular nuclease resistant entities. However, the origin and function of extracellular circulating miRNA remain ...
Depurination of Brome mosaic virus RNA3 inhibits its packaging into virus particles
01-09-2011 | Karran, R. A., Hudak, K. A., Nucleic Acids Research, 2011
Packaging of the segmented RNA genome of Brome mosaic virus (BMV) into discrete particles is an essential step in the virus life cycle; however, questions remain regarding the mechanism of RNA packaging and the degree to which the viral coat protein controls the process. In this study, we ...
Design principles for bifunctional targeted oligonucleotide enhancers of splicing
01-09-2011 | Owen, N., Zhou, H., Malygin, A. A., Sangha, J., Smith, L. D., Muntoni, F., Eperon, I. C., Nucleic Acids Research, 2011
Controlling the patterns of splicing of specific genes is an important goal in the development of new therapies. We have shown that the splicing of a refractory exon, SMN2 exon 7, could be increased in fibroblasts derived from patients with spinal muscular atrophy by using bifunctional ...
PROMoter uPstream Transcripts share characteristics with mRNAs and are produced upstream of all three major types of mammalian promoters
01-09-2011 | Preker, Pascal; Almvig, Kristina; Christensen, Marianne S.; Valen, Eivind; Mapendano, Christophe K.; Sandelin, Albin ..., Nucleic Acids Research, 2011
PROMoter uPstream Transcripts (PROMPTs) were identified as a new class of human RNAs, which are heterologous in length and produced only upstream of the promoters of active protein-coding genes. Here, we show that PROMPTs carry 3'-adenosine tails and 5'-cap structures. However, unlike mRNAs, ...
G4 Resolvase 1 tightly binds and unwinds unimolecular G4-DNA
01-09-2011 | Giri, B., Smaldino, P. J., Thys, R. G., Creacy, S. D., Routh, E. D., Hantgan, R. R., Lattmann, S., Nagamine, Y., Akm ..., Nucleic Acids Research, 2011
It has been previously shown that the DHX36 gene product, G4R1/RHAU, tightly binds tetramolecular G4-DNA with high affinity and resolves these structures into single strands. Here, we test the ability of G4R1/RHAU to bind and unwind unimolecular G4-DNA. Gel mobility shift assays were used to ...
Avoiding cytotoxicity of transposases by dose-controlled mRNA delivery
01-09-2011 | Galla, M., Schambach, A., Falk, C. S., Maetzig, T., Kuehle, J., Lange, K., Zychlinski, D., Heinz, N., Brugman, M. H. ..., Nucleic Acids Research, 2011
The Sleeping Beauty (SB) transposase and its newly developed hyperactive variant, SB100X, are of increasing interest for genome modification in experimental models and gene therapy. The potential cytotoxicity of transposases requires careful assessment, considering that residual integration ...
Adenine and guanine recognition of stop codon is mediated by different N domain conformations of translation termination factor eRF1
01-09-2011 | Bulygin, K. N., Khairulina, Y. S., Kolosov, P. M., Ven'yaminova, A. G., Graifer, D. M., Vorobjev, Y. N., Frolova, L. ..., Nucleic Acids Research, 2011
Positioning of release factor eRF1 toward adenines and the ribose-phosphate backbone of the UAAA stop signal in the ribosomal decoding site was studied using messenger RNA (mRNA) analogs containing stop signal UAA/UAAA and a photoactivatable cross-linker at definite locations. The human eRF1 ...
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