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292 Newest Publications in mutagenesis
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Does the recommended lymphocyte cytokinesis-block micronucleus assay for human biomonitoring actually detect DNA damage induced by occupational and environmental exposure to genotoxic chemicals?
01-07-2013 | Günter Speit, Mutagenesis, 2013
This commentary challenges the paradigm that the cytokinesis-block micronucleus assay (CBMN assay) with cultured human lymphocytes, as it is performed currently, is a sensitive and useful tool for detecting genotoxic effects in populations exposed occupationally or environmentally to ...
Kinetics of nuclear phosphorylation ({gamma}-H2AX) in human lymphocytes treated in vitro with UVB, bleomycin and mitomycin C
01-07-2013 | Roberto Scarpato; Sara Castagna; Rosamaria Aliotta; Alessia Azzarà; Francesco Ghetti; Erika Filomeni; Caterina Giova ..., Mutagenesis, 2013
After double-strand break induction, formation of -H2AX foci due to phosphorylation at Ser-139 of histone H2AX represents an early event of the DNA damage response (DDR). -H2AX foci are then rapidly dephosphorylated as signal for the subsequent recruitment of effector proteins. The induction ...
DNA damage-independent apoptosis induced by curcumin in normal resting human T cells and leukaemic Jurkat cells
01-07-2013 | Zbigniew Korwek; Anna Bielak-Zmijewska; Grazyna Mosieniak; Olga Alster; Maria Moreno-Villanueva; Alexander Burkle; E ..., Mutagenesis, 2013
Curcumin, a phytochemical derived from the rhizome of Curcuma longa, is a very potent inducer of cancer cell death. It is believed that cancer cells are more sensitive to curcumin treatment than normal cells. Curcumin has been shown to act as a prooxidant and induce DNA lesions in normal ...
The comet assay, DNA damage, DNA repair and cytotoxicity: hedgehogs are not always dead
01-07-2013 | Yolanda Lorenzo; Solange Costa; Andrew R. Collins; Amaya Azqueta, Mutagenesis, 2013
DNA damage is commonly measured at the level of individual cells using the so-called comet assay (single-cell gel electrophoresis). As the frequency of DNA breaks increases, so does the fraction of the DNA extending towards the anode, forming the comet tail. Comets with almost all DNA in the ...
Necrosis is increased in lymphoblastoid cell lines from children with autism compared with their non-autistic siblings under conditions of oxidative and nitrosative stress
01-07-2013 | Penelope A. E. Main; Philip Thomas; Adrian Esterman; Michael F. Fenech, Mutagenesis, 2013
Autism spectrum disorders are a heterogeneous group of neurodevelopmental conditions characterised by impairments in reciprocal social interaction, communication and stereotyped behaviours. As increased DNA damage events have been observed in a range of other neurological disorders, it was ...
Relationships among micronuclei, nucleoplasmic bridges and nuclear buds within individual cells in the cytokinesis-block micronucleus assay
01-07-2013 | Han S. J. Cheong; Isheeta Seth; Michael C. Joiner; James D. Tucker, Mutagenesis, 2013
Micronuclei have been used extensively in studies as an easily evaluated indicator of DNA damage but little is known about their association with other types of damage such as nucleoplasmic bridges and nuclear buds. Here, radiation-induced clastogenic events were evaluated via the ...
Seven benzimidazole pesticides combined at sub-threshold levels induce micronuclei in vitro
01-07-2013 | Sibylle Ermler; Martin Scholze; Andreas Kortenkamp, Mutagenesis, 2013
Benzimidazoles act by disrupting microtubule polymerisation and are capable of inducing the formation of micronuclei. Considering the similarities in their mechanisms of action (inhibition of microtubule assembly by binding to the colchicine-binding site on tubulin monomers), combination ...
Thirdhand smoke causes DNA damage in human cells
01-07-2013 | Bo Hang; Altaf H. Sarker; Christopher Havel; Saikat Saha; Tapas K. Hazra; Suzaynn Schick; Peyton Jacob III; Virender ..., Mutagenesis, 2013
Exposure to thirdhand smoke (THS) is a newly described health risk. Evidence supports its widespread presence in indoor environments. However, its genotoxic potential, a critical aspect in risk assessment, is virtually untested. An important characteristic of THS is its ability to undergo ...
The involvement of WT1 in the regulation of GADD45a in response to genotoxic stress
01-07-2013 | Donna Johnson; Paul W. Hastwell; Richard M. Walmsley, Mutagenesis, 2013
Expression of the human GADD45a gene is increased in TK6 cells exposed to mutagens, clastogens and aneugens. It is known to be regulated through both p53-dependent and p53-independent pathways and WT1 has been implicated in both cases. This article reports an investigation into the effect ...
Sensitivity of the Pig-a assay for detecting gene mutation in rats exposed acutely to strong clastogens
01-07-2013 | Javed A. Bhalli; Joseph G. Shaddock; Mason G. Pearce; Vasily N. Dobrovolsky, Mutagenesis, 2013
Clastogens are potential human carcinogens whose detection by genotoxicity assays is important for safety assessment. Although some endogenous genes are sensitive to the mutagenicity of clastogens, many genes that are used as reporters for in vivo mutation (e.g. transgenes) are not. In this ...
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