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1,595 Newest Publications in journal of proteome research
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Metabolomics as a Potential New Approach for Investigating Human Reproductive Disorders
17-05-2013 | Frédérique Courant; Jean-Philippe Antignac; Fabrice Monteau; Bruno Le Bizec, Journal of Proteome Research, 2013
Metabolomics has been emerging for several years as a global chemical phenotyping approach offering fascinating descriptive capabilities for addressing life complexity. It facilitates the understanding of the mechanisms of biological and biochemical processes in complex systems and promises ...
Systemic Responses of Mice to Dextran Sulfate Sodium-Induced Acute Ulcerative Colitis Using 1H NMR Spectroscopy
17-05-2013 | Fangcong Dong; Lulu Zhang; Fuhua Hao; Huiru Tang; Yulan Wang, Journal of Proteome Research, 2013
The interplay between genetic mutation and environmental factors is believed to contribute to the etiology of inflammatory bowel disease (IBD). While focused attention has been paid to the aforementioned research, time-specific and organ-specific metabolic changes associated with IBD are ...
Understanding the Biological Context of NS5A–Host Interactions in HCV Infection: A Network-Based Approach
17-05-2013 | Lokesh P. Tripathi; Hiroto Kambara; Yi-An Chen; Yorihiro Nishimura; Kohji Moriishi; Toru Okamoto; Eiji Morita; Takay ..., Journal of Proteome Research, 2013
Hepatitis C virus (HCV) is a major cause of chronic liver disease. HCV NS5A protein plays an important role in HCV infection through its interactions with other HCV proteins and host factors. In an attempt to further our understanding of the biological context of protein interactions between ...
An Improved Stable Isotope N-Terminal Labeling Approach with Light/Heavy TMPP To Automate Proteogenomics Data Validation: dN-TOP
16-05-2013 | Diego Bertaccini; Sebastian Vaca; Christine Carapito; Florence Arsène-Ploetze; Alain Van Dorsselaer; Christine Scha ..., Journal of Proteome Research, 2013
In silico gene prediction has proven to be prone to errors, especially regarding precise localization of start codons that spread in subsequent biological studies. Therefore, the high throughput characterization of protein N-termini is becoming an emerging challenge in the proteomics and ...
Ultradepletion of Human Plasma using Chicken Antibodies: A Proof of Concept Study
16-05-2013 | Sock-Hwee Tan; Abidali Mohamedali; Amit Kapur; Mark S. Baker, Journal of Proteome Research, 2013
Human plasma arguably represents the most comprehensive version of the human proteome. Despite its immense theoretical discovery potential, plasma has many high and medium abundance proteins that mask low abundance protein disease biomarkers of relevance, making the discovery of novel ...
Application of Label-Free Shotgun nUPLC–MSE and 2-DE Approaches in the Study of Botrytis cinerea Mycelium
16-05-2013 | Raquel Gonzalez-Fernandez; Kerman Aloria; Jesus M Arizmendi; Jesus V. Jorrin-Novo, Journal of Proteome Research, 2013
The phytopathogenic fungus Botrytis cinerea infects more than different 200 plant species and causes substantial losses in numerous crops. The B05.10 and T4 wild-type strain genomes have been recently sequenced, becoming a model system for necrotrophic pathogens, as well as opening up new ...
A Combination of Transcriptomics and Metabolomics Uncovers Enhanced Bile Acid Biosynthesis in HepG2 Cells Expressing CCAAT/Enhancer-Binding Protein β (C/EBPβ), Hepatocyte Nuclear Factor 4α (HNF4α), and Constitutive Androstane Receptor (CAR)
15-05-2013 | Marina Blazquez; Aitor Carretero; James K. Ellis; Toby J. Athersuch; Rachel Cavill; Timothy M. D. Ebbels; Hector C. ..., Journal of Proteome Research, 2013
The development of hepatoma-based in vitro models to study hepatocyte physiology is an invaluable tool for both industry and academia. Here, we develop an in vitro model based on the HepG2 cell line that produces chenodeoxycholic acid, the main bile acid in humans, in amounts comparable to ...
MScDB: A Mass Spectrometry-centric Protein Sequence Database for Proteomics
14-05-2013 | Harald Marx; Simone Lemeer; Susan Klaeger; Thomas Rattei; Bernhard Kuster, Journal of Proteome Research, 2013
Protein sequence databases are indispensable tools for life science research including mass spectrometry (MS)-based proteomics. In current database construction processes, sequence similarity clustering is used to reduce redundancies in the source data. Albeit powerful, it ignores the ...
Methylation of γ-Carboxylated Glu (Gla) Allows Detection by Liquid Chromatography–Mass Spectrometry and the Identification of Gla Residues in the γ-Glutamyl Carboxylase
10-05-2013 | K. W. Hallgren; D. Zhang; M. Kinter; B. Willard; K. L. Berkner, Journal of Proteome Research, 2013
γ-Carboxylated Glu (Gla) is a post-translational modification required for the activity of vitamin K-dependent (VKD) proteins that has been difficult to study by mass spectrometry due to the properties of this negatively charged residue. Gla is generated by a single enzyme, the γ-glutamyl ...
Gut Microbiota Composition Modifies Fecal Metabolic Profiles in Mice
10-05-2013 | Ying Zhao; Junfang Wu; Jia V. Li; Ning-Yi Zhou; Huiru Tang; Yulan Wang, Journal of Proteome Research, 2013
The gut microbiome is known to be extensively involved in human health and disease. In order to reveal the metabolic relationship between host and microbiome, we monitored recovery of the gut microbiota composition and fecal profiles of mice after gentamicin and/or ceftriaxone treatments. ...
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