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485 Newest Publications in molecular carcinogenesis
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Chemoprevention of lung carcinogenesis by the combination of aerosolized budesonide and oral pioglitazone in A/J mice
03-03-2011 | Fu, Huijing; Zhang, Jingjie; Pan, Jing; Zhang, Qi; Lu, Yan; Wen, Weidong; Lubet, Ronald A.; Szabo, Eva; Chen, Ruth; ..., Molecular Carcinogenesis, 2011
Abstract Budesonide, a synthetic glucocorticoid used for treating asthma, and pioglitazone, a synthetic peroxisome proliferator‐activated receptors γ ligand used for the treatment of diabetes, were evaluated for their combinational chemopreventive efficacy on mouse lung cancer using female ...
Hodgkin lymphoma risk: Role of genetic polymorphisms and gene–gene interactions in DNA repair pathways
03-03-2011 | Monroy, Claudia M.; Cortes, Andrea C.; Lopez, Mirtha; Rourke, Elizabeth; Etzel, Carol J.; Younes, Anas; Strom, Sara ..., Molecular Carcinogenesis, 2011
Abstract DNA repair variants may play a potentially important role in an individual's susceptibility to developing cancer. Numerous studies have reported the association between genetic single nucleotide polymorphisms (SNPs) in DNA repair genes and different types of hematologic cancers. ...
Analysis of HP1α regulation in human breast cancer cells
03-03-2011 | Thomsen, Rune; Christensen, Dennis B.; Rosborg, Sanne; Linnet, Toke E.; Blechingberg, Jenny; Nielsen, Anders L., Molecular Carcinogenesis, 2011
Abstract The three mammalian HP1 proteins, HP1α/CBX5, HP1β/CBX1, and HPγ/CBX3, are involved in chromatin packing and gene regulation. The HP1α protein is down‐regulated in invasive compared to non‐invasive breast cancer cells and HP1α is a suppressor of cell migration and invasion. In this ...
Hypermethylation of apoptotic genes as independent prognostic factor in neuroblastoma disease
01-03-2011 | Elena Grau; Francisco Martinez; Carmen Orellana; Adela Canete; Yania Yañez; Silvestre Oltra; Rosa Noguera; Miguel He ..., Molecular Carcinogenesis, 2011
Abstract Neuroblastoma (NB) is an embryonal tumour of neuroectodermal cells, and its prognosis is based on patient age at diagnosis, tumour stage and MYCN amplification, but it can also be classified according to their degree of methylation. Considering that epigenetic aberrations could ...
Ah receptor antagonism inhibits constitutive and cytokine inducible IL6 production in head and neck tumor cell lines
01-03-2011 | DiNatale, Brett C.; Schroeder, Jennifer C.; Perdew, Gary H., Molecular Carcinogenesis, 2011
Abstract There is increasing evidence that the aryl hydrocarbon receptor (AHR) plays a role in tumor progression through numerous mechanisms. We have previously shown that, in certain cancer cell lines that are typically nonresponsive to cytokine‐mediated IL6 induction, activation of the ...
Oncogenic H‐Ras, FK228, and exogenous H2O2 cooperatively activated the erk pathway in selective induction of human urinary bladder cancer j82 cell death
01-03-2011 | Choudhary, Shambhunath; Wang, Kwo‐Kwang Abraham; Wang, Hwa‐Chain Robert, Molecular Carcinogenesis, 2011
Abstract More than 35% of human urinary bladder cancers involve oncogenic H‐Ras activation. The goal of this study was to investigate the role of the ERK pathway in mediating apoptotic signals induced by oncogenic H‐Ras, FK228 treatment, and exogenous H2O2 treatment to increase Nox‐1 ...
Vascular endothelial growth factor (VEGF) gene polymorphisms and gastric cancer risk in a Chinese Han population
01-03-2011 | Zhou, Yong; Li, Ni; Zhuang, Wen; Wu, Xiaoting, Molecular Carcinogenesis, 2011
Abstract The association between vascular endothelial growth factor (VEGF) gene polymorphisms and gastric cancer risk is still controversial and ambiguous. The objective of this study was to investigate the association between VEGF gene polymorphisms and gastric cancer risk in Chinese Han ...
Association of IL‐1 polymorphisms and IL‐1 serum levels with susceptibility to nasopharyngeal carcinoma
01-03-2011 | Yang, Zhi‐Hui; Dai, Qiong; Zhong, Li; Zhang, Xu; Guo, Qing‐Xi; Li, Shi‐Ning, Molecular Carcinogenesis, 2011
Abstract Previous studies demonstrated that the polymorphism of interleukin‐1 (IL‐1) produce alterations of the protein expression and may contribute to oncogenetic processes. The aim of this study was to investigate the relationship between IL‐1A gene polymorphisms and NPC susceptibility ...
Methanol exposure does not lead to accumulation of oxidative DNA damage in bone marrow and spleen of mice, rabbits or primates
01-03-2011 | McCallum, Gordon P.; Siu, Michelle; Ondovcik, Stephanie L.; Sweeting, J. Nicole; Wells, Peter G., Molecular Carcinogenesis, 2011
Abstract Genotoxicity tests indicate methanol (MeOH) is not mutagenic, but a rodent study has suggested carcinogenic potential, which could result from free radical‐initiated oxidative DNA damage. To investigate this possibility we treated male CD‐1 mice, New Zealand white rabbits, and ...
The association of XPC polymorphisms and tea drinking with colorectal cancer risk in a Chinese population
01-03-2011 | Wu, Yinyin; Jin, Mingjuan; Liu, Bing; Liang, Xia; Yu, Yunxian; Li, Qilong; Ma, Xinyuan; Yao, Kaiyan; Chen, Kun, Molecular Carcinogenesis, 2011
Abstract The xeroderma pigmentosum complementation group C (XPC) is responsible for removal of bulky helix‐distorting DNA lesions. Several polymorphisms of XPC gene may modulate the colorectal cancer (CRC) susceptibility. We assessed the association of XPC Lys939Gln (A/C), Ala499Val (C/T), ...
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