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399 Newest Publications in glycobiology
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Annotation and structural elucidation of bovine milk oligosaccharides and determination of novel fucosylated structures
01-06-2013 | Danielle L Aldredge; Maria R Geronimo; Serenus Hua; Charles C Nwosu; Carlito B Lebrilla; Daniela Barile, Glycobiology , 2013
Bovine milk oligosaccharides (BMOs) are recognized by the dairy and food industries, as well as by infant formula manufacturers, as novel, high-potential bioactive food ingredients. Recent studies revealed that bovine milk contains complex oligosaccharides structurally related to those ...
Inhibition of galectin-3 reduces atherosclerosis in apolipoprotein E-deficient mice
01-06-2013 | Alison C MacKinnon; Xiaojun Liu; Patrick WF Hadoke; Mark R Miller; David E Newby; Tariq Sethi, Glycobiology , 2013
Atherosclerosis is a major risk factor for cardiovascular disease (CVD) and stroke. Galectin-3 is a carbohydrate-binding lectin implicated in the pathophysiology of CVD and is highly expressed within atherosclerotic lesions in mice and humans. The object of this present study was to use ...
Advanced mass spectrometry and chemical analyses reveal the presence of terminal disialyl motif on mouse B-cell glycoproteins
01-06-2013 | Shui-Hua Wang; Chih-Ming Tsai; Kuo-I Lin; Kay-Hooi Khoo, Glycobiology , 2013
The occurrence of a terminal disialyl motif on mammalian O-glycans is increasingly being identified through recent mass spectrometry (MS)-based glycomic profiling. In most cases, it is carried on simple core 1 structures in which both the galactose and N-acetyl galactosamine can be ...
Endothelial heterogeneity and adhesion molecules N-glycosylation: Implications in leukocyte trafficking in inflammation
01-06-2013 | David W Scott; Rakesh P Patel, Glycobiology , 2013
Inflammation is a major contributing element to a host of diseases with the interaction between leukocytes and the endothelium being key in this process. Much is understood about the nature of the adhesion molecule proteins expressed on any given leukocyte and endothelial cell that modulates ...
Overexpression of Sulf2 in idiopathic pulmonary fibrosis
01-06-2013 | Xinping Yue; Jingning Lu; Linda Auduong; Mark D Sides; Joseph A Lasky, Glycobiology , 2013
Previously, we have shown that heparan sulfate (HS) 6-O-endosulfatase 1 (Sulf1) is a transforming growth factor-β1 (TGF-β1)-responsive gene in normal human lung fibroblasts and functions as a negative feedback regulator of TGF-β1 and that TGF-β1 induces the expression of Sulf1 as well as ...
Occurrence of free deaminoneuraminic acid (KDN)-containing complex-type N-glycans in human prostate cancers
01-06-2013 | Masahiko Yabu; Hiroaki Korekane; Koji Hatano; Yasufumi Kaneda; Norio Nonomura; Chihiro Sato; Ken Kitajima; Yasuhide ..., Glycobiology , 2013
We previously reported on the accumulation of a substantial amount of free N-acetylneuraminic acid (Neu5Ac)-containing complex-type N-glycans in human pancreatic cancer cells (Yabu M, Korekane H, Takahashi H, Ohigashi H, Ishikawa O, Miyamoto Y. 2013. Accumulation of free Neu5Ac-containing ...
A non-enzymatic function of Golgi glycosyltransferases: Mediation of Golgi fragmentation by interaction with non-muscle myosin IIA
01-06-2013 | Armen Petrosyan; Pi-Wan Cheng, Glycobiology , 2013
The Golgi apparatus undergoes morphological changes under stress or malignant transformation, but the precise mechanisms are not known. We recently showed that non-muscle myosin IIA (NMIIA) binds to the cytoplasmic tail of Core 2 N-acetylglucosaminyltransferase mucus-type (C2GnT-M) and ...
Mucin-type fusion proteins with blood group A or B determinants on defined O-glycan core chains produced in glycoengineered Chinese hamster ovary cells and their use as immunoaffinity matrices
01-06-2013 | Linda Lindberg; Jining Liu; Stefan Gaunitz; Anki Nilsson; Tomas Johansson; Niclas G Karlsson; Jan Holgersson, Glycobiology , 2013
Assays for quantification, and methods for removal, of anti-A and anti-B antibodies are the key for the success of ABO incompatible organ transplantation programs. In order to produce tools that can be used as substrates in tests for anti-A/anti-B quantification and specificity determination ...
Expression of Shiga toxin 2e glycosphingolipid receptors of primary porcine brain endothelial cells and toxin-mediated breakdown of the blood–brain barrier
01-06-2013 | Iris Meisen; Regina Rosenbrück; Hans-Joachim Galla; Sabine Hüwel; Ivan U Kouzel; Michael Mormann; Helge Karch; Johan ..., Glycobiology , 2013
Shiga toxin (Stx) 2e, released by certain Stx-producing Escherichia coli, is presently the best characterized virulence factor responsible for pig edema disease, which is characterized by hemorrhagic lesions, neurological disorders and often fatal outcomes. Although Stx2e-mediated brain ...
Identification and characterization of endo-{beta}-N-acetylglucosaminidase from methylotrophic yeast Ogataea minuta
01-06-2013 | Satoshi Murakami; Yuki Takaoka; Hisashi Ashida; Kenji Yamamoto; Hisashi Narimatsu; Yasunori Chiba, Glycobiology , 2013
In four yeast strains, Ogataea minuta, Candida parapolymorpha, Pichia anomala and Zygosaccharomyces rouxii, we identified endo-β-N-acetylglucosaminidase (ENGase) homologous sequences by database searches; in each of the four species, a corresponding enzyme activity was also confirmed in ...
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