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138 Newest Publications in journal of cell communication and signaling
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Immunosuppression for interstitial lung disease in systemic sclerosis – novel insights and opportunities for translational research
04-08-2012 | Marie Hudson, Russell Steele, Canadian Scleroderma Research Group, Murray Baron, Journal of Cell Communication and Signaling, 2012
Immunosuppression for interstitial lung disease in systemic sclerosis – novel insights and opportunities for translational research Content Type Journal Article Category Commentary Pages 1-4 DOI 10.1007/s12079-012-0172-4 Authors Marie Hudson, Jewish General Hospital, Lady Davis ...
A common response to common danger? Comparison of animal and plant signaling pathways involved in cadmium sensing
04-08-2012 | Jagna Chmielowska-Bąk, Joanna Deckert, Journal of Cell Communication and Signaling, 2012
Exposure to cadmium results in disturbances in cell homeostasis in all living organisms. The first response to stress factors, including cadmium, is activation of signal transduction pathways that mobilize cell defense mechanisms. The aim of this review is a comparison between the signaling ...
Receptor type protein tyrosine phosphatases (RPTPs) – roles in signal transduction and human disease
31-07-2012 | Yiru Xu, Gary J. Fisher, Journal of Cell Communication and Signaling, 2012
Protein tyrosine phosphorylation is a fundamental regulatory mechanism controlling cell proliferation, differentiation, communication, and adhesion. Disruption of this key regulatory mechanism contributes to a variety of human diseases including cancer, diabetes, and auto-immune diseases. Net ...
CCN1 and CCN2: blood brothers in angiogenic action
26-07-2012 | Lester F. Lau, Journal of Cell Communication and Signaling, 2012
CCN2/connective tissue growth factor (CTGF) is a matricellular protein essential for skeletal development during embryogenesis. In adulthood, aberrant CCN2 expression is associated with many malignancies and fibrosis of virtually every organ. Despite its prominent expression in endothelial ...
Apoptotic potential of Fas-associated death domain on regulation of cell death regulatory protein cFLIP and death receptor mediated apoptosis in HEK 293T cells
12-07-2012 | Kishu Ranjan, Avadhesha Surolia, Chandramani Pathak, Journal of Cell Communication and Signaling, 2012
Fas-associated death domain (FADD) is a common adaptor molecule which plays an important role in transduction of death receptor mediated apoptosis. The FADD provides DED motif for binding to both procaspase-8 and cFLIP molecules which executes death receptor mediated apoptosis. Dysregulated ...
Erratum to: CCN3: the-pain-killer inside me
11-07-2012 | Bernard Perbal, Journal of Cell Communication and Signaling, 2012
Erratum to: CCN3: the-pain-killer inside me Content Type Journal Article Category Erratum Pages 1-1 DOI 10.1007/s12079-012-0167-1 Authors Bernard Perbal, International CCN Society, Paris, France Journal Journal of Cell Communication and Signaling Online ISSN ...
Integrin β1 is required for maintenance of vascular tone in postnatal mice
06-07-2012 | Shangxi Liu, Andrew Leask, Journal of Cell Communication and Signaling, 2012
Connective tissue is required for maintaining the integrity of tissues. Integrins are the cell surface receptors responsible for cell attachment to extracellular matrix; however, their tissue-specific role in this process is poorly understood. Here, we test whether integrin β1 is required for ...
A pathway map of prolactin signaling
09-06-2012 | Aneesha Radhakrishnan, Rajesh Raju, Nirvana Tuladhar, Tejaswini Subbannayya, Joji Kurian Thomas, Renu Goel, Deepthi ..., Journal of Cell Communication and Signaling, 2012
A pathway map of prolactin signaling Content Type Journal Article Category Technical Report Pages 1-5 DOI 10.1007/s12079-012-0168-0 Authors Aneesha Radhakrishnan, Institute of Bioinformatics, International Tech Park, Bangalore, 560 066 India Rajesh Raju, Institute of ...
Gadolinium-induced fibrosis is counter-regulated by CCN3 in human dermal fibroblasts: a model for potential treatment of nephrogenic systemic fibrosis
31-05-2012 | Bruce L. Riser, Narasimharao Bhagavathula, Patricia Perone, Kendra Garchow, Yiru Xu, Gary J. Fisher, Feridoon Najmab ..., Journal of Cell Communication and Signaling, 2012
We recently show that CCN3 is a counter-regulatory molecule for the pro-fibrotic protein CCN2, and a potentially novel fibrosis therapy. The goal of this study was to assess the role of CCN3 in fibroproliferative/fibrotic responses in human dermal fibroblasts exposed to Omniscan, one of the ...
Molecular mechanisms underlying the fetal programming of adult disease
24-05-2012 | Thin Vo, Daniel B. Hardy, Journal of Cell Communication and Signaling, 2012
Adverse events in utero can be critical in determining quality of life and overall health. It is estimated that up to 50 % of metabolic syndrome diseases can be linked to an adverse fetal environment. However, the mechanisms linking impaired fetal development to these adult diseases remain ...
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