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305 Newest Publications in naunyn-schmiedeberg's archives of pharmacology
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The type 2 CCK/gastrin receptor antagonist YF476 acutely prevents NSAID-induced gastric ulceration while increasing iNOS expression
26-11-2012 | Dominic-Luc Webb, Tobias Rudholm-Feldreich, Linda Gillberg, Md. Abdul Halim, Elvar Theodorsson, Gareth J. Sanger, Co ..., Naunyn-Schmiedeberg's Archives of Pharmacology, 2012
YF476 differs from the proton pump inhibitor (PPI) esomeprazole in mode of action by antagonizing the type 2 receptor of cholecystokinin/gastrin (CCK-2R). YF476 protection against diclofenac-induced gastric ulcers was compared to esomeprazole and correlated with plasma levels of hormones ...
Interaction of D3 preferring agonist (−)-N
6-(2-(4-(biphenyl-4-yl)piperazin-1-yl)ethyl)-N
6-propyl-4,5,6,7-tetrahydrobenzo[d]thiazole-2,6-diamine (D-264) with cloned human D2L, D2S, and D3 receptors: potent stimulation of mitogen-activated protein kinases and G protein-coupled inward rectifier potassium channels
19-11-2012 | Eldo V. Kuzhikandathil, Samantha Cote, Soumava Santra, Aloke K. Dutta, Naunyn-Schmiedeberg's Archives of Pharmacology, 2012
This study aims to determine the effect of the novel D3 dopamine receptor agonist, D-264, on activation of D3 and D2 dopamine receptor signal transduction pathways and cell proliferation. AtT-20 neuroendocrine cells stably expressing human D2S, D2L, and D3 dopamine receptors were treated with ...
Nitrosonifedipine ameliorates angiotensin II-induced vascular remodeling via antioxidative effects
13-11-2012 | Takumi Sakurada, Keisuke Ishizawa, Masaki Imanishi, Yuki Izawa-Ishizawa, Shoko Fujii, Erika Tominaga, Teppei Tsuneis ..., Naunyn-Schmiedeberg's Archives of Pharmacology, 2012
Nifedipine is unstable under light and decomposes to a stable nitroso analog, nitrosonifedipine (NO-NIF). The ability of NO-NIF to block calcium channels is quite weak compared with that of nifedipine. Recently, we have demonstrated that NO-NIF reacts with unsaturated fatty acid leading to ...
Modulation by the noble gas argon of the catalytic and thrombolytic efficiency of tissue plasminogen activator
11-11-2012 | Hélène N. David, Benoît Haelewyn, Jean-Jacques Risso, Jacques H. Abraini, Naunyn-Schmiedeberg's Archives of Pharmacology, 2012
Argon has been shown to provide cortical as well as, under certain conditions, subcortical neuroprotection in all models so far (middle cerebral artery occlusion, trauma, neonatal asphyxia, etc.). This has led to the suggestion that argon could be a cost-efficient alternative to xenon, a ...
Cross-regulation between cardiac muscarinic acetylcholine receptors and β-adrenoceptors: lessons for use of knock-out mice
09-11-2012 | Stefan Dhein, Sandy von Salisch, Martin C. Michel, Naunyn-Schmiedeberg's Archives of Pharmacology, 2012
Cross-regulation between cardiac muscarinic acetylcholine receptors and β-adrenoceptors: lessons for use of knock-out mice Content Type Journal Article Category Editorial Pages 1-3 DOI 10.1007/s00210-012-0805-4 Authors Stefan Dhein, Clinic for Cardiac Surgery, University Leipzig, ...
Antiangiogenic role of miR-361 in human umbilical vein endothelial cells: functional interaction with the peptide somatostatin
05-11-2012 | Massimo Dal Monte, Debora Landi, Davide Martini, Paola Bagnoli, Naunyn-Schmiedeberg's Archives of Pharmacology, 2012
Somatostatin (SRIF) acts as antiangiogenic factor, but its role in the regulation of microRNAs (miRNAs) targeting proangiogenic factors is unknown. We used human umbilical vein endothelial cells (HUVEC) to investigate whether (1) miRNAs targeting proangiogenic factors are influenced by ...
Antiulcerogenic activity of chlorogenic acid in different models of gastric ulcer
05-11-2012 | André T. Shimoyama, José Roberto Santin, Isabel D. Machado, Ana Mara de Oliveira e Silva, Illana L. Pereira de Melo, ..., Naunyn-Schmiedeberg's Archives of Pharmacology, 2012
Chlorogenic acid (CGA) is found in many foods, including coffee, berries, potatoes, carrots, wine, apples, and various herbs, and has anti-inflammatory, antidiabetic, and antitumoral actions. The CGA is well absorbed orally, and its effects on gastric ulcer have not been previously reported. ...
Dopamine D3 receptor antagonism—still a therapeutic option for the treatment of schizophrenia
05-11-2012 | Gerhard Gross, Karsten Wicke, Karla U. Drescher, Naunyn-Schmiedeberg's Archives of Pharmacology, 2012
The potential of D3 receptor antagonism to treat positive, negative, and cognitive symptoms of schizophrenia is reviewed on the basis of preclinical results and preliminary clinical data. Dopamine D3 receptors are expressed in mesencephalic, limbic, and cortical areas relevant to psychotic ...
Rationale in support of the use of selective dopamine D3 receptor antagonists for the pharmacotherapeutic management of substance use disorders
28-10-2012 | Christian Heidbreder, Naunyn-Schmiedeberg's Archives of Pharmacology, 2012
Growing evidence indicates that dopamine (DA) D3 receptors are involved in the control of drug-seeking behavior and may play an important role in the pathophysiology of substance use disorders. First, DA D3 receptors are distributed in strategic areas belonging to the mesolimbic DA system ...
Voltage-dependent open-channel block of G protein-gated inward-rectifying K+ (GIRK) current in rat atrial myocytes by tamoxifen
24-10-2012 | Svenja Vanheiden, Lutz Pott, Marie-Cécile Kienitz, Naunyn-Schmiedeberg's Archives of Pharmacology, 2012
Tamoxifen (Tmx) is a nonsteroidal selective estrogen receptor antagonist and is frequently used in the treatment and prevention of breast cancer. The compound and its metabolites have been reported to inhibit functions of different classes of membrane proteins, including various ion channels. ...
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