09-04-2012 | Sushanta K. Banerjee, Snigdha Banerjee, Journal of Cell Communication and Signaling, 2012

The gain of plasticity by a subset of cancer cells is a unique but common sequence of cancer progression from epithelial phenotype to mesenchymal phenotype (EMT) that is followed by migration, invasion and metastasis to a distant organ, and drug resistance. Despite multiple studies, it is ...

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30-03-2012 | Bernard Perbal, International CCN Society, Journal of Cell Communication and Signaling, 2012

There is increasing evidence that metalloproteinases are involved in neuropathic pain [Dev et al., Expert Opin Investig Drugs 19:455–468 2010] Hence, the identification of molecules that can regulate MMP9 and MMP2 is warranted. In a recent publication, Kular et al. (2012) claim that CCN3 ...

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18-03-2012 | Véronique Ouellet, Peter M. Siegel, Journal of Cell Communication and Signaling, 2012

The CCN family of proteins is composed of six secreted proteins (CCN1-6), which are grouped together based on their structural similarity. These matricellular proteins are involved in a large spectrum of biological processes, ranging from development to disease. In this review, we focus on ...

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15-03-2012 | Andrew Leask, Journal of Cell Communication and Signaling, 2012

Fibrosis is a major cause of end-stage renal disease (ESRD) a progressive loss in renal function that occurs over a period of months or years, is characterized by a decreased capability of the kidneys to excrete waste products. There is no specific treatment unequivocally shown to slow the ...

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16-02-2012 | Elizabeth F. Martinez, Pollyanna T. Montaldi, Ney S. de Araújo, Albina Altemani, Vera C. de Araújo, Journal of Cell Communication and Signaling, 2012

A proposal of an in vitro model which mimics in situ areas of carcinoma Content Type Journal Article Category Report Pages 1-3 DOI 10.1007/s12079-012-0159-1 Authors Elizabeth F. Martinez, Laboratory of Oral Pathology, São Leopoldo Mandic Institute and Research Center, R. José ...

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15-02-2012 | Andrew Leask, Journal of Cell Communication and Signaling, 2012

Scleroderma, an autoimmune disorder characterized by skin and organ fibrosis, has no treatment. Although over the past decade valuable insights into the molecular mechanisms underlying scleroderma have been generated, results in clinical trials have been disappointing. This issue is likely to ...

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07-01-2012 | Logan A. Walsh, Mario A. Cepeda, Sashko Damjanovski, Journal of Cell Communication and Signaling, 2012

Matrix metalloproteinases (MMPs) are secreted endopeptidases that play an essential role in remodeling the extracellular matrix (ECM). MMPs are primarily active during development, when the majority of ECM remodeling events occurs. In adults, elevated MMP activity has been observed in many ...

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30-11-2011 | Bernard Perbal, Journal of Cell Communication and Signaling, 2011

ICCNS-sponsored meetings Content Type Journal Article Category Editorial Pages 1-2 DOI 10.1007/s12079-011-0155-x Authors Bernard Perbal, President of the ICCNS, Paris, France Journal Journal of Cell Communication and Signaling Online ISSN 1873-961X Print ISSN ...

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15-11-2011 | Andrew Leask, Journal of Cell Communication and Signaling, 2011

Meeting report: novel targets for cancer and connective tissues diseases Content Type Journal Article Category Report Pages 1-2 DOI 10.1007/s12079-011-0153-z Authors Andrew Leask, Departments of Dentistry and Physiology and Pharmacology, University of Western Ontario, London, ON, ...

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13-08-2011 | Journal of Cell Communication and Signaling, 2011

Abstract Living cells communicate with their microenvironment and exchange information through signaling pathways in order to carry out most biological processes. The CCN family of proteins has the ability to coordinate the extracellular and intracellular signaling pathways and ...

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