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525 Newest Publications in journal of molecular neuroscience
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Roles of Wnt/β-Catenin Signaling in Retinal Neuron-Like Differentiation of Bone Marrow Mesenchymal Stem Cells from Nonobese Diabetic Mice
15-11-2012 | Yue Xu, Zhifeng Gu, Biyu Shen, Guofeng Xu, Tianqiu Zhou, Jinxia Jiang, Jing Xing, Suzhe Liu, Man Li, Wei Tan, Guijua ..., Journal of Molecular Neuroscience, 2012
Recent studies have shown that mesenchymal stem cells (MSCs) are expected to become promising therapeutic agents for the treatment of diabetic retinopathy (DR); moreover, we previously demonstrated that bone marrow (BM)-MSCs from nonobese diabetic (NOD) mice (an ideal DR model) had abnormal ...
Neurotrophic Peptides, ADNF-9 and NAP, Prevent Alcohol-Induced Apoptosis at Midgestation in Fetal Brains of C57BL/6 Mouse
15-11-2012 | Youssef Sari, Jason M. Weedman, Maxwell Nkrumah-Abrokwah, Journal of Molecular Neuroscience, 2012
Prenatal alcohol exposure is known to induce fetal brain growth deficits at different embryonic stages. We focused this study on investigating the neuroprotective effects against alcohol-induced apoptosis at midgestation using activity-dependent neurotrophic factor (ADNF)-9, a peptide ...
Decompressive Hemicraniectomy Reduces Mortality in an Animal Model of Intracerebral Hemorrhage
14-11-2012 | R. Omary, D. Chernoguz, V. Lasri, R. R. Leker, Journal of Molecular Neuroscience, 2012
Decompressive hemicraniectomy (DHC) significantly reduces mortality in patients with large hemispheric ischemic strokes but has not been studied in intracranial hemorrhage (ICH). Male Sabra mice were subjected to large experimental ICH. The animals then underwent DHC or sham surgery. Early (1 ...
Associations Between EEG Beta Power Abnormality and Diagnosis in Cognitive Impairment Post Cerebral Infarcts
13-11-2012 | Yanping Wang, Xiaoling Zhang, Junjun Huang, Minchu Zhu, Qiaobing Guan, Chunfeng Liu, Journal of Molecular Neuroscience, 2012
Cerebral infarct is a common disease of older adults, which could increase the risk for cognitive impairment and dementia. Electroencephalogram (EEG) characteristics were analyzed to investigate the applied value in the assessment of cognitive impairment of the cerebral infarct patients. One ...
Extracellular Signal-Regulated Kinase 5 in the Cerebrospinal Fluid-Contacting Nucleus Contributes to Morphine Physical Dependence in Rats
11-11-2012 | Chun-Guang Wang, Yan-Ling Ding, Tian-Fang Zheng, Jing-Qiu Wei, He Liu, Yu-Feng Chen, Jia-You Wang, Li-Cai Zhang, Journal of Molecular Neuroscience, 2012
The cerebrospinal fluid-contacting nucleus (CSF-CN) may influence actual composition of the CSF for non-synaptic signal transmission via releasing or absorbing bioactive substances, which distributes and localizes in the ventral periaqueductal central gray of the brainstem. Previous studies ...
Protective Effects of BDNF Overexpression Bone Marrow Stromal Cell Transplantation in Rat Models of Traumatic Brain Injury
10-11-2012 | Zhitao Wang, Weifeng Yao, Quanjun Deng, Xiaohui Zhang, Jianning Zhang, Journal of Molecular Neuroscience, 2012
Bone marrow stromal cells (MSCs) were used as cell therapy for various diseases in recent years. Some reports showed that transplanted MSCs promote functional recovery in animal models of brain trauma. But other studies indicate that tissue replacement by this method may not be the main ...
The Role of C-Terminal Binding Protein 2 in Schwann Cell Differentiation After Sciatic Nerve Crush
09-11-2012 | Xingjian Cao, Ping Zhao, Guohua Tao, Yihua Zhu, Feng Zhou, Zhiming Cui, Guofeng Bao, Dawei Xu, Guowei Zhang, Xiang Chen, Journal of Molecular Neuroscience, 2012
C-terminal binding protein 2 (CtBP2), as a transcriptional repressor, plays an essential role in development and tumorigenesis. However, its distribution and function in peripheral system lesion and repair are still unknown. Here, we investigated the spatiotemporal expression of CtBP2 in rat ...
Simultaneous Inhibition of COX-2 and Activation of PPAR-γ Resulted in the Same Level and Pattern of Neuroprotection as They were Targeted Separately
06-11-2012 | Shahnaz Babaei Abraki, Leila Khalaj, Fatemeh Shaerzadeh, Fariba Khodagholi, Journal of Molecular Neuroscience, 2012
The inflammatory response is an immune response of the body when exposed to internal and external stimuli. Cyclooxygenases (COX) are major inflammatory mediators implicated in inflammation. COX-2 is reported to be involved in neuroinflammation. Moreover, 15-Deoxy-d 12,14-prostaglandin J2 ...
Influence of Intra- and Extracellular Acidification on Free Radical Formation and Mitochondria Membrane Potential in Rat Brain Synaptosomes
05-11-2012 | Tatyana G. Pekun, Valeriya V. Lemeshchenko, Tamara I. Lyskova, Tatyana V. Waseem, Sergei V. Fedorovich, Journal of Molecular Neuroscience, 2012
Brain ischemia is accompanied by lowering of intra- and extracellular pH. Stroke often leads to irreversible damage of synaptic transmission by unknown mechanism. We investigated an influence of lowering of pHi and pHo on free radical formation in synaptosomes. Three models of acidosis were ...
Scavenger Receptor A Deficiency Accelerates Cerebrovascular Amyloidosis in an Animal Model
30-10-2012 | Veronica Lifshitz, Ronen Weiss, Hilit Levy, Dan Frenkel, Journal of Molecular Neuroscience, 2012
Cerebrovascular amyloidosis caused by amyloid accumulation in blood vessel walls may lead to hemorrhagic stroke and cognitive impairment. Expression of TGF-β1 under glial fibrillary acidic protein promoter in mice leads to age-related deposition of amyloid, including β-amyloid (Aβ), around ...
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