To use all functions of this page, please activate cookies in your browser.
My watch list
my.bionity.com
my.bionity.com
With an accout for my.bionity.com you can always see everything at a glance – and you can configure your own website and individual newsletter.
- My watch list
- My saved searches
- My saved topics
- My newsletter
1,595 Newest Publications in journal of proteome research
rss
Reproducibility of Protein Identification of Selected Cell Types in Barrett’s Esophagus Analyzed by Combining Laser-Capture Microdissection and Mass Spectrometry
07-01-2011 | Christoph Stingl; Frederike G. I. van Vilsteren; Coskun Guzel; Fiebo J. W. ten Kate; Mike Visser; Kausilia K. Krishn ..., Journal of Proteome Research, 2011
Barrett’s esophagus (BE) is associated with increased risk of esophageal adenocarcinoma (EAC) and characterized by replacement of normal esophageal squamous epithelium by columnar epithelium. These alterations are also reflected in changes in the protein-expression profiles of the cell types ...
Mass Spectrometry Mapping of Epidermal Growth Factor Receptor Phosphorylation Related to Oncogenic Mutations and Tyrosine Kinase Inhibitor Sensitivity
07-01-2011 | Guolin Zhang; Bin Fang; Richard Z. Liu; Huiyi Lin; Fumi Kinose; Yun Bai; Umut Oguz; Elizabeth R. Remily-Wood; Jianno ..., Journal of Proteome Research, 2011
The epidermal growth factor receptor (EGFR) plays an important role in cancer by activating downstream signals important in growth and survival. Inhibitors of EGFR are frequently selected as treatment for cancer including lung cancer. We performed an unbiased and comprehensive search for EGFR ...
Collision Energy Optimization of b- and y-Ions for Multiple Reaction Monitoring Mass Spectrometry
07-01-2011 | Carly A. Holstein (Sherwood); Philip R. Gafken; Daniel B. Martin, Journal of Proteome Research, 2011
Multiple reaction monitoring (MRM) is a highly sensitive and increasingly popular method of targeted mass spectrometry (MS) that can be used to selectively detect and quantify peptides and their corresponding proteins of interest within biological samples. The sensitivity of MRM-MS is highly ...
Metabolic Signatures of Lung Cancer in Biofluids: NMR-Based Metabonomics of Urine
07-01-2011 | Joana Carrola; Cláudia M. Rocha; António S. Barros; Ana M. Gil; Brian J. Goodfellow; Isabel M. Carreira; ..., Journal of Proteome Research, 2011
In this study, 1H NMR-based metabonomics has been applied, for the first time to our knowledge, to investigate lung cancer metabolic signatures in urine, aiming at assessing the diagnostic potential of this approach and gaining novel insights into lung cancer metabolism and systemic effects. ...
Protein Microarray Signature of Autoantibody Biomarkers for the Early Detection of Breast Cancer
07-01-2011 | Karen S. Anderson; Sahar Sibani; Garrick Wallstrom; Ji Qiu; Eliseo A. Mendoza; Jacob Raphael; Eugenie Hainsworth; Wa ..., Journal of Proteome Research, 2011
Cancer patients spontaneously generate autoantibodies (AAb) to tumor-derived proteins. To detect AAb, we have probed novel high-density custom protein microarrays (NAPPA) expressing 4988 candidate tumor antigens with sera from patients with early stage breast cancer (IBC), and bound IgG was ...
Global Metabolic Phenotyping in an Experimental Laparotomy Model of Surgical Trauma
07-01-2011 | James M. Kinross; Nawar Alkhamesi; Richard H. Barton; David B. Silk; Ivan K. S. Yap; Ara W. Darzi; Elaine Holmes; Je ..., Journal of Proteome Research, 2011
Surgical trauma initiates a complex series of metabolic host responses designed to maintain homeostasis and ensure survival. 1H NMR spectroscopy was applied to intraoperative urine and plasma samples as part of a strategy to analyze the metabolic response of Wistar rats to a laparotomy model. ...
Mapping the Disease Protein Interactome: Toward a Molecular Medicine GPS to Accelerate Drug and Biomarker Discovery
07-01-2011 | Benoit Coulombe, Journal of Proteome Research, 2011
Genomic approaches such as genome-wide association studies (GWAS), disease genome sequencing projects, and genome-wide expression profiling analyses, in conjunction with classical genetic approaches, can identify human genes that are altered in disease, thereby suggesting a role for the ...
Proteomics Profiling of Microdissected Low- and High-Grade Prostate Tumors Identifies Lamin A as a Discriminatory Biomarker
07-01-2011 | Sergej Skvortsov; Georg Schäfer; Taras Stasyk; Christian Fuchsberger; Guenther Karl Bonn; Georg Bartsch; Helmu ..., Journal of Proteome Research, 2011
Proteomics screening methods for the identification of diagnostic and prognostic biomarkers in cancer are still lagging behind DNA- or RNA-based analysis. We used two-dimensional differential gel electrophoresis (2D-DIGE) in combination with laser capture microdissection (LCM) and ...
Quantification of Cholesterol-Metabolizing P450s CYP27A1 and CYP46A1 in Neural Tissues Reveals a Lack of Enzyme−Product Correlations in Human Retina but Not Human Brain
07-01-2011 | Wei-Li Liao; Gun-Young Heo; Nathan G. Dodder; Rachel E. Reem; Natalia Mast; Suber Huang; Pier Luigi DiPatre; Illario ..., Journal of Proteome Research, 2011
Cytochrome P450 enzymes (CYP or P450) 46A1 and 27A1 play important roles in cholesterol elimination from the brain and retina, respectively, yet they have not been quantified in human organs because of their low abundance and association with membrane. On the basis of our previous development ...
Proteomic Signature of Apolipoprotein J in the Early Phase of New-Onset Myocardial Infarction
07-01-2011 | Judit Cubedo; Teresa Padró; Xavier García-Moll; Xavier Pintó; Juan Cinca; Lina Badimon, Journal of Proteome Research, 2011
Acute myocardial infarction (AMI) is one of the major causes of mortality and morbidity worldwide. Despite all the efforts, there is a lack of early markers for prevention, diagnosis, and treatment of ischemic syndromes. By applying a proteomic expression profiling approach to identify ...
Netmeeting
